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All Journal Journal of Fundamental and Applied Pharmaceutical Science Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Sains dan Praktis JURNAL JAMU KUSUMA Duta Pharma Journal Proceeding of International Conference Health, Science And Technology (ICOHETECH) Cerdika: Jurnal Ilmiah Indonesia Prosiding Seminar Informasi Kesehatan Nasional Usada Nusantara: Jurnal Kesehatan Tradisional Journal of Educational Innovation and Public Health Detector: Jurnal Inovasi Riset Ilmu Kesehatan Jurnal Medika Nusantara Parapemikir Jurnal Ilmiah Farmasi Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian
Desy Ayu Irma Permatasari
Universitas Duta Bangsa Surakarta
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary

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Uji Aktivitas Antioksidan Ekstrak dan Fraksi Buah Jambu Biji Australia (Psidium Guajava L.) Metode DPPH Marshela Duta Larasati; Desy Ayu Irma Permatasari; Isna Nur Khasanah
Journal of Educational Innovation and Public Health Vol. 1 No. 4 (2023): Oktober : Journal of Educational Innovation and Public Health
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/innovation.v1i4.1878

Abstract

Australian guava fruit (Psidium guajava L.) is thought to have antioxidant activity. Antioxidants are compounds that are useful for treating oxidative damage caused by free radicals in the body. The aim of this study was to determine the secondary metabolite content and IC50 value on the antioxidant activity of extracts and fractions from Australian guava fruit. This research used four solvents, including 70% ethanol extract, n-hexane fraction, ethyl acetate fraction and water fraction with varying concentrations of 50 ppm, 100 ppm, 150 ppm, 200 ppm and 250 ppm. The antioxidant test was carried out using a UV-Vis spectrophotometry tool with the DPPH method at a wavelength of 515 nm with an incubation time of 15 minutes. Antioxidant activity tests show that Australian guava fruit is effective as an antioxidant in capturing free radicals. The IC50 value for the ethanol extract is 0.784 µg/mL, the n-hexane fraction is 2.448 µg/mL, the ethyl acetate fraction is 1.015 µg/mL and the water fraction is 0.676 µg/mL. All samples were included in the very strong category, but the water fraction had the best antioxidant activity among the ethanol extract, n-hexane and ethyl acetate fractions.
PENETAPAN KADAR FENOLIK SERTA UJI AKTIVITAS ANTIOKSIDAN EKSTRAK DAN FRAKSI BATANG BAJAKAH KALALAWIT (Uncaria gambir Roxb) DENGAN METODE FRAP Siti Nur Indriyah; Desy Ayu Irma Permatasari; Kharisma Jayak Pratama
USADA NUSANTARA : Jurnal Kesehatan Tradisional Vol. 1 No. 2 (2023): Juli: USADA NUSANTARA
Publisher : Institut Nalanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47861/usd.v1i2.347

Abstract

Antioxidants are compounds prevent oxidative damage by stabilizing free radicals by donating electrons. Phenolics are compounds that can be used as antioxidants because they can counteract free radicals. This study aims to determine the total phenolic content and antioxidant activity of the extract and fraction of the kalalawit (Uncaria gambir Roxb) stem. Extract preparation by maceration using 96% ethanol solvent. Testing for phenolic content with the Folin Ciocalteu method using UV-Vis spectrophotometry on extracts. Antioxidant activity test using the FRAP method on extracts with concentrations of 80, 90, 100, 110, and 120 ppm. The test results showed that the extract of the bajakah kalalawit stem (Uncaria gambir Roxb) had a phenolic content of 31.734 mg GAE/gr sample, there was antioxidant activity in the extract and fraction of the stem of the kalalawit (Uncaria gambir Roxb) indicated by the formation of a purplish blue color when reacted with FRAP solution , and the IC50 value of the ethanol extract was 29.842 ppm which was in the very strong category, water fraction was 39.865 ppm which was in the very strong category, n-hexane fraction was 75.319 ppm which was in the strong category and ethyl fraction was 12.572 ppm which was very strong.      
ANALISIS KADAR KURKUMIN JAMU KUNYIT ASAM MENGGUNAKAN METODE KLT-DENSITOMETRI Desy Ayu Irma Permatasari; Gezha Icsvanditra; Muladi Putra Mahardhika
Prosiding Seminar Informasi Kesehatan Nasional 2021: SIKesNas 2021
Publisher : Fakultas Ilmu Kesehatan Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (189.108 KB) | DOI: 10.47701/sikenas.v0i0.1260

Abstract

Indonesia kaya akan sumber daya alam, termasuk diantaranya tanaman herbal yang telah dipercaya oleh masyarakat untuk digunakan sebagai obat. Salah satu obat herbal yang banyak dikenal masyarakat adalah Jamu Kunyit Asam. Jamu ini dijual dengan cara digendong oleh pedagang di pasar tradisional. Jamu Kunyit Asam terdiri dari kunyit ( Curcuma domestica ) dan asam ( Tamarindus indica ). Kunyit memiliki kandungan zat aktif yang paling umum diketahui adalah kurkumin, yang memiliki aktivitas biologis sebagai analgetik, antipiretik dan antiinflamasi. Penelitian ini bertujuan untuk mengetahui kadar kurkumin pada jamu kunyit asam yang ada di Desa Palur.Metode penelitian ini menggunakan KLT-Densitometri. Sampel penelitian adalah produsen jamu gendong kunyit asam yang berada di Desa Palur. Jenis penelitian ini menggunakan analisa kualitatif yaitu dengan metode KLT dan Kuantitatif menggunakan metode KLT-Densitometri.Hasil Penelitian menunjukkan bahwa sampel jamu kunyit asam memiliki nilai Rf = 0,5 dan kadar kurkumin dari metode KLT-Densitometri pada sampel 1 sebesar 47,68ppm, sampel 2 sebesar 41,11ppm. Berdasarkan penelitian ini dapat disimpulkan bahwa kadar kurkumin dari produsen jamu gendong kunyit asam adalah mendekati sama.Kata Kunci : Kurkumin, Jamu, KLT-Densitometri, Kunyit Asam
Formulasi dan Uji Aktivitas Antibakteri Sediaan Gel Hand Sanitizer Kombinasi Ekstrak Etanol Daun Sirsak (Annona muricata L.) dan Ekstrak Etanol Batang Sereh (Cymbopogon citratus) terhadap Bakteri Staphylococcus aureus ATCC 25923 Weri veranita; Hasanah Nurul Hijjah; Desy Ayu Irma Permatasari; Rony setianto
Prosiding Seminar Informasi Kesehatan Nasional 2022 : SIKesNas 2022
Publisher : Fakultas Ilmu Kesehatan Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (183.304 KB) | DOI: 10.47701/sikenas.vi.2081

Abstract

Saat ini mencuci tangan dengan sabun dan air mengalir bukanlah satu-satunya carauntuk membersihkan tangan, terdapat cara yang lebih praktis yaitu menggunakan cairan gelantiseptik yang dapat digunakan kapan dan dimana saja tanpa harus dibilas dengan air, yangdikenal dengan hand sanitizer. Penambahan zat aktif pada sediaan yang berasal dari ekstraktumbuhan yang memiliki aktivitas antibakteri dapat memberikan efek penghambatan padapertumbuhan bakteri seperti Staphylococcus aureus. Daun sirsak (Annona muricata L.)mengandung senyawa flavonoid, saponin, tanin, dan alkaloid, serta tanaman sereh (Cymbopogoncitratus) memiliki kandungan kimia antara lain minyak atsiri, saponin, polifenol dan flavonoid,kedua tanaman ini memiliki aktivitas antibakteri yang cukup besar.Pada penelitian ini, dilakukan kombinasi Ekstrak Etanol Daun Sirsak (Annona muricataL.) dan Ekstrak Etanol Batang Sereh (Cymbopogon citratus) untuk memformulasikan gelhandsanitizer dengan bahan alami. Uji karakteristik gel yang dilakukan adalah uji viskositas, ujidaya sebar, uji pH, uji organoleptis dan uji homogenitas. Uji aktivitas antibakteri dilakukandengan pengukuran zona hambat menggunakan metode disc diffusion test terhadap variasiformula yaitu F1, F2, dan F3.Hasil penelitian didapatkan kombinasi ekstrak etanol daun sirsak (Annona mricata L.)dan ekstrak etanol batang sereh (Cymbopogon citratus) pada konsentrasi 2,5%, 5%, 10% denganperbandingan ekstrak 2:1 dapat diformulasikan menjadi sediaan gel hand sanitizer yang baik danmemenuhi persyaratan sediaan gel yang baik. Kombinasi kedua ekstrak ini memberikan efekantibakteri yang lebih baik, dibuktikan dengan konsentrasi 10% kombinasi ekstrak memiliki efekantibakteri terhadap bakteri Staphylococcus aureus dengan nilai zona hambat 16 mm yangmanatermasuk kategori kuat.
Uji Aktivitas Antioksidan Ekstrak dan Fraksi n-Heksan, Etil asetat, dan Air Kulit Jambu Biji Australia (Psidium guajava L.) Dengan Metode DPPH (1,1-Difenil-2-Pikrilhidrazil) Ning Rusmiyati; Desy Ayu Irma Permatasari; Isna Nur Khasanah
Detector: Jurnal Inovasi Riset Ilmu Kesehatan Vol. 1 No. 4 (2023): November : Jurnal Inovasi Riset Ilmu Kesehatan
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/detector.v1i4.2553

Abstract

Free radicals work by binding to molecules or cells in the body and are very dangerous because they can damage cells in the body and trigger disease. Antioxidants are compounds that can counteract the effects of free radicals. This study aims to determine the antioxidant activity of ethanol extract and the n-hexane, ethyl-acetate and water fractions of Australian guava peel (Psidium guajava L.). Extraction was carried out by maceration method using 70% ethanol. The skin of the Australian guava (Psidium guajava L.) contains alkaloids, flavonoids, tannins, triterpenoids and saponins. Fractionation was carried out with solvents based on polarity differences obtained by the n-hexane fraction, ethyl acetate fraction, and air fraction. Antioxidant test by inhibiting DPPH free radicals (1,1-Diphenyl-2-Picrylhydrazyl) on ethanol extract and n-hexane fraction, ethyl acetate fraction and air at several concentrations, namely 50 ppm, 100 ppm, 150 ppm, 200 ppm, and 250 ppm. The IC50 calculation results obtained for the ethanol extract were 4.406 µg/mL, the n-hexane fraction was 4.131 µg/mL, the ethyl acetate fraction was 3.812 µg/mL and the air fraction was 3.312 µg/mL. The antioxidant activity with the best IC50 value was the fraction air.
Co-Authors Ahda Maulida Ulufan Nurinnafi'a Anita Dwi Septiarini Anita Dwi Septiarini Annisa Nurlaila Sari Bangkit Riska Permata Bangkit Riska Permata Budi Santoso Danang Raharjo elva wahyu kurnia cici Eva Kholifah Febriyanto Eko Syahputra Fevi Indri Oktaviani Gezha Icsvanditra Hasanah Nurul Hijjah Ikrima Rahmasari Isna Nur Khasanah Kezia Putri Maha Dewi Kharisma Jayak Pratama Kusumaningtyas Siwi Artini Listyani, Tiara Ajeng Lutfi Indah Irmayanti Marshela Duta Larasati Muladi Putra Mahardhika Muladi Putra Mahardika Muladi Putra Mahardika Muladi Putra Mahardika Ning Rusmiyati Novalisa Nindhi Soraya Novita Kurniasri Putri Solihah Kartika Sari Qonitaatun Nur Hidayah Ratna Sari Dewi Regita Fortunata Rifda Husna Arifah Rini Setyowati Setianto, Rony Silvia Devi Siti Nur Indriyah Tatiana Siska Wardani Veranita, Weri Wardani, Tatiana Siska Weri veranita