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All Journal Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis JURNAL PHARMASCIENCE Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Medical Sains : Jurnal Ilmiah Kefarmasian Khazanah: Jurnal Mahasiswa JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Farmasi Sains dan Praktis Media Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian
Yandi Syukri
Department Of Pharmacy, Faculty Of Mathemathics And Natural Sciences, Universitas Islam Indonesia
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Public Health Social Sciences

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SISTEM PENGHANTARAN OBAT MELEWATI BARRIER DARAH OTAK Syukri, Yandi
Jurnal Ilmiah Farmasi Vol. 1 No. 1 (2004)
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACTBrain barrier is effective barrier in drug delivery to brain. For effectiveness drug deliveryneed be desaigned a delivery with nanoparticle technology. Nanoparticles are solid colloidalparticles ranging in size from 1 to 1000 nm that are utilized as drug delivery agents. The primaryadvantages of nanoparticle carrier technology is that nanoparticles mask the blood – brain barrierlimiting characteristics of the therapeutic drug molecule. Furthermore, this system may slow drugrelease in the brain, decreasing peripheral toxicity. The method which elaboration in manufacturenanoparticles are emulsion polimerization, interfacial polimerization, desolvation evaporation andsolvent deposition. Currently, report evaluating nanoparticles for brain delivery have studiedanesthetic and chemoterapeutic agent. These studies are reviewed for efficacy and mechanisms oftransport. Physiological factors such as phagocytic activity of the reticuloendothelial system andprotein opsonization may limit the amount of brain delivered drug. Nanoparticle technology appearsto have significant promise in delivering therapeutic molecules across the blood-brain barrier.Key Word : Drug Delivery System, Nanoparticle, Blood-Brain Barrier
DEVELOPMENT OF LABRASOL®-BASED SNEDDS FOR ENHANCED DELIVERY OF COMBINATION PROPOLIS, SEA CUCUMBER, AND CENTELLA ASIATICAEXTRACTS Fitriani, Hannie; Syukri, Yandi; Taher, Muhammad
Jurnal Farmasi Sains dan Praktis Vol 11 No 3 (September-December 2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v11i3.14470

Abstract

The therapeutic efficacy of natural extracts such as propolis, sea cucumber or gamat (Stichopus hermanii), and pegagan (Centella asiatica) is supported by their anti-inflammatory, antioxidant, and regenerative properties. However, their pharmaceutical application is limited due to poor solubility and low bioavailability. This study aimed to develop and characterize a Self-Nanoemulsifying Drug Delivery System (SNEDDS) using Labrasol to enhance the delivery and stability of a combination of these three extracts, that exhibit synergistic effects as tissue regeneration, antimicrobial, anti-inflammatory, and antioxidant properties. SNEDDS formulations were prepared by a high energy method with Labrasol, Tween 80, and propylene glycol. The formulations were evaluated for droplet size, polydispersity index (PDI), zeta potential, and thermodynamic stability test. The optimized SNEDDS exhibited nano-sized droplets (151.13 nm ± 17.26) with low PDI (0.39 ± 0.01) and zeta potential (-50.30 ± 1.04) within the stable range, indicating a uniform, physically stable nanoemulsion, and passed the thermodynamic stability test. In conclusion, the optimized SNEDDS formulation demonstrated nano-sized droplets with low PDI and stable zeta potential, indicating good physical stability.
Genus Begoniaceae: A Review of Phytochemical and Pharmacological Activity: Genus Begoniaceae: Kajian Review Fitokimia dan Aktivitas Farmakologis Ayunanda, Nurul Putri Ramadhani; Fitriani, Hannie; Syukri, Yandi; Zubair, Muhammad Sulaiman
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 11 No. 2 (2025): October 2025
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2025.v11.i2.17636

Abstract

Background: Begonia sp. (Begoniaceae) contains phytochemical compounds that possess significant pharmacological activities such as antioxidants, antibacterials, anticancer agents, and even immunostimulants. Objective: Provide information about the phytochemical compounds and pharmacological activities of Begonia species. Methods: This narrative review was conducted by searching the literature using journal databases such as Google Scholar, PubMed, and ScienceDirect relevant from 2014 to 2024. Results: Based on review of various literature studies, 19 articles were found that met the inclusion and exclusion criteria of this research. The literature obtained explains that Begonia sp. has been proven to possess various pharmacological activities influenced by phytochemical compounds. Conclusions: Phytochemical compounds in Begonia species can support research and present opportunities in drug development.
Formulasi Self-Nanoemulsifying Drug Delivery System (SNEDDS) yang Memanfaatkan Tanaman Obat: Narrative Review Asita, Nur; Zubair, Muhammad Sulaiman; Syukri, Yandi
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 2 (2023): J Sains Farm Klin 10(2), Agustus 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.2.184-196.2023

Abstract

Pemanfaatan tanaman obat sebagai terapi pengobatan memiliki hambatan untuk sampai ke target aksi karena rendahnya kelarutan dan bioavaibilitas zat aktif dalam air. Self-Nanoemulsifying Drug Delivery System (SNEDDS) merupakan salah satu metode yang dikembangkan untuk meningkatkan kelarutan dan bioavaibilitas zat aktif termasuk ekstrak dari tanaman. Studi literatur ini bertujuan untuk mengkaji formula SNEDDS yang memanfaatkan tanaman obat dengan mengulas informasi yang dikumpulkan dari original article yang relevan. Penelusuran referensi dilakukan pada website seperti Google Scholar, Pub-Med dan ScienceDirect. Beberapa tanaman obat yang diformulasikan menjadi sediaan SNEDDS yaitu sirsak, grapefruits, beetroot, kunyit, propolis, daun salam, sarang semut, daun papaya, buah parijoto, pegagan, temulawak, kelor, ketepeng dan manggis menghasilkan karakteristik yang baik. Sediaan SNEDDS dari tanaman herbal tersebut memiliki nilai transmitan dari rentang 72,74% hingga 100%, waktu emulsifikasi pada sediaan kurang dari 5 menit, zeta potensial -0,2 mV hingga -56 mV. Nilai polydispersity index kurang dari 0,4 dan ukuran partikel yang kurang dari 100 nm. SNEDDS memiliki kemampuan untuk memperbaiki bioavaibilitas dan kelarutan dari senyawa sehingga menghasilkan aktivitas farmakologis yang lebih baik dibandingkan dengan pemberian ekstrak, fraksi maupun senyawa aktif yang tanpa menggunakan sistem penghantaran. Kemampuan SNEDDS dalam meningkatkan bioavaibilitas serta kelarutan senyawa dalam air yang menyebabkan aktivitas farmakologis menjadi semakin tinggi. Formulasi SNEDDS dapat meningkatkan aktivitas senyawa pada tanaman obat hal ini ditandai dengan peningkatan bioavaibilitas obat sehingga SNEDDS dapat menjadi alternatif untuk meningkatkan efisiensi penyembuhan suatu penyakit
Pharmacological Activity of Plant Extracts in Self-Nanoemulsifying Drug Delivery System Dosage Form: Narrative Review Julio, Ivan; Zubair, Muhammad Sulaiman; Syukri, Yandi
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 1 (2024): J Sains Farm Klin 11(1), April 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.1.7-16.2024

Abstract

The utilization of medicinal plants as therapeutic agents has obstacles to achieving the target action due to their low solubility. Self-Nanoemulsifying Drug Delivery System (SNEDDS) is a method developed to increase the solubility of poorly water-soluble substances, such as medicinal plant extracts. This review aims to present a narrative overview of the potential utilization of SNEDDS in enhancing the pharmacological activity of plant extracts. Article searches were conducted on several websites, such as Google Scholar, PubMed, and ScienceDirect. Literature studies showed that the use of SNEDDS formulations in several medicinal plants such as dayak onion, soursop leaf, papaya leaf, bay leaf, kale, sidaguri, black cumin, mangosteen peel, harendong, pineapple peel, and cocoa is more effective than the administration of extracts alone because it can increase the solubility and bioavailability of a compound. Pharmacologically, SNEDDS shows its success in enhancing antioxidant, anti-inflammatory, analgesic, antidiabetic, antihyperglycemic, antimalarial, immunostimulant, antimicrobial, anticancer, wound healing, and hepatoprotective activities in various plant extracts. The utilization of SNEDDS formulations in plant-based drugs has a positive impact on the advancement of drug therapy, especially for compounds that have low solubility.
Formulation and Characterization of Solid Self Nano Emulsifying Drug Delivery System (S-SNEDDS) Loading Curcuma xanthorrhiza Extract Yandi Syukri; Yuvina Seran; Hannie Fitriani; Arba Pramundita Ramadhani; Muhammad Taher
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 3 (2024): J Sains Farm Klin 11(3), December 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.3.169-178.2024

Abstract

Curcuma xanthorrhiza has an active component xanthorrhizol that is poorly soluble in water, resulting in limited absorption and bioavailability. Liquid Self Nano Emulsifying Drug Delivery System (SNEDDS) dosage formulations can improve its solubility and absorption due to its small particle size. Solid SNEDDS technology significantly overcomes some of problems in liquid SNEDDS preparations to improve the stability of liquid formulations. This study aims to formulate and characterize Curcuma xanthorrhiza S-SNEDDS preparation. SNEDDS was characterized by particle size and thermodynamic tests. Method of making S-SNEDDS uses two ways, absorption of porous compounds and spray drying. S-SNEDDS were characterized by testing infrared spectra, X-ray diffraction, scanning electron microscopy, microbial contamination and particle flow properties. Optimal S-SNEDDS formulation with 2 formulas namely F7 and F11 mannitol carrier. FTIR testing showed no interacting compounds. SEM and X-ray diffraction testing of F7 showed that the preparation was semicrystalline. While F11 described the preparation as much more crystalline due to the high content of mannitol. The microbial contamination test detected no microorganism compounds. In addition, the particle flow properties obtained a result of 02.53 seconds with a height of 24.95 mm. It is concluded that the S-SNEDDS formula F7 of Curcuma xanthorrhiza has semicrystalline preparation criteria.
Self-Nanoemulsifying Drug Delivery System (SNEDDS): Challenges and Opportunities in Enhancing Drug Solubility Farhad Aulan Sabillah; Hannie Fitriani; Muhammad Sulaiman Zubair; Yandi Syukri
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 3 (2025): J Sains Farm Klin 12(3), December 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.3.217-225.2025

Abstract

For oral medications, especially those in BCS Classes II and IV, poor aqueous solubility continues to be a significant formulation challenge. This problem restricts dosage consistency, therapeutic efficacy, and bioavailability. A promising method for improving the solubility and absorption of lipophilic drug compounds is the Self-Nanoemulsifying Drug Delivery System (SNEDDS). With ramifications for the pharmaceutical and medical domains, this narrative review attempts to investigate the synthesis, characterization, difficulties, and possible uses of SNEDDS in improving drug solubility. According to the standards of scientific merit, accessibility, and relevance, a total of 25 articles released within the previous five years were included. When SNEDDS meet gastrointestinal fluids, they spontaneously form nanoemulsions, which improves drug solubility. Oil, surfactant, and co-surfactant make up this system, which is optimized according to zeta potential (±30 mV), polydispersity index (<0.3), and particle size (<200 nm). Numerous studies have shown how well it works to enhance the pharmacokinetics and solubility of medications like thymoquinone, rosuvastatin, and curcumin. However, issues with excipient safety, formulation scalability, and long-term stability still exist. SNEDDS offers a versatile and efficient method for enhancing oral drug delivery, especially for nutraceuticals and health supplements. To fully realize its therapeutic and industrial potential, more research involving clinical validation, regulatory harmonization, and quality-by-design approaches is required.
Co-Authors Ade Herlin Aditya Sewanggara Amatyawangsa Wicaksana Aditya Sewanggara Amatyawangsa Wicaksana Agita Dyah Permatasari Agung Endro Nugroho Agung Endro Nugroho Aji Winanta Aldia Dwi Karina Ningrum Aldia Dwi Karina Ningrum Amalia Humairah Amelia Arum Prasetya Anik Ariyani Anisa Nur Fazzri Annisa Fitria Annisa Fitria Arba Pramundita Ramadani Arba Pramundita Ramadhani Arifa Caryn Dea Aris Perdana Kusuma, Aris Perdana Asih Lestari Asih Triastuti Asita, Nur Ayunanda, Nurul Putri Ramadhani Bambang Hernawan Nugroho Bambang Hernawan Nugroho, Bambang Hernawan Budy Wijiyanto Denox Asih Pertiwi Diny Rizayulianty Elfi Susanti V. H. Endang Lukitaningsih Endang Lukitaningsih Farhad Aulan Sabillah Farida Ulfa Feris Firdaus Fernenda, Larysa Fissy Rizki Utami Fitriani, Hannie Galuh Annaba Maharani Hakim, Lukman Hakim, Sherina Nabila Putri Hannie Fitriani Hannie Fitriani Hannie Fitriani Hayati, Farida Herianto Pandapotan Herianto Pandapotan, Herianto Iqmal Tahir Isna Qiftayati Isnatin Miladiyah Istanti Istanti Istanti Istanti, Istanti Joko Tri Wibowo Julio, Ivan Kartika Puspitasari Kholidah, Ziyyatul Larysa Fernenda Laryssa Fernenda Lelita Ayu Saputri Lisnawati Tiara Putri Lukman Hakim Lutfi Chabib, Lutfi M. Hatta Wibowo Maulia Ulfa mega octavia Melinda Dewi M Mira Amaliasari Sitorus Muhammad Sulaiman Zubair Muhammad Taher Muhammad Taher Mulyanti, Eka Mulyanti, Eka Mutiara Herawati, Mutiara Nadia Hazami Nur Asita Nurul Ainah Octavia, Mega Prima Aulia Putra Primadara Damayanti Ramadhani, Arba Pramundita Ratih Dyah Listianingrum Ratih Lestari Ratih Lestari Redjeki, Tri Rini Utami Rio Fandi Sholehuddin Ririk Purwati Rochmy Istikaharah Rochmy Istikharah Romdhonah Romdhonah Ronny Martien Ronny Martien Saepudin Saepudin Septiani Eka Cahyani Sherina Nabila Putri Hakim Shinta Dewi Sista Werdyani Sista Werdyani Siti Zahliyatu Suryadi Budi Utomo Syafira Tri Nurmala Sari T. N. Saifullah Taher, Muhammad Tamhid, Hady Anshory Tasya Salsabila Tatang Shabur Julianto Tedjo Yuwono Tiara Putri, Lisnawati Werdyani, Sista Wintari Taurina Yoga Febriana Yuni Darty Yuvina Seran Yuwono, Tedjo Ziyyatul Kholidah