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All Journal Althea Medical Journal Indonesian Journal of Urology Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Medical Laboratory Technology Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Syntax Literate: Jurnal Ilmiah Indonesia Care : Jurnal Ilmiah Ilmu Kesehatan Oceana Biomedicina Journal Biomolecular and Health Science Journal Medical Laboratory Analysis and Sciences Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Prosiding Seminar Nasional Multidisiplin Journal Orthopaedi and Traumatology Surabaya (JOINTS) Majalah Biomorfologi (Biomorphology Journal) JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology Jurnal Widya Medika
Agung Dwi Wahyu Widodo
Department Of Clinical Microbiology, Faculty Of Medicine Universitas Airlangga, Surabaya, Indonesia – Dr. Soetomo General Hospital Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Perbandingan Distribusi Dan Pola Kepekaan Acinetobacter baumannii Terhadap Antimikroba Di RSUD Dr. Soetomo Surabaya Periode Januari–Maret 2015, April–Juni 2015, dan Januari–Maret 2016 Silvia Sutandhio; Agung Dwi Wahyu Widodo; Lindawati Alimsardjono; Eddy Bagus Wasito
JURNAL WIDYA MEDIKA Vol. 4 No. 1 (2018)
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v4i1.1782

Abstract

Acinetobacter baumannii is an environmental bacteria that can cause opportunistic infections such as ventilator-associated pneumonia, burn wound infection, urinary tract infection, and sepsis in immunocompromised patients. A. baumannii infections are troublesome because the bacteria resistance to many antimicrobial agents. Surveillance of distribution and sensitivity pattern of A. baumannii is best to be done frequently in hospitals.Venous blood as much as 10 milliliters was drawn aseptically and transferred into liquid medium Bactec® to be sent to Clinical Microbiology Laboratory of Dr. Soetomo General and Teaching Hospital. Medium that showed bacterial growth was subcultured on Blood Agar Plate and MacConkey Agar, and incubated for 18-24 hours in aerobic condition. Identification and susceptibility test were done with semi-automated system BD Phoenix, and interpreted based onClinical and Laboratory Standards Institute 2015.A. baumannii collected on trimester January-March 2015 were 30 isolates, with 19 isolates being Multidrug Resistant(MDR) A. baumannii (63%) and 6 isolatesPandrug Resistant(PDR)A. baumannii (20%). Isolates from trimester April-June 2015 were 32 isolates, with 21 isolates being MDR A. baumannii (66%) and 2 isolates PDR A. baumannii (6%). Isolates from trimester January-March 2016 were 40 isolates, with 22 isolates being MDR A. baumannii (55%) and 2 isolates PDR A. baumannii (5%).A. baumannii mostly isolated from Intensive Care Unit, followed by Internal medicine ward, Pediatric ward, Surgery ward and Emergency Department. High sensitivity of A. baumanniion trimester January-March 2016 was to imipenem (50%), meropenem (50%), amikacin (53%), cotrimoxazole (53%), dan cefoperazone-sulbactam (55%).. MDRA. baumannii mostly isolated from ICU, which reflects high burden of antimicrobial use. At this moment, antimicrobial agents that can be used as empirical therapy for A. baumannii infection are imipenem, meropenem, amikacin, cotrimoxazole, and cefoperazone-sulbactam. The entire hospital member must implement the Infection Control and Prevention and Antimicrobial Stewardship Program to preventnosocomial infections byA. baumanniiand the emergence of MDRA. baumannii.
Distribusi dan Antibiogram MRSA dari Spesimen Darah selama Empat Semester di RSUD Dr. Soetomo Surabaya Silvia Sutandhio; Agung Dwi Wahyu Widodo; Eddy Bagus Wasito
JURNAL WIDYA MEDIKA Vol. 4 No. 2 (2018)
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v4i2.1812

Abstract

MRSA bloodstream infection is hospital-acquired problem that is difficult to treat. Bacteria spread to body organs, create multiple loci of infection, and survive in the presence of beta-lactam antibiotics. Study of distribution and antibiogram of MRSA from blood specimens was done in four semesters; i.e. July–December 2014, January–June 2015, July–December 2015, and January–June 2016. Blood of patients suspected for bloodstream infection was drawn aseptically, transferred into liquid medium, and sent to Clinical Microbiology Laboratory of Dr. Soetomo General Hospital. Medium with microbial growth was subcultured on solid medium, and incubated for 18-24 hours in aerobic condition. Identification and susceptibility test were done with BD Phoenix, and interpreted based on Clinical and Laboratory Standards Institute 2015. Of total 107 MRSA isolates; 23 isolates (22%) were collected on July–December 2014, 12 isolates (11%) on January–June 2015, 25 isolates (23%) on July–December 2015, and 47 isolates (44%) on January–June 2016. MRSA mostly isolated from internal disease wards (45%). Isolates are sensitive to linezolid (91%), quinupristin-dalfopristin (83%), fosfomycin (82%), and vancomycin (80%). Trend of MRSA bloodstream infection is increasing. Although antibacterial agents against MRSA are available, it is best to prevent MRSA transmissions and infections.
Analysis of Risk Factors for Antimicrobial Resistance in Bacterial Infections among Diabetic Foot Ulcer Patients William, Andrew; Sembiring, Yan Efrata; Widodo, Agung Dwi Wahyu; Novida, Hermina
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 2 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i2.64804

Abstract

Introduction: Diabetic foot ulcer (DFU) is a chronic and progressive complication of diabetes mellitus resulting from macroangiopathy and microangiopathy disorders. Acknowledging the relationship between the Wagner diabetic foot ulcer classification system and infection severity may offer a promising instrument for guiding empirical antibiotic selections in clinical settings. This study aimed to assess the relationship between Wagner grades and the pathogen profiles of patients with DFU, along with their susceptibility to antibiotic therapy.Methods: A cross-sectional study was conducted from January 2021 to August 2023, utilizing 33 secondary datasets obtained from electronic medical records. The data contained the patients' Wagner grades alongside the results of their complete microbiological analysis and antibiotic susceptibility test. The association between determinant factors and patients' pathogen profiles and antibiotic susceptibility patterns was examined using the Chi-square bivariate analysis (p<0.05).Results: Positive culture results were observed in 32 patients (97%), with 59% exhibiting resistance to first-line antibiotics. The most commonly isolated pathogen was Staphylococcus aureus. The antibiotic susceptibility patterns indicated that gentamicin-syn demonstrated the highest activity against Gram-positive bacteria (GPB) isolates, while erythromycin was the most effective against Gram-negative bacteria (GNB) isolates. With escalating Wagner grades, there was an increased proportion of mixed infections, GNB infections (n=8, X²=23.28, p=0.003), and antibiotic resistance (n=8, X²=39.97, p=0.000). GNB isolates showed higher resistance compared to GPB isolates (n=18, X²=42.15, p=0.001).Conclusion: Our findings suggest that DFU patients with varying Wagner grades exhibit different bacterial profiles, infection patterns, and antibiotic sensitivities.   Highlights:1. This is the first study conducted in Indonesia to analyze the relationship between the Wagner diabetic foot ulcer classification system and patients' pathogen profiles and antimicrobial susceptibility.2. This study incorporated an in-depth analysis of several infection patterns and the occurrence of antimicrobial resistance, hence offering valuable information on the application of the Wagner classification system not only as a tool for grading infection severity but also for guiding clinicians in selecting the appropriate antibiotics for patients with diabetic foot ulcers.
PROFIL RASIO NEUTROFIL TERHADAP LIMFOSIT PADA PASIEN DENGAN DUGAAN DEMAM TIFOID DI RSUD DR. SOETOMO SURABAYA Nurhidayah, Meiwinda Rizky; Arfijanto, Muhammad Vitanata; Widodo, Agung Dwi Wahyu; Kholili, Ulfa
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 9, No 1 (2021): EDITION MARCH 2021
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/jc.v9i1.2042

Abstract

Demam tifoid merupakan penyakit multisistem akut yang disebabkan oleh Salmonella typhi dan bersifat endemis. Rendahnya sensitivitas alat diagnostik menyebabkan under diagnosed maupun over diagnosed. Beberapa studi menggunakan rasio neutrofil limfosit sebagai parameter status inflamasi. Studi ini untuk mengetahui gambaran rasio neutrofil limfosit pada pasien dengan dugaan demam tifoid. Sebuah studi deskriptif observasional dengan desain lintang potong menggunakan data sekunder dari rekam medis di Rumah Sakit Umum Daerah Dr. Soetomo Surabaya tahun 2016-2018. Teknik pengambilan sampel adalah total sampling dan diperoleh 64 sampel. Jumlah pasien dengan jenis kelamin laki-laki sebanyak 53,1% dan perempuan sebanyak 46,9% Perbandingan pasien laki-laki dan perempuan 1,3:1 dengan rentang usia terbanyak 17-25 tahun. Gambaran klinis rerata lama demam yaitu 6,95 hari dengan rentang lama demam terbanyak 1-7 hari. Demam ditunjukkan pada semua pasien (100%). Pemeriksaan hematologi kadar hemoglobin, leukosit dan trombosit dalam batas normal. Hasil neutrofil dan limfosit dalam batas normal. Gambaran rasio neutrofil limfosit memiliki median 3,97 dengan rentang nilai dalam batas normal.
Pola Kuman Serta Kepekaan Antibiotik pada Pasien Sepsis di Ruang Rawat Inap Penyakit Dalam RSUD dr. Soetomo Surabaya Nabila, Nabila; Bramantono, Bramantono; Kusumaningrum, Deby; Widodo, Agung Dwi Wahyu
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v9i8.17294

Abstract

Sepsis adalah disfungsi organ yang mengancam jiwa yang disebabkan oleh disregulasi respon host terhadap infeksi. Penatalaksanaan sepsis salah satunya adalah pemberian antibiotik spesifik, namun pengobatan awal adalah pemberian antibiotik spektrum luas sebelum ada hasil kultur. Penggunaan antibiotik yang tidak tepat pada pasien septik dapat menyebabkan resistensi bakteri dan memperburuk kondisi pasien. Tujuan penelitian ini adalah mempelajari pola sensitivitas bakteri dan antibiotik pada pasien sepsis di RSUD Dr. Soetomo Surabaya Metode. Penelitian deskriptif retrospektif ini dilakukan di RSUD Dr. Soetomo pada bulan Januari sampai dengan Desember 2019. Sampel penelitian ini adalah seluruh data rekam medis pasien sepsis yang memiliki hasil kultur darah bakteri positif di Laboratorium Mikrobiologi Klinik RSUD Dr. Soetomo Surabaya di Hasil 2019. Hasil penelitian menunjukkan bahwa dari 722 sampel darah, termasuk 124 (17,2%) sampel dengan hasil kultur positif. Pasien termuda berusia 16 tahun dan tertua berusia 97 tahun. Hasil ini juga menunjukkan bahwa sebagian besar pasien sepsis adalah perempuan. Bakteri yang paling banyak ditemukan adalah Staphylococcus spp. 80,4%. Bakteri gram positif (Staphylococcus spp.) sensitif terhadap linezolid, vankomisin, teicoplanin Kesimpulan. Bakteri yang paling banyak ditemukan adalah Staphylococcus spp, sedangkan antibiotik yang paling sensitif terhadap Staphylococcu spp gram positif adalah antibiotik linezolid, vankomisin, dan teicoplanin.
Co-Authors A.A. Ketut Agung Cahyawan W Adil Jihad Muhammad Adityawardhana, Taufan Ahmad Veri Erianto Alimsardjono, Lindawati Annisa Aulia Maghfirani Sudarmadi Asmarawati, Tri Pudy BaiqIsti Hijriani Boerhan Hidayat Bramantono Bramantono, Bramantono Deby Kusumaningrum Doddy M Soebadi Dominicus Husada Dwikora Novembri Utomo Eddy Bagus Wasito Fiqih Faizara Ustadi Florentina Sustini Hardiono Hardiono, Hardiono heri budiono Hermina Novida, Hermina Hidajat, Boerhan Indiastuti, Danti Nur Jihan Kalishah Jonathan Christianto Sutadji Jusak Nugraha Khairunnida Rahma Larantika Hidayati Lenny Octavia ManikRetno Wahyunitisari Muhammad Vitanata Arfijanto, Muhammad Vitanata Musofa Rusli Nabila, Nabila Nanda Amalia Ramadhanti Nurhidayah, Meiwinda Rizky Pudji Lestari Rachman, Brian Eka Rebekah Setiabudi, Rebekah Rehatta, Nancy Margaritta Ronald Pratama Adiwinoto Rusli, Musofa savitri, Lisa Sembiring, Yan Efrata Shabira, Naura Ghina Silvia Sutandhio Siti Nurul Jannah Soelistijo, Soebagijo Adi Subur Prajitno Sunaryo Hardjowijoto Tarmono Djojodimedjo Ulfa Kholili Usman Hadi Warella, Juen Carla Wibisono, Raden Taufan Mulyo William, Andrew Willy Sandhika Winona May Hendrata Yuani Setiawati