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Efektivitas Oral Isotretinoin Sebagai Pengobatan Acne Vulgaris Derajat Sedang Dan Berat Ratih Pramuningtyas; Niken Sari Oktafiani
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (381.807 KB) | DOI: 10.36418/syntax-literate.v7i10.9630

Abstract

Akne Vulgaris merupakan gangguan inflamasi yang melibatkan folikel rambut dan kelenjar polisebasea dengan prevalensi 40 – 80% di Asia. Akne vulgaris memiliki dampak terhadap kehidupan sehari-hari seperti nyeri dan gatal maupun cemas, depresi dan membuat kepercayaan diri seseorang turun. Salah satu obat untuk mengatasi akne vulgaris derajat sedang dan berat adalah isotretinoin. Tujuan: Mengetahui efektivitas oral isotretinoin sebagai pengobatan acne vulgaris derajat sedang dan berat. Penelitian ini merupakan studi literatur review. Data yang diperoleh adalah data sekunder yaitu hasil penelitian yang sudah dilakukan oleh peneliti terdahulu. Pencarian artikel dalam literature review ini menggunakan tiga database yaitu Pubmed, Science Direct, dan Google Scholar. Kriteria inklusi adalah jurnal penelitian tanpa batasan tahun, penelitian kuantitatif dan berbahasa Inggris atau bahasa Indonesia. Terdapat 1049 jurnal yang ditemukan kemudian diekslusi sesuai kriteria restriksi sehingga didapatkan 10 jurnal untuk di review. Hasil analisis 10 jurnal didapatkan bahwa isotretinoin oral dosis rendah lebih efektif dan minimal efek samping (8 jurnal), isotretinoin dosis tinggi pada awal terapi dan dilanjutkan dosis rendah sebagai terapi pemeliharaan lebih efektif dibandingkan dengan pemberian dosis rendah dari awal terapi (2 jurnal). Isotretinoin oral efektif untuk pengobatan akne vulgaris derajat sedang dan berat.
The Epidemiologic and Sociodemographic Features of Superficial Fungal Infection Among Children in East Java Suburban Public Hospital Prakoeswa, Flora Ramona Sigit; Pramuningtyas, Ratih; Dimawan, Rully Setia Agus
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 2 (2022): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.2.2022.120-124

Abstract

Background: Superficial fungal infection is a common skin disease among children, causing morbidity and reducing quality of life. The disease's prevalence and etiological agents change with geographic area, age, humidity, and sex. The data on this matter is still limited in Indonesia. Purpose:  To determine the current epidemiologic and sociodemographic features of superficial fungal infection among children. Methods: This descriptive study examined all the pediatric inpatients and outpatients at the Department of Dermatology and Venerology of East Java suburban Public Hospital in Indonesia from 2016 to 2020 who met the inclusion criteria. Result:  From 2016 to 2020, the number of fungal infection patients was 12.3% (n = 175) among 1,427 dermatology patients. Pityriasis versicolor (PVC) is the most common fungal skin disease (4.1%), followed by tinea capitis (2.2%), tinea cruris (1.6%), and tinea corporis (1.4%). Subjects aged 6 to 12 years old were the most likely to be infected with a fungus. Boys were more likely to develop this infection. Conclusion: From 2017 to 2020, there was a downward trend in children's superficial fungal infections. Pityriasis versicolor (PVC) is a fungal skin ailment that cause the most cases compared to other fungal infections. Boys and children between the ages of 6 to 12 years old were the most susceptible to fungal infection.
Pengaruh Penggunaan Alat Pelindung Diri (APD) Fisik dan Cream Pelindung Terhadap Kejadian Melasma Pada Petani di Kabupaten Wonosobo Mibawani, Aliza; Pramuningtyas, Ratih
Health Information : Jurnal Penelitian Content Digitized
Publisher : Poltekkes Kemenkes Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kabupaten Wonosobo dengan karakteristik dataran tinggi semakin memperbesar potensi bagi petani terkena melasma. Faktor resiko penyebab melasma paling sering karena paparan UV dan APD. Tujuan penelitian untuk menganalisis hubungan penggunaan APD fisik dan cream pelindung dengan kejadian melasma pada petani di Kabupaten Wonosobo. Penelitian dengan analitik observasional, desain cross sectional. Sampel sebanyak 92 petani diambil secara purposive sampling, dan berdasarkan kriteria restriksi (kriteria inklusi: minimal 10 tahun bertani dan 30-60 tahun) dan kriteria ekslusi (petani dengan penyakit kulit bawaan, pengunaan obat hormonal, dan penggunaan KB). Hasil penelitian menunjukkan bahwa terdapat hubungan signifikan terhadap penggunaan APD pakaian pelindung dan cream pelindung. Resiko yang paling tinggi yaitu penggunaan cream pelindung dengan resiko (4,239). Studi tersebut menyimpulkan adanya hubungan erat antara penggunaan APD dan cream pelindung dengan kejadian melasma pada petani di Kabupaten Wonosobo.
The Effectiveness of Lactobacillus plantarum Administration in Patients with Atopic Dermatitis Izzati, Ismatu Aghni Fatwa; Pramuningtyas, Ratih; Bestari, Rochmadina Suci; Nurhayani, Nurhayani
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 9, No 1 (2022): February
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.9.1.2022.43-50

Abstract

Background: Atopic dermatitis is a chronic and residual inflammatory skin disease with increased prevalence in every year. The medications that are often given can cause serious side effects if it given in the long-term. The treatment of Lactobacillus plantarum is expected to be safer long-term treatment option for patient with atopic dermatitis.Objective: The objective is to determine the effectiveness treatment of Lactobacillus plantarum in patients with atopic dermatitis.Method: The research design was a Systematic Review with a qualitative approach using meta-synthesis analysis type. The search was conducted on 3 databases: PubMed, Science Direct, and Google Scholar. Result: Total articles obtained were 239 with 16 duplicate data. 211 articles were included in the exclusion criteria and 5 articles were interventions with combination probiotics. So there are 7 articles included in the research with clinical trials, open trials, pilot studies, and 4 research using the randomized controlled trial Double Blind design. All results showed improvement in symptoms with the SCORAD index or Skindex-16. Several studies also measured IgE, IL-4, IL-10, IL-13, IL-17, the percentage of Th1, Th2, Treg, TGF-β, IFN-γ and obtained different  results. Conclusion: Treatment of Lactobacillus plantarum in patients with atopic dermatitis is effective to reducing symptoms and as an immunomodulator.
Effectiveness of Emollient Topical Therapy on Hand Dermatitis Events Pranesti, Rahma; Sutrisna, Em; Faradisa, Nida; Pramuningtyas, Ratih
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 11, No 1 (2024): February
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.11.1.2024.60-70

Abstract

Background: Clinically, hand dermatitis manifests as either irritant contact dermatitis (ICD) or allergy contact dermatitis (ACD). Patients with hand dermatitis typically use emollients to reduce transepidermal water loss (TEWL).Objective: This investigation aims to evaluate the efficacy of emollient topical therapy on hand dermatitis.Methods: The study's design was based on a literature review, and the research samples were obtained through online searches on Google Scholar, PubMed, and ScienceDirect.Results: 495 items were subsequently excluded based on the restriction criteria. We obtained eight research articles for evaluation. Hand Eczema Severity Index (HECSI), TEWL, Dermatology Life Quality Index (DLQI), Health-related quality of life (HRQoL), Modified Total Lesion Symptom Score (mTLSS), Investigator Global Assessment (IGA), and Visual analog score (VAS) were used to measure hand dermatitis, and there was a significant increase in these measurements for emollients. In the conclusion of the eight articles, six stated that they were significant, and two stated that emollients were effectively used as topical therapy.Conclusion: Emollients typically act on the epidermis, particularly the stratum corneum, which can reduce TEWL so that antigen penetration and inflammation spread are not facilitated.
The Effectiveness Of Salicylic acid Therapy In Mild and Moderate Acne Vulgaris Nafila, Alfin; Nursanto, Dodik; Sintowati, Retno; Pramuningtyas, Ratih
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 11, No 1 (2024): February
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.11.1.2024.71-82

Abstract

Background: Acne vulgaris is a chronic inflammatory disease of polysebaceous follicles characterized by lesions that include blackheads, papules, pustules, nodules, and cysts. The prevalence of acne vulgaris is most significant among adolescents aged 15 to 18. In mild and moderate acne vulgaris, topical treatment enhances skin conditions. It is believed that the ability of salicylic acid to reach the stratum corneum, which exfoliates due to its comedolytic properties, aids in the healing of acne vulgaris.Objective: Evaluate the efficacy of salicylic acid as a treatment for mild and moderate acne vulgaris.Methods: This study's design involved a literature search using the terms acne vulgaris and salicylic acid in Google Scholar, PubMed, and Science Direct.Results: The investigation found 108 articles were discovered and excluded based on the restriction criteria; 8 articles were reviewed. Salicylic acid substantially improved mild and moderate acne, according to all studies. Improvement was measured based on the lesion's severity, the lesion type, and Goodman's qualitative global scarring grading system. There is an improvement in inflammatory, non-inflammatory, and hyperpigmented lesions.Conclusion: Salicylic acid is clinically beneficial for mild to moderate acne vulgaris.
The Pattern of Pediatric Parasitic Skin Diseases in a Secondary Hospital in East Java: A Retrospective Study Prakoeswa, Flora Ramona Sigit; Pramuningtyas, Ratih; Dimawan, Rully Setia Agus
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 35 No. 1 (2023): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V35.1.2023.52-56

Abstract

Background: Epidermal parasitic skin diseases (EPSDs) are a group of neglected infectious diseases caused by parasites that infect the upper layer of the skin. A parasitic infection of the skin is caused by small insects or worms that burrow into the skin to live there or lay their eggs. EPSDs are a public health issue and can occur in children of all ages. Purpose: This study aims to describe the pattern and incidences of parasitic skin infections in children. Methods: This is a cross-sectional study utilizing medical records from the Dermatology and Venereology Clinic of Dr. Harjono Ponorogo General Public Hospital from 2016 to 2020. Result: Our study showed that, of the 1426 children brought to our clinic, parasitic infection was the second most common skin disease found in children with a prevalence of 27.1%. Parasitic infection in children was dominated by males with a proportion of 69.7%, and occurred mostly in the ≥13-year-old age group. Among all ages, scabies is the most frequent parasitic infection found, followed by cutaneous larva migrant (CLM) and pediculosis. Conclusion: The prevalence of EPSDs is increasing with age and is more common in males. This high prevalence is probably due to increased intensity of contact with other people, decreased parental care, and low socio-economic status.
SKABIES: INFESTASI PARASIT YANG TIDAK HANYA MEMENGARUHI KULIT Sigit Prakoeswa, Flora Ramona; Pramuningtyas, Ratih; Risanti, Erika Diana; Suci Bestari, Rochmadina; Dewi, Listiana Masyita
Journals of Ners Community Vol 13 No 3 (2022): Journals of Ners Community
Publisher : Fakultas Ilmu Kesehatan Universitas Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55129/jnerscommunity.v13i2.1789

Abstract

Skabies adalah salah satu penyakit infestasi parasit pada kulit yang paling umum di dunia dan memiliki dampak yang bervariasi tergantung pada situasi klinis. Beberapa waktu yang lalu, World Health Organization (WHO) telah menambahkan skabies ke dalam daftar penyakit tropis yang terabaikan dalam upaya untuk mengendalikan dan mengeradikasi skabies. Skabies tidak hanya memengaruhi kulit, namun juga berdampak terhadap terhadap aspek psikis, sosial, dan ekonomi pasien. Hal ini mengakibatkan terjadinya penurunan kualitas hidup pasien skabies, bahkan pada populasi tertentu skabies sudah dianggap hal yang biasa. Tidak hanya itu, skabies juga dapat menimbulkan komplikasi yang berat seperti glomerulonefritis, penyakit ginjal kronik, dan demam rematik akut. Prognosis yang baik dapat diperoleh jika pasien diberi tata laksana yang tepat dan holistik.
The Effect of Radiotherapy on Skin Reactions in Nasopharynx Cancer Patient Putri, Elsya Nur Fadhilla; Prakoeswa, Flora Ramona Sigit; Pramuningtyas, Ratih
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5507

Abstract

Nasopharyngeal cancer is a squamous cell carcinoma with a high frequency in East and Southeast Asia. Radiotherapy is the main treatment method often used in the management of nasopharyngeal cancer. Although effective in destroying cancer cells, radiotherapy often causes significant skin reactions, including radiation dermatitis, which can appear as erythema, desquamation, and even ulceration. These reactions can affect the sufferers' quality of life and interfere with the continuity of therapy. This study aims to explore factors that affect the intensity of radiation dermatitis, including location of radiotherapy and concurrent chemotherapy. In addition, radiation dermatitis management strategies, such as the use of moisturizers, topical steroid therapy, and sun protection, are packaged to accelerate the healing process and reduce symptoms. Assessment criteria such as CTCAE and RTOG are used to assess The intensity of dermal responses. It is expected that a thorough understanding of the causes and management of radiation dermatitis would improve the prognosis for patients with nasopharyngeal cancer and increase the effectiveness of therapy. More research is needed to develop more effective preventative and therapeutic measures for radiation-induced dermatitis.
Drinking Coffee and Learning Approach, Not Learning Style, Support Medical Students' Block Completion Fithriyah, Saidatul; Nafasadila, Fatma; Pramuningtyas, Ratih; Sintowati, Retno
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5538

Abstract

Purpose: This research was conducted to determine and analyse the relationship between drinking coffee, learning styles, and approaches with block completion in medical students. Methodology: The research method used was observational analytics with 80 third-year students of the Faculty of Medicine, Universitas Muhammadiyah Surakarta (FK UMS), Sukoharjo, Central Java, Indonesia as the samples. Purposive random sampling was used to select samples who met the restriction criteria. To identify relationships and influences between variables, the collected data was analysed using Chi-square test with the alternative Fisher exact test and logistic regression test. Results: There was a significant relationship between drinking coffee (p=0.012) and learning approach (p=0.001) with block completion, but not between learning style with block completion (p=0.594). Learning approach had a stronger relationship. The probability of block completion reaching 98.4% if students drink coffee and use a deep learning approach to prepare for the block exam. Applications/Originality/Value: Drinking coffee and applying a deep approach to learning, support a greater block completion rate.