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All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences The Journal of Experimental Life Sciences (JELS) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan METASASTRA: Jurnal Penelitian Sastra Jurnal Ilmu Peternakan dan Veteriner Tropis (Journal of Tropical Animal and Veterinary Sciences) Jurnal Masyarakat Merdeka (JMM) Jurnal Mandala Pharmacon Indonesia Jurnal Lingko : Jurnal Kebahasaan dan Kesastraan Jurnal Ekonomi Regional Unimal Molekul: Jurnal Ilmiah Kimia Jurnal Pendidikan Refleksi STEM Education International
Musdalipah Musdalipah, Musdalipah
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Social Sciences Veterinary Other

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Steroidal and Potential Anti-inflammatory Properties of Carteriospongia sp from the Southeast Sulawesi Sea Coast Daud, Nur Saadah; Yodha, Agung Wibawa Mahatva; Musdalipah, Musdalipah; Fusvita, Angriani; Firdayanti, Firdayanti; Sahidin, Sahidin; Arfan, Arfan; Fristiohady, Adryan; Sadarun, Baru
ILMU KELAUTAN: Indonesian Journal of Marine Sciences Vol 30, No 3 (2025): Ilmu Kelautan
Publisher : Marine Science Department Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/ik.ijms.30.3.453-464

Abstract

Marine sponges are an abundant yet underutilized resource in Southeast Sulawesi, Indonesia, despite their ecological roles and pharmacological potential. Steroidal metabolites are dominant in many sponge species and have been widely recognized for their strong anti-inflammatory activity. However, the chemical composition and biological potential of Carteriospongia sp from Indonesian waters remain unexplored. Carteriospongia sp was extracted using the Soxhlet method, and the chemical profile was analyzed by Gas Chromatography–Mass Spectrophotometry (GC-MS). Anti-inflammatory activity was evaluated in vitro using the Bovine Serum Albumin (BSA) protein denaturation assay, with methylprednisolone as the positive control. Molecular docking studies were performed to assess the interactions between steroidal compounds and BSA protein. GC-MS analysis identified eight steroidal compounds such as 2-methylenecholestan-3-ol (S1), stigmasterol (S2), 4,4-dimethyl-cholesta-8,24-dien-3-ol (S3), 8,14-seco-3,19-epoxyandrostane-8,14-dione, 17-acetoxy-3ß-methoxy-4,4-dimethyl (S4), cholic acid ethyl ester (S5),  (3ß,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-3,24,25-triol (S6), stigmastan-3-en-6-ol (S7), ß-sitosterol (S8). The extract demonstrated concentration-dependent inhibition of protein denaturation, achieving 84.81% inhibition at 128 mg.L-1. The IC50 value was 3.71 mg.L-1, comparable to methylprednisolone (IC50 4.45 mg.L-1). Molecular docking revealed that compound S1 and S4 exhibited lower binding energies than other steroids, suggesting stronger stabilization of BSA protein. The findings demonstrate that Carteriospongia sp extract possesses significant anti-inflammatory potential, comparable to methylprednisolone. This study provides novel insights into the bioactive potential of Indonesian marine sponges and emphasizes the importance of further pharmacological and molecular studies to develop sponge-derived steroidal compounds as alternative or complementary anti-inflammatory therapeutics.
PENGARUH INFLASI, PRODUK DOMESTIK REGIONAL BRUTO DAN INVESTASI TERHADAP PENGANGGURAN TERDIDIK DI KOTA LHOKSEMAWE TAHUN 2008-2022 Rahmah, Mutia; Musdalipah, Musdalipah; Juliansyah, Hijri; Syafira, Syarifah
Jurnal Ekonomi Regional Unimal Vol. 7 No. 1 (2024): Jurnal Ekonomi Regional Unimal
Publisher : LPPM UNIMAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/jeru.v7i1.17732

Abstract

The aim of this research is to analyze the influence of Inflation, Gross Regional Domestic Product (GRDP) and Investment on Educated Unemployment in Lhokseumawe City. The data used in this research is secondary data obtained from publications by the Central Statistics Agency (BPS) and the Medium Term Development Plan (RPJM) of Lhokseumawe City for 15 years (2008-2022). This research uses the Multiple Linear Regression analysis method using Eviews. The results of this research show that inflation has a positive effect on educated unemployment in the city of Lhokseumawe. Gross Regional Domestic Product (GRDP) has no effect on educated unemployment in the city of Lhokseumawe. And investment has a positive effect on educated unemployment in the city of Lhokseumawe. Based on the results of tests carried out simultaneously on inflation, Gross Regional Domestic Product (GRDP) and investment have a significant effect on educated unemployment in Lhokseumawe City.
The Use of Podcasts among University Students in Learning English Vocabulary Musdalipah, Musdalipah; Sunra, La; Sakkir, Geminastiti
STEM Education International Vol. 2 No. 1 (2026): STEM Education International
Publisher : PT Ahan Group Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71289/stem.v2i1.20

Abstract

This study aims to describe how students use podcasts to learn vocabulary and to explore their perceptions of using podcasts in vocabulary learning. This study employed a descriptive qualitative research design. Data were collected through semi-structured interviews with ten students from the English Language Education Study Program at Universitas Negeri Makassar, selected using purposive sampling. The findings reveal that students use podcasts flexibly, either for focused learning or during daily activities, and they gain new vocabulary through exposure to authentic language.
Risk Prevention of Ventilator-Associated Pneumonia Thorough Oral Hygiene: A Literature Review Musdalipah, Musdalipah; Syam, Yuliana; Tahir, Takdir
The Journal of Experimental Life Science Vol. 11 No. 1 (2021)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jels.2021.011.01.05

Abstract

Ventilator-Associated Pneumonia (VAP) is a type of nosocomial infection that mostly occurs in intensive care units, generally occurring 48 hours after intubation. Endotracheal intubation and the use of a mechanical ventilator are invasive measures by patients, having a therapeutic effect. This paper aimed to identify the use of oral hygiene materials for the incidence of pneumonia related to the use of a ventilator. The research design was by searching literature in five databases, namely PubMed, Proquest, Science Direct, Wiley Online Library, and Google Scholar, by taking all databases in English and Indonesian, published in the last ten years (2010-2020). There were six articles about the effectiveness of using oral hygiene as risk prevention for Ventilator-Associated Pneumonia (VAP) with various concentrations and volumes. Several oral health assessment tools that can be used are Oral Assessment Guide, Beck Oral Assessment Scale, or Mucosal-Plaque Score. Comprehensive implementation of oral hygiene can improve the oral health of patients with mechanical ventilation, so bacterial colonization that causes VAP can be prevented. Therefore, nurses need to understand and apply oral assessment instruments as a basis for giving intervention.Keywords: Intensive care unit, Oral hygiene, Ventilator-Associated Pneumonia
Co-Authors Ado, Moldefya Wahid Ado, Moldefya Wahid Asman, Muhammad Audina, Fina Baehaqi Baru Sadarun Daud, Nur Saadah Fauziah, Yulianti Firdayanti, Firdayanti Fristiohady, Adryan Fusvita, Angriani Geminastiti Sakkir Hijri Juliansyah Karmilah, Karmilah Malaka, Muhammad Hajrul Mega Fatimah Rosana Muh. Azdar Setiawan NUR FITRIANI Nurhikmah, Eny Prasetyo, Mulyadi Rini Hamsidi Rusli, Nirwati Sahidin . Santi, Eria Setiawan, Muh. Azdar Setiawan, Muhammad Azdar Sitti Nurani Sirajuddin Sofyan, Suhikma Sunra, La Syafira, Syarifah Syam, Yuliana Syukur, Syamsinar Takdir Tahir Tee, Selfyana Austin Tee, Selfyana Austin Wulaisfan, Randa Yodha, Agung Wibawa Mahatva Yusuf, Muh. Ilyas