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Saktivi Harkitasari, Saktivi
Universitas Warmadewa
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Journal : Biomedika

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External Validation of AI-powered GeNose C19 to Diagnose Volatile Organic Compounds in COVID-19 Patients Tested at Udayana University Academic Hospital Purnamasidhi, Cokorda Agung Wahyu; Darwinata, Agus Eka; Utama, I Made Susila; Merati, Ketut Tuti Parwati; Harkitasari, Saktivi; Junior, Darren; Diksha, I Gusti Ngurah Ariestha Satya; Suteja, Richard Christian
Biomedika Vol 16, No 2 (2024): Biomedika Agustus 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v16i2.3940

Abstract

In search for potential alternatives to RT-PCR, Gadjah Mada University developed GeNose C19 which was deemed to have high sensitivity, specificity, PPV, and NPV. The objective of this study is to contribute to the development of GeNose C19 by means of external validation conducted in Udayana University Academic Hospital, Bali. This was a cross-sectional study conducted on adults above 17 years old. Demographic variables, symptoms, vaccination status, GeNose C19 results, and RT-PCR results were measured. We analyzed the sensitivity, specificity, PPV, and NPV using respective appropriate formulas and the impact of other variables gathered towards accuracy by means of Chi-squared test, Mann-Whitney U test and independent-samples T test. The results showed that the subjects included in this study were 50.8% female and had a mean (IQR) age of 23.0 (21.0-27.5) years old. Only three subjects (2.5%) showed COVID-19-related symptoms such as cough (1.7%), flu (0.8%), fever (0.8%), and headache (0.8%). GeNose C19 yields a sensitivity of 83.1%, a specificity of 73.6%, PPV of 79.4%, and NPV of 78.0%. There were no variables that significantly affect the accuracy of GeNose C19. Further study is still required to validate GeNose C19’s performance in different environmental conditions and multiple different races.
Co-Authors Agus Eka Darwinata Anak Agung Bagus Ngurah Nuartha Anak Agung Ngurah Agung Bayu Sutha Asri Lestarin Audria, Intan Safira Cokorda Agung Wahyu Purnamasidhi Dewa Ayu Agung Alit Suka Astini Dewa Ayu Sri Shita Meliani Dewi Manuaba, Ida Ayu Laxmi Ananda Diksha, I Gusti Ngurah Ariestha Satya Giovanca Verentzia Purnama I Dewa Ayu Inten Dwi Primayanti, I Dewa Ayu Inten Dwi I Gede Purna Weisnawa I Gusti Ngurah Agung Cahyadi Putra I Komang Hotra Adiputra I Made Wandia I Wayan Sumardika Ida Bagus Giri Sena Putra Jerry Junior, Darren Kadek Ayu Astuti Ketut Tuti Parwati Merati Komang Trisna Sumadewi Komang Triyani Kartinawati Made Ilora Hiranandasastri Ni Made Kharisma Praba Yuanika Ni Putu Diah Witari, Ni Putu Ni Putu Sukarini Pratiwi, Cokorda Agung Primatanti, Putu Asih Putra Parwati, Tjok Istri Putu Asih Primatanti R. A.T. Kuswardhani Richard Christian Suteja Rima Kusuma Ningrum Sumadewi, Komang Trisna Suteja, Richard Christian Suyasning Hastiko Indonesia Tanjung Subrata Thomas Eko Purwata Tjok Istri Putra Parwati Toddy Hendrawan Yupardhi, Toddy Hendrawan Utama, I Made Susila Wiranatha, I Gede Wulandari, Putu Kintan