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All Journal Medali Jurnal : Media Dental Intelektual ODONTO Dental Journal Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Majalah Obat Tradisional Dentino: Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) Odonto dental journal Jurnal Pengabdian Masyarakat Dentmas Journal of Fisheries & Marine
Islamy Rahma Hutami, Islamy Rahma
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Public Health

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UPAYA MENINGKATKAN PENGETAHUAN KESEHATAN GIGI DAN MULUT MELALUI EDUKASI BAHAYA PENGGUNAAN “BEHEL FASHION” PADA MASYARAKAT MARGASARI Suhartono, Budi; Hutami, Islamy Rahma; Mayangsari, Regilia Shinta; Yuniar, Savira Nurazky; Indrawati, Silvia Vera; Dimas P. P., Muhammad
Jurnal Pengabdian Masyarakat DentMas Vol 1, No 1 (2023): Juni 2023
Publisher : Faculty of Dentistry Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/dentmas.1.1.21-25

Abstract

Background: Today, many teenagers in Indonesia are using braces not as orthodontic appliances for the treatment of malocclusion but only as a ‘fashion’ . Dental treatment that carried out by incompetent operators can actually cause far greater dangers and losses. The impact that can occur due to the use of braces by dental technicians can arise from tooth decay, plaque accumulation, root resorption, bone resorption, inflammation of the supporting tissues of the teeth, to disorders of the temporomandibular joint. Method: The solution to the problem is carried out by educating the community, one of them are in Margasari, Tegal. Dental Health Education is carried out using poster media to make it more interactive, effective and efficient. Evaluation of the implementation is done by using a questionnaire. The results of the questionnaire were tabulated using SPSS with the Wilcoxon non-parametric test method. Result: wilcoxon signed rank shows that there are 0 negative ranks, 24 positive ranks, and 1 ties. Z value based on negative ranks are -4.322 Conclusion: There is an increase in knowledge of respondents after being given education.
ACTIVE EDUCATIONAL METHOD THROUGH THE GAMES OF THE TEMPOROMANDIBULAR JOINT’S TO IMPROVE KNOWLEDGE OF THE MARGASARI COMMUNITY RELATED TO JAW JOINT DISORDERS Hutami, Islamy Rahma; Rahadian, Arief; Mayangsari, Regilia Shinta; Nurazky, Savira; Indrawati, Silvia Vera
Jurnal Pengabdian Masyarakat DentMas Vol 1, No 1 (2023): Juni 2023
Publisher : Faculty of Dentistry Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/dentmas.1.1.41-45

Abstract

Background: This TMJ problem or jaw joint disorder is classified as an emergency, so treatment must be done immediately. The causes of this jaw joint problem are multifactorial. Generally divided into two, namely structural disorders and functional disorders. Functional disorders arise due to deviant function due to abnormalities in the position or function of the teeth and chewing muscles. Treatment, when someone has TMJ problems, is usually a reduction action that is carried out directly by a doctor. This cannot be done by ordinary people. However, sometimes people self-diagnose and resort to invalid sources which can actually lead to more serious problems. Method: The educational method is carried out by active counseling and discussions given to the people of Margasari Village. Then, the community was asked to fill out a questionnaire to assess the effectiveness of delivering material about this TMJ. Result: People who have filled out the questionnaire were found to have a significant difference between before and after being given the material. People become more aware of the material and are expected to be able to apply it in everyday life. Conclusion: There is a significant difference between before and after being given TMJ games.
TREATMENT OF ANTERIOR CROSSBITE USING ORTHODONTIC REMOVABLE APLLIANCE (A CASE REPORT) Novianty, Shella Indri; Salma, Nuris; Suhartono, Budi; Hutami, Islamy Rahma; Aditya, Grahita; Safangat, Muhamat Muhtar; Putranto, Rama
Jurnal Medali Vol 7, No 1 (2025): Media Dental Intelektual February 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.7.1.70-75

Abstract

Background: The management of anterior crossbite, especially in non-growing patients, is a challenging yet crucial aspect of orthodontic treatment. Anterior crossbite, if left untreated, can lead to significant functional and aesthetic issues, including abnormal dental wear, TMD, and compromised facial aesthetic. The correction of this type of malocclusion is essential to prevent long-term complications. In a non-growing patient, fixed orthodontic appliances have historically been the recommended treatment option for anterior crossbite. However, the use of orthodontic removable appliances has number of benefits, including patient comfort, ease of maintenance, and removability for oral hygiene purposes. This treatment modality is particularly advantageous for patients who seek a less invasive and more flexible approach to managing their dental condition.Case Report: The patient was a 24-year-old woman with a crossbite of the maxillary left permanent central and lateral incisors. Upper acrylic removable appliance, with an expansion jackscrew, was used to correct the crossbite. The total active treatment time was 2 months. In that 2-months period, the orthodontic treatment was not yet complete, but it was already showing good results.Discussion: The application of orthodontic removable appliance with expansion screw has shown promising results in addressing the challenge in anterior crossbite treatment. One of the primary benefits of using expansion screw in orthodontic removable appliance is its ability to apply gradual and controlled expansion forces. This allows for the realignment of teeth without causing undue stress on the periodontal ligaments and surrounding structure.Conclusion: The treatment of anterior crossbite in non-growing patients using orthodontic removable appliance presents a viable and effective alternative to fixed appliances. The positive outcomes observed in this case underscore the potential of orthodontic removable appliance to address similar malocclusions in non-growing patients.
Marine Biota-Derived Hydroxyapatite as a Bone Graft Material: A Scoping Review of Hydroxyapatite from Shell-Based Sources Rahadian, Arief; Hutami, Islamy Rahma
Jurnal Medali Vol 7, No 2 (2025): Media Dental Intelektual August 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.7.2.91-102

Abstract

Backgrounds: Restoring damaged or diseased bone is a major challenge in dentistry. Marine biota, such as seashells, crustacean shells, and fish bones, are rich in calcium and can be processed into safe, biodegradable materials that support bone healing. These natural sources are gaining attention for use as bone graft substitutes because they are biocompatible, widely available, and promote bone growth. Purpose: This review aims to discuss and analyze the potential of marine biota as bone graft materials rich in calcium hydroxyapatite for use in bone regeneration, with a particular focus on their clinical relevance in dentistry. Methods: A scoping review was conducted using Google Scholar, PubMed, and ScienceDirect databases to identify relevant studies published between 2015 and 2025. Results: An initial total of 134.007 articles were identified across the three databases. After removing duplicates and screening based on title and abstract relevance to the inclusion criteria, 2.836 articles remained. A further selection process narrowed these down to 452 full-text articles, of which 433 were excluded due to incompatibility with the review focus. Finally, 19 studies were included in this review and analyzed for their methodology, findings, and clinical implications. Discussion: Many studies have shown that marine biota can be used as effective bone graft materials. Their high calcium content, porous structure, and compatibility with body tissues help support cell attachment, growth, and new bone formation. These materials can be used in dental procedures to help regenerate bone and repair defects. Conclusion: Marine-derived materials, especially from mollusks and crustaceans, are similar to human bone and show great potential as alternatives to synthetic bone grafts. Their natural properties and ability to support bone healing make them a promising, sustainable option for dental and oral bone repair.
Saltwater Fish Nanoparticles: Biological Effects on COL1A1 Expression in Fetal Mice and Tablet Formula Optimization Christiono, Sandy; Hutami, Islamy Rahma; Suparmi, Suparmi; Afroz, Shaista; Clarasya, Amara Danish; Ahmad, Rayyan Orvin Pradipta; Subiyono, Amelia Febriani
Jurnal Ilmiah Perikanan dan Kelautan 2026: JIPK VOLUME 18 ISSUE 1 YEAR 2026 (FEBRUARY 2026, ISSUE IN PROGRESS)
Publisher : Faculty of Fisheries and Marine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Graphical Abstract  Highlight Research Saltwater fish Nano powder modulates the expression of matrix proteins, influencing early dental tissue development. Administration significantly decreases COL1A1 expression in fetal mouse teeth, affecting biomineralization. Increasing talc concentration improves flowability and formulation stability by reducing angle of repose, Carr’s index, and Hausner ratio. Findings suggest marine-derived nanoparticles regulate cellular differentiation during dental development. Supports potential applications of marine natural materials in prenatal nutrition and dental tissue engineering.   Abstract Saltwater fish nanoparticle-based tablets represent a novel nutritional strategy aimed enhancing dental hard tissue density, particularly enamel. These tablets incorporate bioactive proteins, omega-3 fatty acids, and essential minerals such as calcium, phosphate, and magnesium to support enamel biomineralization. The nanoparticle formulation facilitates efficient cellular absorption, thereby increasing the expression of key enamel proteins like collagen type I alpha 1 chain (COL1A1) during enamel matrix development. This study investigated the effect of saltwater fish nanoparticles on COL1A1 expression in ameloblast cells and evaluated the physicochemical properties of tablets with talc concentrations of 1%, 5%, and 10%. Using a true experimental design with a post-test only control group, two groups of mice were assigned: a control group fed standard diet, and a treatment group fed a standard diet supplemented with saltwater fish nanoparticles (2.17 mg/0.5 mL). Tablet formulations were analyzed across the three talc concentrations. Data were subjected to independent T-tests for COL1A1 expression and One-way ANOVA for physicochemical properties. Results revealed a significant reduction in COL1A1 expression in the treatment group. Additionally, talc concentration significantly influenced tablet physicochemical characteristics, with the 10% talc formulation exhibiting the most optimal properties. These findings suggest potential for nanoparticle-based nutritional interventions to promote enamel formation.
Saltwater Fish Powder for Amelogenesis in Zebrafish Larvae (Danio rerio) Christiono, Sandy; Pradopo, Seno; Hutami, Islamy Rahma; Indasari, Novia; Nurhapsari, Arlina; Rochmah, Yayun Siti Rochmah; Ibrahim, Zurairah; Yuniar, Savira Nurazky; Suparmi
Jurnal Ilmiah Perikanan dan Kelautan Vol. 16 No. 2 (2024): JURNAL ILMIAH PERIKANAN DAN KELAUTAN
Publisher : Faculty of Fisheries and Marine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jipk.v16i2.54677

Abstract

Graphical Abstract Highlight Research 1. The saltwater fish powder is rich in omega3, vitamin D, and calcium which helps tooth amelogenesis. 2. LC50 Toxicity Test was carried out using zebrafish larvae (Danio rerio) with negative control, positive control using 3,4-dichloroanilin, and treatment groups with saltwater fish powder solution in 6 different concentration. 3. No signs of zebrafish embryo mortality or developmental abnormalities on treatment group from the lowest (125μg/ml) nor highest concentration (4000μg/ml). 4. Saltwater fish powder has proven lack of toxicity. Abstract Many nutrients found in saltwater fish are thought to promote amelogenesis in ameloblast cells during tooth development. Although its toxicity is uncertain, saltwater fish powder provided benefits for amelogenesis. Zebrafish embryos have complex metabolic pathways and comprehensive physiological reactions. The LC50 toxicity of saltwater fish powder on zebrafish embryos was investigated in this study. The aim of the of the study is to determine the effect of LC50 toxicity on saltwater fish powder on zebrafish embryos. The experimental research method was a post-test-only control group design, consisting of eight groups, namely the negative control and the internal group using embryo media, the positive control using 3,4-dichloroanillin, and the treatment group 125μg / ml, 250μg / ml, 500μg / ml, 1000μg / ml, 2000μg / ml, and 4000μg / ml using 384 zebrafish embryos. Saltwater fish powder is diluted and observed for 96 hours, controlled every 24 hours. It was found that saltwater fish powder was not toxic because there were no dead zebrafish embryos from various concentrations, negative control, and internal control.
The Roles Of Sphingosine-1-Phosphate (S1p) On Arthritis: Review Article HUTAMI, ISLAMY RAHMA
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.115-123

Abstract

Arthritis is a pathological condition that results in degeneration of the joints. RA and OA are the most common types of arthritis. RA is a chronic joint inflammation caused by the immune system's self-attack on tissues. By contrast, OA is chronic joint inflammation caused by cartilage breakdown. Both illnesses cause joint discomfort, stiffness, and edema. One genetic factor in arthritis is sphingosine-1-phosphate (S1P). S1P regulates bone homeostasis and growth using 5 receptors: 1, 2, 3, 4, and 5. Thus, this literature review intends to investigate the impact of S1P on arthritis. Methods: The eligibility criteria comprised cross-sectional studies that were published in English until January 2024 and exclusively addressed the role of S1P in arthritis. Results and discussion: From 396 publications, 17 relevant articles were located, and 6 were chosen for the review. The S1P/S1P2 signaling pathway releases osteoclasts to degrade cartilage in osteoarthritis. S1P also promotes bone growth by differentiating osteoblasts and forming blood vessels in the bone marrow. The miR-25 rs41274221 polymorphism may reduce osteoporosis risk. IL-6 is also produced by osteoblasts with S1P. Osteoarthritis is associated with elevated blood S1P and MMP-3 levels. Cyclic strain and inflammation increase Sphk1 upregulation and S1P release, suggesting a role in osteoarthritis. In conclusion, the expression of S1P by osteoclasts, osteoblasts, chondrocytes, and tenocytes is believed to play a crucial role in regulating cell migration and the production of cytokines or chemokines throughout the process of bone formation. Focusing on the S1P pathway may help treat bone and joint diseases.
The Roles Of Sphingosine-1-Phosphate (S1p) On Arthritis: Review Article HUTAMI, ISLAMY RAHMA
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.115-123

Abstract

Arthritis is a pathological condition that results in degeneration of the joints. RA and OA are the most common types of arthritis. RA is a chronic joint inflammation caused by the immune system's self-attack on tissues. By contrast, OA is chronic joint inflammation caused by cartilage breakdown. Both illnesses cause joint discomfort, stiffness, and edema. One genetic factor in arthritis is sphingosine-1-phosphate (S1P). S1P regulates bone homeostasis and growth using 5 receptors: 1, 2, 3, 4, and 5. Thus, this literature review intends to investigate the impact of S1P on arthritis. Methods: The eligibility criteria comprised cross-sectional studies that were published in English until January 2024 and exclusively addressed the role of S1P in arthritis. Results and discussion: From 396 publications, 17 relevant articles were located, and 6 were chosen for the review. The S1P/S1P2 signaling pathway releases osteoclasts to degrade cartilage in osteoarthritis. S1P also promotes bone growth by differentiating osteoblasts and forming blood vessels in the bone marrow. The miR-25 rs41274221 polymorphism may reduce osteoporosis risk. IL-6 is also produced by osteoblasts with S1P. Osteoarthritis is associated with elevated blood S1P and MMP-3 levels. Cyclic strain and inflammation increase Sphk1 upregulation and S1P release, suggesting a role in osteoarthritis. In conclusion, the expression of S1P by osteoclasts, osteoblasts, chondrocytes, and tenocytes is believed to play a crucial role in regulating cell migration and the production of cytokines or chemokines throughout the process of bone formation. Focusing on the S1P pathway may help treat bone and joint diseases.
Amelogenin and alkaline phosphatase expression in ameloblast after saltwater fish consumption in pregnant mice (Mus musculus) Christiono, Sandy; Pradopo, Seno; Sudiana, I Ketut; Hutami, Islamy Rahma; Mayangsari, Regilia Shinta; Rochmah, Yayun Siti; Ibrahim, Zurairah
Dental Journal (Majalah Kedokteran Gigi) Vol. 56 No. 3 (2023): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v56.i3.p166-171

Abstract

Background: The intricate process of tooth formation during embryonic development ensures sufficient nutrition for the growth of healthy dental tissues. Amelogenin and alkaline phosphatase (ALP) are serine proteinases secreted by the ameloblast during the transition and maturation phases of the amelogenesis process. Consumption of saltwater fish is predicted to increase the expression of amelogenin and ALP in ameloblast cells during tooth formation. Only now have the function of each gene, tooth-forming cells, and the proteins they produce in the biomolecular amelogenesis of tooth enamel, which began during prenatal development, been clarified. Purpose: This study aims to determine how saltwater fish powder affects the ability of mother mice to increase the expression of amelogenin and ALP in cell ameloblast. Methods: Using a completely randomized design, this study was experimental and aimed to examine the effects of sardine (Sardinella fimbriata), splendid ponyfish (Leiognathus splendens), and tuna (Euthynnus affinis) powder. As samples, twenty-four female mice (Mus musculus) were used. Two groups of mice were created: group 1 (2.14 mg/0.5 ml) and the control group. The expression of amelogenin and ALP was determined using immunohistochemistry (IHC) and t-test (p0.05). Results: Expression of ameloblast was significantly different between the treatment and control groups (p0.05). Conclusion: The consumption of saltwater fish reduces the amelogenin and ALP expressions of mouse fetal ameloblast cells during tooth development in vivo.
Co-Authors Afroz, Shaista Ahmad, Rayyan Orvin Pradipta Arlina Nurhapsari Azka Putri Anisa Clarasya, Amara Danish Dewi, Rizqa Citra Dimas P. P., Muhammad Evy Tri Utami Evy Tri Utami Finsa Tisna Sari Finsa Tisna Sari, Finsa Tisna Grahita Aditya Helmi Fathurrahman, Helmi Ibrahim, Zurairah Iftitah Nabiilah Ramadhani Indasari, Novia Indrawati, Silvia Vera Juni Handajani Mayangsari, Regilia Shinta Naila Salsabila Noor Aziza Novia Indasari Nurazky, Savira Rahadian, Arief Rama Putranto Rebecca Azary Kuncoro Rebecca Azary Kuncoro, Rebecca Azary Recita Indraswary Rizki Amalina Rochmah, Yayun Siti Rochmah Rochman Mujayanto Rosa Pratiwi, Rosa S.Pd. M Kes I Ketut Sudiana . Safangat, Muhamat Muhtar Salma, Nuris Salwa Febria Monica Sandy Christiono Savira Nurazky Yuniar Seno Pradopo Seno Pradopo Shella Indri Novianty, Shella Indri Silvia Vera Indrawati Siska Nurlivia Subiyono, Amelia Febriani Suhartono, Budi Sukarno, M. Faiz Faz Sunnah, Tahta Danifatis Suparmi Suparmi Suparmi Suparmi Suryono Suryono Welly Anggarani Yayun Siti Rochmah Yayun Siti Rochmah Rochmah Yuniar, Savira Nurazky Zurairah Ibrahim