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Ika Trisharyanti Dian Kusumowati
Universitas Muhammadiyah Surakarta
Agriculture, Biological Sciences & Forestry Arts Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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HUBUNGAN STRUKTUR TURUNAN N-KLOROBENZOILAMOKSISILIN DAN AKTIVITAS ANTIBAKTERINYA TERHADAP Pseudomonas aeruginosa ATCC 27853 Kusumowati, Ika Trisharyanti Dian; Siswandono, .; Rudyanto, Marcellino
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 5, No 3 (2011)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The aim of this research is to determine structure-activity relationship N-chlorobenzoylamoxicillin derivatives against Pseudomonas aeruginosa ATCC 27853. Antibacterial activities of the N-benzoylamoxicillin­ derivatives against Pseudomonas aeruginosa ATCC 27853 were tested using dilution method. The result showed that there was significance MIC of amoxycillin with N-benzoylamoxycillin, N-2-chlorobenzoylamoxycillin, and N-3-chlorobenzoylamoxycillin. Non linier regression between log MIC and lypophilic parameter N-chlorobenzoylamoxycillin derivatives showed -log KHM = 3,963 p2 - 3,001 p - 2,477, r = 0,906. To see more clearly quantitative strucuture-activity relationship of N-benzoylamoxicillin derivatives, further similar studies need to be done by increasing numbers of another N-benzoylamoxicillin derivative compounds.  ABSTRAK Penelitian ini bertujuan mengetahui hubungan struktur-aktivitas antibakteri senyawa-senyawa turunan N-kolorobenzoilamoksisilin terhadap Pseudomonas aeruginosa ATCC 27853. Uji aktivitas antibakteri turunan senyawa N-klorobenzoilamoksisilin terhadap Pseudomonas aeruginosa ATCC 27853 dilakukan dengan metode dilusi. Nilai KHM menunjukkan adanya perbedaan aktivitas yang bermakna antara amoksisilin dengan N-benzoilamoksisilin, N-2-klorobenzoilamoksisilin, dan N-3-klorobenzoilamoksisilin. Persamaan non linier log KHM dengan sifat lipofilik senyawa turunan N-klorobenzoilamoksisilin diperoleh -log KHM = 3,963 p2 - 3,001 p - 2,477, dengan harga r = 0,906.
HUBUNGAN STRUKTUR TURUNAN N-KLOROBENZOILAMOKSISILIN DAN AKTIVITAS ANTIBAKTERINYA TERHADAP Pseudomonas aeruginosa ATCC 27853 Kusumowati, Ika Trisharyanti Dian; Siswandono, .; Rudyanto, Marcellino
Jurnal Farmasi Indonesia Vol 5, No 3 (2011)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i3.49

Abstract

The aim of this research is to determine structure-activity relationship N-chlorobenzoylamoxicillin derivatives against Pseudomonas aeruginosa ATCC 27853. Antibacterial activities of the N-benzoylamoxicillin­ derivatives against Pseudomonas aeruginosa ATCC 27853 were tested using dilution method. The result showed that there was significance MIC of amoxycillin with N-benzoylamoxycillin, N-2-chlorobenzoylamoxycillin, and N-3-chlorobenzoylamoxycillin. Non linier regression between log MIC and lypophilic parameter N-chlorobenzoylamoxycillin derivatives showed -log KHM = 3,963 p2 - 3,001 p - 2,477, r = 0,906. To see more clearly quantitative strucuture-activity relationship of N-benzoylamoxicillin derivatives, further similar studies need to be done by increasing numbers of another N-benzoylamoxicillin derivative compounds.  ABSTRAK Penelitian ini bertujuan mengetahui hubungan struktur-aktivitas antibakteri senyawa-senyawa turunan N-kolorobenzoilamoksisilin terhadap Pseudomonas aeruginosa ATCC 27853. Uji aktivitas antibakteri turunan senyawa N-klorobenzoilamoksisilin terhadap Pseudomonas aeruginosa ATCC 27853 dilakukan dengan metode dilusi. Nilai KHM menunjukkan adanya perbedaan aktivitas yang bermakna antara amoksisilin dengan N-benzoilamoksisilin, N-2-klorobenzoilamoksisilin, dan N-3-klorobenzoilamoksisilin. Persamaan non linier log KHM dengan sifat lipofilik senyawa turunan N-klorobenzoilamoksisilin diperoleh -log KHM = 3,963 p2 - 3,001 p - 2,477, dengan harga r = 0,906.
Co-Authors Afifah Mujahidah Shalihah Ahya Nafila Fatihati Ajeng, Jessica Sastry Amanda Wahyu Kurniawan Ambar Yunita Ambar Yunita Nugraheni Andi Suhendi Andieni , Herdania Puan Angga Prasetyawan Angga Prasetyawan, Angga Anggraeni, Safitri Nur Anindya, Talitha Ahnaf Anita Sukmawati Anjati, Yasinta Widia Arifah Sri Wahyuni Arina Nisyya Nadhira Asmitha, Suci Miranda Asti Arum Sari Astrina Dewi Ratnaningrum Astrina Dewi Ratnaningrum, Astrina Dewi Audi Tahta Aurellia Azistyna, Delvi Yulia Balqis, Moetia Rahman Brainandiva Ade Fitria Broto Santoso Cahya Rahma Utami Cholisoh, Zakky Dedi Hanwar Dian Kusumowati Elma Arifatul Sugito Em Sutrisna Endang Setyaningsih Erindyah Retno Wikantyasning Firdaus, Farhand Ahmad Fransisda Aulia Zatsyia Hamidah, Ummi Harindasari, Amorita Azzah Heppy Purbasari Isnaniyah, Dhevi Zahra Latifatul Jessica Sastry Ajeng Kartikaning Ratri Kartikaning Ratri, Kartikaning Kasful Asra Sakika Khoirunnisa Khoirunnisa Larasati, Arindra Lestari, Kurnia Livia Purwati Luluk Ria Rakhma Marcellino Rudyanto Merlindasari, Aulia Pungky Muhammad Da'i Muhammad Ikhsan Al Af Ghani Nazilah, Siti Umi Nobela, Deandra Nur Chasanah Nur ‘Azah Peni Indrayudha Purwati, Livia Rahmadani, Sandika Rahmatillah, Annie Ramadhani Dwi Sula Ramdani, Tasya Eka Refsya Azanti Putri Rima Munawaroh Rosita Melannisa Rosita Melannisa Rosita Melannisa, Rosita Sacharina, Dewi Safira Maharani Sania Nayasari Khoirunnisa Septiani, Adiva Metri Setyo Nurwaini Shofiah, Mira Siswandono, Siswandono Siti Umi Nazilah Sukamto, Dandi Febrian Suprapto . Suprapto . Tanti Azizah Sujono Triyatno, Sabrina Azizah Ujiantya, Sabrina Dian Parasika Ulil Fikri Nurhakimah Ummi Hamidah UTARI SITA ARDANI Wahyu Utami Wahyu Utami, Wahyu Wahyuningsih, Putri Dewi Wanudya Atmajani Wati, Abil Lia Yuhdi, Fajrin Ahidannisa Yuka Aulia Rahma YULIANA RIZQI DWI RATNA ZAKIAH FATHIANA