Article Per Year (5 Year)
p-Index From 2021 - 2026
1.116
P-Index
This Author published in this journals
All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan METASASTRA: Jurnal Penelitian Sastra Jurnal Ilmu Peternakan dan Veteriner Tropis (Journal of Tropical Animal and Veterinary Sciences) Jurnal Masyarakat Merdeka (JMM) Jurnal Mandala Pharmacon Indonesia Jurnal Lingko : Jurnal Kebahasaan dan Kesastraan Jurnal Ekonomi Regional Unimal Molekul: Jurnal Ilmiah Kimia Jurnal Pendidikan Refleksi
Musdalipah Musdalipah, Musdalipah
Unknown Affiliation
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences Veterinary Other

Published : 12 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 12 Documents
Search

 1   2 
Steroidal and Potential Anti-inflammatory Properties of Carteriospongia sp from the Southeast Sulawesi Sea Coast Daud, Nur Saadah; Yodha, Agung Wibawa Mahatva; Musdalipah, Musdalipah; Fusvita, Angriani; Firdayanti, Firdayanti; Sahidin, Sahidin; Arfan, Arfan; Fristiohady, Adryan; Sadarun, Baru
ILMU KELAUTAN: Indonesian Journal of Marine Sciences Vol 30, No 3 (2025): Ilmu Kelautan
Publisher : Marine Science Department Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/ik.ijms.30.3.453-464

Abstract

Marine sponges are an abundant yet underutilized resource in Southeast Sulawesi, Indonesia, despite their ecological roles and pharmacological potential. Steroidal metabolites are dominant in many sponge species and have been widely recognized for their strong anti-inflammatory activity. However, the chemical composition and biological potential of Carteriospongia sp from Indonesian waters remain unexplored. Carteriospongia sp was extracted using the Soxhlet method, and the chemical profile was analyzed by Gas Chromatography–Mass Spectrophotometry (GC-MS). Anti-inflammatory activity was evaluated in vitro using the Bovine Serum Albumin (BSA) protein denaturation assay, with methylprednisolone as the positive control. Molecular docking studies were performed to assess the interactions between steroidal compounds and BSA protein. GC-MS analysis identified eight steroidal compounds such as 2-methylenecholestan-3-ol (S1), stigmasterol (S2), 4,4-dimethyl-cholesta-8,24-dien-3-ol (S3), 8,14-seco-3,19-epoxyandrostane-8,14-dione, 17-acetoxy-3ß-methoxy-4,4-dimethyl (S4), cholic acid ethyl ester (S5),  (3ß,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-3,24,25-triol (S6), stigmastan-3-en-6-ol (S7), ß-sitosterol (S8). The extract demonstrated concentration-dependent inhibition of protein denaturation, achieving 84.81% inhibition at 128 mg.L-1. The IC50 value was 3.71 mg.L-1, comparable to methylprednisolone (IC50 4.45 mg.L-1). Molecular docking revealed that compound S1 and S4 exhibited lower binding energies than other steroids, suggesting stronger stabilization of BSA protein. The findings demonstrate that Carteriospongia sp extract possesses significant anti-inflammatory potential, comparable to methylprednisolone. This study provides novel insights into the bioactive potential of Indonesian marine sponges and emphasizes the importance of further pharmacological and molecular studies to develop sponge-derived steroidal compounds as alternative or complementary anti-inflammatory therapeutics.
PENGARUH INFLASI, PRODUK DOMESTIK REGIONAL BRUTO DAN INVESTASI TERHADAP PENGANGGURAN TERDIDIK DI KOTA LHOKSEMAWE TAHUN 2008-2022 Rahmah, Mutia; Musdalipah, Musdalipah; Juliansyah, Hijri; Syafira, Syarifah
Jurnal Ekonomi Regional Unimal Vol. 7 No. 1 (2024): Jurnal Ekonomi Regional Unimal
Publisher : LPPM UNIMAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/jeru.v7i1.17732

Abstract

The aim of this research is to analyze the influence of Inflation, Gross Regional Domestic Product (GRDP) and Investment on Educated Unemployment in Lhokseumawe City. The data used in this research is secondary data obtained from publications by the Central Statistics Agency (BPS) and the Medium Term Development Plan (RPJM) of Lhokseumawe City for 15 years (2008-2022). This research uses the Multiple Linear Regression analysis method using Eviews. The results of this research show that inflation has a positive effect on educated unemployment in the city of Lhokseumawe. Gross Regional Domestic Product (GRDP) has no effect on educated unemployment in the city of Lhokseumawe. And investment has a positive effect on educated unemployment in the city of Lhokseumawe. Based on the results of tests carried out simultaneously on inflation, Gross Regional Domestic Product (GRDP) and investment have a significant effect on educated unemployment in Lhokseumawe City.
Co-Authors Ado, Moldefya Wahid Ado, Moldefya Wahid Arfan Arfan Asman, Muhammad Audina, Fina Baehaqi Baru Sadarun Daud, Nur Saadah Fauziah, Yulianti Firdayanti, Firdayanti Fristiohady, Adryan Fusvita, Angriani Hijri Juliansyah Karmilah, Karmilah Malaka, Muhammad Hajrul NUR FITRIANI Nurhikmah, Eny Prasetyo, Mulyadi Rini Hamsidi Rusli, Nirwati Sahidin . Santi, Eria Setiawan, Muh. Azdar Setiawan, Muh. Azdar Setiawan, Muhammad Azdar Sitti Nurani Sirajuddin Sofyan, Suhikma Syafira, Syarifah Syukur, Syamsinar Tee, Selfyana Austin Tee, Selfyana Austin Wulaisfan, Randa Yodha, Agung Wibawa Mahatva Yusuf, Muh. Ilyas