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PENGEMBANGAN BASIS COLD CREAM EKSTRAK KULIT BUAH MANGGIS (Garcinia mangostana L.) YANG MEMENUHI SIFAT FARMASETIS IGN Agung Dewantara; Eka Indra Setyawan
Media Farmasi: Jurnal Ilmu Farmasi Vol 11, No 2: September 2014
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4246.234 KB) | DOI: 10.12928/mf.v11i2.1873

Abstract

Ekstrak kulit buah manggis (Garcinia mangostana L.), telah diteliti memiliki aktivitas anti luka bakar. Formula cold cream dirancang dengan menggunakan ekstrak tersebut dan diharapkan dapat mempermudah pengaplikasian. Tujuan dari penelitian ini untuk mengetahui sifat fisik farmasetis sediaan cold cream.  Pencampuran cold cream dilakukan pada suhu 60oC kemudian dilakukan pengujian sifat fisik farmasetis sediaan pada hari ke-0 sampai hari ke-28 setelah sediaan jadi. Pengujian sediaan meliputi uji homogenitas, distribusi ukuran droplet, tipe krim, rheologi, dan derajat pemisahan fase, secara deskriptif. Hasil penelitian menunjukkan sifat fisik yang baik, krim homogen, dengan ukuran droplet  <10µm, tipe krim a/m, dengan rheologi tiksotropik dan derajat pemisahan 1.  
Influence of Patient Characteristics on The Type of Insulin Therapy Obtained by Diabetes Type 2 Outpatient in Denpasar Municipality Luh Putu Febrayana Larasanty; I GNA. Dewantara Putra; Rhyce Dewata Sari; Komang Dede Saputra; I GA. Gede Minanjaya; I Made Arya Wiraguna; I Made Wiracana
Udayana Journal of Social Sciences and Humanities Vol 1 No 2 (2017): UJoSSH, September 2017
Publisher : Research and Community Services Institutes of Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (285.853 KB) | DOI: 10.24843/UJoSSH.2017.v01.i02.p03

Abstract

This study aims to investigate the influence of patient characteristics on the choice of insulin therapy in type 2 diabetes mellitus outpatients in Denpasar municipality. This is a descriptive analysis study using the patient's medical records as research material. Patients who meet inclusion and exclusion criteria are being recorded based on their medical records. Characteristics that are taken are age, gender, fasting blood glucose level (FBG), 2-hour postprandial blood glucose level (2-hours PPG) and HbA1c values of patients. Types of insulin therapy gained from patient medical records and drug use report in pharmacy. Characteristics data and type of insulin analyzed using correlation test to determine the effect of the patient characteristics on the selection of insulin therapy. 43 patients became the research subject. Males gendered patients (72.09%) and the patients aged less than 65 years (90.70%) are the dominant characteristics of the research subjects. The average value of FBG of patients is 212 mg / dL; 2-hours PPG 280 mg / dL and HbA1c 10.1%. There is a correlation between sex, age, HbA1c value and FBG with the type of insulin obtained by patients (p <0.05). Based on the results of statistical tests, age and gender have a strong correlation on insulin choice, HbA1c and FBG level has a moderate influence and 2-hours PPG have a weak correlation. Patient characteristics had an influence on the type of insulin choice for diabetes mellitus type 2 outpatient in the Denpasar municipality.
Optimization Of Isolation Method Of Carrageenan From Kappaphycuss Alvarezii Doty Using Factorial Experimental Design Ketut Widyani Astuti; Ni Putu Ayu Dewi Wijayanti; I Gusti Ngurah Agung Dewantara Putra; Ni Putu Linda Laksmiani
Journal of Health Sciences and Medicine Vol 1 No 2 (2017): JHSM (September 2017)
Publisher : Institute for Research and Community Services Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (232.941 KB)

Abstract

Kappaphycus alvarezii Doty is a species of red algae ( Rhodophyceae) producing kappa carrageenan. The value of carrageenan will increase if it is able to form thermoreversible gels. The quality of carrageenan is determined by the isolation method which includes several stages, namely soaking, extraction, purification, and drying. This study aims to obtain an optimum isolation method of carrageenan from seaweed Kappaphycus alvarezii Doty using the factorial experimental design software, Design Expert Version.7.0.0. with the characteristics that meet the standards set by FAO. The seaweed was collected from the sea in Nusa Lembongan, Bali Province. The carrageenan isolation method was optimized by varying three factors, namely the concentration of NaOH (4% and 8%), extraction time (0.5 hour and 3 hours), and precipitation time (0.25 hour and 0.5 hour) in order to obtain 8 formulae which then went through an evaluation of the physical and chemical characteristics of the carrageenan. The physical and chemical characteristics include the yield, viscosity, sulfate content, and ash content, analyzed using Design Expert Version 7.0.0 program to determine the optimum method of isolation. The analysis showed that the optimum method of carrageenan isolation was using NaOH with a concentration of 4.40%, the extraction time of 2.16 hours and the precipitation time of 0.29 hour. The physical and chemical characteristics of carrageenan with the optimum isolation method include the yield of 25.73%, the viscosity of 11.92 cPs, sulfate content of 31.95% and the ash content of 26.16% which have met the standards set by FAO.
TOTAL BIAYA TERAPI INSULIN PADA KASUS DIABETES MELLITUS TIPE 2 RAWAT JALAN DI KOTAMADYA DENPASAR Luh Putu Febryana Larasaty; I Gusti Ngurah Agung Dewantara Putra; Made Ary Sarasmita
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 7, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.361

Abstract

Insulin merupakan salah satu terapi obat untuk pasien diabetes mellitus (DM) tipe 2. Terdapat 4 jenis insulin berdasarkan onset kerjanya. Tiap jenis insulin memiliki besaran biaya dan effektivitasnya masing - masing. Telah banyak penelitian dilakukan untuk menilai effektivitas penggunaan insulin, di lain pihak penelitian yang membandingkan biaya total tiap jenis insulin masih sangat sedikit. Tujuan penelitian ini adalah untuk mengetahui total biaya yang dibutuhkan untuk terapi insulin pada pasien DM tipe 2 rawat jalan di rumah sakit kotamadya Denpasar. Penelitian ini merupakan penelitian deskriptif yang dilakukan pada bulan Maret sampai dengan bulan Juni 2016 di rumah sakit pemerintah di Kotamadya Denpasar. Subyek penelitian adalah pasien DM tipe 2 rawat jalan. Data regimen terapi insulin dan biayanya diperoleh dari rekam medis pasien, data resep, lembar administrasi, laporan terapi pasien pada instalasi farmasi dan juga riwayat sosial pasien. Total biaya dihitung berdasarkan biaya medis langsung (jasa dokter, tes laboratorium, biaya obat dan biaya penyiapan obat serta alat kesehatan), biaya non medis langsung (biaya administrasi dan transportasi) serta biaya non medis tidak langsung (hilangnya gaji/upah karena tidak masuk kerja). Terdapat 8 nama dagang insulin yang diresepkan untuk pasien DM tipe 2, dengan masing – masing persentase penggunaannya adalah sebagai berikut : Apidra Solostar (12,50%), Humalog Mix (4,35%), Humalog Quickpen (3,80%), Humulin N (2,17%), Lantus Solostar (28,26%), Levemir (11,96%), Novomix (1,09%) and Novorapid (35,87%). Total biaya terendah regimen terapi insulin adalah penggunaan Lantus Solostar (Rp 528.480,-) dan total biaya tertinggi adalah Humalog Mix (Rp. 685.066,-). Rata – rata total biaya terapi insulin adalah sebesar Rp. 565.474,-
Pemodelan perhitungan biaya pengadaan persediaan bahan baku menggunakan metode EOQ di perusahaan kosmetika I Gusti Ngurah Agung Dewantara; N. P. A. D. Wijayanti; A. A. Yastawa
Intisari Sains Medis Vol. 8 No. 1 (2017): (Available online: 1 April 2017)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (271.041 KB) | DOI: 10.15562/ism.v8i1.108

Abstract

Background: The process of procurement of supplies is a very important in manufacturing company, without supplies, the company will face a difficult continuity of the production process. Aim: This research is to compare the amount of raw material purchase, frequency of purchase of raw materials, the frequency of delivery of raw materials, and the total cost of procurement of raw material inventories carried out using traditional methods and modeling methods EOQ in Cosmetics Company. Method: Data were collected using the data of the company in 2014-2015 and interviews with the owners and employees of the Company Cosmetics. Results: From this research is obtained the comparison of traditional methods and modeling EOQ ie the amount of raw material purchases in one message 1000kg: 8.440kg increased by 8.44 times, frequency of purchase of raw materials 24: 6 times, frequency of delivery of raw materials 24: 6 times. Conslusions: Total savings cost of raw material inventory control 70% of the total cost of procurement of raw material inventory by the company using traditional methods.
Analysis of the Influence of Digital Marketing and Product Quality on Customer Loyalty Julie Abdullah; Uli Wildan Nuryanto; Pandu Adi Cakranegara; Firstianty Wahyuhening Fibriany; I Gusti Ngurah Agung Dewantara Putra
Quantitative Economics and Management Studies Vol. 3 No. 6 (2022)
Publisher : PT Mattawang Mediatama Solution

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (386.833 KB) | DOI: 10.35877/454RI.qems1126

Abstract

The purpose of this study was to analyze the effect of digital marketing and product quality on customer loyalty. This research is a quantitative research with a descriptive and verification approach. From the research that has been done, it is obtained that the value of t count > t table so that digital marketing and product quality have a positive and significant effect on customer loyalty. The R-square value obtained is 0.852 which states that digital marketing and product quality variables affect customer loyalty by 85.20% and the remaining 14.80% is influenced by other variables.
Analysis of the Influence of Workload and Work Environment on Employee Turnover at PT. XYZ Teguh Setiawan Wibowo; Pandu Adi Cakranegara; I Gusti Ngurah Agung Dewantara Putra; Eka Kurnia Saputra; Mekar Meilisa Amalia
Quantitative Economics and Management Studies Vol. 3 No. 6 (2022)
Publisher : PT Mattawang Mediatama Solution

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (341.781 KB) | DOI: 10.35877/454RI.qems1173

Abstract

The purpose of this study was to analyze the influence of workload and work environment on employee turnover at PT. XYZ. The research design used in this study used quantitative associative methods. Based on the results of data analysis that has been carried out in the first hypothesis (H1), the value of t count > t table is 11,892 > 1,678 and in the second hypothesis (H2) the value of t count > t table is 13,968 > 1,678 which means that the workload and work environment has a positive and significant effect on employee turnover at PT. XYZ while the R-square value obtained is 0.869 which states that the workload and work environment variables affect employee turnover at PT. XYZ is 86.90% and the remaining 13.10% is influenced by other variables.
Uji Modifikasi Lemari Pengering Pati Talas Kimpul (Xanthosoma sagittifolium) sebagai Eksipien dalam Formulasi Tablet Terhadap Lama Pengeringan Shan Amadeus; I Gusti Ngurah Agung Dewantara Putra
JOURNAL SCIENTIFIC OF MANDALIKA (JSM) e-ISSN 2745-5955 | p-ISSN 2809-0543 Vol. 3 No. 12 (2022): Desember
Publisher : Institut Penelitian dan Pengembangan Mandalika Indonesia (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/ jomla.v3i12.1168

Abstract

The physical properties of excipients are very important to know for the manufacture of good tablets. Starch or amylum is an additional material that is often used in the manufacture of tablets. The physical properties of starch or powder that are good for tablets can give the desired effect if they have good quality. Unmodified starch does not have good compressibility and has great friability, and capping will occur in the tablet. Taro taro as a potential starch can be used as an excipient in the manufacture of tablets because it has a high starch content. Taro taro used as an excipient needs to be modified physically and chemically to produce derivatives that have better and more specific pharmaceutical characteristics, especially for the manufacture of tablets. The purpose of this study was to determine whether the physical properties of taro starch matched the parameters of good physical properties. Tests carried out included organoleptic tests which obtained powder like flour, had no odor, had no taste and had a white color, Knowledge test obtained dark blue in modified taro starch solution after being given iodine, Microscopic tests obtained taro starch results which had the arrangement is clustered with the hilus located in the middle, the shape of the hilus is in the form of a point, a straight line. The water content test obtained the water content value of each modified starch based on the length of drying time using a drying cabinet of 9.40% for drying for 24 hours, 8.42 % for drying for 48 hours, and 7.9% for drying for 72 hours and pH Test Produces a pH value of 6.52 for drying for 24 hours, 6.22 for drying for 48 hours and 5.92 for drying for 72 hours.
Comparison of the Performance of Cryptocurrency Bitcoin and Stock as an Alternative Investment Shabrina Herawati; Kurniawan Arif Maspul; Heri Sasono; I Gusti Ngurah Agung Dewantara Putra; Muhammad Syafri; Raúl Eleazar Arias Sánchez
ProBisnis : Jurnal Manajemen Vol. 14 No. 5 (2023): October: Management Science
Publisher : Lembaga Riset, Publikasi dan Konsultasi JONHARIONO

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62398/probis.v14i5.306

Abstract

The research aims to test whether there is a real difference between the investment performance of bitcoin and other investment instruments, namely shares. This research is quantitative research. The unit of analysis in this research is the monthly closing price of bitcoin and LQ45 shares for the period January 2018 to April 2021, namely 80 pieces of data. The analytical method used is the comparative method and the data used is secondary data. The results of this research show that there is no real difference between bitcoin and LQ45 shares when viewed from returns, there is a real difference between bitcoin and LQ45 shares when viewed from risk, there is a real difference between bitcoin and LQ45 shares when viewed from Sharpe performance measures. When making an investment, pay close attention to the returns and risks of both bitcoin and shares, don't be tempted by the potential profits without knowing the various risks that could occur and spreading assets across several investment instruments is one of the things recommended by this research.
Optimization of Non-Effervescet Floating Tablets Ranitidine HCL Formula Using Durian Seed Matrix (Durio Zibethinus Murr) Fully Gelatinized Modified Using Simplex Lattice Design Method I Gusti Ngurah Agung Dewantara Putra; Eka Indra Setyawan; Ni Putu Maya Ninditha; Made Tresia Pramasta Diva
Eduvest - Journal of Universal Studies Vol. 3 No. 12 (2023): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v3i12.964

Abstract

This study investigated the use of fully gelatinated durian seed starch as an excipient in Ranitidine HCl Non-Effervescent Buoyancy Tablets (NEFT). The simplex lattice design method was used to formulate the optimum composition of the formula, including fully gelatinated durian seed starch, PVP K30, and magnesium stearate. Physically modified durian seed starch is expected to increase the release time of active substances in the body. The experiment was conducted for six months by measuring the physical properties of the granule, tablet hardness, solubility, and friability. Results showed that the optimum formula (27.74 mg durian seed starch, 1.5 mg PVP K30, 0.76 mg magnesium stearate) produced ranitidine HCl NEFT tablets with optimal properties. This research may contribute to the development of effective tablet formulations.