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All Journal Jurnal Kedokteran Syiah Kuala Indonesian Journal of Urology Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Majalah Kesehatan FKUB Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Respirologi Indonesia Majalah Patologi Indonesia Health and Medical Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indonesian Journal of Electrical Engineering and Computer Science Jurnal Layanan Masyarakat (Journal of Public Service) Indonesian Applied Physics Letters Jurnal Pengabdian Masyarakat dalam Kesehatan Indian Journal of Forensic Medicine & Toxicology Jurnal Pengabdian Masyarakat Bhinneka Jurnal Pengabdian Masyarakat Bangsa Folia Medica Indonesiana Indonesian Journal of Global Health Research
Anny Setijo Rahaju, Anny Setijo
Departemen Patologi Anatomi, Fakultas Kedokteran, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Analisa Ekspresi E-cadherin dan MMP-2 pada Karsinoma Sel Skuamosa Laring Andayani, Tuti; Kusumastuti, Etty Hary; Rahaju, Anny Setijo
Majalah Patologi Indonesia Vol 27 No.3, September 2018
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar belakangKarsinoma laring merupakan keganasan kedua terbanyak pada kepala dan leher dan lebih dari 90% berupa karsinoma sel skuamosa (KSS). Penanganan kanker laring berkaitan dengan diagnostik dan terapi, terutama ketika penyakit ini terdiagnosis pada stadium lanjut dengan keterlibatan kelenjar getah bening (KGB). Metastasis KSS pada KGB melibatkan beberapa protein yang berperan dalam adhesi sel seperti E-cadherin dan matrix metalloproteinase2 (MMP-2). Pada penelitian ini dilakukan analisis ekspresi E-cadherin dan MMP-2 pada KSS laring untuk menilai peran kedua protein tersebut dalam proses metastasis ke KGB leher.MetodePenelitian observasional analitik dengan pendekatan cross sectional. Sampel penelitian adalah blok parafin KSS laring di Departemen Patologi Anatomik RSUD Dr. Soetomo Surabaya selama Januari 2013-Desember 2014. Tiga puluh sampel terdiri atas dua kelompok, yaitu metastasis KGB dan non metastasis KGB dan dilakukan pemeriksaan imunohistokimia dengan antibodi E-cadherin dan MMP-2. Ekspresi E-cadherin dan MMP-2 dinilai secara semi kuantitatif dan dianalisis dengan tes Mann-Whitney, sedangkan korelasi antara ekspresi E-cadherin dan MMP-2 dengan tes Spearman.HasilTidak terdapat korelasi yang signifikan antara ekspresi E-cadherin dan MMP-2 pada KSS laring. Tidak terdapat perbedaan ekspresi E-cadherin dan MMP-2 yang signifikan antara KSS laring metastasis dan non metastasis ke KGB leher.KesimpulanEkspresi E-cadherin dan MMP-2 tidak berbeda bermakna karsinoma sel akuamosa laring tanpa dan metastasis ke KGB leher. Tidak terdapat korelasi ekspresi E-cadherin dan MMP-2 pada kejadian metastasis KGB leher pada KSS laring.
Cardiorespiratory Adaptations to Yoga: Mechanisms, Training Stimulus, and Implications for Vo₂Max: A Literature Review Alifa Nabila Putri; Anny Setijo Rahaju; Rimbun Rimbun
Indonesian Journal of Global Health Research Vol. 8 No. 6 (2026): Indonesian Journal of Global Health Research: December 2026
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i6.2661

Abstract

The effects of yoga on cardiorespiratory fitness and VO₂max remain inconsistent, partly because yoga practices vary substantially in modality and physiological training stimulus. This literature review synthesized evidence on the effects of yoga on VO₂max and cardiorespiratory fitness, with emphasis on training stimulus and potential physiological mechanisms. A total of 1,072 records published between 2001 and 2024 were identified through PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar using keywords related to yoga, VO₂max, aerobic capacity, cardiorespiratory fitness, and physiological adaptation. Following screening and eligibility assessment, 13 studies were included in the review. Data were synthesized according to yoga modality, training frequency, intervention duration, participant characteristics, and methods used to assess cardiorespiratory fitness. Most chronic intervention studies reported improvements in VO₂max or aerobic capacity, with increases of approximately 1.9–9.8 mL/kg/min. Improvements were observed following Hatha, intensive Hatha, integrated yoga, and high-intensity cardio yoga, whereas Bikram yoga, once-weekly high-intensity Hatha yoga, and habitual yoga practice showed no significant improvements. The findings suggest that cardiorespiratory adaptation may depend more on the magnitude and cumulative dose of physiological training stimulus than on the yoga modality itself. Yoga may improve cardiorespiratory fitness when practiced with sufficient and repeated physiological stimulus. However, substantial heterogeneity limits generalization across modalities.
Co-Authors Abdurrahman Hasyim Asy’ari Alifa Nabila Putri Alphania Rahniayu Andayani, Tuti Aniek Meidi, Aniek Aniek Meidy Utami Ariadna Anggi Pasang Ariani, Grace Arifa Mustika Arifa Mustika Aulia Nur Fadila Budi Harjanto Budi Harjanto Dewi Sartika A. W. Dewi, Rosa Amalia DWI SURYANTO DYAH FAUZIAH, DYAH Eddie Saputra Ferdinant Martinus Djawa Fira Soraya Gondo Mastutik HERAWATI, LILIK Heriyawati, Heriyawati Heryanto Heryanto Heryanto Heryanto I'tishom, Reny Ilmiah, Khafidhotul Imam Susilo Isnin Anang Marhana Izzan Khalidah Binti Muhamad I’tishom, Reny Katherine Kho Khafidhotul Ilmiah Khafidhotul Ilmiah Krismaningrum, Veronika Intan Kusumastuti, Etty Hari KUSUMASTUTI, ETTY HARY Leonita Agustin Hambalie Linda Dewanti Mas`udi, Achmad Fayyad Mohammad Fathul Qorib Naibaho, Ardy Hamonangan Nila Kurniasari Novalia Chumaladewi Guntarno Nur Arfian, Nur Osmalina Nur Rahma PUNGKY MULAWARDHANA, PUNGKY Qonitatillah, Ana Rahmi Alia Rahmi Alia Rahmi Alia, Rahmi Renny I’tishom Reza Wangsanagara Ridholia Ridholia Ridholia Ridholia, Ridholia Rifatus Solicha Rimbun Rimbun Riries Rulaningtyas Roostantia Indrawati S.Pd. M Kes I Ketut Sudiana . Salman Aziz, Muhamad Abi Sari, Aditya Sita Sheilla Matheos Sjahjenny Mustokoweni, Sjahjenny Soetojo Soetojo Suhartono Taat Putra Tarmono Djojodimedjo Tri Wulanhandarini Trianto, Heru Fajar Tuti Andayani Ummi Hanifah Utami, Aniek Meidy Vicky Sumarki Waasilah, Hadiyyatan Willy Sandhika Winarno Winarno Wira Santoso Ongko Wiratama, Priangga Adi Yohana Octavianda