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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran Diponegoro Indonesian Journal of Cancer Chemoprevention Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmaseutik JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat) Generics: Journal of Research in Pharmacy Innovation in Health for Society Generics : Journal of Research in Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Eva Annisaa
Program Studi Farmasi, Universitas Diponegoro, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Education Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences

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Hubungan Persepsi dengan Perilaku Penggunaan Internet sebagai Media Pencarian Informasi Obat selama Pandemi Covid-19 pada Masyarakat di Kota Semarang Nurhafizha, Dika; Annisaa', Eva; Dianingati, Ragil Setia
Generics: Journal of Research in Pharmacy Vol 3, No 2 (2023): Generics: Journal of Research in Pharmacy, Volume 3, Edisi 2, 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/genres.v3i2.20057

Abstract

Penggunaan internet sebagai media pencarian informasi obat kian meningkat selama pandemi Covid-19. Hal ini tidak selalu memberikan dampak positif karena tidak semua informasi di internet adalah fakta sehingga pencarian informasi obat selama masa pandemi Covid-19 perlu kewaspadaan agar tidak terjebak dalam persepsi yang salah. Persepsi akan memengaruhi perilaku masyarakat setelah membaca informasi di internet. Mengetahui persepsi, perilaku, dan hubungan persepsi dengan perilaku penggunaan internet sebagai media pencarian informasi obat selama pandemi pada masyarakat Covid-19 di Kota Semarang. Penelitian ini merupakan penelitian observasional deskriptif dengan desain cross sectional. Teknik pengambilan sampel menggunakan snowball sampling pada 108 orang masyarakat Kota Semarang. Uji statistik yang digunakan yaitu uji chi-square. Hasil penelitian menunjukkan bawah persepsi masyarakat di Kota Semarang memiliki persepsi baik (44%), cukup (31%), dan kurang (26%). Perilaku masyarakat yang tergolong baik (44%), cukup (31%), dan kurang (26%). Terdapat hubungan yang signifikan antara persepsi dan perilaku penggunaan internet sebagai media pencarian informasi obat selama pandemi Covid-19 pada Masyarakat di Kota Semarang (nilai p = 0,000). Mayoritas responden memiliki perilaku dan persepsi yang baik. Terdapat hubungan yang signifikan antara persepsi dengan perilaku penggunaan internet sebagai media pencarian informasi obat selama pandemi Covid-19 pada masyarakat di Kota Semarang.
Evaluasi Rasionalitas Penggunaan Antihipertensi Golongan Angiotensin II Receptor Blocker (ARB) pada Pasien Penyakit Ginjal Kronis Momuat, Annastasia Gabriella Francie; Annisaa', Eva
Generics: Journal of Research in Pharmacy Vol 3, No 1 (2023): Generics: Journal of Research in Pharmacy, Volume 3, Edisi 1, 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/genres.v3i1.17210

Abstract

Penyakit Ginjal Kronis (PGK) adalah abnormalitas struktur atau fungsi ginjal yang ditandai dengan nilai GFR (Glomerular Filtration Rate) < 60 mL/menit/1,73 m2 selama > 3 bulan. Salah satu faktor risiko dari PGK adalah hipertensi. Golongan antihipertensi yang direkomendasikan pada pasien PGK salah satunya adalah Angiotensin II Receptor Blocker (ARB). Hipertensi dapat memperburuk fungsi ginjal, sebaliknya penurunan fungsi ginjal dapat memperburuk hipertensi. Oleh karena itu, penting untuk mengontrol tekanan darah pasien PGK menggunakan antihipertensi dengan penggunaan yang rasional. Penelitian ini bertujuan untuk mengetahui rasionalitas penggunaan antihipertensi golongan ARB pada pasien PGK di RSUP Dr. Kariadi Semarang tahun 2020. Penelitian ini merupakan penelitian observasional deskriptif dengan pengambilan data secara retrospektif. Sampel yang diteliti adalah 80 pasien PGK yang menggunakan golongan ARB dan dipilih menggunakan metode purposive sampling. Data diperoleh dari rekam medis yang dianalisis rasionalitasnya berdasarkan kriteria tepat indikasi, tepat pasien, tepat obat, dan tepat dosis. Hasil yang diperoleh pada penelitian ini adalah 80 pasien dinyatakan tepat indikasi (100%), 80 pasien dinyatakan tepat pasien (100%), 74 pasien dinyatakan tepat obat (92,5%), dan 80 pasien dinyatakan tepat dosis (100%). Oleh karena itu, rasionalitas penggunaan antihipertensi golongan ARB berdasarkan empat kriteria tersebut sudah cukup baik, yaitu sebesar 92,5%.
THE EFFECT OF MUNTINGIA CALABURA ETHANOLIC LEAVES EXTRACT FOR ASPIRIN-INDUCED GASTRIC MUCOSAL DAMAGE Rizky, Almaarif Faiq; Annisaa', Eva; Maharani, Nani; Utomo, Astika Widy
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 3 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i3.54192

Abstract

Background: Muntingia calabura leaves have been claimed to relieve pain, fever, inflammation, and many others. Many studies has already prove the potential of these leaves as anti-inflammation, anti-nociceptive, and anti-proliferative. It might have capability to protect gaster from ulcer. Objective: This study aimed to know the effect of Muntingia calabura ethanolic leaves extract (MCELE) for aspirin-induced gastric mucosal damage on wistar rats. Methods: Twenty-five wistar rats is divided into 5 groups. K2 group (aspirin 300 mg/kg. K1, P1, P2, and P3 group received misoprostol 100 mcg/kg, MCELE 100 mg/kg, MCELE 250 mg/kg, and MCELE 500 mg/kg respectively 1 hour before the administration of aspirin 300 mg/kg. All treatments were administered orally once daily for 7 consecutives days. On day 8, all rats were sacrificed, and gastric tissues were collected for histopathological examination. The tissues were stained with hematoxylin and eosin (H&E) and evaluated under light microscopy to assess mucosal damage, including desqumasion, epithelial erosion, and ulceration. Statistical analysis was performed using the Kruskal-Wallis test, followed by the Mann-Whitney test for pairwise comparisons. Differences were considered statictically siginificant at p<0.05. Results: Histopathology test result showed a significant difference between K1 group and K2 group (p=0.003). Each treatment group also showed a significant difference when compared to K2 group (p<0.05). P3 group and K1 group showed a similar effect on rat’s gastric mucosa (p=1.000). Conclusion: Administration of MCELE may lower gastric mucosal damage on wistar rats induced by aspirin, with 500 mg/kg dose is almost as effective as standard drugs (Misoprostol).
RELATIONSHIP BETWEEN KNOWLEDGE LEVELS AND ATTITUDES WITH ADHERENCE TO ANTIRETROVIRAL (ARV) THERAPY OF HIV/AIDS PATIENTS IN RSUP Dr. KARIADI, SEMARANG Ginitri, Arumdipta; Annisaa', Eva; Wulandari, Fitri
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 3 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i3.52589

Abstract

Background: Antiretrovirals (ARV) are drugs that People Living with HIV/AIDS (PLWHA) take to enhance quality of life. Therapy adherence (>95%) is required to attain virologic suppression, prevent resistance, therapy failure, and death. Factors affecting adherence are the level of knowledge and attitude. Objective: This study aims to identify the relationship between knowledge level and attitude with adherence to ARV therapy of HIV/AIDS patients at RSUP Dr. Kariadi, Semarang. Methods: Analytical observational research with cross-sectional design using questionnaires, sampling method using purposive sampling. Adherence questionnaire using MARS-5, knowledge and attitude questionnaires were developed by the researcher, and validity and reliability tests were carried out. Univariate analysis using frequency distribution table, and bivariate analysis using Chi-Square test. Results: The level of knowledge of respondents was good at 88.30%, and poor at 11.70%. The attitude was good at 96.81%, and poor at 3.19%. The compliance was high at 65.96%, and low at 34.04%. A significant association was observed between the level of knowledge (p = 0.028) and attitude (p = 0.014) with adherence to ARV therapy. Conclusion: The majority of HIV/AIDS patients at RSUP Dr. Kariadi, Semarang, who received ARVs, the knowledge level was good, the attitude was good, and the adherence was high. There is a relationship between the level of knowledge and attitude with adherence to ARV therapy of HIV/AIDS patients at RSUP Dr. Kariadi, Semarang.
Co-Authors Abdul Ghofir Abdul Ghofir Andani, Dea Fildatul Antari, Arlita Leniseptaria Astika Widy Utomo, Astika Widy Aulia Sandriani Desy Armalina Dewi, Dina Nurlita Dini, Intan Rahmania Eka Dodik Pramono Donna Hermawati Ekawati, Nuraini Endang Sri Sunarsih Era Ayuk Adistia Faizurrahman Andi Kusuma Fitri Wulandari Fulyani, Faizah Ginitri, Arumdipta Hanum, Nora Fauziah Hardian Hardian Indah Saraswati Intan Rahmania Eka Dini Intan Rahmania Eka Dini Isnaini Nur Jannah Julia Zahra Ardianti Krongthaeo, Suphanna Kurniadewi, Komang Sukmaloka Kurniasari, Teny Lusiana Batubara Momuat, Annastasia Gabriella Francie Mumtaz, Ananda Rifda Fairuz Mumtaz, Syakira Nabilah Saniyya Wahyudi Nabilla, Fira Nani Maharani Nuraini Ekawati Nurhafizha, Dika Raditiya Firda Maulany Ragil Setia Dianingati Ragil Setia Dianingati Ramadhani, Raihan Rezha Nur Amalia Rezha Nur Amalia Rezha Nur Amalia Riewpaiboon, Arthorn Rizky, Almaarif Faiq Rizky, Wardhiana Agung Safira, Adella Ghalda Santoso Santoso Sarah Melinda Sasikirana, Widyandani Setiadianingati, Ragil Thuy, Luu Thi Vivi Nurmalita Widyandani Sasikirana