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All Journal Jurnal Kesehatan Andalas Sari Pediatri Paediatrica Indonesiana Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) International Journal of Medicine and Health Jurnal Riset Ilmiah Frontiers on Healthcare Research
Amirah Zatil Izzah
Bagian Ilmu Kesehatan Anak FK Unand/RSUP Dr. M. Djamil Padang
Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Paediatrica Indonesiana

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Relationship between serum ferritin and zinc levels in patients with major thalassemia Hervita Yeni; Finny Fitry Yani; Amirah Zatil Izzah; Gustina Lubis
Paediatrica Indonesiana Vol 59 No 3 (2019): May 2019
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (244.731 KB) | DOI: 10.14238/pi59.3.2019.144-9

Abstract

Background In thalassemia patients, reduced zinc absorption results from increased serum iron due to repeated blood transfusions, increased iron absorption due to ineffective erythropoiesis, and competitive inhibition between iron and zinc in binding to transferrin, a means of transporting both types of minerals in the blood. Few studies have been done to examine zinc levels in thalassemia patients and its relationship with ferritin. Objective To compare serum zinc in thalassemia patients and healthy controls and to assess for a possible correlation between serum ferritin and zinc in thalassemia patients. Methods This cross-sectional study in 68 subjects was done from October 2016 to August 2017. Serum ferritin measured by chemiluminescence immunoassay and serum zinc by inductively coupled plasma mass spectrometry (ICP-MS). Wilcoxon test was used to analyze for differences between serum zinc in thalassemia patients and controls. Spearman’s correlation test was used to analyze for a possible correlation between ferritin and serum zinc in thalassemia patients. Results There were 34 patients with thalassemia and 34 healthy control subjects. The median serum zinc was 119.34 µg/dL (IQR=71.27) in the thalassemia group and 120.08 µg/dL (IQR=26.28) in the control group (P=0.36). There was no significant correlation between serum ferritin and zinc in thalassemic children (r=-0.023; P=0.895). Conclusion There is no significant difference in serum zinc levels between thalassemic children and healthy controls. There is no significant correlation between serum ferritin and zinc in thalassemic children.
Troponin-I and left ventricular function in pediatric high-risk acute lymphoblastic leukemia after daunorubicin treatment Rinche Annur; Didiko Hariyant; Amirah Zatil Izzah
Paediatrica Indonesiana Vol 61 No 2 (2021): March 2021
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi61.2.2021.107-14

Abstract

Background Daunorubicin is a chemotherapy drug for leukemia treatment, but it can cause cardiotoxicity. When heart damage occurs, myocardial sarcomeres release troponin-I, which could potentially be useful as a cardiotoxicity biomarker. Objective To assess for possible correlations between troponin-I and echocardiographic parameters of left ventricular function after administration of daunorubicin in children with high-risk acute lymphoblastic leukemia (ALL). Methods This cross-sectional study on 37 children with high-risk ALL was performed from July 2017 to December 2018, in Padang, West Sumatera. The left ventricular systolic function parameters measured were ejection fraction (EF) and fractional shortening (FS); the left ventricular diastolic function parameter was E/A ratio. Troponin-I measurements and echocardiography were performed after daunorubicin treatment at the end of induction phase chemotherapy. Pearson’s correlation test was used to analyze for a correlation between troponin-I and echocardiographic parameters. Results Subjects had a mean age of 6.27 (SD 4.43) years, and males comprised 56.8%. Subjects’ mean troponin-I concentration was 5.49 (SD 0.86) ng/mL, and mean EF, FS, and E/A values were 65 (SD 5) %, 36 (SD 4) %, and 1.52 (SD 0.56), respectively. Troponin-I was not significantly correlated with EF (r=0.062; P=0.715) or FS (r=0.309; P=0.172). However, there was a weak, significant negative correlation between troponin-I and E/A ratio (r=-0.383; P=0.019). Conclusion Troponin-I level has no significant correlations with the echocardiographic parameters of left ventricular systolic function. However, there is a weak significant negative correlation between troponin-I level and the left ventricular diastolic parameter of E/A ratio.
Co-Authors Abdurrahman Arsyad As Siddiqi Alkamdani, Riki Amelin, Fitrisia Andani Eka Putra Anggi Setiawan Anggia Perdana Harmen Anggraini, Syahzalya As Siddiqi, Abdurrahman Arsyad Asrawati Asrawati, Asrawati Bari'ah, Puti Asma Didik Hariyanto Didiko Hariyant Dwitya Elvira, Dwitya Efrida Efrida, Efrida Eka Agustia Rini Eny Yantri Fadil Oenzil Farid I Hussein Fika Tri Anggraini Finny Fitry Yani Firman Arbi Firman Arbi Gustina Lubis Gustina Lubis Hanif, Rayhendra Hervita Yeni Hervita Yeni Ihsan, Indra Indra Ihsan Iskandar Syarif Julispen Syafruddin Muhi Laila Isrona Laksono Trisnantoro Masnadi, Nice Rachmawati Mayang Permata Sari Mayetti Mayetti Melisha Lisman Gaya Miftahul Fikrah Netti Suharti, Netti Nice Rachmawati Masnadi Nivolla, Rhona Nova Linda Nur Indrawaty Lipoeto Nurhayati Nurhayati Prima Astuti Handayani Rahmatini . Raniathia Frieska Ratno Widoyo, Ratno Rinang Mariko, Rinang Rinche Annur Rismawati Yaswir Rizki Rahmadian Rosfita Rasyid Rudy Afriant Russilawati, Russilawati Sherly Vanessa Putri Hadiyanto Shinta Ayudhia Siti Nurhajjah Yoga Gandha Prasetya Yulfiwanti, Idha Yusri Dianne Jurnalis Yustini Alioes Zahira, Aisyah Dhia zahra salsabila Zelly Dia Rofinda