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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Biomedika Pharmacon Jurnal Surya Medika JPSCR : Journal of Pharmaceutical Science and Clinical Research JFIOnline Jurnal Ilmu Kefarmasian Indonesia Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Jurnal Insan Farmasi Indonesia Indonesian Community Journal Abdi Geomedisains Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding Seminar Nasional Pengabdian Masyarakat Usadha Journal of Pharmacy Borneo Journal of Pharmacy Journal of Tropical Pharmacy and Chemistry

Ika Trisharyanti Dian Kusumowati

Universitas Muhammadiyah Surakarta

Author-ID : 509895

Agriculture, Biological Sciences & Forestry Arts Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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KORELASI KANDUNGAN FENOLIK DAN AKTIVITAS ANTIRADIKAL EKSTRAK ETANOL DAUN EMPAT TANAMAN OBAT INDONESIA (Piper bettle, Sauropus androgynus, Averrhoa bilimbi, dan Guazuma ulmifolia) Kusumowati, Ika Trisharyanti Dian
Pharmacon: Jurnal Farmasi Indonesia Vol 13, No 1 (2012)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v13i1.19

Fenolik merupakan senyawa yang memiliki kemampuan untuk merubah atau mereduksi radikal bebas. Penelitian ini dilakukan untuk melihat korelasi antara kadar fenolik total terhadap aktivitas penangkap radikal ekstrak etanol daun Piper betle (Sirih), Sauropus androgynus (Katuk), Averrhoa bilimbi (Belimbing Wuluh), dan Guazuma ulmifolia (Jati belanda). Penentuan aktivitas antiradikal dilakukan dengan metode DPPH (1,1-difenil-2-pikrilhidrazil) terhadap ekstrak etanol daun keempat spesies. Absorbansi dibaca pada ? 517,6 nm pada waktu 30 menit. Penelitian dilanjutkan dengan penetapan kadar fenolik total dengan metode Follin Ciocalteu yang dinyatakan dalam Gallic Acid Equivalent. Hasil penelitian menunjukkan bahwa ekstrak etanol daun Sirih (IC50 = 22,067 µg/mL; GAE = 210,11 mg/g sampel) mempunyai aktivitas antiradikal lebih besar dibandingkan ekstrak etanol daun Jati Belanda (IC50 = 126,29 µg/mL; GAE = 95,465 mg/g sampel), ekstrak etanol daun Belimbing Wuluh (IC50 = 112,82 µg/mL; GAE = 64,84 mg/g sampel), dan ekstrak etanol daun Katuk (IC50 = 310,82 µg/mL; GAE = 42,79 mg/g sampel). Koefisien korelasi dari persamaan regresi linier antara IC50 dan kadar fenolik total dalam GAE menunjukkan 64,9% aktivitas antiradikal ekstrak disumbangkan oleh kandungan fenolik totalnya. Kata kunci: Piper betle, Sauropus androgynus, Averrhoa bilimbi, Guazuma ulmifolia, antiradikal, fenolik, DPPH.

HUBUNGAN STRUKTUR TURUNAN N-KLOROBENZOILAMOKSISILIN DAN AKTIVITAS ANTIBAKTERINYA TERHADAP Pseudomonas aeruginosa ATCC 27853 Kusumowati, Ika Trisharyanti Dian; Siswandono, .; Rudyanto, Marcellino
Jurnal Farmasi Indonesia Vol 5, No 3 (2011)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i3.49

The aim of this research is to determine structure-activity relationship N-chlorobenzoylamoxicillin derivatives against Pseudomonas aeruginosa ATCC 27853. Antibacterial activities of the N-benzoylamoxicillinÂ derivatives against Pseudomonas aeruginosa ATCC 27853 were tested using dilution method. The result showed that there was significance MIC of amoxycillin with N-benzoylamoxycillin, N-2-chlorobenzoylamoxycillin, and N-3-chlorobenzoylamoxycillin. Non linier regression between log MIC and lypophilic parameter N-chlorobenzoylamoxycillin derivatives showed -log KHM = 3,963 p2 - 3,001 p - 2,477, r = 0,906. To see more clearly quantitative strucuture-activity relationship of N-benzoylamoxicillin derivatives, further similar studies need to be done by increasing numbers of another N-benzoylamoxicillin derivative compounds.Â ABSTRAK Penelitian ini bertujuan mengetahui hubungan struktur-aktivitas antibakteri senyawa-senyawa turunan N-kolorobenzoilamoksisilin terhadap Pseudomonas aeruginosa ATCC 27853. Uji aktivitas antibakteri turunan senyawa N-klorobenzoilamoksisilin terhadap Pseudomonas aeruginosa ATCC 27853 dilakukan dengan metode dilusi. Nilai KHM menunjukkan adanya perbedaan aktivitas yang bermakna antara amoksisilin dengan N-benzoilamoksisilin, N-2-klorobenzoilamoksisilin, dan N-3-klorobenzoilamoksisilin. Persamaan non linier log KHM dengan sifat lipofilik senyawa turunan N-klorobenzoilamoksisilin diperoleh -log KHM = 3,963 p2 - 3,001 p - 2,477, dengan harga r = 0,906.

FORMULASI SUSPENSI DOKSISIKLIN MENGGUNAKAN SUSPENDING AGENT PULVIS GUMMI ARABICI: UJI STABILITAS FISIK DAN DAYA ANTIBAKTERI Chasanah, Nur; Trisharyanti DK, Ika; Indrayudha, Peni
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 1, No 2 (2011): Oktober 2010 - Maret 2011
Publisher : University of Muhammadiyah Malang

Suspension is a dosage contain solid drug material with insoluble form and smooth. Doxycycline is an antibiotic which difficult dissolve in water. Stable doxycycline suspension during 2 week if it kept at space temperature, stable on the air but will change to be dark if it influence sunshine. The aim of the research to evaluate physical stability and ability antibacterial stability doxycycline suspension with PGA as suspending agent. Research category are: Independent variable : concentration of suspending agent (PGA), suspension holding time. Dependent variable: physical stability (sedimentation volume, viscosity, redispersibility, easy to pour, and particle size) and antibacterial of doxycycline suspension, and variabel control is temperature suspension making, create of suspension. Data collecting with measuring physical stability and ability antibacterial of doxycycline suspension. The result shows doxycycline suspension with suspending agent PGA had physical stability and antibacterial ability is good. Physical Stability test showÂ formula 1 rate PGA 5% is formula had physical stability better than formula 2 with rate PGA 7,5% and formula 3 withrate PGA 10%. stability ability test antibacterial show formula 2 is theÂ best in pursues Staphylococcus aureus.

Skrining Aktivitas Antibakteri Ekstrak Etanol Daun Terhadap Salmonella Typhi Resisten Kloramfenikol Trisharyanti, Ika
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 2, No 2 (2017)
Publisher : Universitas Sebelas Maret

Typhoid fever is an infectious disease caused by Salmonella typhi, antibiotic chloramphenicol can be use to treatment, but S. typhi resistant with antibiotic choramphenicol so need to alternative treatment. The purpose of this study was to determine the antibacterial activity of ethanol extract of ten leaves against Salmonella typhi, and knowing the compounds contained in extracts of leaves that have the best antibacterial activity. The leaves was extracted withÂ ethanol 96% by maceration method. Screening antibacterial activity used disk diffusion method with 10% extract concentration. The best antibacterial activity was determined Minimum Inhibitory Concentration and Minimum Bactericidal Concentration used liquid dilution method, identification test of compounds with thin-layer chromatograpy (TLC), and bioautografi test. There were six extracts had antibacterial activity against S. Typhi, Phaleria macrocarpa leaves, Acalypha siamensis leaves, cherry leaves, clove leaves, tea leaves, and Eugenia polyantha leaves. Minimum Bactericidal Concentration from clove leaf extract was 2,5%. The results of identification by TLC compounds were alkaloids, phenolics, flavonoids, terpenoids, triterpenoids, and saponins. Based on bioautografi test,Â phenolic can inhibit the growth of Salmonella typhi.

FORMULASI SUSPENSI DOKSISIKLIN MENGGUNAKAN SUSPENDING AGENT PULVIS GUMMI ARABICI: UJI STABILITAS FISIK DAN DAYA ANTIBAKTERI Nur Chasanah; Ika Trisharyanti DK; Peni Indrayudha
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 1 No. 2 (2011): Oktober 2010 - Maret 2011
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/far.v1i2.1165

Suspension is a dosage contain solid drug material with insoluble form and smooth. Doxycycline is an antibiotic which difficult dissolve in water. Stable doxycycline suspension during 2 week if it kept at space temperature, stable on the air but will change to be dark if it influence sunshine. The aim of the research to evaluate physical stability and ability antibacterial stability doxycycline suspension with PGA as suspending agent. Research category are: Independent variable : concentration of suspending agent (PGA), suspension holding time. Dependent variable: physical stability (sedimentation volume, viscosity, redispersibility, easy to pour, and particle size) and antibacterial of doxycycline suspension, and variabel control is temperature suspension making, create of suspension. Data collecting with measuring physical stability and ability antibacterial of doxycycline suspension. The result shows doxycycline suspension with suspending agent PGA had physical stability and antibacterial ability is good. Physical Stability test show formula 1 rate PGA 5% is formula had physical stability better than formula 2 with rate PGA 7,5% and formula 3 withrate PGA 10%. stability ability test antibacterial show formula 2 is the best in pursues Staphylococcus aureus.

KORELASI KANDUNGAN FENOLIK DAN AKTIVITAS ANTIOKSIDAN DAUN JAMBU METE Ika Trisharyanti Dian Kusumowati; Rosita Melannisa; Kartikaning Ratri
Biomedika Vol 3, No 2 (2011): Biomedika Agustus 2011
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v3i2.251

The ethanolic extract of Anacardium occidentale L. leaves contains phenolic compounds,  avonoids, alkaloids, saponins, tannins, and steroids that could have antioxidant activity. The aim of this research was to determine the correlation between the antioxidant activity and the phenolic compounds of the ethanol extract of Anacardium occidentale L. leaf. The DPPH methode was used to determine the antioxidant activity. The total phenolic determined using Folin-Ciocalteu reagent. There was a positive correlation between antioxidant activity and total phenolic content in the ethanolic extract of cashew leaf with correlation coef cient R2 = 0.5888.Keywords: Anacardium occidentale L., antioxidant, phenolic compounds

DAYA ANTIBAKTERI EKSTRAK ETANOL DAUN SENGGANI (Melastoma affine D. Don) Ika Trisharyanti Dian Kusumowati; Rosita Melannisa; Angga Prasetyawan
Biomedika Vol 6, No 2 (2014): Biomedika Agustus 2014
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v6i2.278

Melastoma affine D. Don had some activities such as anthelmintic, antibacteria, antiinfiammation, antifungal, and antitumor. The aims of this research was determine antibacteria activity of ethanolic extract of Melastoma affine D. Don. The antimicrobial activity was tested by solid dilution method to get Minimum Inhibition Concentration (MIC). The compounds in Melastoma affine D. Don was analyzed by tube test method and Thin Layer Chromatography (TLC) with chloroform : methanol : formic acid (8,5:1,5:0,5) as mobile phase and silica gel GF254 as stationary phase. The result showed ethanolic extract of Melastoma affine D. Don contains alkaloid, polyphenol, fiavonoid, saponin, and essential oil. The MIC of Senggani against Staphylococcus aureus was 2% and 3% against Escherichia coli and the extract could not inhibit Staphylococcus aureus and Escherichia coli multiresistant until concentration 7% extract ethanol.Keywords: Melastoma affine D. Don, Staphylococcus aureus, Escherichia coli

KORELASI KANDUNGAN FENOLIK DAN AKTIVITAS ANTIRADIKAL EKSTRAK ETANOL DAUN EMPAT TANAMAN OBAT INDONESIA (Piper bettle, Sauropus androgynus, Averrhoa bilimbi, dan Guazuma ulmifolia) Ika Trisharyanti Dian Kusumowati
Pharmacon: Jurnal Farmasi Indonesia Vol 13, No 1 (2012)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v13i1.19

Fenolik merupakan senyawa yang memiliki kemampuan untuk merubah atau mereduksi radikal bebas. Penelitian ini dilakukan untuk melihat korelasi antara kadar fenolik total terhadap aktivitas penangkap radikal ekstrak etanol daun Piper betle (Sirih), Sauropus androgynus (Katuk), Averrhoa bilimbi (Belimbing Wuluh), dan Guazuma ulmifolia (Jati belanda). Penentuan aktivitas antiradikal dilakukan dengan metode DPPH (1,1-difenil-2-pikrilhidrazil) terhadap ekstrak etanol daun keempat spesies. Absorbansi dibaca pada λ 517,6 nm pada waktu 30 menit. Penelitian dilanjutkan dengan penetapan kadar fenolik total dengan metode Follin Ciocalteu yang dinyatakan dalam Gallic Acid Equivalent. Hasil penelitian menunjukkan bahwa ekstrak etanol daun Sirih (IC50 = 22,067 µg/mL; GAE = 210,11 mg/g sampel) mempunyai aktivitas antiradikal lebih besar dibandingkan ekstrak etanol daun Jati Belanda (IC50 = 126,29 µg/mL; GAE = 95,465 mg/g sampel), ekstrak etanol daun Belimbing Wuluh (IC50 = 112,82 µg/mL; GAE = 64,84 mg/g sampel), dan ekstrak etanol daun Katuk (IC50 = 310,82 µg/mL; GAE = 42,79 mg/g sampel). Koefisien korelasi dari persamaan regresi linier antara IC50 dan kadar fenolik total dalam GAE menunjukkan 64,9% aktivitas antiradikal ekstrak disumbangkan oleh kandungan fenolik totalnya. Kata kunci: Piper betle, Sauropus androgynus, Averrhoa bilimbi, Guazuma ulmifolia, antiradikal, fenolik, DPPH.

UJI AKTIVITAS ANTIRADIKAL EKSTRAK ETANOL DAUN Elephantopus schaber L., Ocimum basilicum L.forma citratum Back., Graptophylum pictum Griff, dan Gynura procumbens Merr. DENGAN METODE DPPH (1,1- Difenil-2- Pikril Hidrazil) SERTA PENETAPAN KADAR FENOLIK TOT Muhammad Da'i; Astrina Dewi Ratnaningrum; Arifah Sri Wahyuni; Rosita Melannisa; Ika Trisharyanti Dian Kusuma
Pharmacon: Jurnal Farmasi Indonesia Vol 13, No 2 (2012)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v13i2.8

Daun Elephantopus schaber L. (tapak liman), Ocimum basilicum L.forma citratum Back., (selasih) Graptophylum pictum Griff (daun ungu), dan Gynura procumbens Merr. (sambung nyawa) memiliki kandungan kimia yang dapat berperan sebagai antiradikal, diantaranya adalah senyawa fenolik. Penelitian ini dilakukan untuk melihat korelasi kandungan fenolik total keempat daun terhadap aktivitas antiradikalnya. Sampel uji yaitu ekstrak etanol daun selasih, ungu, sambung nyawa, dan tapak liman ditentukan aktivitas antiradikal dengan menggunakan metode DPPH (1,1 difenil-2-pikrilhidrazil) kemudian dihitung nilai inhibitory concentration (IC50). Kandungan fenolik total ditentukan secara spektrofotometri menggunakan pereaksi Folin-Ciocalteu dan dihitung sebagai GAE (gallic acid equivalent) yaitu jumlah kesetaraan miligram asam galat dalam satu gram sampel. Penelitian menunjukkan ekstrak etanol daun selasih, ungu, sambung nyawa dan tapak liman memiliki aktivitas antiradikal dengan nilai IC50 berturut-turut 36,028; 54,998; 103,650; 252,857µg/mL dan kadar fenolik total berturut-turut 167,451; 147,064; 39,371 dan 20,539 mg/g sampel. Hasil penelitian secara keseluruhan menunjukkan ekstrak etanol daun selasih, ungu, sambung nyawa dan tapak liman berkorelasi positif terhadap aktivitas antiradikalnya. Kata kunci: Antiradikal, DPPH, IC50, fenolik total, Elephantopus schaber L., Ocimum basilicum L.forma citratum Back., Graptophylum pictum Griff, Gynura procumbens Merr.

Daya Antibakteri Ekstrak dan Fraksi-Fraksi Daun Jambu Mete (Anacardium occidentale L.) terhadap Bakteri Staphylococcus aureus Sensitif dan Multiresisten YULIANA RIZQI DWI RATNA; UTARI SITA ARDANI; ZAKIAH FATHIANA; ANNIE RAHMATILLAH; IKA TRISHARYANTI D K
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (511.309 KB)

Daun jambu mete memiliki daya antibakteri terhadap bakteri Gram positif dan negatif yang sensitif dan multiresisten. Tujuan penelitian ini adalah untuk mengetahui daya antibakteri ekstrak dan fraksi-fraksi daun jabu mete dan menentukan komponen senyawa yang terkandung di dalamnya. Metode ekstraksi dilakukan dengan maserasi menggunakan etanol 96%. Fraksinasi ekstrak etanol daun jambu mete dilakukan dengan metode partisi. Ekstrak dan fraksi-fraksi diuji daya antibakterinya menggunakan metode dilusi padat untuk menentukan konsentrasi hambat minimum (KHM). Hasil KHM dilanjutkan ke pengujian berikutnya untuk menentukan konsentrasi bunuh minimum (KBM). Analisis kandungan bahan aktif dilakukan dengan metode kromatografi lapis tipis (KLT). Hasil penelitian menunjukkan bahwa ekstrak etanol, fraksi kloroform dan fraksi etil asetat memiliki daya bunuh terhadap Staphylococcus sensitif dan multiresisten, sedangkan fraksi metanol-air hingga konsentrasi 2% tidak menunjukkan daya bunuh terhadap S. aureus sensitif, dan hingga 3% terhadap S. aureus multiresiten. Hasil pengujian KLT menunjukkan bhawa ekstrak dan fraksi-fraksi daun jambu mete mengandung alkaloid, flavonoid, minyak atsiri dan fenol.

Co-Authors Afifah Mujahidah Shalihah Ahya Nafila Fatihati Ajeng, Jessica Sastry Amanda Wahyu Kurniawan Ambar Yunita Ambar Yunita Nugraheni Andi Suhendi Angga Prasetyawan Angga Prasetyawan, Angga Anggraeni, Safitri Nur Anindya, Talitha Ahnaf Anita Sukmawati Anjati, Yasinta Widia Arifah Sri Wahyuni Arina Nisyya Nadhira Asmitha, Suci Miranda Asti Arum Sari Astrina Dewi Ratnaningrum Astrina Dewi Ratnaningrum, Astrina Dewi Audi Tahta Aurellia Azistyna, Delvi Yulia Balqis, Moetia Rahman Brainandiva Ade Fitria Broto Santoso Cahya Rahma Utami Cholisoh, Zakky Dedi Hanwar Dian Kusumowati Elma Arifatul Sugito Em Sutrisna Endang Setyaningsih Erindyah Retno Wikantyasning Firdaus, Farhand Ahmad Fransisda Aulia Zatsyia Hamidah, Ummi Harindasari, Amorita Azzah Heppy Purbasari Isnaniyah, Dhevi Zahra Latifatul Jessica Sastry Ajeng Kartikaning Ratri Kartikaning Ratri, Kartikaning Kasful Asra Sakika Khoirunnisa Khoirunnisa Larasati, Arindra Lestari, Kurnia Livia Purwati Luluk Ria Rakhma Marcellino Rudyanto Merlindasari, Aulia Pungky Muhammad Da'i Muhammad Ikhsan Al Af Ghani Nazilah, Siti Umi Nobela, Deandra Nur Chasanah Peni Indrayudha Purwati, Livia Rahmadani, Sandika Rahmatillah, Annie Ramadhani Dwi Sula Ramdani, Tasya Eka Refsya Azanti Putri Rima Munawaroh Rosi Hayyu Anjani Rosita Melannisa Rosita Melannisa Rosita Melannisa, Rosita Sacharina, Dewi Safira Maharani Sania Nayasari Khoirunnisa Septiani, Adiva Metri Setyo Nurwaini Shofiah, Mira Siswandono, Siswandono Siti Umi Nazilah Sukamto, Dandi Febrian Suprapto . Suprapto . Tanti Azizah Sujono Triyatno, Sabrina Azizah Ujiantya, Sabrina Dian Parasika Ulil Fikri Nurhakimah Ummi Hamidah UTARI SITA ARDANI Wahyu Utami, Wahyu Wahyuningsih, Putri Dewi Wanudya Atmajani Wati, Abil Lia Yuhdi, Fajrin Ahidannisa Yuka Aulia Rahma YULIANA RIZQI DWI RATNA ZAKIAH FATHIANA

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