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All Journal ACTA VETERINARIA INDONESIANA Jurnal Veteriner Jurnal Ilmiah Ilmu-Ilmu Peternakan Jurnal Kedokteran Hewan The International Journal of Tropical Veterinary and Biomedical Research Jurnal Medika Veterinaria
Henni Vanda
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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POTENTIAL ANTIVIRAL OF CATECHINS AND THEIR DERIVATIVES TO INHIBIT SARS-COV-2 RECEPTORS OF M pro PROTEIN AND SPIKE GLYCOPROTEIN IN COVID-19 THROUGH THE IN SILICO APPROACH Frengki, Frengki; Putra, Deddi Prima; Wahyuni, Fatma Sri; Khambri, Daan; Vanda, Henni; Sofia, Vivi
Jurnal Kedokteran Hewan Vol 14, No 3 (2020): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v14i3.16652

Abstract

Catechin and their derivatives have been studied to have antiviral potential against COVID-19 through in silico method pharmacokinetics screening and molecular docking. Pharmacokinetics and toxicity profiles were obtained through the ADMETSAR server and SwissADME server. Then proceed with the prediction of affinity through the method molecular docking using the software application MOE 2007.09. The testmaterial is in the form of a 3D catechin structure and its derivatives as well as several control ligands downloaded via Pubmed. While templatethe Receptor M pro protein and the Spike glycoprotein are downloaded from pdb.org (PDB ID: 6LU7 and 6LXT). The pharmacokinetic profile of catechins is relatively better than all control ligands with the lowest toxicity. Molecular docking results also show that catechins and theirderivatives have a stronger affinity than control ligands. This research proves that catechin has antiviral potential through inhibition of Mpro protein and Spike glycoprotein COVID-19 virus.
Co-Authors Abu Hassan Ahmad Ahmad Khairi Abadi Akram, Saydul Amalia Sutriana Azhar, Nurul Sakinah Daan Khambri Daniel Daniel Daulay, Dina Khairani Deddi Prima Putra Dian Masyitha Dwinna Aliza Ellyawardani Ellyawardani Erdiansyah Rahmi Erdiansyah Rahmi Farida Athailah Farida Athaillah Farida Athaillah Fatma Sri Wahyuni FRENGKI FRENGKI Frengki Frengki, Frengki Khairunisa, Fauzia M. Hanafiah M. Nur Salim Muhammad Hambal Muhammad Hambal Muhammad Hambal Muhammad Hasan Muhammad Isa Musni, Nailah Mustafa Sabri Muttaqien Bakri Muttaqien Muttaqien, Muttaqien NURLIANA NURLIANA Nuzul Asmilia Paula, Wita Rasmaidar Rasmaidar Rizka Ayuni Rosmaidar Rosmaidar, Rosmaidar Sari, Wahyu Eka Sugito - T Armansyah TR Teuku Reza Ferasyi Vivi Sofia Yudha Fahrimal Zainuddin, Zainuddin Zakya Ardi Zulfayanto, Indri