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All Journal Althea Medical Journal Indonesian Journal of Urology Berkala Ilmu Kesehatan Kulit dan Kelamin Medical Laboratory Technology Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Syntax Literate: Jurnal Ilmiah Indonesia Care : Jurnal Ilmiah Ilmu Kesehatan Oceana Biomedicina Journal Biomolecular and Health Science Journal Medical Laboratory Analysis and Sciences Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Prosiding Seminar Nasional Multidisiplin Journal Orthopaedi and Traumatology Surabaya (JOINTS) Majalah Biomorfologi (Biomorphology Journal) JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology Jurnal Widya Medika Folia Medica Indonesiana
Agung Dwi Wahyu Widodo
Department Of Clinical Microbiology, Faculty Of Medicine Universitas Airlangga, Surabaya, Indonesia – Dr. Soetomo General Hospital Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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PROFIL RASIO NEUTROFIL TERHADAP LIMFOSIT PADA PASIEN DENGAN DUGAAN DEMAM TIFOID DI RSUD DR. SOETOMO SURABAYA Nurhidayah, Meiwinda Rizky; Arfijanto, Muhammad Vitanata; Widodo, Agung Dwi Wahyu; Kholili, Ulfa
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 9, No 1 (2021): EDITION MARCH 2021
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/jc.v9i1.2042

Abstract

Demam tifoid merupakan penyakit multisistem akut yang disebabkan oleh Salmonella typhi dan bersifat endemis. Rendahnya sensitivitas alat diagnostik menyebabkan under diagnosed maupun over diagnosed. Beberapa studi menggunakan rasio neutrofil limfosit sebagai parameter status inflamasi. Studi ini untuk mengetahui gambaran rasio neutrofil limfosit pada pasien dengan dugaan demam tifoid. Sebuah studi deskriptif observasional dengan desain lintang potong menggunakan data sekunder dari rekam medis di Rumah Sakit Umum Daerah Dr. Soetomo Surabaya tahun 2016-2018. Teknik pengambilan sampel adalah total sampling dan diperoleh 64 sampel. Jumlah pasien dengan jenis kelamin laki-laki sebanyak 53,1% dan perempuan sebanyak 46,9% Perbandingan pasien laki-laki dan perempuan 1,3:1 dengan rentang usia terbanyak 17-25 tahun. Gambaran klinis rerata lama demam yaitu 6,95 hari dengan rentang lama demam terbanyak 1-7 hari. Demam ditunjukkan pada semua pasien (100%). Pemeriksaan hematologi kadar hemoglobin, leukosit dan trombosit dalam batas normal. Hasil neutrofil dan limfosit dalam batas normal. Gambaran rasio neutrofil limfosit memiliki median 3,97 dengan rentang nilai dalam batas normal.
Pola Kuman Serta Kepekaan Antibiotik pada Pasien Sepsis di Ruang Rawat Inap Penyakit Dalam RSUD dr. Soetomo Surabaya Nabila, Nabila; Bramantono, Bramantono; Kusumaningrum, Deby; Widodo, Agung Dwi Wahyu
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v9i8.17294

Abstract

Sepsis adalah disfungsi organ yang mengancam jiwa yang disebabkan oleh disregulasi respon host terhadap infeksi. Penatalaksanaan sepsis salah satunya adalah pemberian antibiotik spesifik, namun pengobatan awal adalah pemberian antibiotik spektrum luas sebelum ada hasil kultur. Penggunaan antibiotik yang tidak tepat pada pasien septik dapat menyebabkan resistensi bakteri dan memperburuk kondisi pasien. Tujuan penelitian ini adalah mempelajari pola sensitivitas bakteri dan antibiotik pada pasien sepsis di RSUD Dr. Soetomo Surabaya Metode. Penelitian deskriptif retrospektif ini dilakukan di RSUD Dr. Soetomo pada bulan Januari sampai dengan Desember 2019. Sampel penelitian ini adalah seluruh data rekam medis pasien sepsis yang memiliki hasil kultur darah bakteri positif di Laboratorium Mikrobiologi Klinik RSUD Dr. Soetomo Surabaya di Hasil 2019. Hasil penelitian menunjukkan bahwa dari 722 sampel darah, termasuk 124 (17,2%) sampel dengan hasil kultur positif. Pasien termuda berusia 16 tahun dan tertua berusia 97 tahun. Hasil ini juga menunjukkan bahwa sebagian besar pasien sepsis adalah perempuan. Bakteri yang paling banyak ditemukan adalah Staphylococcus spp. 80,4%. Bakteri gram positif (Staphylococcus spp.) sensitif terhadap linezolid, vankomisin, teicoplanin Kesimpulan. Bakteri yang paling banyak ditemukan adalah Staphylococcus spp, sedangkan antibiotik yang paling sensitif terhadap Staphylococcu spp gram positif adalah antibiotik linezolid, vankomisin, dan teicoplanin.
The Examination of ESAT-6, CFP-10, MPT-64 Antigens of Mycobacterium tuberculosis in Urine of Pediatric Tuberculosis Patient with Immunochromatography to Support the Diagnosis Budiarti, Anita; Nugraha, Jusak; Widodo, Agung Dwi Wahyu
Folia Medica Indonesiana Vol. 54, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

Tuberculosis in children is often a systemic complication because of their imperfect cellular immune system. ESAT-6, CFP-10, and MPT-64 are small molecular dominant antigens secreted by Mtb into the blood and filtered by the kidneys into urine. The high proportion of children with TB cases according to the Ministry of Health of the Republic of Indonesia in 2013 was 7.9%-12%. Diagnis is difficult to establish with sputum and blood samples. Therefore, it is necessary to support the diagnosis using urine samples with ICT rapid test. The purpose of this study was to determine the examination of Mtb ESAT-6, CFP-10, and MPT-64 antigens in the urine of pediatric TB patients with ICT to support the diagnosis. The method used was analytic observation with case control design. The results of the study showed that 32 of the urine of children with TB who were examined with ICT, 22 showed ESAT-6, CFP-10, and MPT-64 positive and 10 negative. Whereas, from 32 urine of healthy children, 25 were negative and 7 were positive. Analysis results showed 95% confidence (CI), p = 0.0002 (p <0.05), 78% specificity and 68.8% sensitivity compared to TB diagnosis from pediatricians. As a conclusion, Mtb ESAT-6, CFP-10, and MPT-64 antigens can be examined in the urine of pediatric TB patients with ICT to support the diagnosis.
Antifungal Activity of Selaginella plana (Desv. ex Poir.) Hieron Extract Against Candida albicans In Vitro Warella, Juen Carla; Rahma, Khairunnida; Widodo, Agung Dwi Wahyu; Setiabudi, Rebekah Juniati
Folia Medica Indonesiana Vol. 59, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: 1. A study on the medical benefits of Selaginella plana has significant academic value due to its extensive traditional usage among the Moluccan people as a medicinal remedy, especially for its antifungal properties. 2. The findings of this study will allow further screening to determine the mechanism of action of bioactive compounds in inhibiting the growth of Candida albicans Abstract Candidiasis is an opportunistic infection caused by Candida albicans. This infection commonly affects the skin, oral mucosa, vagina, and gastrointestinal tract. Excessive use of azole antifungals in the treatment of Candida albicans infections can lead to the development of resistance. Therefore, it is necessary to explore alternative treatments using medicinal plants such as Selaginella plana, commonly referred to as "rutu-rutu” in a local language spoken across Maluku, Indonesia. Selaginella plana contains active compounds belonging to various chemical classes, including terpenoids, steroids, flavonoids, and saponins. This study aimed to determine the ability of Selaginella plana extract as an antifungal agent against Candida albicans by evaluating its inhibitory and antifungal effects. This study used an actual experimental design and broth dilution method. The research methodology involved the extraction of Selaginella plana using a solvent of 96% ethanol. The extract was then prepared in various concentrations, i.e., 100%, 50%, 25%, 12.5%, 6.25%, and 3.125%. Additionally, ketoconazole and distilled water were included in the experiment for the positive and negative controls, respectively. The results of this study demonstrated that Selaginella plana extract inhibited the growth of Candida albicans when administered starting at a concentration of 12.5%. However, the antifungal potential of Selaginella plana extract that induced cell death was only observed at a concentration of 100%. The fungicidal activity was exclusively identified in the undiluted, pure extract. The inhibitory and cytotoxic effects of Selaginella plana on Candida albicans cells were attributed to the presence of bioactive compounds in Selaginella plana, including flavonoids, tannins, terpenoids, and saponins. These bioactive compounds had the ability to inhibit cell growth by altering membrane permeability, causing mitochondrial dysfunction, and disrupting ergosterol biosynthesis. It can be concluded that Selaginella plana extract can act as a fungistatic agent against the proliferation of Candida albicans.
Mortality Comparison of Using Anti Interleukin-6 Therapy and Using Standard Treatment in Severe Covid-19 Sutadji, Jonathan Christianto; Widodo, Agung Dwi Wahyu; Indiastuti, Danti Nur
Folia Medica Indonesiana Vol. 57, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Severe Coronavirus Disease 19 (COVID-19) can cause serious lung inflammation and death. COVID-19 is characterized by a high mortality rate. This severity is associated with the overproduction of proinflammatory cytokines called "cytokine storms". One of the cytokines that play a central role is Interleukin-6 (IL-6). High IL-6 levels are associated with mortality. Expectedly, the IL-6 blockade could reduce cytokine storms and thus reduce deaths in severe COVID-19 patients. This systematic review aimed to summarize the comparison between mortality using anti-IL-6 therapy and mortality using standard treatment in severe COVID-19 patients. We systematically searched the PubMed, ScienceDirect, and ProQuest databases until 13 August 2020. After screening, twelve studies matched the inclusion criteria. The mortality of the anti-IL-6 therapy group was lower than the standard treatment group without anti-IL-6 therapy in COVID-19 patients in 10 of the 12 studies obtained. Four of the ten studies statistically found a significant difference in mortality of the anti-IL-6 therapy group and the standard treatment group. Confirmation of anti-IL-6 therapy effectiveness in reducing mortality in severe COVID-19 patients will require randomized controlled trials.
Bacterial Profile and Antibiotic Use in Catheter-Associated Urinary Tract Infection Patients at a Tertiary Referral Hospital in Surabaya, Indonesia Erianto, Ahmad Veri; Asmarawati, Tri Pudy; Widodo, Agung Dwi Wahyu; Rachman, Brian Eka
Folia Medica Indonesiana Vol. 59, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: • This study examined patients with catheter-associated urinary tract infections (CAUTI) to find the prevalent bacteria and the frequency of antibiotic use. • Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli sensitive to amikacin was found to be the most common pathogen in CAUTI, while ceftriaxone was the most commonly used antibiotic. Abstract Catheter-associated urinary tract infection (CAUTI) is the most typical type of infection associated with healthcare. This infection constitutes a significant health problem due to its complications and frequent recurrence. The high annual incidence of CAUTI leads to infectious complications and a high cost of treatment. Antibiotic-resistant bacteria further complicate the problem because multiresistant pathogenic bacteria are often responsible for these infections. Moreover, the lack of a comprehensive case reporting system in Indonesia hinders the determination of CAUTI incidence. This study aimed to determine the bacterial profile and antibiotic use in CAUTI patients (n=22) at the Internal Medicine Inpatient Unit of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. This retrospective descriptive study collected data from patient medical records to describe the incidence, type of bacteria, sensitivity patterns, and antibiotic use in CAUTI patients. The data collection process included collecting medical records, recording information on data collection sheets, and recapitulating and analyzing the data. The criteria for CAUTI diagnosis were a bacterial count of ≥105 CFU/mL and a catheterization that lasted more than 48 hours. Samples were selected using non-probability sampling, also known as saturation sampling. Meanwhile, variables analyzed in this study were the type of pathogenic bacteria, antibiotics used, age, and sex. Descriptive analysis was employed to analyze the data. The findings suggested that the most common bacteria were Escherichia coli, with eight of nine bacteria showing extended-spectrum beta-lactamase (ESBL) production. Female patients aged 35–65 years were the majority of the CAUTI patients. Amikacin was the antibiotic with the highest sensitivity (90.9%), while ceftriaxone was the most common type of antibiotic administered to the patients. In addition, intravenous (IV) administration was the most common route of antibiotic administration, with an average therapy duration of seven days. In conclusion, identifying the type of pathogenic bacteria and performing antibiotic susceptibility testing can help minimize antibiotic resistance and prevent more severe complications in CAUTI patients.
EXPLORING ETHANOL EXTRACT OF KERSEN FRUIT (<i>MUNTINGIA CALABURA</i> L) AS ANTIMICROBIAL AND ANTIBIOFILM Firmanda, Hafidz; Widodo, Agung Dwi Wahyu; Wahyunitisari, Manik Retno
Folia Medica Indonesiana Vol. 61, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Infections caused by microbial biofilms pose a clinical treat in terms of patient morbidity and mortality rates. For potential treatment this study aims to determine antimicrobial and antibiofilm activity of kersen fruit extract (Muntingia calabura L) on Staphylococcus aureus, Escherichia coli, and Candida albicans. This research used true experimental method with posttest only control group design. Using 6 kersen fruit extract concentration and 4 replications. Antimicrobial test used tube dilution method and antibiofilm test used two different scenario, biofilm growth inhibition test and biofilm degradation test. MIC result against Staphylococcus aures and Escherichia coli at extract concentration of 6.25% and Candida albicans at concentration 12.5%. MBC result against Staphylococcus aures and Escherichia coli at extract concentration of 12.5% and Candida albicans at concentration 25%. Biofilm growth inhibition test found that kersen fruit extract was able to inhibit biofilm growth of Staphylococcus aures, highest inhibition value at 76.3% and Escherichia coli highest inhibition percentage at 18.18%. Biofilm degradation test showed that kersen fruit extract was able to degrade biofilm of Staphylococcus aures highest degradation value is 26.5%. Kersen fruit extract was shown has antimicrobial activity as bacteriostatic and bactericidal against these microbes. Antibiofilm activity of kersen fruit extract obtained good result at preventing biofilm growth against Staphylococcus aures, while against Escherichia coli obtained weak growth inhibition. In biofilm degradation test, Kersen fruit extract was able to degrade biofilm from Staphylococcus aures with moderate strength.
Comparative Efficacy of Alcohol-Based Chloroxylenol, Triclosan, and Gentamicin in Inhibiting Staphylococcus aureus Biofilm Formation Ashari, Muhammad Jundi Aziz; Widodo, Agung Dwi Wahyu; Rachman, Brian Eka
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 17 No. 1 (2026): JANUARY 2026 (IN-PROGRESS ISSUE)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V17I12026.56-62

Abstract

Highlights: The combination of alcohol with triclosan and alcohol with chloroxylenol was effective in inhibiting the growth of S. aureus biofilms. Lower concentrations of gentamicin resulted in optical density (OD) values above the cut-off, suggesting that these doses were insufficient for biofilm inhibition and might potentially contribute to the persistence or stimulation of S. aureus biofilm growth.   Abstract Introduction: This study investigated the comparative efficacy of alcohol-based chloroxylenol, alcohol-based triclosan, and gentamicin in inhibiting Staphylococcus aureus biofilm formation. Biofilms formed by S. aureus present significant clinical challenges due to their antibiotic resistance and persistence in nosocomial infections. Methods: This study used the crystal violet assay with an enzyme-linked immunosorbent assay (ELISA) reader to evaluate S. aureus cultures treated with various antimicrobials. The treatments included chloroxylenol (10, 100, 1,000 ppm), triclosan (0.3, 3, 30 µg/ml), and gentamicin (5, 10, 15 mg/ml). The experiment consisted of three groups based on treatment type (n=72), each with three dosage levels (n=8). It was analyzed using International Business Machines Corporation (IBM) Statistical Package for the Social Sciences (SPSS) version 27. A probability p<0.05 was considered significant. Results: The first group, chloroxylenol with alcohol, demonstrated significant inhibitory effects (n=24, p=0.007). The second group, triclosan with alcohol, exhibited the strongest antibiofilm activity (n=24, p=0.001). In contrast, the third group, gentamicin, showed no significant inhibitory effect (n=24, p=0.21). Conclusion: Chloroxylenol and triclosan exhibited significant inhibition (p=0.007 and p=0.001), whereas gentamicin did not (p=0.21). It also suggested that suboptimal gentamicin doses may contribute to biofilm persistence and adaptive responses in S. aureus. These findings underscore the potential of alcohol-based chloroxylenol and triclosan as effective agents for biofilm inhibition and highlight the need for reconsidering the role of gentamicin in treating biofilm-associated infections. Further research is warranted to explore optimal dosing strategies and the mechanisms underlying biofilm resistance.
Co-Authors A.A. Ketut Agung Cahyawan W Adil Jihad Muhammad Adityawardhana, Taufan Ahmad Veri Erianto Alimsardjono, Lindawati Annisa Aulia Maghfirani Sudarmadi Ashari, Muhammad Jundi Aziz Asmarawati, Tri Pudy BaiqIsti Hijriani Boerhan Hidayat Bramantono Bramantono, Bramantono Budiarti, Anita Deby Kusumaningrum Doddy M Soebadi Dominicus Husada Dwikora Novembri Utomo Eddy Bagus Wasito Erianto, Ahmad Veri Fiqih Faizara Ustadi Firmanda, Hafidz Florentina Sustini Hardiono Hardiono, Hardiono heri budiono Hermina Novida, Hermina Hidajat, Boerhan Indiastuti, Danti Nur Jihan Kalishah Jonathan Christianto Sutadji Jusak Nugraha Khairunnida Rahma Larantika Hidayati Lenny Octavia ManikRetno Wahyunitisari Muhammad Vitanata Arfijanto, Muhammad Vitanata Musofa Rusli Nabila, Nabila Nanda Amalia Ramadhanti Nurhidayah, Meiwinda Rizky Pudji Lestari Rachman, Brian Eka Rahma, Khairunnida Rebekah Setiabudi, Rebekah Rehatta, Nancy Margaritta Ronald Pratama Adiwinoto Rusli, Musofa savitri, Lisa Sembiring, Yan Efrata Shabira, Naura Ghina Silvia Sutandhio Siti Nurul Jannah Soelistijo, Soebagijo Adi Subur Prajitno Sunaryo Hardjowijoto Sutadji, Jonathan Christianto Tarmono Djojodimedjo Ulfa Kholili Usman Hadi Wahyunitisari, Manik Retno Warella, Juen Carla Wibisono, Raden Taufan Mulyo William, Andrew Willy Sandhika Winona May Hendrata Yuani Setiawati