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Differences in Mean Anti-Pertussis Antibody Levels in Children with Acellular Pertussis Immunization and Whole Pertussis Without Booster Rezki, Wenny Rahmalia; Rinang Mariko; Rizanda Machmud; Rusdi; Asrawati; Indra Ihsan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 7 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i7.1022

Abstract

Background: The incidence of pertussis is increasing every year, especially in developing countries. Low immunization coverage and decreased immunity are some of the factors causing the re-increase in pertussis cases. The protection provided by the pertussis vaccine whole and acellular pertussis given as a baby will decrease with age. This study aims to determine the difference in mean levels of anti-pertussis antibodies in children who received acellular pertussis and whole pertussis immunization without a booster. Methods: A cross-sectional study was carried out at the pediatric polyclinic of Dr. M. Djamil General Hospital Padang from December 2022 to December 2023. Research subjects were children aged 5-9 years with a history of whole pertussis immunization (DPwT) 3 times or acellular pertussis immunization (DPaT) 3 times. The research subjects were examined for anti-pertussis antibody titers using the ELISA technique. Results: Thirty-four children with a history of DPwT immunization 3 times and 34 children with a history of DPwT immunization 3 times were research subjects, with mean age 6.94±1.49 in the DPwT group and 6.88 ±1.61 in the DPaT group. The mean anti-pertussis antibody level in the DPwT group (9.54 IU/mL) was higher than the DPaT group (6.96 IU/mL) but was not statistically significant (p>0.05). The average antibody results showed that the antibody levels in both groups were below the antibody titer threshold that provides protection against pertussis. The results of the analysis showed that there was a significant difference in the incidence of AEFI between the DPwT and DPaT immunization groups (p<0.05). Conclusion: There was no difference in anti-pertussis antibody levels in children who received DPwT and DPaT immunization 3 times. Pertussis immunization is a required booster so that antibody levels are sufficient to provide protection against pertussis.
Unraveling the Link between Obesity and Tuberculosis: A Systematic Review of the Underlying Mechanisms Deddy Herman; Rizanda Machmud; Nur Indrawaty Lipoeto
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 2 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i2.1205

Abstract

Background: Tuberculosis (TB) and obesity are significant global health concerns with potentially complex interactions. Obesity, through its effects on metabolism, inflammation, and the immune system, may influence TB susceptibility, progression, and treatment outcomes. This systematic review aims to analyze the published literature on the relationship between obesity and TB, focusing on the underlying mechanisms. Methods: A systematic search of PubMed, Science Direct, and Google Scholar was conducted for articles published in the last 10 years. The search strategy included keywords such as "tuberculosis," "TB," "obesity," and "BMI." Articles were selected using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) method. Results: The review identified 11 studies that met the inclusion criteria. The studies revealed a complex relationship between obesity and TB, with nutritional status, immunity, and diabetes mellitus (DM) playing key roles. Obesity can alter the immune response to TB, potentially increasing the risk of disease and affecting treatment efficacy. Conclusion: The relationship between obesity and TB is multifaceted, with obesity potentially influencing both disease susceptibility and outcomes. Further research is needed to fully elucidate the underlying mechanisms and to develop targeted interventions for individuals with both obesity and TB.
Iron Deficiency and Anemia of Inflammation in Tuberculosis: A Systematic Review of the Evidence Deddy Herman; Rizanda Machmud; Nur Indrawaty Lipoeto
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 2 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i2.1207

Abstract

Background: Tuberculosis (TB) remains a major global health problem, with anemia being a frequent comorbidity. Anemia in TB is multifaceted, with iron deficiency and anemia of inflammation (AI) being the most common types. This systematic review aims to synthesize the evidence on iron deficiency and AI in TB, their prevalence, impact on outcomes, and management strategies. Methods: A systematic search of PubMed and ScienceDirect databases was conducted for articles published in the last 10 years. Observational studies examining the prevalence, types, and impact of anemia on TB outcomes were included. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Results: The review included 7 studies involving 1,133 participants. Anemia prevalence ranged from 61% to 89% in TB patients. AI was the predominant type, with iron deficiency also prevalent. Anemia was associated with increased mortality, delayed sputum culture conversion, and impaired TB treatment response. Conclusion: Anemia, primarily AI and iron deficiency, is highly prevalent in TB and negatively impacts treatment outcomes and survival. Effective management of anemia is crucial for improving TB outcomes. Further research is needed to optimize diagnostic and treatment strategies for iron deficiency and AI in TB.
Komitmen Organisasi Perawat di Rumah Sakit Dr. Reksodiwiryo Padang Firda Damba Wahyuni; Rizanda Machmud; Jafril
Jurnal Endurance Vol. 4 No. 3 (2019): Jurnal Endurance: Kajian Ilmiah Problema Kesehatan
Publisher : LLDIKTI Wilayah X

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Abstract

Nurses who stay at the hospital show employees who have organizational commitment. Low organizational commitment can increase workplace accidents, wound infections, increase mortality and turnover rates. This study aims to obtain an overview of the factors associated with organizational commitment at Dr. Reksodiwiryo Padang. This type of quantitative research with cross sectional design. The number of respondents was 142 nurses. The sampling technique in this study is proportionate stratified random sampling. Data analysis uses Chi-Square test. The results found there is a relationship between workload factors with organizational commitment of nurses (p = 0.006, α = 0.05), there is a relationship between work stress factors and nurse organizational commitment (p = 0.003, α = 0.05), there is a significant relationship between job satisfaction factors with organizational commitment of nurses (p = 0.002, α = 0.05). The conclusion of this research is that there is a relationship between workload, work stress and job satisfaction with organizational commitment. It is recommended to the Hospital Director to make policies for optimizing the welfare of nurses based on career paths that are included in the calculation of remuneration with achieving 100% remuneration Perawat yang bertahan pada rumah sakit menunjukkan karyawan yang mempunyai komitmen organisasi. Rendahnya komitmen organisasi dapat meningkatkan kejadian kecelakaan di tempat kerja, infeksi luka, peningkatan mortalitas dan turnover rate. Penelitian ini bertujuan untuk memperoleh gambaran faktor-faktor yang berhubungan dengan komitmen organisasi di RS Dr. Reksodiwiryo Padang. Jenis penelitian kuantitatif dengan desain cross sectional. Jumlah responden adalah 142 perawat. Teknik pengambilan sampling dalam penelitian ini adalah proportionate stratified random sampling. Analisa data menggunakan uji Chi – Square. Hasil penelitian didapatkan ada hubungan faktor beban kerja dengan komitmen organisasi perawat (p=0.006, α=0.05), ada hubungan faktor stress kerja dengan komitmen organisasi perawat (p=0.003, α=0.05), ada hubungan yang bermakna antara faktor kepuasan kerja dengan komitmen organisasi perawat (p=0.002, α=0.05). Kesimpulan penelitian diketahui ada hubungan faktor beban kerja, stres kerja dan kepuasan kerja dengan komitmen organisasi. Disarankan kepada Direktur Rumah Sakit membuat kebijakan pengoptimalan kesejahteraan perawat berbasis jenjang karir yang dimasukkan pada perhitungan remunerasi dengan pencapaian remunerasi 100%.
Conduct Problem Pada Siswa SMA di Kabupaten Pasaman Sumatera Barat Dian Eka Putri; Rizanda Machmud
Jurnal Endurance Vol. 4 No. 3 (2019): Jurnal Endurance: Kajian Ilmiah Problema Kesehatan
Publisher : LLDIKTI Wilayah X

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Abstract

Teenagers have a tendency to do things that are destructive to themselves and others, called behavioral problems (conduct problems). As many as 20% of adolescents in the world experience mental health problems and behavior problems (conduct problems). This study aims to obtain an overview of the factors associated with conduct problems in high school students in Pasaman Regency. The study design was cross sectional. The number of respondents was 336 high school students in Pasaman Regency. The sampling technique is Proportional Random Sampling. Data collection was carried out using a questionnaire. Data analysis using chi square technique and logistic regression with Backward Stepwise method. The results showed that there was a significant relationship between parenting (P value 0,041 OR 2, 205), school environment ( p value 0,000 OR 3,797 ), peer environment ( p value 0,000 OR 7,323), economic status ( pvalue 0,027 OR 2,125 ) and conduct problems. Peer environment is the most related factor in conduct problems with an OR score of 6.089. The conclusion in this resarch is that there is a significant relationship between the family environment: parenting with conduct problems, there is a significant relationship between peer environment and conduct problems, there is a significant relationship between the school environment and conduct problems, there is a significant relationship between economic status and conduct problems. Remaja memiliki kecenderungan untuk melakukan perbuatan yang merusak bagi dirinya dan orang lain yang disebut dengan conduct problem. Sebanyak 20% remaja di dunia mengalami masalah kesehatan mental dan conduct problem. Penelitian ini bertujuan untuk memperoleh gambaran faktor-faktor yang berhubungan dengan conduct problem pada siswa SMA di Kabupaten Pasaman Desain penelitian adalah cross sectional. Jumlah responden adalah 336 siswa SMA di Kabupaten Pasaman. Teknik pengambilan sampel adalah Proporsional Random Sampling. Pengumpulan data dilakukan menggunakan kuesioner. Analisis data dengan teknik chi square dan regresi logistik dengan metode Backward Stepwise. Hasil penelitian didapatkan ada hubungan signifikan pola asuh (P value 0,041 OR 2, 205) lingkungan sekolah ( p value 0,000 OR 3,797 ), lingkungan teman sebaya ( p value 0,000 OR 7,323) status ekonomi ( pvalue 0,027 OR 2,125 ) dengan conduct problem. Teman sebaya merupakan faktor yang paling berhubungan dengan OR 6,089. Kesimpulan penelitian diketahui terdapat hubungan signifikan antara lingkungan keluarga : pola asuh dengan conduct problem, terdapat hubungan signifikan antara lingkungan teman sebaya dengan conduct problem, terdapat hubungan signifikan antara lingkungan sekolah dengan conduct problem, terdapat hubungan signifikan antara status ekonomi dengan conduct problem.
Peningkatan Kapasitas Kader Kesehatan Remaja Melalui Program Asmara - Ayo Selamatkan Masa Remaja Untuk Pencegahan Perilaku Berisiko di SMPN 23 Padang Husna Yetti; Ida Rahmah Burhan; Rosfita Rasyid; Yuniar Lestari; Rima Semiarty; Adila Kasni Astiena; Zurayya Fadila; Nelmi Silvia; Abdiana; Rizanda Machmud; Firdawati; Hardisman
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 8 No. 3 (2025)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v8i3.798

Abstract

Adolescence is a transitional period that is vulnerable to the emergence of risky behaviors, such as smoking, promiscuity, and lack of health concern. These behaviors can negatively impact adolescent growth and development physically, mentally, and socially. This community service activity aims to increase knowledge and awareness regarding preventing risky behaviors through a health education program for students of SMPN 23, Padang City. The activity methods include preparation and problem identification stages, coordination with partners, and implementation stages, including interactive counseling, group discussions, and distribution of leaflets and promotional banners. The first day of education targeted all students in grades VII and VIII of SMPN 23 Padang. On the second day, education focused on members of the Adolescent Health Cadre (KKR) and the Student Council (OSIS), totaling 27 people. Evaluation was carried out with pre-tests and post-tests to measure the increase in knowledge. The activity results showed a significant increase in the average knowledge score of the cadre students (77.78 to 94.07). In addition, the students showed enthusiasm and active involvement throughout the activity. This educational activity was successfully implemented smoothly and brought about an increase in knowledge among students, KKR cadres, and OSIS. Cadre students understand their role and are expected to be able to serve as peer educators when their peers encounter health issues or risky behavior. Similar activities, involving teachers and parents, need to be implemented continuously to optimize risky behavior prevention.