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All Journal Jurnal Pendidikan Vokasi Medicina E-Jurnal Medika Udayana Jurnal Kesehatan Andalas MNJ (Malang Neurology Journal) Bali Journal of Anesthesiology Adimas : Jurnal Pengabdian Kepada Masyarakat Callosum Neurology Journal : Jurnal Berkala Neurologi Bali ISM (Intisari Sains Medis) : Jurnal Kedokteran DIKEMAS (Jurnal Pengabdian Kepada Masyarakat) Bioscientia Medicina : Journal of Biomedicine and Translational Research Majalah Kedokteran Neurosains Kumawula: Jurnal Pengabdian Kepada Masyarakat Bali Anatomy Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Jurnal Locus Penelitian dan Pengabdian Hang Tuah Medical Journal Eduvest - Journal of Universal Studies Neurona Cermin Dunia Kedokteran
I Putu Eka Widyadharma
Departemen Neurologi, Fakultas Kedokteran Universitas Udayana, Denpasar, Bali
Aerospace Engineering Automotive Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Cermin Dunia Kedokteran

 1 
Efektivitas Pregabalin untuk Terapi Nyeri Kronis: Evidence-based Review Widyadharma, I Putu Eka
Cermin Dunia Kedokteran Vol 42, No 3 (2015): Nyeri
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (195.618 KB) | DOI: 10.55175/cdk.v42i3.1032

Abstract

Pregabalin ((S)-3-aminomethyl-5-methyl hexanoic acid) merupakan obat baru yang memiliki struktur analog neurotransmiter penghambat, yaitu GABA (g-aminobutyric acid). Pregabalin berikatan dengan α-2-δ subunit saluran kalsium (voltage-gated calcium channels), sehingga dapat mengurangi pelepasan beberapa neurotransmiter eksitatorik dan menghambat terjadinya hiperalgesia dan sensitisasi sentral. Pregabalin memiliki efek antikonvulsan, antihiperalgesik dan ansiolitik yang mirip gabapentin, namun memiliki sifat farmakokinetik lebih baik. Pregabalin secara umum diindikasikan untuk beberapa kondisi nyeri kronis, seperti nyeri pasca-trauma medula spinalis, post-herpetic neuralgia, fibromialgia, neuralgia trigeminal, diabetic peripheral neuropathy (DPN), dan penyakit neuropati lainnya.Pregabalin ((S)-3-aminomethyl-5-methyl hexanoic acid) is a new drug with structure similar to GABA (g-aminobutyric acid), an inhibitory neurotransmitter. Pregabalin binds to α-2-δ subunit of voltage-gated calcium channel to inhibit the release of excitatory neurotransmitter to prevent hyperalgesia and central sensitization. Pregabalin has anticonvulsant, antihyperalgesia and anxiolytic properties similar to gabapentin, with better pharmacokinetic profile. It is indicated for several chronic condition as post-spinal trauma pain, post-herpetic neuralgia, fibromyalgia, trigeminal neuralgia, diabetic peripheral neuropathy (DPN), and other neuropathies
Nilai Normal Kecepatan Hantar Saraf di RSUP Sanglah Denpasar P, Sukarini; PE, Widyadharma; Putra IGN, Purna; Samatra DPG, Purwa
Cermin Dunia Kedokteran Vol 42, No 3 (2015): Nyeri
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (142.638 KB) | DOI: 10.55175/cdk.v42i3.1029

Abstract

Latar Belakang: Pemeriksaan Kecepatan Hantar Saraf (KHS) adalah bagian dari prosedur elektrodiagnostik untuk menegakkan diagnosis penyakit sistem saraf perifer. Pengukuran KHS dapat dipengaruhi oleh berbagai faktor fisiologis dan non-fisiologis, sehingga acuan nilai normal di tiap tempat dapat berbeda; oleh karena itu, sebaiknya setiap tempat pemeriksaan memiliki nilai normalnya sendiri. Saat ini di RSUP Sanglah belum memiliki acuan nilai normal KHS. Tujuan: Mengetahui nilai rata-rata normal KHS di RSUP Sanglah Denpasar. Metode: Penelitian potong lintang consecutive sampling selama bulan Juli 2013. Setiap orang dewasa normal berusia 20-30 tahun yang memenuhi kriteria diperiksa di lengan dan tungkai kanan, untuk menilai latensi, amplitudo, dan KHS. Data diolah menggunakan SPSS 16. Hasil: Dari 30 sampel pemeriksaan Compound Muscle Action Potential (CMAP), rerata hasil secara berurutan latensi, amplitudo, KHS nervus medianus 2,95±0,34 mdet; 4,33±1,54 mV; 67,16±6,73 m/det; nervus ulnaris 2,41±0,29 mdet; 3,46±0,89 mV; 66,65±7,36 m/det; nervus radialis 3,48±0,86 mdet; 1,00±0,33 mV; 59,34±10,01 m/det; nervus tibialis 4,47±1,15 mdet; 6,59±1,85 mV; 53,95±6,65 m/det; nervus peroneus 3,29±1,15 mdet; 2,25±0,84 mV; 54,67±8,25 m/det. Rerata hasil pemeriksaan Sensory Nerve Action Potential (SNAP) secara berurutan latensi, amplitudo, KHS nervus medianus 2,62±0,31 mdet; 12,15±5,24 µV; 65,16±10,29 m/det; nervus ulnaris 2,49±0,3 0 mdet; 13,88±7,21 µV; 63,44±9,79 mdet; nervus radialis 2,38±0,61 mdet; 11,37±5,58 µV; 70,40±10,33 m/det; nervus suralis 4,17±0,67 mdet; 6,73±2,98 µV; 59,06±9,12 m/det. Simpulan: Didapatkan nilai rata-rata normal KHS motorik dan sensorik di RSUP Sanglah Denpasar yang dapat digunakan sebagai nilai acuan.Background: Nerve conduction study is electrodiagnostic procedures important in the diagnosis of peripheral nervous system disease. Nerve conduction velocity (NCV) measurements can be affected by various physiological and non-physiological factors, so the reference normal values can be different in each place; therefore, each center is encouraged to have their own normal reference value. Currently in Sanglah General Hospital not have a reference normal values of NCV. Objective: To obtain normal mean value of nerve conduction velocity (NCV) in Sanglah General Hospital, Denpasar. Method: A cross-sectional study with consecutive sampling technique was done during July 2013. A sample of 30 eligible normal adult, 20-30 year-old, were examined in the right arm and right leg, assessed for latency, amplitude, and NCV. The data is analyzed with SPSS 16.Result: The mean of Compound Muscle Action Potential for latency, amplitude, NCV of median nerve is 2,95±0,34 msec; 4,33±1,54 mV; 67,16±6,73 m/sec; ulnar nerve 2,41±0,29 msec; 3,46±0,89 mV; 66,65±7,36 m/sec; radial nerve 3,48±0,86 msec; 1,00±0,33 mV; 59,34±10,01 m/sec; tibial nerve 4,47±1,15 msec; 6,59±1,85 mV; 53,95±6,65 m/sec; peroneal nerve 3,29±1,15 msec; 2,25±0,84 mV; 54,67±8,25 m/sec. The mean of Sensory Nerve Action Potential for latency, amplitude, NCV of median nerve is 2,62±0,31 msec; 12,15±5,24 µV; 65,16±10,29 m/sec; ulnar nerve 2,49±0,30 msec; 13,88±7,21 µV; 63,44±9,79 m/sec; radial nerve 2,38±0,61 msec; 11,37±5,58 µV; 70,40±10,33 m/sec; sural nerve 4,17±0,67 msec; 6,73±2,98 µV; 59,06±9,12 m/sec. Conclusion: Normal average value of motor and sensory NCV in Sanglah General Hospital Denpasar were obtained, and can be used as a reference.
Efektivitas Pregabalin untuk Terapi Nyeri Kronis: Evidence-based Review I Putu Eka Widyadharma
Cermin Dunia Kedokteran Vol 42, No 3 (2015): Nyeri
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v42i3.1032

Abstract

Pregabalin ((S)-3-aminomethyl-5-methyl hexanoic acid) merupakan obat baru yang memiliki struktur analog neurotransmiter penghambat, yaitu GABA (g-aminobutyric acid). Pregabalin berikatan dengan α-2-δ subunit saluran kalsium (voltage-gated calcium channels), sehingga dapat mengurangi pelepasan beberapa neurotransmiter eksitatorik dan menghambat terjadinya hiperalgesia dan sensitisasi sentral. Pregabalin memiliki efek antikonvulsan, antihiperalgesik dan ansiolitik yang mirip gabapentin, namun memiliki sifat farmakokinetik lebih baik. Pregabalin secara umum diindikasikan untuk beberapa kondisi nyeri kronis, seperti nyeri pasca-trauma medula spinalis, post-herpetic neuralgia, fibromialgia, neuralgia trigeminal, diabetic peripheral neuropathy (DPN), dan penyakit neuropati lainnya.Pregabalin ((S)-3-aminomethyl-5-methyl hexanoic acid) is a new drug with structure similar to GABA (g-aminobutyric acid), an inhibitory neurotransmitter. Pregabalin binds to α-2-δ subunit of voltage-gated calcium channel to inhibit the release of excitatory neurotransmitter to prevent hyperalgesia and central sensitization. Pregabalin has anticonvulsant, antihyperalgesia and anxiolytic properties similar to gabapentin, with better pharmacokinetic profile. It is indicated for several chronic condition as post-spinal trauma pain, post-herpetic neuralgia, fibromyalgia, trigeminal neuralgia, diabetic peripheral neuropathy (DPN), and other neuropathies
Tension-type Headache and Migraine as Manifestations of Chronic Post-Traumatic Headache Eric Hartono Tedyanto; -I Made Oka Adnyana; I Putu Eka Widyadharma
Cermin Dunia Kedokteran Vol 50 No 2 (2023): Penyakit Dalam
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v50i2.528

Abstract

Introduction: A subsequent headache within seven days of a head injury (or after regaining consciousness after the head trauma)is referred to as a post-traumatic headache (PTHA); it is referred to as chronic or chronic post-traumatic headache (CPTHA) if it lasts longer than three months after the injury. Case : A 17-year-old male with headache since 3 months ago, 3 days after suffered a blow to his left head from falling from a chair. At that time, the patient fainted for about 15 minutes but had no complaints after regained consciousness. Pain is felt on the left side of the head, throbbing, mild-moderate intensity, and feels heavier with a loud sound or a too-bright light. Discussion: Post-traumatic headache is clinically diagnosed. Laboratory and routine diagnostic imaging studies are unnecessary and have minimal clinical utility. Conclusion: Chronic post-traumatic headaches often occur, especially after minimally traumatic brain injury. The clinical picture is variable and may be similar to tension-type headaches and/or migraines.   Pendahuluan: Nyeri kepala dalam tujuh hari setelah cedera kepala atau setelah sadar kembali dari trauma kepala disebut nyeri kepala pasca-trauma (post-traumatic headache/PTHA); disebut sakit kepala pasca-trauma kronis atau kronis (CPTHA) jika berlangsung lebih dari tiga bulan setelah cedera. Kasus: Seorang laki-laki berusia 17 tahun dengan keluhan nyeri kepala sejak 3 bulan, 3 hari setelah kepala kiri terbentur karena jatuh dari kursi. Saat itu, pasien pingsan sekitar 15 menit, tidak ada keluhan setelah sadar. Nyeri dirasakan di sisi kiri kepala, berdenyut, intensitas ringan-sedang, terasa lebih berat jika ada suara keras atau cahaya terlalu terang. Diskusi: Nyeri kepala pasca-trauma didiagnosis secara klinis. Laboratorium dan studi pencitraan diagnostik rutin tidak diperlukan dan memiliki utilitas klinis minimal. Simpulan: Nyeri kepala pasca-trauma kronis sering terjadi, terutama setelah cedera otak traumatis minimal. Gambaran klinisnya bervariasi dan dapat mirip nyeri kepala tipe tegang dan/atau migrain  
Co-Authors A.A Gde Agung Anom Arie W Abdullah, Fachrul Rizky Adhiyoga Santosa Agung Bagus S. Satyarsa Agung Wiwiek Indrayani Anak Agung Ayu Putri Laksmidewi Anak Agung Ayu Suryapraba Anak Agung Bagus Ngurah Nuartha Angelia Carolin Angga Dwi Saputra Anna Marita Gelgel Aria Wibawa Arimbawa, I Komang Ariswanda, I Gusti Agung Gede Ayu Inten Dwi Primayanti, I Dewa Belinda Orline Olivia Singgih Candra, Alamanda Clarissa Tertia Daniel Siagian Desak Ketut Indrasari Utami Devi, Gusti Ayu Putu Giti Livia Dewa Ngurah Suprapta Dewa Putu Gede Purwa Samatra Dian Rizki Fitria Dwijo Anargha Sindhughosa Eric Hartono Tedyanto ERIC HARTONO TEDYANTO Eric Hartono Tedyanto Faldi Yaputra Florence Diana Thomas G, Gayathridayawasi Gede Yoni Komalasari, Ni Luh Gitari, Ni Made Haditya, Yogi hakim, aulia el I Gusti Ngurah Ketut Budiarsa I Ketut Sumada I Komang Arimbawa I Made Jawi I Made Oka Adnyana I Made Oka Adnyana I MADE OKA ADNYANA I Made Pramana Dharmatika I Wayan Niryana Ida Ayu Sri Indrayani Ida Ayu Sri Wijayanti Ida Bagus Kusuma Putra IGN Budiarsa Indah Permata Dewi, Komang Indrasari Utami, Desak Ketut Indrayani, I.A. Sri Juhanna, Indira Vidiari Junaedi, Imam Kesanda, I Made Phala Ketut Widyastuti Kusmarini, Putu Elmamira Kusuma, Yohan Intan Laksmidwei, A A A Putri Lim, Demetria Jesica Limalvin, Nicholas Prathama Luh Made Mas Rusyati Made Oka Adnyana MADE OKA ADNYANA Mahadewi, Ni Putu Ayu Putri Mahmud, Ahmad Ulil Albab Nadia, Hana Jasmine Naomi Valencia Simbolon Ni Kadek Mulyantari Ni Ketut Candra Wiratmi Ni Luh Gede Yoni Komalasari, Ni Luh Gede Yoni Ni Made Dwita Pratiwi Ni Made Susilawathi Ni Made Wira Tania Astarini Ni Nyoman Ayu Dewi Ni Putu Sukarini, Ni Putu Nila Wahyuni Nila Wahyuni Nugraha, Boya P, Sukarini Pramana, Nyoman Angga Krishna Pranitha, Putu Diva Pratiwi, Ni Made Dwita Priandwika, Muhammad Rifki Agung Pusaka, Semerdanta Putra IGN, Purna Putri Rossyana Dewi Putu Emilia Dewi Putu Indah Mahardika Putri Putu Sutirta Yasa, Wayan Raka-Sudewi A. A. Rakhmad Gusta Putra Richard Suherlim Rindha Dwi Sihanto Risky Ilona Saputra Rizaldy Pinzon Rumai, I Made Winarsa Sanjaya, Feliani Setiawan, Okky Yani Sofyan Faridi Sri Wijayanti, Ida Ayu Sudirman, Dirvi Juliando Sulfan Bagus Setyawan Suryamulyawan, Kadek Adi Susilawathi, Ni Made Sutama, I Komang Reno Sutantohadi, Alief Syah Putra, Muhammad Dio Tedyanto, Eric Hartono Tertia, Clarissa Thomas Eko Purwata Tini, Kumara Tresna Erawan, I Gusti Ngurah Agung Trisnawati, Sri Yenni Vania Rau, Chiquita Putri Wahyu Pribadi Widya Trio Pangestu Widyastuti, Ketut Witari, Ni Putu Y, Yudiyanta Yes Matheos Lasarus Malaikosa Yudha, R. Gaguk Pratama Yudhiatama, Galang Dafa Yuniarni, Ruth Sharon