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UJI PENENTUAN NILAI SPF (Sun Protection Factor) FRAKSI BUNGA ROSELA (Hibiscus Sabdariffa L.) SEBAGAI ZAT AKTIF TABIR SURYA Vivin Nopiyanti; Siti Aisiyah
Jurnal Farmasi (Journal of Pharmacy) Vol 9, No 1 (2020): Maret
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v9i1.99

Sun Protection Factor atau SPF didefinisikan sebagai perbandingan antara banyaknya energi sinar surya (dalam hal ini UV-B) yang dibutuhkan untuk menimbulkan eritema minimal pada kulit yang dilindungi tabir surya dengan yang tidak dilindungi tabir surya. Bunga rosela mengandung flavonoid, antosian, dan polifenol. Senyawa flavonoid mempunyai potensi sebagai tabir surya karena memiliki gugus kromofor (ikatan rangkap tunggal terkonjugasi) yang mampu menyerap sinar UV-A maupun UV-B sehingga mengurangi intensitas pada kulit. Penelitian ini dilakukan untuk mengetahui berapa nilai SPF dari fraksi n-heksana, fraksi etil asetat dan fraksi air dari bunga rosela. Dan diketahui fraksi yang mempunyai nilai SPF tertinggi yang bisa dimanfaatkan sebagai tabir surya. Bunga rosela dibuat ekstrak kemudian difraksinasi dengan pelarut n-heksana, etil asetat dan air. Fraksi yang dihasilkan berupa fraksi n-heksana, fraksi etil asetat dan fraksi air serta ekstrak tersebut diukur nilai SPF nya. Pengukuran SPF dapat dilakukan secara in vitro dengan menggunakan spektrofotometri UV- Vis. Pengujian secara in vitro berguna untuk tes pendahuluan dalam proses pengembangan produk tabir surya.Nilai SPF dari ekstrak etanol 70%, fraksi n-heksana, fraksi etil asetat dan fraksi air dari ekstrak bunga rosela yaitu berturut-turut 6,63±0,23; 10,11±0,61; 13,83±1,50; 11,15±0,47. Fraksi etil asetat adalah fraksi yang mempunyai nilai SPF tertinggi yang bisa dimanfaatkan sebagai tabir surya.

Determination of SPF value in Serum Preparation of Ethyl acetat fraction ethanol extract of Roselle Petals (Hibiscus sabdarifa L.) Vivin Nopiyanti; Reslely Harjanti; Siti Aisiyah
Jurnal Farmasi (Journal of Pharmacy) Vol 11, No 1 (2022)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v11i1.163

The ethyl acetate fraction of the ethanol extract of roselle flower petals (Hibiscus sabdariffa L.) was reported to have an SPF value of 13.83 ± 1.50 which was higher than the ethanol extract. So with the SPF value, the ethyl acetate fraction of roselle flower ethanol extract can be used as a sunscreen. One of the cosmetic preparations that is currently growing rapidly is serum. The purpose of this study was to formulate the ethyl acetate fraction of roselle petals into a serum that had good physical quality with variations in the concentration of xanthan gum and then the SPF value was determined. This research begins with the manufacture of ethanol extract of roselle petals. Then fractionation (liquid-liquid partition) was carried out using solvents with different polarities, namely n-hexane and ethyl acetate. Furthermore, the ethyl acetate fraction was formulated into serum with variations in the concentration of xanthan gum 0.3%, respectively; 0.6% and 1.2% were then tested for physical quality and stability. The next step is to determine the SPF value of the serum by using the UV spectrophotometric method and its calculation using the Mansur equation. The results showed that the serum ethyl acetate fraction of the ethanolic extract of roselle petals could be made into gel preparations with good physical qualities including organoleptic, viscosity, pH and homogeneity. Serum ethyl acetate fraction ethanol extract of roselle flower formulas 1, 2 and 3 had SPF values F1 respectively, namely 6.8595 ± 0.08 which included moderate protection potential; F2 is 7.0089 ± 0.17; and F3 which is 8.2251 ± 0.32 with extra protection potential. Variations in the concentration of xanthan gum in the serum formula affect the physical quality of the viscosity and potency of sunscreen preparations..

FORMULATION AND TEST OF ANTIBACTERIAL Staphylococcus aureus PAPERSOAP SOURSOP’S LEAVES EXTRACT (Annona muricata L.) WITH VARIATIONS OF GLYCERIN AS PLASTICIZER Vivin Nopiyanti; Din Samsudin; Anita Nilawati
Jurnal Farmasi (Journal of Pharmacy) Vol 11, No 2 (2022)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v11i2.208

Papersoap is a thin printed solid soap product as a unique innovation because it resembles paper. Soursop leaves contain flavonoid compounds, tannins, alkaloids and saponins that are useful as antibacterial. preparations papersoap with soursop leaf extract require glycerin as a plasticizer is believed to produce good physicochemical properties. This study aims to determine the physical quality of papersoap from the effect of soursop leaf extract and variations of glycerin and to test the antibacterial activity of the Papersoap against Staphylococcus aureus ATCC 25923.Soursop leaf extract was obtained by maceration method with 96% ethanol as solvent. The concentration of soursop leaf extract 5% was formulated into papersoap with three variations of glycerin formula, namely 10%, 15%, and 20%.preparation papersoap includes organoleptic, pH, homogeneity, foam stability, water content, and free alkali tests which have passed the curing for two weeks as the preparation evaluation stage. Antibacterial activity test against Staphylococcus aureus ATCC 25923 using well diffusion method. The data obtained were processed using Shapiro-wilk, one way ANOVA/Kruskal.The results showed that the formula of the papersoap preparation of soursop leaf ethanol extract (Annona muricata L.) with glycerin variations can provide differences in the physical quality of papersoap preparations and have an inhibitory diameter against Staphylococcus aureus bacteria ATCC 25923 successively 25.26; 24,67; 23.47 mm

Uji Penentuan Nilai SPF (Sun Protection Factor) Fraksi Bunga Rosela (Hibiscus Sabdariffa L.) Sebagai Zat Aktif Tabir Surya Nopiyanti, Vivin; Aisiyah , Siti
Jurnal Farmasi (Journal of Pharmacy) Vol. 9 No. 1 (2020): Jurnal Farmasi (Journal of Pharmacy), April 2020
Publisher : Jurnal Farmasi (Journal of Pharmacy)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Sun Protection Factor or SPF is defined as the ratio between the amount of sunlight energy (in this case UV-B) needed to cause minimal erythema on sun-protected skin with the amount of energy needed to cause minimal erythema on skin that is not protected by sunscreen. Rosela flowers contain flavonoids, anthocyanes, and polyphenols. Flavonoids compound have the potential as sunscreens because they have a chromophore group (single conjugated double bond) that is able to absorb UV-A and UV-B rays so that it reduces the intensity of the skin. This research was conducted to find out the SPF value of the n-hexane fraction, the ethyl acetate fraction and the water fraction from the rosela flower. And it is known that the faction that has the highest SPF value can be used as sunscreen. Rosela flower extract then fractionated with n hexane, ethyl acetate and water solvents. The resulting fractions in the form of n-hexane fraction, ethyl acetate fraction and water and extract fractions were measured for their SPF values. SPF measurements can be done in vitro using UV-Vis spectrophotometry. In vitro testing was useful for preliminary tests in the process of developing sunscreen products. The SPF value of the extract, the n-hexane fraction, the ethyl acetate fraction and the water fraction from the rosela flower extract, respectively 6,63±0,23; 10,11±0,61; 13,83±1,50; 11,15±0,47. The ethyl acetate fraction was the fraction that has the highest SPF value that can be used as a sunscreen.

Formulasi Dan Uji Aktivitas Tabir Surya Gel Kitosan Menggunakan Karbopol 940 Dan Hpmc K100 Sebagai Gelling Agent Ahmad Fahrezi, Mukhlis; Nopiyanti, Vivin; Priyanto, Widodo
Jurnal Farmasi (Journal of Pharmacy) Vol. 10 No. 1 (2021): Jurnal Farmasi (Journal of Pharmacy), April 2021
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Ultraviolet (UV) radiation can penetrate the epidermis layer of the skin so that it can irritate and damage skin tissue. Chitosan containing chitin compounds has the potential to provide protection against ultraviolet (UV) exposure. This study aims to determine the activity of chitosan gel sunscreen seen from the SPF value, the influence of the use of variations in concentration in a combination of carbopol and HPMC as a gelling agent on the activity of chitosan gel sunscreens, concentration variations in the combination of carbopol and HPMC which are able to provide good physical properties and gel stability. The variation of concentration in the combination of carbopol and HPMC as a gelling agent was made into 3 formulas, F1 (100% carbopol: 0% HPMC), F2 (50% carbopol: 50% HPMC), F3 (0% carbopol: 100% HPMC). Chitosan gel sunscreen activity test was carried out with the SPF (Sun Protection Factor) test using UV-VIS spectrophotometry. The SPF value price is calculated using the mansyur method. SPF test results were statistically analyzed using One Way ANOVA. SPF test results from variations in concentration in a combination of carbopol and HPMC as a gelling agent, F1 (9,091348), F2 (5,419107), F3 (6,437869). SPF test results that were statistically analyzed using One Way ANOVA showed that all the data tested were significantly different from the most active formula, F1 (100% carbopol: 0% HPMC) with the SPF value price 9,091348.

Uji Aktivitas Antihiperglikemia Ekstrak Etanol Daun Delima Putih (Punica granatum L.) pada Mencit Jantan (Mus musculus L.) yang Diinduksi Aloksan Pangesti, Clara; Nopiyanti, Vivin; Hayu Widyasti, Jena
Jurnal Farmasi (Journal of Pharmacy) Vol. 10 No. 2 (2021): Jurnal Farmasi (Journal of Pharmacy), October 2021
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Pomegranate leaves (Punica granatum L.) contain flavonoids as a decrease in blood glucose levels and prevent tissue damage due to oxidative stress. This study aims to determine the effect of white pomegranate leaf ethanol extract on blood glucose levels, body weight, and the effective dose of white pomegranate leaf ethanol extract in reducing blood glucose levels in mice induced by alloxan. A total of 30 male mice were divided into 6 treatment groups, namely group I (normal), group II (negative control of CMC-Na 0.5%), group III (positive control of glibenclamide), group IV (extract 140 mg/Kg BW), group V (extract 280 mg/Kg BW) and group VI (extract 560 mg/Kg BW). The treatment was given for 14 days by measuring blood glucose levels and body weight on days 0, 3,10, and 17. The results of the analysis of blood glucose levels and body weight were carried out statistically through the Multivariate Test and Tukey Post Hoc test, while the decrease in glucose levels analyzed using One-Way Anova test and Tukey Post Hoc test. The results showed that the extract had antihyperglycemic activity in alloxan-induced mice. The ethanol extract of white pomegranate leaves at a dose of 280 mg/Kg BW had an effective antihyperglycemic activity compared to doses of 140 mg/Kg BW and 560 mg/Kg BW which were comparable to the positive control group.

Penentuan Nilai SPF pada Serum Fraksi Etil Asetat Ekstrak Etanol Kelopak Bunga Rosela (Hibiscus sabdarifa L.) Nopiyanti, Vivin; Harjanti, Reslely; Aisiyah, Siti
Jurnal Farmasi (Journal of Pharmacy) Vol. 11 No. 1 (2022): Jurnal Farmasi (Journal of Pharmacy), April 2022
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/0c0qrh09

The ethyl acetate fraction of the ethanol extract of roselle flower petals (Hibiscus sabdariffa L.) was reported to have an SPF value of 13.83 ± 1.50 which was higher than the ethanol extract. So with the SPF value, the ethyl acetate fraction of roselle flower ethanol extract can be used as a sunscreen. One of the cosmetic preparations that is currently growing rapidly is serum. The purpose of this study was to formulate the ethyl acetate fraction of roselle petals into a serum that had good physical quality with variations in the concentration of xanthan gum and then the SPF value was determined. This research begins with the manufacture of ethanol extract of roselle petals. Then fractionation (liquid-liquid partition) was carried out using solvents with different polarities, namely n-hexane and ethyl acetate. Furthermore, the ethyl acetate fraction was formulated into serum with variations in the concentration of xanthan gum 0.3%, respectively; 0.6% and 1.2% were then tested for physical quality and stability. The next step is to determine the SPF value of the serum by using the UV spectrophotometric method and its calculation using the Mansur equation. The results showed that the serum ethyl acetate fraction of the ethanolic extract of roselle petals could be made into gel preparations with good physical qualities including organoleptic, viscosity, pH and homogeneity. Serum ethyl acetate fraction ethanol extract of roselle flower formulas 1, 2 and 3 had SPF values F1 respectively, namely 6.8595 ± 0.08 which included moderate protection potential; F2 is 7.0089 ± 0.17; and F3 which is 8.2251 ± 0.32 with extra protection potential. Variations in the concentration of xanthan gum in the serum formula affect the physical quality of the viscosity and potency of sunscreen preparations.

FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI Staphylococcus aureus PAPERSOAP EKSTRAK DAUN SIRSAK (Annona muricata L.) DENGAN VARIASI GLISERIN SEBAGAI PLASTICIZER Samsudin, Din; Nopiyanti, Vivin; Nilawati, Anita
Jurnal Farmasi (Journal of Pharmacy) Vol. 11 No. 2 (2022): Jurnal Farmasi (Journal of Pharmacy), October 2022
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/xrkc0m26

Papersoap is a thin printed solid soap product as a unique innovation because it resembles paper. Soursop leaves contain flavonoid compounds, tannins, alkaloids and saponins that are useful as antibacterial. preparations papersoap with soursop leaf extract require glycerin as a plasticizer is believed to produce good physicochemical properties. This study aims to determine the physical quality of papersoap from the effect of soursop leaf extract and variations of glycerin and to test the antibacterial activity of the Papersoap against Staphylococcus aureus ATCC 25923. Soursop leaf extract was obtained by maceration method with 96% ethanol as solvent. The concentration of soursop leaf extract 5% was formulated into papersoap with three variations of glycerin formula, namely 10%, 15%, and 20%.preparation papersoap includes organoleptic, pH, homogeneity, foam stability, water content, and free alkali tests which have passed the curing for two weeks as the preparation evaluation stage. Antibacterial activity test against Staphylococcus aureus ATCC 25923 using well diffusion method. The data obtained were processed using Shapiro-wilk, one way ANOVA/Kruskal. The results showed that the formula of the papersoap preparation of soursop leaf ethanol extract (Annona muricata L.) with glycerin variations can provide differences in the physical quality of papersoap preparations and have an inhibitory diameter against Staphylococcus aureus bacteria ATCC 25923 successively 25.26; 24,67; 23.47 mm.

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