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All Journal VALENSI Jurnal Farmasi Andalas JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Kesehatan Medika Saintika Jurnal Katalisator Jurnal Teladan: Jurnal Ilmu Pendidikan dan Pembelajaran Jurnal Jamu Indonesia Pharmacoscript Jurnal Pengabdian Harapan Ibu (JPHI) Khazanah Intelektual Journal Pharmasci (Journal of Pharmacy and Science) Pharmaceutical And Biomedical Sciences Journal (PBSJ) PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Jurnal Katalisator Riset Informasi Kesehatan Jurnal Pengabdian Harapan Ibu (JPHI) Journal of Pharmaceutical and Sciences. Jurnal Sains dan Kesehatan Jurnal Abdimas Kesehatan Indonesian Journal of Jamu
Rahmadevi
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

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FORMULASI NANOKAPSUL BIJI LABU (Cucurbita moschata) SEBAGAI SUPLEMEN ZAT BESI DAN ZINK UNTUK STUNTING Rahmadevi, Rahmadevi; Khutami, Chindiana; Oktavia, Nazifa
Jurnal Kesehatan Medika Saintika Vol 15, No 2 (2024): Desember 2024
Publisher : Stikes Syedza Saintika Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jkms.v15i2.2950

Abstract

 Kasus stunting di Indonesia sampai tahun 2022 masih terbilang tinggi menurut riskesdas yaitu 21,6% dari seluruh populasi penduduk Indonesia. Salah satu faktor yang menyebabkan kasus ini adalah kurangnya asupan mineral untuk pertumbuhan terutama zink dan Fe (zat besi). Zink bertanggung jawab terhadap pembelahan sel pada manusia, sedangkan Fe (zat besi) sangat berperan dalam pembentukan sel darah merah. Masalh ini dapat diatasi dengan cepat jika ada produk atau suplemen yang mengandung zink dan Fe. Suplemen ini telah beredar dipasaran, namun yang berasal dari alam masih sangat sedikit didapat. Kelangkaan ini dapat diatasi dengan melakukan eksplorasi produk dari alam yang mengandung banyak mineral terutama zink dan Fe. Salah tumbuhan yang memiliki kandungan mineral yang cukup banyak terutama zink adalah labu kuning. Penelitian ini bertujuan untuk membuat suplemen berbentuk nanokapsul dengan teknik freeze drying. Sampel merupakan campuran antara serbuk biji labu kuning dengan maltodekstrin yang dilarutkan dalam aquadest dengan perbandingan (0,5:5; 1,5:5 dan 3:5). Dan dibekukan dengan freeze drying. Sampel dikarakterisasi dengan AAS, FTIR, PSA dan SEM. Hasil yang diperoleh Formulasi terbaik adalah sampel 3 dengan persentase maltodekstrin 90,9%, ukuran partikel nanokapsul (214,6 nm) dengan indeks polidipersitas terendah yaitu 0,47, nilai rendemen 95,64%, dan bentuk morfologi cenderung bulat, permukaan sedikit cekungan (hampir sempurna). Serbuk biji labu kuning dan maltodekstrin dengan Teknik freeze drying merupakan suplemen yang menjanjikan sebagai suplemen untuk penanganan stunting. Kata kunci : Stunting; Zink; Biji labu kuning
Lempuyang Rhizome Extract Lempuyang Rhizome Extract Microcapsule Formulation (Zingiber zerumbet) For Enhancer Appetite in Children Rahmadevi, Rahmadevi; Lestari, Siti Marwah; Khasanah, Isti Mufidhatun Nur; Putri, Carrel Windyana
Riset Informasi Kesehatan Vol 12 No 2 (2023): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/rik.v12i2.824

Abstract

Stunting is a public health problem that must be treated seriously. Findings Riskesdas showed that stunting cases were relatively stagnant at around 36.8% (2007) and reached 37.2% (2013). The problem of stunting (short children) has one of the problems of malnutrition become the focus of the Government of Indonesia. Malnutrition is often caused by a child's reduced appetite. This is very important to pay attention to when making supplement products could increase appetite. These supplements must be safe and effective to use. One of the safe products used comes from nature, such as many rhizomes grows in Indonesian soil such as: turmeric, ginger, ginger, ginger and lempuyang. Lempuyang rhizomes (Zingiber zerumbet) contain alkaloids, saponins, flavonoids, polyphenols and essential oils. This rhizome has many properties such as: tonic, anti-seizure and appetite enhancer. Supplements made from lempuyang extract are packaged in microcapsule form. Based on this, the researchers aimed to make lempuyang extract microcapsules. The supplement has been in microcapsule form used by a spray drying technique. The obtained microcapsules were evaluated using a Scanning Electron microscope, particle size analyzer which obtained 10 - 500 mm microcapsules and HPLC to determine the percentage of lempuyang extract trapped in the microcapsules (% Entrapment efficiency) of 72%.
Comparative Anti-Inflammatory Effect of Aceclofenac with Saccharin and Aceclofenac in Carrageenan-Induced Granuloma Pouch Model in Mice Usman, Hendrizal; Umar, Salman; Aldi, Yufri; Rahmadevi, Rahmadevi; Zaini, Erizal
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 7, No 1 (2025)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.48792

Abstract

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) and suppresses prostaglandin synthesis. Its clinical utility, however, is limited by poor aqueous solubility and low bioavailability. This study evaluates the anti-inflammatory activity of a multicomponent crystal (MC) of aceclofenac with saccharin using a carrageenan-induced granuloma pouch model in mice. Male mice were divided into three groups (n = 3 per group): control, aceclofenac, and aceclofenac-saccharin multicomponent crystal, administered intraperitoneally. Inflammatory response was assessed via exudate volume and TNF-α levels. Both aceclofenac and MC significantly reduced exudate volume and TNF-α compared to the control (p < 0.05), with the MC group showing the greatest reduction. Although not statistically different from aceclofenac in TNF-α suppression, the MC demonstrated superior performance overall. The enhanced efficacy may be attributed to improved solubility and drug delivery. These outcomes support co-crystallization as a promising approach to optimize NSAID therapy.
Peningkatan Efek Antiinflamasi Multikomponen Etorikoksib terhadap Penurunan TNF-α Rahmadevi, Rahmadevi; Zaini , Erizal; Yuliandra , Yori
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1097

Abstract

Etoricoxib, a selective COX-2 inhibitor, is widely used for its anti-inflammatory effects but is associated with dose-dependent adverse events. Multicomponent formulations with coformers or solubilizing agents offer a potential strategy to improve efficacy while minimizing toxicity. This study aimed to evaluate the anti-inflammatory efficacy of pure etoricoxib and its multicomponent formulations with nicotinamide, N-methyl glucamine, and piperine using TNF-α as a coformer. A controlled laboratory experiment was conducted in Wistar rats using a carrageenan-induced granuloma pouch model. TNF-α levels were measured at baseline (0 hours) and at 6 hours post-treatment. Normality tests, two-way ANOVA, and Tukey HSD post-hoc analyses were applied to assess group differences and time effects. All treatment groups significantly reduced TNF-α levels compared to the control (p < 0.001). While pairwise comparisons between treatments were not statistically significant, the P4 formulation (etoricoxib–piperine) showed the most consistent reduction. P3 (etoricoxib–N-methyl glucamine) exhibited a near-significant difference from pure etoricoxib (P1), suggesting enhanced efficacy. The main effect of time confirmed the temporal decline of TNF-α (p = 0.0101), without significant group × time interaction. Multicomponent formulations, particularly those containing piperine and N-methyl glucamine, enhance the anti-inflammatory action of etoricoxib. These research support further development of bioenhanced etoricoxib as safer alternatives for antiinflammatory.
Phytochemical Analysis and Determination of MIC and MFC of Cacao Leaves Extract (Theobroma cacao L.) against Malassezia furfur Lestari, Siti Marwah; Camelia, Leonyta; Rizki, Widya Twini; Pratama, Septa; Khutami, Chindiana; Amelia, Amraini; Rahmadevi, Rahmadevi; Andriani, Yuni
Jurnal Jamu Indonesia Vol. 9 No. 2 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i2.316

Abstract

Pityriasis versicolor is a disease caused by Malassezia furfur. One of the plants that can potentially act as antifungal is cacao leaves (Theobroma cacao L.), which contain several secondary metabolite compounds, including alkaloids, flavonoids, tannins, quinones, terpenoids, and saponins. This study aims to determine the phytochemical analysis and the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) of cacao leaves ethanolic extract against M. furfur. Extracts were obtained by maceration using 70% ethanol and phytochemicals analysis using Herborne’s method. Furthermore, the extracts were made into concentrations’ variations of 3.125%; 6.25%; 12.5%; 25%; 50%; and 100% for testing antifungal activity, with 10% DMSO as negative control and 2% Ketoconazole and Itraconazole as positive controls. MIC was performed with liquid macrodilution method, and MFC was performed with spread method. The results of phytochemical analysis showed that the extract contained alkaloids, flavonoids, phenols, tannins, quinones, terpenoids and saponins. MIC value was obtained at concentration of 50% and MFC value was obtained at 100%. Cacao leaves ethanolic extract with concentration of 50% can inhibit M. furfur’s growth and with 100% can eliminate M. furfur.
Analisis Bahan Kimia Obat Parasetamol pada Jamu Pegal Linu yang dijual di Kecamatan Pasar Jambi, Kota Jambi Siti Marwah Lestari; Widya Twiny Rizki; Rahmadevi; Nindi Sepdina Yanti
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 1 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Chemical drugs that were often added to pegal linu herbal medicine was paracetamol. Paracetamol added as analgesic. Objective: This study aims to analyze qualitatively the content of Paracetamol in the pegal linu herbal medicine, which is sold in Pasar Jambi District, Jambi City. Method: This study was conducted qualitatively, samples were taken by purposive sampling, and 8 samples (SA, SB, SC, SD, SE, SF, SG, and SH) were selected from pegal linu medicine that met the inclusive criteria. Samples were tested organoleptically, microscopically, spot test, and TLC. Results: In the organoleptic test, all herbs were in powder form, SA had a brownish-yellow color with an aromatic odor, SB had a light brown color with an aromatic odor, SC had a greenish-brown color with an aromatic odor, SD had a light brown color with an aromatic odor, SE had a yellowish-brown color with an aromatic odor, SF has a yellowish-brown color with an aromatic odor, SG has a light brown color with an aromatic odor, SH has a greenish-brown color with an aromatic odor. In the spot test, no herbs were found that had the same color reaction as paracetamol. In the TLC test, there were several herbs that had the same Rf value as standard paracetamol. In the 1st, 2nd, and 3rd tests, the Rf value of paracetamol respectively were 0.36; 0.33; and 0.40. Meanwhile, in the sample, it was found that the Rf value was the same as that of paracetamol. In the first test, the samples coded SD and SG, in the second test there were none, in the third test, the herbal medicine samples coded SC and SD. Conclusion: Pegal linu herbal medicine didn’t contain paracetamol.
Formulasi Tablet Effervescent Ekstrak Daun Kelor (Moringa oleifera L.) sebagai Pemenuhan Nutrisi untuk Pencegahan Stunting Zola, Elpa Giovana; Syafitri , Eka; Rahmadevi , Rahmadevi; Agustina , Dea Ayu
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1239

Abstract

Stunting remains a significant nutritional problem in Indonesia, requiring practical and acceptable nutritional interventions. Moringa oleifera L. leaves are known to contain essential minerals such as zinc, iron, and iodine, which play an important role in supporting optimal growth. This study aimed to formulate effervescent tablets of Moringa leaf extract and evaluate their physical quality as an alternative nutritional supplement for stunting prevention. Moringa leaf extract was obtained through maceration and formulated into four effervescent tablet formulas with varying extract concentrations. The evaluations included granule flow properties, angle of repose, pH, size uniformity, weight uniformity, dispersion time, FTIR analysis, and hedonic testing. The results showed that all formulas met the physical quality requirements of effervescent tablets. The granules exhibited good flow characteristics with an angle of repose below 40°, while the tablet pH values ranged from 4,4 -5,8, indicating suitability for oral administration. All formulas complied with the standards for size and weight uniformity, and the dispersion time ranged from 1 to 2 minutes. FTIR analysis confirmed the presence of hydroxyl, carbonyl, nitroso, and benzene functional groups associated with flavonoids, saponins, and tannins, which contribute beneficial mineral content. Based on physical and organoleptic evaluations, Formula 2 showed the best combination of extract content and granule flow properties, while Formula 1 was the most preferred in terms of taste.
Teh Herbal Daun Kelakai (Stenochlaena palustris) sebagai Potensi Fitoestrogen Untuk Produksi ASI : Terinspirasi dari Kearifan Lokal Suku Anak Dalam Jambi Intami, Eprina; Mustakim , Ardi; Rahmadevi, Rahmadevi; Mulyati , Sri
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1177

Abstract

This study was conducted in response to the problem of low breast milk production among some breastfeeding mothers, which may adversely affect infant growth and development. One approach to enhancing breast milk production is the utilization of natural substances containing phytoestrogens. Kelakai leaves (Stenochlaena palustris) are a plant traditionally used by the Suku Anak Dalam community as part of local wisdom to support maternal health during the postpartum period. This study aimed to develop kelakai leaf herbal tea as a natural source of phytoestrogens with potential to support increased breast milk production. The research employed a quasi-experimental design using a one-group pre-test and post-test with control group approach, complemented by laboratory analyses including identification of active compounds, simplicia processing, herbal tea formulation, phytochemical screening, and phytoestrogen content analysis. The results demonstrated that kelakai leaves contain flavonoids, saponins, and phytoestrogenic compounds that may contribute to the stimulation of prolactin and oxytocin secretion. Statistical analysis revealed a p-value of 0.000 (p < 0.05), indicating a significant effect of kelakai herbal tea administration on breast milk production among breastfeeding mothers. Based on these findings, it can be concluded that kelakai herbal tea has potential as an alternative herbal beverage derived from local wisdom that may support the success of exclusive breastfeeding programs.
Co-Authors Agustina , Dea Ayu Alfiana, Dessinta Amraini Amelia Anggresani, Lia Ara Ofiana Armayana Firda Armini Hadriyati Astridawati, Indah Auzal Halim Ayu Aprilya Barmi Hartesi Bunga Debi Lestari Camelia, Leonyta Chindiana Khutami Desi Sagita Eprina Intami Erizal Zaini Fauziah, Wiwin Fhatia Medina Fidya Rizky Bardani Fitriani Arin Indah Astridawati Indri Meirista Khasanah, Isti Mufidhatun Nur Lia Anggresani Lia Anggresani Lia Anggresani Lili Andriani Lili Andriani Masril Malik Medina, Fhatia Muhammad Randa Mulyati , Sri Mustakim , Ardi Nindi Sepdina Yanti Nofriyaldi, Ali Oktavia, Nazifa Oktaviani Puspita Putri, Carrel Windyana Randa, Muhammad Rizka Afrina Rizki, Widya Twini Rizki, Widya Twiny Rizky Yulion Ryan Afandi Salman Umar Santi Perawati Santi Perawati Santi Perawati, Santi Sanuddin, Mukhlis Sari, Ririn Depita Satiya Ningsih Siti Hamidatul 'Aliyah Siti Marwah Lestari Sutrisno , Deny Syafitri , Eka Usman, Hendrizal Wahyuni, Winika Sri Widya Twiny Rizki Wulandari, Konita Yasnawati Yasnawati Yoli Nopita Sari Yufri Aldi Yuliandra , Yori Yuni Andriani Zaini , Erizal Zola, Elpa Giovana