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All Journal Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN Majalah Obat Tradisional Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ JPSCR : Journal of Pharmaceutical Science and Clinical Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Pharmaceutical Journal of Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Indonesian Journal of Pharmaceutical and Clinical Research Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Insan Farmasi Indonesia Media Farmasi Indonesia Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Journal Pharmacy of Tanjungpura
Liza Pratiwi
Department Of Pharmaceutical Technology, Faculty Of Medical, Tanjungpura University Pontianak
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Physics Public Health Social Sciences Other

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Efektivitas SNEDDS Kombinasi Fraksi Etil Asetat Daun Cengkodok (Melasthoma malabathricum)-Antibiotik terhadap Bakteri Hasil Isolat dari Pasien Ulkus Diabetik Sari, Rafika; Apridamayanti, Pratiwi; Pratiwi, Liza
Pharmaceutical Journal of Indonesia Vol. 7 No. 2 (2022)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2022.007.02.5

Abstract

Diabetic ulcer is a condition where there are neurological abnormalities and peripheral arterial vascular disease that causes infection, ulceration, and/or damage to the deepest skin tissue on the feet of people with diabetes mellitus (DM). The long duration of wound healing is due to the wrong use of antibiotics for a long time, and bacteria tend to become resistant to antibiotics. Antimicrobial compound fraction of cengkodok combined with gentamicin and ciprofloxacin antibiotics for prevention and reduction of antibiotic resistance in the cause of diabetic ulcers. The drug preparation is in the form of self nanoemulsifiying drug delivery system (SNEDDS), which is the optimum combination of cengkodok leaf fraction with gentamicin and ciprofloxacin antibiotics. The use of SNEDDS in this study is because the SNEDDS made from nanoemulsion formulations has small particle size, large surface absorption, and good dispersion, so that it can be evenly dispersed on the skin and penetrates the skin layer. This study aims to determine the effectiveness of the formulation cengkodok leaf fraction with gentamicin and ciprofloxacin antibiotics against B. cereus and S. aureususing the SNEDDS drug delivery system. The test uses the spotless diffusion method without using paper discs. The results showed that the combination of cengkodok leaf fraction with gentamicin and ciprofloxacin antibiotics had better activity against B. cereus and S. aureus than cengkodok leaf fraction, gentamicin and ciprofloxacin only.
Co-Authors Achmad Fudholi Achmad Fudholi Adelita Ahyanurri Agvina Felicia Esperanza Andhi FAHRURROJI Apridamayanti, Pratiwi Bambang WIJIANTO Damanik, Virna Helena Defiga Kasrin Dermawan, Abdurraafi Maududi Diah Ismarani Diah Ismarani Diah Ismarani, Diah Fajar Nugraha Fajar Nugraha Fajriaty, Inarah Felisitas Feli Fitri, Aulia Kemala Hadi Kurniawan Harum Nadyanti Usman Hervianto, Willy Indri Kusharyanti Isnindar Isnindar Istiqomah, Rifqi Luliana, Sri Melania Niken Safira Nera Umilia Purwanti, Nera Umilia Novia Novia Pratiwi Apridamayanti Pratiwi Apridamayanti Pratiwi Apridamayanti Pratiwi Apridamayanti, Pratiwi Rafika Sari Rafika Sari Rafika Sari Ronny Martien Ronny Martien Safrilla Anggraeni Shinta Nia Putri Shoma Rizkifani Siti Nani Nurbaeti Sri Wahdaningsih Suhartaty, Lindy Suwidjiyo Pramono Suwidjiyo Pramono SYF. OCTY NOVY FISSY Tendianus, Tendianus Ulfa Sri Mandasari Utami, Amanda Yanasari Wendy Wendy Wijianto, Bambang Wijianto Willy Hervianto Yulnalia Mariella Delavega Yuswar, Muhammad Akib