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All Journal VALENSI Jurnal Farmasi Andalas JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Kesehatan Medika Saintika Jurnal Katalisator Jurnal Teladan: Jurnal Ilmu Pendidikan dan Pembelajaran Jurnal Jamu Indonesia Pharmacoscript Jurnal Pengabdian Harapan Ibu (JPHI) Khazanah Intelektual Journal Pharmasci (Journal of Pharmacy and Science) Pharmaceutical And Biomedical Sciences Journal (PBSJ) PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Jurnal Katalisator Riset Informasi Kesehatan Jurnal Pengabdian Harapan Ibu (JPHI) Jurnal Sains dan Kesehatan Jurnal Abdimas Kesehatan Indonesian Journal of Jamu
Rahmadevi
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Comparative Anti-Inflammatory Effect of Aceclofenac with Saccharin and Aceclofenac in Carrageenan-Induced Granuloma Pouch Model in Mice Usman, Hendrizal; Umar, Salman; Aldi, Yufri; Rahmadevi, Rahmadevi; Zaini, Erizal
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 7, No 1 (2025)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.48792

Abstract

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) and suppresses prostaglandin synthesis. Its clinical utility, however, is limited by poor aqueous solubility and low bioavailability. This study evaluates the anti-inflammatory activity of a multicomponent crystal (MC) of aceclofenac with saccharin using a carrageenan-induced granuloma pouch model in mice. Male mice were divided into three groups (n = 3 per group): control, aceclofenac, and aceclofenac-saccharin multicomponent crystal, administered intraperitoneally. Inflammatory response was assessed via exudate volume and TNF-α levels. Both aceclofenac and MC significantly reduced exudate volume and TNF-α compared to the control (p < 0.05), with the MC group showing the greatest reduction. Although not statistically different from aceclofenac in TNF-α suppression, the MC demonstrated superior performance overall. The enhanced efficacy may be attributed to improved solubility and drug delivery. These outcomes support co-crystallization as a promising approach to optimize NSAID therapy.
Phytochemical Analysis and Determination of MIC and MFC of Cacao Leaves Extract (Theobroma cacao L.) against Malassezia furfur Lestari, Siti Marwah; Camelia, Leonyta; Rizki, Widya Twini; Pratama, Septa; Khutami, Chindiana; Amelia, Amraini; Rahmadevi, Rahmadevi; Andriani, Yuni
Jurnal Jamu Indonesia Vol. 9 No. 2 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i2.316

Abstract

Pityriasis versicolor is a disease caused by Malassezia furfur. One of the plants that can potentially act as antifungal is cacao leaves (Theobroma cacao L.), which contain several secondary metabolite compounds, including alkaloids, flavonoids, tannins, quinones, terpenoids, and saponins. This study aims to determine the phytochemical analysis and the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) of cacao leaves ethanolic extract against M. furfur. Extracts were obtained by maceration using 70% ethanol and phytochemicals analysis using Herborne’s method. Furthermore, the extracts were made into concentrations’ variations of 3.125%; 6.25%; 12.5%; 25%; 50%; and 100% for testing antifungal activity, with 10% DMSO as negative control and 2% Ketoconazole and Itraconazole as positive controls. MIC was performed with liquid macrodilution method, and MFC was performed with spread method. The results of phytochemical analysis showed that the extract contained alkaloids, flavonoids, phenols, tannins, quinones, terpenoids and saponins. MIC value was obtained at concentration of 50% and MFC value was obtained at 100%. Cacao leaves ethanolic extract with concentration of 50% can inhibit M. furfur’s growth and with 100% can eliminate M. furfur.
Analisis Bahan Kimia Obat Parasetamol pada Jamu Pegal Linu yang dijual di Kecamatan Pasar Jambi, Kota Jambi Siti Marwah Lestari; Widya Twiny Rizki; Rahmadevi; Nindi Sepdina Yanti
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 1 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

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Abstract

Background: Chemical drugs that were often added to pegal linu herbal medicine was paracetamol. Paracetamol added as analgesic. Objective: This study aims to analyze qualitatively the content of Paracetamol in the pegal linu herbal medicine, which is sold in Pasar Jambi District, Jambi City. Method: This study was conducted qualitatively, samples were taken by purposive sampling, and 8 samples (SA, SB, SC, SD, SE, SF, SG, and SH) were selected from pegal linu medicine that met the inclusive criteria. Samples were tested organoleptically, microscopically, spot test, and TLC. Results: In the organoleptic test, all herbs were in powder form, SA had a brownish-yellow color with an aromatic odor, SB had a light brown color with an aromatic odor, SC had a greenish-brown color with an aromatic odor, SD had a light brown color with an aromatic odor, SE had a yellowish-brown color with an aromatic odor, SF has a yellowish-brown color with an aromatic odor, SG has a light brown color with an aromatic odor, SH has a greenish-brown color with an aromatic odor. In the spot test, no herbs were found that had the same color reaction as paracetamol. In the TLC test, there were several herbs that had the same Rf value as standard paracetamol. In the 1st, 2nd, and 3rd tests, the Rf value of paracetamol respectively were 0.36; 0.33; and 0.40. Meanwhile, in the sample, it was found that the Rf value was the same as that of paracetamol. In the first test, the samples coded SD and SG, in the second test there were none, in the third test, the herbal medicine samples coded SC and SD. Conclusion: Pegal linu herbal medicine didn’t contain paracetamol.
Tannin Extraction from Bark of Cinnamomum burmannii and Its Application for use as Natural Dye and as Antioxidant Widya Twiny Rizki; Winika Sri Wahyuni; Ririn Depita Sari; Siti Marwah Lestari; Rahmadevi Rahmadevi
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 9, No 1 (2024): February 2024
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24845/ijfac.v9.i1.35

Abstract

Cinnamon bark (Cinnamomum burmannii) contains tannins which have the potential to act as natural dyes. This research is to synthesize natural dye from cinnamon bark extract (Cinnamomum burmannii). The research was carried out by making cinnamon bark extract by comparing the amount of solvent by maceration using 96% ethanol, calculating the yield, tannin analysis, FTIR analysis, and stability test color. The comparison of the amount of cinnamon bark extraction solvent affected the resulting yield. Testing the tannin compound with 1% gelatin reagent in 10% NaCl showed a white precipitate and 1% FeCl3 reagent produced a greenish-brown color so the extract was positive for tannin, analysis FTIR ratio 1:10 for the presence of O-H, C-H, C=C, C-O groups, ratio 1:15 for the presence of O-H, C-H, C=C, C-O group. The color stability test of cinnamon bark extract is more stable than Rhodamine-B. Based on the extraction results, it was concluded that cinnamon bark extract can be used as an alternative to natural dye in cosmetic products.Keywords: Cinnamon Bark, Extract, FTIR Analysis, Natural dyes, Tannin
FORMULASI NANOKAPSUL BIJI LABU (Cucurbita moschata) SEBAGAI SUPLEMEN ZAT BESI DAN ZINK UNTUK STUNTING Rahmadevi Rahmadevi; Chindiana Khutami; Nazifa Oktavia
Jurnal Kesehatan Medika Saintika Vol 15, No 2 (2024): Desember 2024
Publisher : Stikes Syedza Saintika Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jkms.v15i2.2950

Abstract

 Kasus stunting di Indonesia sampai tahun 2022 masih terbilang tinggi menurut riskesdas yaitu 21,6% dari seluruh populasi penduduk Indonesia. Salah satu faktor yang menyebabkan kasus ini adalah kurangnya asupan mineral untuk pertumbuhan terutama zink dan Fe (zat besi). Zink bertanggung jawab terhadap pembelahan sel pada manusia, sedangkan Fe (zat besi) sangat berperan dalam pembentukan sel darah merah. Masalh ini dapat diatasi dengan cepat jika ada produk atau suplemen yang mengandung zink dan Fe. Suplemen ini telah beredar dipasaran, namun yang berasal dari alam masih sangat sedikit didapat. Kelangkaan ini dapat diatasi dengan melakukan eksplorasi produk dari alam yang mengandung banyak mineral terutama zink dan Fe. Salah tumbuhan yang memiliki kandungan mineral yang cukup banyak terutama zink adalah labu kuning. Penelitian ini bertujuan untuk membuat suplemen berbentuk nanokapsul dengan teknik freeze drying. Sampel merupakan campuran antara serbuk biji labu kuning dengan maltodekstrin yang dilarutkan dalam aquadest dengan perbandingan (0,5:5; 1,5:5 dan 3:5). Dan dibekukan dengan freeze drying. Sampel dikarakterisasi dengan AAS, FTIR, PSA dan SEM. Hasil yang diperoleh Formulasi terbaik adalah sampel 3 dengan persentase maltodekstrin 90,9%, ukuran partikel nanokapsul (214,6 nm) dengan indeks polidipersitas terendah yaitu 0,47, nilai rendemen 95,64%, dan bentuk morfologi cenderung bulat, permukaan sedikit cekungan (hampir sempurna). Serbuk biji labu kuning dan maltodekstrin dengan Teknik freeze drying merupakan suplemen yang menjanjikan sebagai suplemen untuk penanganan stunting. Kata kunci : Stunting; Zink; Biji labu kuning
Co-Authors Alfiana, Dessinta Amraini Amelia Anggresani, Lia Ara Ofiana Armayana Firda Armini Hadriyati Astridawati, Indah Auzal Halim Ayu Aprilya Barmi Hartesi Bunga Debi Lestari Camelia, Leonyta Chindiana Khutami Desi Sagita Erizal Zaini Fauziah, Wiwin Fhatia Medina Fidya Rizky Bardani Fitriani Arin Indah Astridawati Indri Meirista Khasanah, Isti Mufidhatun Nur Lia Anggresani Lia Anggresani Lia Anggresani Lili Andriani Lili Andriani Masril Malik Medina, Fhatia Muhammad Randa Nazifa Oktavia Nindi Sepdina Yanti Nofriyaldi, Ali Oktaviani Puspita Putri, Carrel Windyana Randa, Muhammad Ririn Depita Sari Rizka Afrina Rizki, Widya Twini Rizky Yulion Ryan Afandi Salman Umar Santi Perawati Santi Perawati Santi Perawati, Santi Sanuddin, Mukhlis Satiya Ningsih Siti Hamidatul 'Aliyah Siti Marwah Lestari Sutrisno , Deny Usman, Hendrizal Widya Twiny Rizki Widya Twiny Rizki Winika Sri Wahyuni Wulandari, Konita Yasnawati Yasnawati Yoli Nopita Sari Yufri Aldi Yuni Andriani