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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Biotechnology WARTA Pharmacon Majalah Obat Tradisional AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat ALCHEMY Jurnal Penelitian Kimia Jurnal Kreativitas PKM Jurnal Karinov Jurnal Abdi Insani Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Pengabdian Pada Masyarakat Warta LPM

Prihapsara, Fea

Prodi Farmasi Universitas Sebelas Maret

Author-ID : 526712

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Transformasi Penjualan Digital Produk Jamu dan Obat Tradisional pada UKM Jamu di Kabupaten Sukoharjo Anif Nur Artanti; Fea Prihapsara; Esti Suryani; Muhammad Hatta Rahmatul Kholiq; Okid Parama Astirin; Endang Siti Rahayu
Aksiologiya: Jurnal Pengabdian Kepada Masyarakat Vol 7 No 1 (2023): Februari
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/aks.v7i1.9033

Dampak pandemi COVID-19 telah menurunkan pendapatan beberapa industri jamu di Kabupaten Sukoharjo. Industri jamu terkendala dalam proses produksi dan penjualan produknya. Cara pemasaran berubah, terutama saat diberlakukan pembatasan kegiatan masyarakat darurat (PPKM Darurat). Salah satu cara alternatif untuk meningkatkan kapasitas penjualan adalah melalui pemasaran digital online yang berfokus pada pemasaran digital melalui website yang digunakan sebagai e-commerce, media sosial, mesin pencari, dan membentuk tim reseller untuk menjual produknya. Di masa pandemi, industri jamu harus cepat beradaptasi seiring dengan PPKM Darurat, karena hal ini akan mengubah tren perilaku konsumen dalam membeli produk jamu. Salah satu industri jamu yang menjadi mitra proyek ini adalah Usaha Kecil Menengah (UKM) Ching Lung. Melalui transformasi digital ini dapat menjadi solusi atas permasalahan yang dihadapi oleh UKM Ching Lung saat ini. Selain itu, dengan meningkatkan kreativitas model penjualan produk, UKM dapat bertahan dengan melakukan diversifikasi produk yang sesuai dengan kebutuhan di masa pandemi COVID-19. Bekerjasama dengan UKM Jamu Ching Lung, dibuatlah website online yang dirancang dengan konsep toko online untuk meningkatkan penjualan jamu dan obat tradisional di Kabupaten Sukoharjo. Melalui kegiatan ini diharapkan dapat membantu UKM untuk memasarkan produknya agar dapat dikenal oleh masyarakat luas.

Aplikasi Mesin Pencuci dan Rotary Dryer untuk Peningkatan Nilai Tambah Produk Empon-Empon di Desa Bandar, Kecamatan Bandar, Pacitan Fea Prihapsara; Okid Parama Astirin; Endang Siti Rahayu; Anif Nur Artanti
Jurnal Pengabdian Pada Masyarakat Vol 7 No 3 (2022): Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Mathla'ul Anwar Banten

APLICATION OF WASHING MACHINE AND ROTARY DRYER FOR INCREASING ADDED VALUE VALUE OF EMPON-EMPON IN BANDAR VILLAGE, BANDAR DISTRICT, PACITAN. Bandar Village is located in Bandar District, Pacitan Regency. The economy of the people in Bandar Village is supported by traditional medicinal plants, especially empon-empon as the main commodity. Most of the farmers in Bandar Village are small farmers who depend on selling their crops to middlemen. The middlemen argue that prices at the farm level are low because the empon-empon is still dirty. The aim of this project is to carry out post-harvest processing activities by applying of washing machine and rotary dryer to increase the added value of the empon-empon products. Washing machine can clean it from dirt while rotary dryer can reduce the water content thereby increasing the yield of the active ingredients of empon-empon. Currently, both machines can function properly. This transfer of technology is very helpful for farmers in processing their harvested products on a large scale and they can sell them at higher prices. Kelompok Tani Suroloyo I as a partner actively participated in this project from post-harvest processing to marketing. This project is carried out on an ongoing basis in collaboration between Pusat Penelitian Lingkungan Hidup Universitas Sebelas Maret Team (PPLH UNS) and Kelompok Tani Suroloyo I.

PENGENALAN VAKSINASI COVID-19 DAN PHBS DI TPQ PERMATA JOMBOR SUKOHARJO Nestri Handayani; Inayatush Sholihah; Novita Dhewi Ikakusumawati; Rasmaya Niruri; Fea Prihapsara; Yeni Farida
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 4 No. 2 (2023): Volume 4 Nomor 2 Tahun 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v4i2.15588

Seiring dengan perkembangan kasus COVID-19 yang melandai, beberapa daerah kini mulai memberlakukan Pembelajaran Tatap Muka (PTM) tidak hanya pada pendidikan formal namun juga pendidikan non-formal. Pendidikan nonformal dapat dilaksanakan dimana saja seperti jalur pendidikan Taman Pendidikan Al Quran (TPQ). Santriwan dan santriwati yang masih tergolong anak-anak juga harus dilindungi supaya tidak terjadi penyebaran virus melalui kegiatan pembelajaran yang diselenggarakan di TPQ. Pemberian pengetahuan tentang PHBS dan vaksinasi COVID-19 sangat penting untuk merubah sikap dan perilaku anak terutama dalam menghadapi pembelajaran tatap muka di masa pandemi. Kegiatan pengabdian ini dilakukan di TPQ Permata Jombor berada di Kecamatan Bendosari, Kabupaten Sukoharjo, Provinsi Jawa Tengah. Penyuluhan diintegrasikan dengan kegiatan TPQ yang pelaksanaannya lebih fleksibel dan mencakup siswa-siswi dari usia 4 hingga 12 tahun. Metode yang digunakan dalam kegiatan ini adalah edukasi berbasis aktivitas untuk menarik perhatian siswa dan mempermudah siswa dalam memahami materi. Informasi disampaikan melalui video edukasi, buku cerita bergambar, leaflet, buletin dan poster. Sebanyak 37 siswa mengikuti kegiatan ini dan semua siswa sangat interaktif. Hasil dari kegiatan ini siswa menjadi paham pentingnya vaksinasi serta penerapan PHBS untuk mencegah penularan virus COVID-19. Dengan vaksinasi dan melaksanakan protokol kesehatan yang ketat akan semakin banyak dan semakin cepat masyarakat terlindungi dari COVID-19

Edukasi tentang Obat serta Perilaku Hidup Bersih dan Sehat pada Siswa SDIT Insan Mulia Surakarta Yeni Farida; Sabella Sekar Betari; Rasmaya Niruri; Adi Yugatama; Nestri Handayani; Fea Prihapsara
Warta LPM WARTA LPM, Vol. 25, No. 1, Januari 2022
Publisher : Universitas Muhammadiyah Surakarta

Anak-anak termasuk ke dalam kelompok usia yang sangat rentan terhadap penularan COVID-19 dari lingkungan sekitarnya. SDIT Insan Mulia Surakarta merupakan sekolah yang berada di zona merah dan sedang mempersiapkan kegitan tatap muka. Pengetahuan tentang Perilaku Hidup Bersih dan Sehat (PHBS) merupakan prioritas yang harus diberikan dan difahamkan kepada siswa agar dapat menjadi salah satu upaya perlindungan siswa dari COVID-19. Selain itu, edukasi tentang obat sejak dini perlu dilakukan agar nantinya tidak timbul permasalahan dalam penggunaan obat. Kegiatan pengabdian berupa edukasi dengan media handout dan buku ajar berbasis aktivitas dilakukan sebagai salah satu upaya peningkatan pengetahuan siswa. Sasaran kegiatan adalah siswa kelas 3 di SDIT Insan Mulia Surakarta pada bulan April 2021. Dalam memahami materi edukasi, siswa dipandu melalui pertemuan virtual dengan platform zoom meetings. Evaluasi keberhasilan program dilakukan melalui penilaian pengetahuan dengan pretes dan postes. Perbedaan nilai pretest dan postest dianalisis menggunakan uji Wilcoxon. Pada akhir rangkaian kegiatan hanya ada 37 siswa yang mengisi postes dengan lengkap. Hasil evaluasi menunjukkan bahwa ada perbedaan pengetahuan yang signifikan sebelum dan sesudah edukasi menggunakan buku ajar berbasis aktivitas dengan nilai p=0,047. Akan tetapi, tidak ada perbedaan yang signifikan pada pengetahuan siswa yang diberikan edukasi melalui media handout dan buku ajar berbasis aktivitas ( p=0,777.; p>0,05). Media edukasi buku ajar berbasis aktivitas lebih tepat digunakan dalam meningkatkan pengetahuan siswa sekolah dasar. Kendala yang dialami selama kegiatan adalah jaringan internet dan fasilitas yang dimiliki siswa. Secara keseluruhan, kegiatan ini telah berjalan dengan lancar dan dapat meningkatkan pengetahuan siswa tentang obat dan PHBS. Melalui media edukasi yang telah disusun oleh tim pengabdian, diharapkan edukasi tentang obat dan PHBS terhadap siswa dapat terus dilakukan secara berkala.

Transformasi Penjualan Digital Produk Jamu dan Obat Tradisional pada UKM Jamu di Kabupaten Sukoharjo Artanti, Anif Nur; Prihapsara, Fea; Suryani, Esti; Rahmatul Kholiq, Muhammad Hatta; Astirin, Okid Parama; Rahayu, Endang Siti
Aksiologiya: Jurnal Pengabdian Kepada Masyarakat Vol 7 No 1 (2023): Februari
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/aks.v7i1.9033

The Influence of Polyvinyl Pyrrolidone (PVP) on Piroxicam Absorption with Everted Intestinal SAC Method Prihapsara, Fea; Artanti, Anif Nur; Murrukmihadi, Mimiek
Media Farmasi: Jurnal Ilmu Farmasi Vol. 12 No. 1: Maret 2015
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v12i1.3028

Oral drug absorption was highly influenced by dissolution rate, especially for poorly and insoluble drugs. Piroxicam is a nonsteroidal anti-inflammatory drug that is practically insoluble in water. The oral absorption rate of piroxicam is dependent on its dissolution rate in the GI tract. Polyvinyl Pyrrolidone (PVP) as surfactant can increase drug solubility by means of a micelle forming mechanism. The aim of the study was to know the influence of addition and variation of Polyvinyl Pyrrolidone (PVP) on Piroxicam absorption with everted intestinal sac method. The concentration of piroxicam solution was prepared by PVP in 1.0,2.0 and 3.0 % respectively. Crane and Wilson tube containing 75 ml of themucosal fluid was taken at 37 0 C in waterbath. Than, serosal solution of 1.5 mlwas added to intestinal sac by turned upside down and tied to a cannula, then put into the tube containing the mucosal fluid and constantly flowing oxygen gas.Serosal solution of 1 ml were taken every 15 minutes and then diluted with 2 ml of Ba (OH) 2 and 2 ml of ZnSO4 then centrifuge until 25 minute. The absorbant of supernatant was measured by UV spectrophotometer and data analyse wascalculated by one-way ANAVA. PVP at 1%,2% and 3% increased piroxicamabsorption from the phosphate buffer pH 7.5 compared with negative control.According to P app , the values were 2.52 ± 0.43 cm/minute (negative control), 3.41 ± 2.17 cm/minute (1% PVP), 2.75± 1.14 cm/minute (2% PVP) and 4.77 ± 4.93 cm/minute (3% PVP) respectively. In conclusion. Lower doses of the surfactant (1%, 2%, and 3% PVP) significantly increased absorption of the drug by altering the membrane permeability.

Synergistic Cytotoxicity Effect by Combination of Methanol Extract of Parijoto Fruit (Medinilla speciosa Reinw. ex. Bl) and Cisplatin Against Hela Cell Line Artanti, Anif Nur; Pujiastuti, Umi Hanik; Prihapsara, Fea; Rakhmawati, Rita
Indonesian Journal of Cancer Chemoprevention Vol 11, No 1 (2020)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev11iss1pp16-21

As one of the leading causes of death in worldwide, cervical cancer requires the effective therapies to reduce its mortality rate. One of the chemotherapy agents that frequently used in the treatment is cisplatin. However, due to drug resistance and its side effects, an agent that can be combined with cisplatin is needed. Parijoto fruit (Medinilla speciosa Reinw.ex.Bl) contains secondary metabolites compounds that have potential as anticancer. The study aims to determine the cytotoxic effect of methanol extract of Parijoto fruit calculated from the IC50 value and the synergicity of the combinational treatment with cisplatin evaluated from the Combination Index (CI) value and its cell viability by using MTT assay. Results showed that methanol extract of Parijoto fruit (MEP) performed cytotoxic effect on HeLa cell line with IC50 of 209.6 μg/mL while the value of IC50 of cisplatin against HeLa cells amounted to 12.8 μg/mL. The combination of 26.205 ppm (1/8 IC50) of MEP and 1.601 ppm (1/8 IC50) of Cisplatin performed synergistic effect on HeLa cell line with the CI value of 0.69. From the above results, it can be concluded that MEP is potential as co-chemotherapy agent based on the synergistic cytotoxicity effect with cisplatin.Keyword: cytotoxic, Medinilla speciosa, cisplatin, co-chemotherapy, MTT

Physicochemical Characterization, Cytotoxic Activity, and Caspase-9 Expression of Nanogold-Parijoto (Medinilla Speciosa Reinw .Ex, Bl ) in Hela Cell Lines Artanti, Anif Nur; Rohmani, Sholichah; Prihapsara, Fea; Utami, Diyah Tri; Amaris Susanto, Nindita Clourisa; Zulphadly, M.Fiqri; Meitasari, Annisa Diyan; Darojati, Ulfa Afrinurfadhilah; Untari, Meta Kartika; Sasongko, Heru; Ermawati, Dian Eka
Indonesian Journal of Cancer Chemoprevention Vol 15, No 3 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss3pp175-185

Parijoto (Medinilla speciosa, Reinw. ex. Bl.), a tropical plant native to Southeast Asia, contains flavonoids, tannins, and saponins, which have the potential as an anticancer. Gold nanoparticle-based drug formulations are applied to increase the anticancer effectiveness of herbal medicines. The compounds in the stalk of parijoto have the potential to be bioreductor in the biosynthesis of gold nanoparticles. This study aims to determine the physicochemical characterization, cytotoxic activity, and expression of protein caspase-9 after treatment with nanogold parijoto (AuNPs-PR) on HeLa cell. The nanogold biosynthesis process was done by reacting 1 mM HAuCl4 with parijoto aqueous extract (EP). Physicochemical characterization measure of particle size, Polydisperse Index (PdI), and zeta potential of AuNPs-PR was carried out using a particle size analyzer. The cytotoxic effect and viability cell of AuNPs- PR were carried out using the MTT assay. The expression of caspase-9 was observed by immunocytochemistry assay. Physicochemical characterization of AuNPs-PR shows that the particle size value is 160.8 nm with PdI and zeta potential values of 0.430 and -4.56 mV respectively. In the MTT assay, both AuNPs-PR and EP demonstrated a reduction in the viability of Hela cells after 24 h in a dose-dependent manner, yielding IC50 values of 3.28 μg/mL and 19.22 μg/mL, respectively. AuNPs-PR and EP showed low cytotoxic activity against Vero normal cells, with IC50 values of over 500 μM. Further, the immunocytochemistry assay indicated that there was upregulation of caspase-9 by their expression. These results indicate that AuNPs-PR could effectively induce apoptosis in HeLa cells by upregulating caspase-9.Keywords: caspase-9, HeLa cells, MTT, nanogold, parijoto.

Cytotoxicity Effect of Self-Nanoemulsifying Drug Delivery System from Chloroform Extract of Bay Leaf (Syzygium Polyanthum (Wight) Walp.) with Oleic Acid as a Carrier Artanti, Anif Nur; Prihapsara, Fea; Rohmani, Sholichah
Indonesian Journal of Cancer Chemoprevention Vol 13, No 2 (2022)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev13iss2pp94-103

Bay leaves are used as food flavoring and also have medicinal properties. They may have cytotoxic effects derived from natural ingredients. The low efficacy of the therapy with an adequate dose preparation of the plant extract is due to its low solubility and oral bioavailability that is less than the maximum. Hence, this study aimed to improve the solubility and oral bioavailability of the extract mainly for the chloroform extract of leaves that are not soluble in water by preparing a self-nanoemulsifying drug delivery system (SNEDDS). Then, the potential cytotoxic effects of the SNEDDS of bay leaves were determined by calculating the value of IC50 on the T47D cell line. The cytotoxic effect of the SNEDDS of bay leaves was determined using an MTT assay, and the findings were read using an ELISA reader. Data analysis is calculated via linear regression methods by using Microsoft Excel software. The results showed that the SNEDDS of bay leaves performed cytotoxic effects on the T47D cell line with IC50 138 μg/mL. The results showed that the optimal composition formula SNEDDS, namely, Tween 20:PG:oleic acid = 2.25:2.25:0.5 in 5 mL SNEDDS preparation, which had a value of transmittance of 83.81% with emulsification time was less than 5 min; the average droplet size was 165.5 nm, and the zeta potential was −0.4 mV. The data analysis showed that the cytotoxicity effect of the SNEDDS of bay leaves is included in the moderate cytotoxic category.Keywords: Bay leaf, optimization, nanoemulsi, cytotoxicity.

Optimization of the Proportion of Surfactant, Co-Surfactant, and Candlenut Oil for Self-Nanoemulsifying Drug Delivery System (SNEDDS) of Secang Heartwood (Caesalpinia sappan L.) Methanolic Extract Anif Nur Artanti; Fea Prihapsara; Nugraha Mas'ud; Dian Eka Ermawati
ALCHEMY Jurnal Penelitian Kimia Vol 17, No 1 (2021): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.17.1.39054.124-131

This study aimed to determine the optimum proportion of hazelnut oil, surfactants, and cosurfactants for SNEDDS of Secang Heartwood using the simplex lattice design (SLD) method using the Design-Expert software. The SNEDDS formula was prepared using Tween 80 and Croduret 50 ss as surfactants, propylene glycol as cosurfactant, and candlenut oil based on physical stability parameters: formula transmittance (%), separation phase, and emulsification time. The optimum SNEDDS formula was compared with the predictive value [p> 0.05] provided by the SLD; then extract the loading dose, accelerated stability test, analysis of particle size, and zeta potential. The optimum proportion of Tween 80-Croduret 50 ss, propylene glycol, and hazelnut oil, based on the SLD, was 62.43%; 22.57%; and 15.0%. The results showed that the transmittance was 93.2%; emulsification time was 74.67 seconds, and; separation phase was 0.89. The SLD's predictive values of the transmittance percentage, emulsification time, and separation phase were 94.98%, 78.97 seconds, 0.84, respectively. The results of the one-sample t-test statistical analysis showed no significant difference between the observative and predictive results. SNEDDS was found capable of loading 25.0 mg of secang heartwood methanolic extract in each system, with a particle size of 23.2 nm, a polydispersity index of 0.142, and zeta potential of +20.8 mV.

Co-Authors Ahmad Ainurofiq Alfiani Amsari Amaris Susanto, Nindita Clourisa Anggraini Febriyanty Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti, Anif Nur Aprilia Saefanan Shofa Betari, Sabella Sekar Darojati, Ulfa Afrinurfadhilah Endang Siti Rahayu ERMAWATI, DIAN EKA Esti Suryani Esti Suryani Farida, Yeni Hana Anisa Fatimi Hartatik Hartatik Heru Sasongko Hilwa Taffanina Imam Prabowo Inayatush Sholihah Insania Dwi Rahmadani Kustati, Fatimah Dwi Marsha Aulia Tazkia Rahma Meitasari, Annisa Diyan Mimiek Murrukmihadi Muhammad Hatta Rahmatul Kholiq Nestri Handayani Nestri Handayani, Nestri Novita Dhewi Ikakusumawati Nugraha Mas'ud Okid Parama Astirin Okid Parama Astirin Okid Parama Astirin Pujiastuti, Umi Hanik Rahmatul Kholiq, Muhammad Hatta Raka Aditya Pratama Ranita Kumalasari Susanto Rasmaya Niruri Rasmaya Niruri Rita Rakhmawati, Rita Rizky Dwi Larasati Sabella Sekar Betari Sheli Gita Revalina Sholichah Rohmani, Sholichah Siti Ma'rufah Syarifa Lukitaningtyas Tsalsa Rizky Ameera untari, meta kartika Utami, Diyah Tri Yeni Farida Yeni Farida Yumna Zulfa Salsabila Zulphadly, M.Fiqri

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