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Yuyun Yueniwati
Departement Of Radiology, Faculty Of Medicine, Universitas Brawijaya/Dr. Saiful Anwar General Hospital, Jl. Jaksa Agung Suprapto No. 2, Malang 65112
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Correlation of BMP2 with Degree of Osteitisin Primary CRS with and without nasal Polyps Handoko, Edi; Santoso, David; Maharani, Iriana; P.W, Yuyun Yueniwati; Agustina, Tanti
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.43-50

Abstract

Chronic rhinosinusitis (CRS) is an inflammation of the nasal mucosa and paranasal sinuses, persisting for over12 weeks. CRS involves a remodeling process and opacification known as osteitis, resulting from type 2 and non-type two inflammation. Osteitis severity is assessed using CT scans and the Global Osteitis Scoring Scale (GOSS). Bone morphogenetic protein-2 (BMP-2) is crucial in osteogenesis and bone remodeling. However, no research has shown a relationship between BMP-2 concentration and osteitis degree, as measured by GOSS, in CRS patients with or without nasal polyps. The objective of this study is to analyze the relationship between BMP-2 concentration and osteitis degree measure with GOSS in primary CRS. A cross-sectional analytic observational study was conducted using primary RSK as the study population. BMP-2 concentration, a marker for bone remodeling, used ELISA. The osteitis of the paranasal sinus walls was assessed with a CT scan and quantified using the GOSS method.  The study included 44 patients, with 8 of them serving as the control group. It was found that BMP-2 concentration (ng/mL) had a linear relationship with the GOSS degree in patients with CRS, showing a correlation of 0.583 (deviation >0.05). Further analysis revealed a significant correlation between BMP-2 concentration and GOSS, with a coefficient of 0.857 (considered very significant, in the range of 0.76-0.99). This strong correlation indicates that as BMP-2 concentration strongly correlates with the occurance of osteitis, which were measured by GOSS. BMP-2, as a marker for osteitis in CRS, shows a significant and linear correlation with the severity degree of osteitis measured by GOSS.
Co-Authors Abd. Rasyid Syamsuri Ade Lina Nur Fadlilah Adiantara, Ken Rangga Galang Agung Setyawan Agus Naba Agustina, Tanti Ahmad DW, Ahmad Aldita Husna Violita Aldita Husna Violita Alfred Julius Petrarizky Alfrina Hany Alimsjah, Yohanes Audric Andrijani Sumarahinsih Arief Iskandar Atsil Lathifa, Jauza Ayu Hardianti Pratiwi Azmi, Mukhammad Azzahra, Balqis Faizah Bambang Rahardjo Basya Adnani Basyar Adnani Begum Fauziyah Berlian Cyntia Devi, Berlian Cyntia DAVID SANTOSO Dewi Kartikawatiningsih Diana Lyrawati Dina Dewi SLI Dini Rachma Erawati Diptya, Ibnu Djatmiko, Ahmad Eko Arisetijono Erawati, Dini Rachma Erlangga, Eggi Esther Palupi Fahanani, Agwin Fahmi Fahmi Fahanani, Agwin Faizah Azzahra, Balqis Fatimah Kunti Hentihu Faturrohmaniah, Ari Fauzi, Adam Habiba Aurora Hafiedz Maulana Handoko, Edi Handono Kalim Happy Kurnia Permatasari Heri Kristianto Husnul Khotimah Irawan, Paulus Lucky Tirma Iriana Maharani, Iriana Johan Andoyo Effendi Noor Johan Andoyo Effendi Noor Karimah Karimah Karimah Ken Rangga Galang Adiantara Lathifa, Jauza Atsil M. Yunus Maharina, Luths Margaretha Berek Masruroh Rahayu Mohamad Hidayat Mokhamad Fahmi Rizki Syaban Muhammad Zacky Hafiyyan Maulana Mukhamad Fathoni Mukhammad Fathoni N. Diana Yulisa Nabilla Hardiyanti, Ginanda Nanik Setijowati Nasir Aslam, Achmad Bayhaqi Nasywa Talitha Zahran Ni Kadek Indah Sunar A Noviyanti Noviyanti, Noviyanti Ns. Rinik Eko Kapti Nugroho, Rafiq Sulistyo Nur Permatasari Nurdiana, Farah Permatasari, Galuh W. Prabata, Adam Pradana, Wisniardhy Suarnata Pradhana, Satwika Purnama, Avief Destian Rachma Erawati, Dini Rachmi Fauziah Rahayu Rahmawan, Fajri Andi Rinik Eko Kapti, Rinik Eko Rislan Faiz Muhammad Rislan Faiz Muhammad Ropitasari Ropitasari Rulli Rosandi Safira Dita Arviana Sakdullah, Istianah Sarni J. Ishak Servasius Ratu Banin Shahdevi Nandar Kurniawan, Shahdevi Nandar Sigma Nur Rismawati Siti Maimunah Tifani, Amara Syifa Titin Andri Wihastuti Tony Suharsono Tony Suharsono, Tony Tri Mukti Lestari Wahyudi, Mgs Ahmad Widya Addiarto Wulansari, Yunita Wahyu Yudisthira, Dewangga Yulian Wiji Utami Yunita Wahyu Wulansari, Yustina Ni Putu yusniawati