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Formulasi Sediaan Clay Stick Ekstrak Bunga Telang (Clitoria ternatea L.) Khairunnisa, Hanifah; Suharsanti, Ririn; Cahyani, Intan Martha
KUNIR: JURNAL FARMASI INDONESIA Vol 2 No 2 (2024): NOVEMBER
Publisher : Program Studi Farmasi (S-1), Fakultas Ilmu Kesehatan, Universitas Bhamada Slawi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36308/kjfi.v2i2.716

Kerusakan oksidatif dapat menyebabkan hilangnya kelembapan yang menyebabkan kulit kering dan kusam. Salah satu kosmetik yang dapat mengatasi kulit kering adalah clay stick dari bahan alam bunga telang (Clitoria ternatea L.) karena mengandung senyawa antioksidan dengan nilai IC50 ekstrak bunga telang sebesar 41,36 ± 1,91 µg/ml, termasuk kategori poten sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian sediaan clay stick selama 4 minggu konsentrasi 5%, 10% dan 15% terhadap kelembapan kulit, kadar minyak, kehalusan kulit dan untuk mengetahui berapa konsentrasi ekstrak bunga telang sediaan Clay Stick yang efektif. Pada penelitian ini, ekstrak diperoleh dengan metode remaserasi menggunakan etanol 96%. Ekstrak bunga telang dilakukan uji bebas etanol, uji skrining fitokimia dan uji penegasan dengan metode KLT, kemudian di formulasikan dalam bentuk sediaan clay stick dengan ekstrak bunga telang konsentrasi 5%, 10% dan 15%. Sediaan clay stick kemudian dilakukan uji karakteristik fisik uji organoleptis, uji homogenitas, uji pH, uji waktu mengering, uji iritasi, uji kelembapan, uji kadar minyak dan uji kehalusan kulit. Hasil yang diperoleh dari penelitian adalah terdapat pengaruh pemberian sediaan clay stick konsentrasi 5%, 10% dan 15% terhadap kelembapan kulit, kadar minyak, kehalusan kulit dan sediaan clay stick ekstrak bunga telang dengan konsentrasi 5% adalah sediaan yang efektif untuk aktivitas tersebut.

Exploring the α-Amylase Inhibitory Potential of Peronema canescens Jack: An In Vitro and In Silico Study Rahardhian, Muhammad Ryan Radix; Aryanti, Ninda; Susilawati, Yasmiwar; Sumiwi, Sri Adi; Putri, Chintiana Nindya; Ramonah, Dewi; Suharsanti, Ririn
HAYATI Journal of Biosciences Vol. 32 No. 3 (2025): May 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.3.712-726

Hyperglycemia in individuals with type 2 diabetes mellitus is primarily driven by the rapid hydrolysis of starch by the enzyme α-amylase in the pancreas and the breakdown of oligosaccharides by α-glucosidase in the intestine. Peronema canescens Jack. (PC) has shown promise as a potential antidiabetic agent. This study aimed to evaluate the total flavonoid, phenolic, and α-amylase inhibitory activity of extracts and fractions derived from PC leaves using both in vitro and in silico approaches. The ethanol extract of PC leaves was fractionated through liquid-liquid extraction using n-hexane, ethyl acetate, and water as solvents. Preliminary phytochemical screening of the extracts and fractions identified the presence of alkaloids, flavonoids, saponins, tannins, and steroids/triterpenoids. The n-hexane fraction exhibited the highest total flavonoid content, averaging 203.37±4.38 mg QE/gram, while the ethyl acetate fraction demonstrated the highest total phenolic content, averaging 147.04±0.79 mg GAE/gram. Furthermore, the ethyl acetate fraction showed the strongest α-amylase inhibitory activity, with an average inhibition rate of 70.38±1.26%. In silico analysis, combined with GC-MS identification, suggested that three compounds, bis(2-ethylhexyl) phthalate, myristyl oleate, and 14 beta H-pregna may contribute to the observed α-amylase inhibitory activity. These findings highlight the potential of PC as a source of natural antidiabetic agents.

Anti-Aging Efficacy of Averrhoa bilimbi Fruit Extract Cream: A Human Clinical Trial Suharsanti, Ririn; Ryan Radix Rahadhian, Muhammad; Sugihartini, Nining; Lukitaningsih, Endang
Jurnal Jamu Indonesia Vol. 10 No. 2 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i2.401

Averrhoa bilimbi, a plant native to Indonesian, exhibits antioxidant, sunscreen, and tyrosinase inhibitory activities due to its polyphenol and flavonoid content. This study aimed to evaluate the anti-aging efficacy of a topical cream containing A. bilimbi fruit extract through a human clinical trial. The extract was obtained by maceration using 70% ethanol and formulated into a water-in-oil (W/O) cream at concentrations of 1% (F1), 3% (F2), and 5% (F3). Each formulation was evaluated for its physical characteristics, including organoleptic properties, homogeneity, pH, and viscosity. Irritation tests were conducted on animals and human volunteers. A total of 24 human subjects applied the cream for 30 days. Skin condition parameters—sebum, moisture, pigmentation, pore size, elasticity, and collagen fibers—were assessed before and after treatment using a skin analyzer. The results showed that the F3 formulation produced the most notable improvements, including increased skin moisture and elasticity, and decreased pigmentation and pore size. Statistical analysis revealed significant improvements (p < 0.05) in pore size and elasticity for the F3 group. These findings indicate that the 5% A. bilimbi extract cream is a safe and effective anti-aging topical formulation.

In Silico Study of Compounds Identified in Curcuma aeruginosa Roxb Rhizome as BRAF V600E Inhibitors in Melanoma Cancer Suharsanti, Ririn; Ryan Radix Rahardhian, Muhammad; Kusmita, Lia
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21589

Curcuma aeruginosa Roxb rhizome contains secondary metabolite compounds and plays a role in various activities such as antioxidant, antibacterial, anthelmintic, antiandrogenic, antinociceptive, and anticancer. Anticancer activity that has been reported in Curcuma aeruginosa Roxb rhizome is limited to breast and cervical cancer. The purpose of this study was to explore the potential of Curcuma aeruginosa Roxb rhizome in melanoma cancer through the mechanism of inhibiting the BRAF V600E. The 96% ethanol extract of Curcuma aeruginosa Roxb rhizome was separated to produce n-hexane (HF), ethyl acetate (EAF), and ethanol (EF) fractions. The GC-MS results showed that there were 31 compounds from the three fractions. The docking validation process was carried out on the native ligand N-(3-{[5-(4-chlorophenyl) -1H-pyrrolo [2,3b]pyridin3yl] carbonyl}2,4difluorophenyl) propane-1-sulfonamide. All compounds were prepared as ligands for molecular docking with the BRAF V600E receptor (PDB ID: 3OG7). Docking validation on native ligand showed RMSD 1.03Å. The smallest binding affinity are 4,4a,5,6,7,8-Hexahydronaphthalen-2(3H)-one (-6,89 kcal/mol); 1Cyclohexyl-2-propen-1-one (-6,68 kcal/mol); Cyclooctenone (-6,23 kcal/mol); and vemuravnib is still better as K+ (-11.11 kcal/mol). All three compounds do not bind to key amino acid residues of BRAF V600E such as vemuravenib at GLN A:530, CYS A:532; ASP A:594. These results indicate that further structural development is needed for better activity.

In Silico Study of Compounds Identified in Curcuma aeruginosa Roxb Rhizome as BRAF V600E Inhibitors in Melanoma Cancer Suharsanti, Ririn; Ryan Radix Rahardhian, Muhammad; Kusmita, Lia
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21589

Curcuma aeruginosa Roxb rhizome contains secondary metabolite compounds and plays a role in various activities such as antioxidant, antibacterial, anthelmintic, antiandrogenic, antinociceptive, and anticancer. Anticancer activity that has been reported in Curcuma aeruginosa Roxb rhizome is limited to breast and cervical cancer. The purpose of this study was to explore the potential of Curcuma aeruginosa Roxb rhizome in melanoma cancer through the mechanism of inhibiting the BRAF V600E. The 96% ethanol extract of Curcuma aeruginosa Roxb rhizome was separated to produce n-hexane (HF), ethyl acetate (EAF), and ethanol (EF) fractions. The GC-MS results showed that there were 31 compounds from the three fractions. The docking validation process was carried out on the native ligand N-(3-{[5-(4-chlorophenyl) -1H-pyrrolo [2,3b]pyridin3yl] carbonyl}2,4difluorophenyl) propane-1-sulfonamide. All compounds were prepared as ligands for molecular docking with the BRAF V600E receptor (PDB ID: 3OG7). Docking validation on native ligand showed RMSD 1.03Å. The smallest binding affinity are 4,4a,5,6,7,8-Hexahydronaphthalen-2(3H)-one (-6,89 kcal/mol); 1Cyclohexyl-2-propen-1-one (-6,68 kcal/mol); Cyclooctenone (-6,23 kcal/mol); and vemuravnib is still better as K+ (-11.11 kcal/mol). All three compounds do not bind to key amino acid residues of BRAF V600E such as vemuravenib at GLN A:530, CYS A:532; ASP A:594. These results indicate that further structural development is needed for better activity.

Pengaruh Konsentrasi Natrium Lauril Sulfat pada Karakteristik Fisik Sediaan Gel Sampo Ekstrak Etanol Bunga Telang (Clitoria ternatea L.) Nurjanah, Hidayatillah; Suharsanti, Ririn; Cahyani, Intan Martha
KUNIR: JURNAL FARMASI INDONESIA Vol 3 No 1 (2025): JULI
Publisher : Program Studi Farmasi (S-1), Fakultas Ilmu Kesehatan, Universitas Bhamada Slawi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36308/kjfi.v3i1.767

Bakteri dapat tumbuh pada kondisi rambut dengan kelenjar minyak berlebih, sehingga kebersihan kulit kepala harus dijaga menggunakan sampo. Penelitian ini bertujuan untuk mengetahui pengaruh natrium lauril sulfat serta konsentrasinya yang dapat menghasilkan sediaan gel sampo ekstrak etanol bunga telang dengan karakteristik yang baik. untuk mengetahui apakah semua konsentrasi natrium lauril sulfat pada sediaan gel sampo memenuhi syarat uji ALT Dirjen POM tahun 1994. Ekstraksi metode maserasi menggunakan pelarut etanol 70%. Konsentrasi natrium lauril sulfat yang digunakan pada sediaan gel sampo yaitu 10% (Formula I), 15% (Formula II), dan 20% (Formula III). Sediaan gel sampo dilakukan uji karakteristik fisik dan angka lempeng total. Hasil pengujian dianalisis menggunakan pendekatan statistika uji parametrik one-way ANOVA. Hasil penelitian menunjukkan bahwa ada pengaruh signifikan konsentrasi natrium lauril sulfat pada karakteristik fisik sediaan gel sampo ekstrak etanol bunga telang dengan nilai P Value (< 0,05). Konsentrasi 15% natrium lauril sulfat dalam sediaan gel sampo merupakan konsentrasi yang memiliki karakteristik fisik yang baik. Semua konsentrasi natrium lauril sulfat pada sediaan gel sampo memenuhi syarat uji ALT Dirjen POM tahun 1994 yaitu < 105 koloni/gram.

Uji Aktivitas Tabir Surya Ekstrak Daun Mint (Mentha Piperita L.) Yang Diekstraksi Dengan Metode Ultrasonic Assisted Extraction Wardhani, Risty Ayu; Cahyani, Intan Martha; Suharsanti, Ririn
KUNIR: JURNAL FARMASI INDONESIA Vol 3 No 1 (2025): JULI
Publisher : Program Studi Farmasi (S-1), Fakultas Ilmu Kesehatan, Universitas Bhamada Slawi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36308/kjfi.v3i1.770

Paparan sinar matahari berlebihan menimbulkan efek merugikan bagi kulit seperti eritema, immediate pigmen darkening, fotoaging dan fotokarsinogenik. Salah satu upaya untuk mencegah yaitu menggunakan tabir surya. Daun mint (Mentha piperita L.) mengandung senyawa flavonoid yang memiliki sifat antioksidan yang sangat tinggi. Selain memiliki antioksidan yang sangat tinggi, flavonoid juga merupakan komponen yang dapat menangkal radikal induksi ultraviolet sehingga berpotensi sebagai tabir surya. Penelitian ini bertujuan untuk mengetahui potensi tabir surya pada daun mint berdasarkan nilai Sun Protection Factor (SPF), persentase transmisi eritema (%Te), dan persentase transmisi pigmentasi (%Tp) secara in vitro. Metode ekstraksi dilakukan dengan metode Ultrasonic Assisted Extraction (UAE) dengan variasi suhu 50˚C, 60˚C, 70˚C dan lama waktu 10 menit, 20 menit, 30 menit. Pengujian aktivitas tabir surya dilakukan tehadap semua sampel pada konsentrasi 100, 200, dan 300 ppm yang meliputi penentuan nilai Sun Protection Factor (SPF), persentase transmisi eritema (%Te), dan persentase transmisi pigmentasi (%Tp) ekstrak daun mint dengan menggunakan spektrofotometer UV (panjang gelombang 2990-320 nm). Hasil pengujian menunjukkan bahwa ekstrak paling baik terdapat pada variasi lama waktu ekstraksi 30 menit dengan suhu ekstraksi 70˚C.

Program Literasi Kosmetik : Peningkatan Pemahaman Remaja Terhadap Resiko Produk Skincare Overklaim Suharsanti, Ririn; Mutiara, Erlita Verdian; Advistasari, Yustisia Dian; Ariani, Lilies Wahyu; Wulandari, Wahyu
Jurnal Pengabdian Masyarakat Bangsa Vol. 3 No. 7 (2025): September
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v3i7.2903

Remaja menjadi target utama berbagai merk skincare yang menawarkan berbagai manfaat seperti mencerahkan kulit, menghilangkan jerawat, dan memperbaiki tekstur kulit. Tidak semua produk yang dipasarkan memiliki klaim yang benar dan sesuai dengan regulasi, sehingga banyak produk yang overclaim atau memberikan janji berlebihan tanpa dasar ilmiah yang kuat. Kurangnya literasi kosmetik membuat mereka rentan terhadap produk yang mengandung bahan berisiko atau tidak memiliki izin edar yang sah. Untuk mengatasi permasalahan tersebut, diperlukan program edukasi yang dapat meningkatkan pemahaman remaja mengenai literasi kosmetik secara komprehensif. Program literasi ini menyangkut beberapa kegiatan antara lain penyuluhan langsung kepada remaja di sekolah-sekolah atau komunitas mengenai dasar-dasar pemilihan skincare yang tepat, pelatihan membaca label dan komposisi produk, simulasi pengecekan legalitas produk menggunakan website BPOM, serta diskusi interaktif dalam kelompok kecil serta pembuatan konten edukasi kosmetik overklaim. Kegiatan berlangsung dengan target 52 siswa jurusan Farmasi SMK Nusapersada Tengaran kelas X dan XI. Pada akhir kegiatan, hasil yang dicapai dari pelaksanaan program ini, diperoleh beberapa hasil positif, antara lain peningkatan pengetahuan peserta berdasarkan rata-rata skor pemahaman peserta dari 60% menjadi 83,2%. Program Literasi Kosmetik memberikan dampak positif yang nyata bagi masyarakat sasaran.

Quantification of Bioactives and Bioactivities in Different Parts of Abelmoschus esculentus Astutiningsih, Christina; Suharsanti, Ririn; Ismail, Wan Ismahanisa; Sufiyanto, Mohammad Imam; Minah, Faidliyah Nilna; Firmiaty, Sri
Biosaintifika: Journal of Biology & Biology Education Vol. 17 No. 2 (2025): August 2025
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v17i2.24073

The presence of natural antioxidants in medicinal plants plays a crucial role in inhibiting the detrimental effects of oxidative stress. The aim of this research is to explore more deeply all parts of A. esculenta L from flowers, fruits, seeds, leaves, and stems for the levels of compounds and antioxidant and enzyme inhibitor activities. The flowers demonstrated the highest TPC with 173.15942 ± 6.5083 mg GAE/g. The stems exhibited the lowest TPC value at 69.1967 ± 2.8408 mg GAE/g. The flowers also showed TFC value of 83.157 ± 2.021 mg QE/g while the stems displayed the lowest with 36.7240 ± 1.337 mg QE/g. IC50 value that the flowers possessed the highest antioxidant activity with 22.6539 ± 1.6452 mg/mL, whereas the stems displayed a slightly lower. In terms of the inhibitor of a-amylase activity, the flowers had an IC50 value of 102.4885 ± 11.4370 mg/mL whereas the stems had a lower. The highest IC50 value of the a-glucosidase inhibitor was 76.95 ± 12.0888 mg/mL in the flowers, and the lowest was in the stems. The highest IC50 of pancreatic lipase inhibitor was 109.5943 ± 9.7391 mg/mL in the flowers, and the lowest was in the stems. This study show that there is a relationship between the high content of total phenolic and total flavonoids on antioxidants, antidiabetic and antilipase activities.

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