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All Journal Jurnal Kimia (Journal of Chemistry) Jurnal Sains Materi Indonesia Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) INDONESIAN JOURNAL OF PHARMACY JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) ISM (Intisari Sains Medis) : Jurnal Kedokteran Management Studies and Entrepreneurship Journal (MSEJ) Udayana Journal of Social Sciences and Humanities (UJoSSH) Journal of Health Sciences and Medicine Quantitative Economics and Management Studies JOURNAL SCIENTIFIC OF MANDALIKA (JSM) ProBisnis : Jurnal Manajemen Indonesian Journal of Multidisciplinary Science Journal Transformation of Mandalika Jurnal Indonesia Sosial Sains Jurnal Cendekia Ilmiah Jurnal Farmasi Sains dan Teknologi
I Gusti Ngurah Agung Dewantara Putra
Program Studi Farmasi, Fakultas MIPA, Universitas Udayana 80361, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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OPTIMASI FORMULA MATRIK PATCH MUKOADHESIF EKSTRAK DAUN SIRIH (Piper betle L.) MENGGUNAKAN MENTOL DAN PEG 400 SEBAGAI PERMEATION ENHANCER DAN PLASTICIZER Setyawan, Eka Indra; Dewantara, IGN Agung; Putra, IMD Dwi
Media Farmasi: Jurnal Ilmu Farmasi Vol. 11 No. 2: September 2014
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v11i2.1872

Abstract

Daun sirih (Piper betle L) adalah tanaman obat tradisional yang secara empirik dimanfaatkan masyarakat untuk pengobatan antiinflamasi gusi. Penelitian ini bertujuan untuk memformulasi ekstrak etanol daun sirih ke dalam sistem penghantaran obat baru yakni patch mukoadhesif. Ekstrak daun sirih sebagai bahan aktif dibuat dengan teknik maserasi sedangkan formulasi patch dibuat menggunakan sistem matrix controlled. Bahan tambahan yang dipergunakan dalam pembuatan patch antara lain; hidroksipropil metilselulosa, polietilenglikol 400, dan mentol. Komposisi pemakaian polietilenglikol 400 dan mentol dalam formula ditentukan dengan menggunakan metode simplex lattice design. Evaluasi matrik patch meliputi; bobot matrik patch, ketebalan matrik patch, folding endurance dan loss on drying. Hasil penelitian memperlihatkan bobot matrik berkisar antara 0,510 - 2,837 g, tebal matrik antara 0,28 - 1,00 mm, folding endurance antara 60 - > 500 lipatan dan loss on drying antara 0,063% - 0,099%. Formula optimal dihasilkan oleh kombinasi mentol dan PEG 400 dengan perbandingan 2:0 atau dengan nilai desirability 0,931.   
PENGEMBANGAN BASIS COLD CREAM EKSTRAK KULIT BUAH MANGGIS (Garcinia mangostana L.) YANG MEMENUHI SIFAT FARMASETIS Dewantara, IGN Agung; Setyawan, Eka Indra
Media Farmasi: Jurnal Ilmu Farmasi Vol. 11 No. 2: September 2014
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v11i2.1873

Abstract

Ekstrak kulit buah manggis (Garcinia mangostana L.), telah diteliti memiliki aktivitas anti luka bakar. Formula cold cream dirancang dengan menggunakan ekstrak tersebut dan diharapkan dapat mempermudah pengaplikasian. Tujuan dari penelitian ini untuk mengetahui sifat fisik farmasetis sediaan cold cream.  Pencampuran cold cream dilakukan pada suhu 60oC kemudian dilakukan pengujian sifat fisik farmasetis sediaan pada hari ke-0 sampai hari ke-28 setelah sediaan jadi. Pengujian sediaan meliputi uji homogenitas, distribusi ukuran droplet, tipe krim, rheologi, dan derajat pemisahan fase, secara deskriptif. Hasil penelitian menunjukkan sifat fisik yang baik, krim homogen, dengan ukuran droplet  <10µm, tipe krim a/m, dengan rheologi tiksotropik dan derajat pemisahan 1.  
Expandable Ranitidine HCl tablets with Salak Bali seed matrix (Salacca zalacca) Putra, I Gusti Ngurah Agung Dewantara; Darmaputra, I Gusti Nyoman; Tamim, Imron Hadi
Indonesian Journal of Multidisciplinary Science Vol. 4 No. 2 (2024): Indonesian Journal of Multidisciplinary Science
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/ijoms.v4i2.1061

Abstract

This research aims to develop ranitidine HCl tablets that can be expanded with a matrix from Balinese salak seeds (Salacca zalacca) as a natural matrix material. This formulation is expected to prolong the release time of the drug in the body, thereby increasing the effectiveness of ranitidine therapy in the treatment of gastric diseases. The research method included the extraction of the active components from Balinese salak seeds and the process of making tablets using the wet granulation method, followed by physical tests of the tablets which included the hardness, crushing time, and ability of the tablets to expand. The results showed that ranitidine HCl tablets with Balinese salak seed matrix had physical characteristics that met the requirements of pharmacopooeia, with a slower drug release time than tablets without a developer matrix. Analysis of development capabilities shows that Balinese salak seeds are effective as natural matrix agents to prolong the release time of ranitidine HCl. In conclusion, Balinese salak seed matrix can be used as an alternative in the development of expandable ranitidine HCl tablets, potentially increasing the therapeutic effect of the drug.
The Effect of Native and Pregelatinized Durian Seed Starch (Durio Zibethinus Murr) on The Dissolution Rate of Paracetamol Tablets Putra, I Gusti Ngurah Agung Dewantara
Jurnal Indonesia Sosial Sains Vol. 7 No. 4 (2026): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v7i4.2300

Abstract

Amylum is widely used as an excipient in pharmaceutical formulations, one of which is inert and can be mixed with any drug without causing a chemical reaction. The aim of this research is to know the preparation method of cassava amylum (Durio zibethinus, Murr) native and pregelatinized which is used as binder to dissolution rate of paracetamol tablet with granulation method. The native and pregelatinized amylum produced from cassava is carried out by a preliminary test to determine the nature of physical characteristics and to know the ability as a binder of the tablet. The paracetamol tablets produced from the two methods were tested dissolution using medium buffer phosphate at 37 ± 0,5 ° C (pH 5.8, 50 rpm). The results showed that cassava starch preparation method had an effect on dissolution rate of tablet. Pregelatinized amylum as binder on paracetamol tablet showed Q value (93,17 ± 0,01)% while native amylum showed value of Q (81,76 ± 0,20)%. The use of pregelatinized cassava starch as a binder on paracetamol tablet has better characteristic properties compared with native starch
Co-Authors A. A. Yastawa Cakranegara, Pandu Adi Darmaputra, I Gusti Nyoman Eka Indra Setyawan Erlina, Ni Putu Natasha Ernianti Fachry Abda El Rahman Farida Akbarina Firstianty Wahyuhening Fibriany I G. N. Jemmy A I GA. Gede Minanjaya I Gusti Agus Tusan Wira Darma I Gusti Ayu Kusuma Dewi I Gusti Ngurah Jemmy Anton Prasetia I Made Arya Wiraguna I Made Wiracana I Nengah Sujaya IMD Dwi Putra Imron Hadi Tamim, Imron Hadi IRIANI SETYAWATI Julie Abdullah Kartini, Ni Komang Triayu Cita Ketut Widyani Astuti Komang Dede Saputra Kurniawan Arif Maspul Luh Ayu Putri Saraswati Luh Putu Febryana Larasanty Luh Putu Febryana Larasaty Made Krisna Adi Jaya Mekar Meilisa Amalia Muhammad Syafri N. P. A. D. Wijayanti Ni Gusti Ketut Roni Ni Made Ary Sarasmita Ni Putu Ayu Dewi Wijayanti Ni Putu Chintya Sandra Bhuana Ni Putu Linda Laksmiani Pangestu, Ade Winanda Pranatha, I Putu Adhi Prasetia Prasetia Raúl Eleazar Arias Sánchez Retno Murwanti Rhyce Dewata Sari Rohman, Abdul Sanita Dhakirah Sapitri, Putu Dian Saputra, Eka Kurnia Sasono, Heri Savitri, Anava Salsa Nur Shabrina Herawati Shan Amadeus Sugianto, Efendi Sulaiman, T.N Saifullah Sutardjo, Agus Syahril Hasan - Politeknik Sains dan Teknologi Wiratama Maluku Utara, Syahril Hasan Teguh Setiawan Wibowo Uli Wildan Nuryanto Umar, Ahmad Ulil Albab Al Yanti, Ni Made Frida