Article Per Year (5 Year)
p-Index From 2021 - 2026
3.036
P-Index
This Author published in this journals
All Journal VALENSI Jurnal Farmasi Andalas JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Kesehatan Medika Saintika Jurnal Teladan: Jurnal Ilmu Pendidikan dan Pembelajaran Jurnal Jamu Indonesia Pharmacoscript Jurnal Pengabdian Harapan Ibu (JPHI) Khazanah Intelektual Journal Pharmasci (Journal of Pharmacy and Science) Pharmaceutical And Biomedical Sciences Journal (PBSJ) PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Jurnal Katalisator Riset Informasi Kesehatan Jurnal Pengabdian Harapan Ibu (JPHI) Journal of Pharmaceutical and Sciences. Jurnal Sains dan Kesehatan Indonesian Journal of Jamu
Rahmadevi
Universitas Adiwangsa Jambi
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

Published : 25 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 25 Documents
Search

 1   2   3 
Comparative Anti-Inflammatory Effect of Aceclofenac with Saccharin and Aceclofenac in Carrageenan-Induced Granuloma Pouch Model in Mice Usman, Hendrizal; Umar, Salman; Aldi, Yufri; Rahmadevi, Rahmadevi; Zaini, Erizal
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 7, No 1 (2025)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.48792

Abstract

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) and suppresses prostaglandin synthesis. Its clinical utility, however, is limited by poor aqueous solubility and low bioavailability. This study evaluates the anti-inflammatory activity of a multicomponent crystal (MC) of aceclofenac with saccharin using a carrageenan-induced granuloma pouch model in mice. Male mice were divided into three groups (n = 3 per group): control, aceclofenac, and aceclofenac-saccharin multicomponent crystal, administered intraperitoneally. Inflammatory response was assessed via exudate volume and TNF-α levels. Both aceclofenac and MC significantly reduced exudate volume and TNF-α compared to the control (p < 0.05), with the MC group showing the greatest reduction. Although not statistically different from aceclofenac in TNF-α suppression, the MC demonstrated superior performance overall. The enhanced efficacy may be attributed to improved solubility and drug delivery. These outcomes support co-crystallization as a promising approach to optimize NSAID therapy.
Peningkatan Efek Antiinflamasi Multikomponen Etorikoksib terhadap Penurunan TNF-α Rahmadevi, Rahmadevi; Zaini , Erizal; Yuliandra , Yori
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1097

Abstract

Etoricoxib, a selective COX-2 inhibitor, is widely used for its anti-inflammatory effects but is associated with dose-dependent adverse events. Multicomponent formulations with coformers or solubilizing agents offer a potential strategy to improve efficacy while minimizing toxicity. This study aimed to evaluate the anti-inflammatory efficacy of pure etoricoxib and its multicomponent formulations with nicotinamide, N-methyl glucamine, and piperine using TNF-α as a coformer. A controlled laboratory experiment was conducted in Wistar rats using a carrageenan-induced granuloma pouch model. TNF-α levels were measured at baseline (0 hours) and at 6 hours post-treatment. Normality tests, two-way ANOVA, and Tukey HSD post-hoc analyses were applied to assess group differences and time effects. All treatment groups significantly reduced TNF-α levels compared to the control (p < 0.001). While pairwise comparisons between treatments were not statistically significant, the P4 formulation (etoricoxib–piperine) showed the most consistent reduction. P3 (etoricoxib–N-methyl glucamine) exhibited a near-significant difference from pure etoricoxib (P1), suggesting enhanced efficacy. The main effect of time confirmed the temporal decline of TNF-α (p = 0.0101), without significant group × time interaction. Multicomponent formulations, particularly those containing piperine and N-methyl glucamine, enhance the anti-inflammatory action of etoricoxib. These research support further development of bioenhanced etoricoxib as safer alternatives for antiinflammatory.
Phytochemical Analysis and Determination of MIC and MFC of Cacao Leaves Extract (Theobroma cacao L.) against Malassezia furfur Lestari, Siti Marwah; Camelia, Leonyta; Rizki, Widya Twini; Pratama, Septa; Khutami, Chindiana; Amelia, Amraini; Rahmadevi, Rahmadevi; Andriani, Yuni
Jurnal Jamu Indonesia Vol. 9 No. 2 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i2.316

Abstract

Pityriasis versicolor is a disease caused by Malassezia furfur. One of the plants that can potentially act as antifungal is cacao leaves (Theobroma cacao L.), which contain several secondary metabolite compounds, including alkaloids, flavonoids, tannins, quinones, terpenoids, and saponins. This study aims to determine the phytochemical analysis and the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) of cacao leaves ethanolic extract against M. furfur. Extracts were obtained by maceration using 70% ethanol and phytochemicals analysis using Herborne’s method. Furthermore, the extracts were made into concentrations’ variations of 3.125%; 6.25%; 12.5%; 25%; 50%; and 100% for testing antifungal activity, with 10% DMSO as negative control and 2% Ketoconazole and Itraconazole as positive controls. MIC was performed with liquid macrodilution method, and MFC was performed with spread method. The results of phytochemical analysis showed that the extract contained alkaloids, flavonoids, phenols, tannins, quinones, terpenoids and saponins. MIC value was obtained at concentration of 50% and MFC value was obtained at 100%. Cacao leaves ethanolic extract with concentration of 50% can inhibit M. furfur’s growth and with 100% can eliminate M. furfur.
Comparative Anti-Inflammatory Effect of Aceclofenac-Saccharin in Mice Granuloma Model Usman, Hendrizal; Aldi, Yufri; Umar, Salman; Rahmadevi; Zaini, Erizal
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 1 (2025)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.49145

Abstract

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) and suppresses prostaglandin synthesis. Its clinical utility, however, is limited by poor aqueous solubility and low bioavailability. This study evaluates the anti-inflammatory activity of a multicomponent crystal (MC) of aceclofenac with saccharin using a carrageenan-induced granuloma pouch model in mice. Male mice were divided into three groups (n = 3 per group): control, aceclofenac, and aceclofenac-saccharin multicomponent crystal, administered intraperitoneally. Inflammatory response was assessed via exudate volume and TNF-α levels. Both aceclofenac and MC significantly reduced exudate volume and TNF-α compared to the control (p < 0.05), with the MC group showing the greatest reduction. Although not statistically different from aceclofenac in TNF-α suppression, the MC demonstrated superior performance overall. The enhanced efficacy may be attributed to improved solubility and drug delivery. These outcomes support co-crystallization as a promising approach to optimize NSAID therapy.
Analisis Bahan Kimia Obat Parasetamol pada Jamu Pegal Linu yang dijual di Kecamatan Pasar Jambi, Kota Jambi Siti Marwah Lestari; Widya Twiny Rizki; Rahmadevi; Nindi Sepdina Yanti
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 1 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Chemical drugs that were often added to pegal linu herbal medicine was paracetamol. Paracetamol added as analgesic. Objective: This study aims to analyze qualitatively the content of Paracetamol in the pegal linu herbal medicine, which is sold in Pasar Jambi District, Jambi City. Method: This study was conducted qualitatively, samples were taken by purposive sampling, and 8 samples (SA, SB, SC, SD, SE, SF, SG, and SH) were selected from pegal linu medicine that met the inclusive criteria. Samples were tested organoleptically, microscopically, spot test, and TLC. Results: In the organoleptic test, all herbs were in powder form, SA had a brownish-yellow color with an aromatic odor, SB had a light brown color with an aromatic odor, SC had a greenish-brown color with an aromatic odor, SD had a light brown color with an aromatic odor, SE had a yellowish-brown color with an aromatic odor, SF has a yellowish-brown color with an aromatic odor, SG has a light brown color with an aromatic odor, SH has a greenish-brown color with an aromatic odor. In the spot test, no herbs were found that had the same color reaction as paracetamol. In the TLC test, there were several herbs that had the same Rf value as standard paracetamol. In the 1st, 2nd, and 3rd tests, the Rf value of paracetamol respectively were 0.36; 0.33; and 0.40. Meanwhile, in the sample, it was found that the Rf value was the same as that of paracetamol. In the first test, the samples coded SD and SG, in the second test there were none, in the third test, the herbal medicine samples coded SC and SD. Conclusion: Pegal linu herbal medicine didn’t contain paracetamol.
Co-Authors Alfiana, Dessinta Amraini Amelia Anggresani, Lia Ara Ofiana Armayana Firda Astridawati, Indah Auzal Halim Ayu Aprilya Barmi Hartesi Bunga Debi Lestari Camelia, Leonyta Desi Sagita Erizal Zaini Fauziah, Wiwin Fhatia Medina Fidya Rizky Bardani Fitriani Arin Indah Astridawati Indri Meirista Khasanah, Isti Mufidhatun Nur Khutami, Chindiana Lia Anggresani Lia Anggresani Lili Andriani Lili Andriani Masril Malik Medina, Fhatia Muhammad Randa Nindi Sepdina Yanti Nofriyaldi, Ali Oktavia, Nazifa Oktaviani Puspita Putri, Carrel Windyana Randa, Muhammad Rizki, Widya Twini Rizki, Widya Twiny Rizky Yulion Ryan Afandi Salman Umar Santi Perawati Santi Perawati Santi Perawati, Santi Sari, Ririn Depita Satiya Ningsih Siti Hamidatul 'Aliyah Siti Marwah Lestari Sutrisno , Deny Usman, Hendrizal Wahyuni, Winika Sri Widya Twiny Rizki Wulandari, Konita Yasnawati Yasnawati Yoli Nopita Sari Yufri Aldi Yuliandra , Yori Yuni Andriani Zaini , Erizal