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All Journal Jurnal Ilmiah Farmasi Natural Science: Journal of Science and Technology Journal of Mathematical and Fundamental Sciences JURNAL PENGABDIAN KEPADA MASYARAKAT INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Ilmu Kefarmasian Indonesia Molekul: Jurnal Ilmiah Kimia
Muhammad Sulaiman Zubair
Department Of Pharmacy, Faculty Of Mathematics And Natural Sciences, Tadulako University, Palu 94118, Indonesia
Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences

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Self-Nanoemulsifying Drug Delivery System (SNEDDS): Challenges and Opportunities in Enhancing Drug Solubility Sabillah, Farhad Aulan; Fitriani, Hannie; Zubair, Muhammad Sulaiman; Syukri, Yandi
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 3 (2025): J Sains Farm Klin 12(3), December 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.3.217-225.2025

Abstract

For oral medications, especially those in BCS Classes II and IV, poor aqueous solubility continues to be a significant formulation challenge. This problem restricts dosage consistency, therapeutic efficacy, and bioavailability. A promising method for improving the solubility and absorption of lipophilic drug compounds is the Self-Nanoemulsifying Drug Delivery System (SNEDDS). With ramifications for the pharmaceutical and medical domains, this narrative review attempts to investigate the synthesis, characterization, difficulties, and possible uses of SNEDDS in improving drug solubility. According to the standards of scientific merit, accessibility, and relevance, a total of 25 articles released within the previous five years were included. When SNEDDS meet gastrointestinal fluids, they spontaneously form nanoemulsions, which improves drug solubility. Oil, surfactant, and co-surfactant make up this system, which is optimized according to zeta potential (±30 mV), polydispersity index (<0.3), and particle size (<200 nm). Numerous studies have shown how well it works to enhance the pharmacokinetics and solubility of medications like thymoquinone, rosuvastatin, and curcumin. However, issues with excipient safety, formulation scalability, and long-term stability still exist. SNEDDS offers a versatile and efficient method for enhancing oral drug delivery, especially for nutraceuticals and health supplements. To fully realize its therapeutic and industrial potential, more research involving clinical validation, regulatory harmonization, and quality-by-design approaches is required.
Co-Authors Abdur Rahman Arif, Abdur Rahman Agus Ritna Agustinus Widodo Ahmad Khumaidi Alfred Trisakti Alwiyah Mukaddas Alwiyah Mukaddas Andry Nur Hidayat Arba Pramundita Ramadani Arba, Muhammad Arfan Arfan Armini Syamsidi Arry Yanuar Arwansyah Arwansyah Asita, Nur Asmiyenti Djaliasrin Djalil Asriana Sultan Ayunanda, Nurul Putri Ramadhani Daryono Hadi Tjahjono David Pakaya DEWI RISMAYANTI Evi Sulastri FIRMANITA DWIMURTI Fitriani, Hannie Hayati, Farida Ibrahim Jantan Ibrahim Jantan Julio, Ivan Lubis, Siska Syahfitri Mohamed Ali Ghandourah Muhammad Arba Muhammad Yusran Musyahidah Musyahidah Nur Asita Nurlina Ibrahim Nurul Ambianti Poluan, Jesica Carine Ramdanil Ramdanil Rusmiyanti Rusmiyanti Sabillah, Farhad Aulan Saipul Maulana Sakung, Jamaludin Musa Sanang Nur Safitri Setyanto Tri Wahyudi Sri Mulyani Sabang Subehan Lallo Syariful Anam Tahril Velincia Tanriono, Levana Walied Mohamed Alarif Yamin Yamin Yandi Syukri Yonelian Yuyun Yuliet Yuliet Yusriadi Yusriadi