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All Journal Jurnal e-Biomedik PHARMACON JURNAL BIOMEDIK CHEMISTRY PROGRESS Briliant: Jurnal Riset dan Konseptual Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Pharmacology and Clinical Pharmacy Research Jurnal Abdi Insani Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Vivabio : Jurnal Pengabdian Multidisiplin Jurnal Perempuan dan Anak Indonesia Jurnal Kesehatan Tambusai Indonesian Biodiversity Journal Indonesian Biodiversity Journal Pharmaceutical Science Journal Jurnal Lentera: Penelitian dan Pengabdian Masyarakat Jurnal Lentera Farma
Meilani Jayanti
Universitas Sam Ratulangi
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : PHARMACON

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TOXICITY TEST OF THE COMBINATION Eleutherine americana Merr. AND Areca vestiaria EXTRACTS AGAINST THE INTESTINAL ORGANS OF Rattus norvegicus Sarai Raehilda Febriansi Korban; Herny Simbala; Meilani Jayanti
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.41911

Abstract

Dayak onions (Eleutherine americana Merr.) and Pinang Yaki (Areca vestiaria) have been used by the community as traditional medicine. The purpose of this study was to determine the safety level of extracts of Dayak onion and Pinang Yaki against the macroscopic appearance of the intestinal organs of Wistar male white rats. This study used an experimental method with 18 male white rats of the Wistar strain who were given ethanol extract of Dayak onion and Pinang Yaki orally at a dose of 10,8mg, 14,4mg, and 21,6mg for 14 days. The results showed that there was a decrease in body weight, in each treatment group but the largest weight loss occurred in the dose group V from 199gram to 182gram while the smallest weight loss occurred in the dose group I from 199gram to 198gram and for the macroscopic picture of the intestinal organs there was no significant difference between the test group with the control group. In conclusion, the administration of extracts of Dayak onion and Pinang Yaki does not affect the macroscopic picture of the intestinal organs.
Evaluasi Penggunaan Antibiotik pada Pasien Covid-19 di RSUP Prof. Dr. R. D. Kandou Manado Periode Januari-Maret 2021 Christian Aseng; Weny Wiyono; Meilani Jayanti
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.42200

Abstract

Covid-19 adalah penyakit infeksi jenis baru yang disebabkan oleh virus Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2). Penelitian ini bertujuan untuk mengetahui profil penggunaan dan kuantitas penggunaan antibiotik yang diberikan pada pasien Covid-19 di RSUP Prof. Dr. R. D. Kandou Manado periode Januari-Maret 2021. Didapatkan sebanyak 60 sampel rekam medis, kemudian dianalisis secara kuantitatif menggunakan metode ATC/DDD. Didapat 7 jenis antibiotik yang diberikan pada pasien Covid-19 yaitu  Azitromisin (51,72%), Seftriakson (22,99%), Levofloksasin (17,24%), Sefadroksil (2,30%), Meropenem (2,30%), Moksifloksasin (2,30%) dan Siprofloksasin (1,15%). Diperoleh nilai total DDD/100 pasien-hari sebesar 97,36 DDD/100 pasien-hari, antibiotik Azitromisin memiliki nilai DDD/100 hari-pasien tertinggi sebesar 44,54 DDD/100 pasien-hari, dan antibiotik yang masuk dalam segmen 90% adalah Azitromisin (45,75%), Seftriakson (29,85%) dan Levofloksasin (16,02%).
ISOLATION AND IDENTIFICATION OF FLAVONOID COMPOUNDS ETHANOL EXTRACT OF SUANGGI LEMON PEEL Citrus limon L. Rizya Marchilia Mamahit; Fatimawali Fatimawali; Meilani Jayanti
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.42204

Abstract

ABSTRACTSuanggi lemon peel is a plant that is often used as a traditional health therapy. The outer skin of the lemon suanggi (Citrus Limon L.) is rich in oil glands, bright yellow in color with a distinctive and fresh citrus aroma. The purpose of this study was to isolate and identify the class of flavonoid compounds from the rind of lemon suanggi (citrus limon L.) by using the UV-Vis spectrophotometer method. The rind of the suanggi lemon was extracted by maceration method using 95% ethanol as solvent which resulted in a thick extract of suanggi lemon rind. Isolation was carried out by thin layer chromatography (TLC) method with Chloroform: n-hexane (4:2) as the eluent. The fourth spot from the result of Thin Layer Chromatography was positive for containing flavonoid compounds. From the spectrum of the UV-Vis spectrophotometer, it can be assumed that the flavonoid compound is a flavonol group, which can be seen from its wavelength range, which is between 200- 500 nm from its wavelength range of 366 nm.Keywords: lemon suanggi, flavonoids, thin layer chromatography, UV-Vis spectrophotometer.
Uji Aktivitas Antioksidan Ekstrak Etanol Spons Lamellodysidea herbacea yang Diperoleh dari Pantai Selatan Kabupaten Minahasa Christian Alexandro Lanes; Adithya Yudistira; Meilani Jayanti
PHARMACON Vol. 12 No. 3 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.49217

Abstract

Spons merupakan salah satu organisme laut yang mempunyai potensi untuk menghasilkan senyawa metabolit sekunder yang mempunyai banyak manfaat. Salah satu fungsi dari metabolit sekunder adalah sebagai antioksidan. Antioksidan merupakan senyawa yang dapat menghambat proses oksidasi yang diakibatkan oleh radikal bebas. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dari spons Lamellodysidea herbacea yang diperoleh dari Pantai Selatan Kabupaten Minahasa. Penelitian ini merupakan eksperimental laboratorium dengan metode ekstraksi maserasi menggunakan pelarut etanol 95%. Pengujian antioksidan menggunakan metode DPPH (1.1-difenil-2-pikrihidrazil) dengan 4 seri konsentrasi sampel (25, 50, 75, 100 ppm) yang diukur menggunakan spektrofotometer UV-Vis dengan nilai absorbansi diukur pada panjang gelombang 517 nm. Hasil penelitian diperoleh rata-rata nilai persen inhibisi yang didapat pada konsentrasi 25, 50, 75, 100 ppm secara berturut-turut adalah 40,068%, 51,446%, 65,25%, 70,369%. Penelitian ini menyimpulkan bahwa ekstrak spons Lamellodysidea herbacea mempunyai aktivitas antioksidan pada konsentrasi 50, 75, dan 100 ppm.
Co-Authors Abdullah, Surya Sumantri Adithya Yudistira Andi Buanasari Andy A.N Hiola Angmalisang, Elvin Clara Antasionasti, Irma Arsyad, Aswin ASARI Asep Rahman Ayu Wati Ningsih Christian Alexandro Lanes Christian Aseng Citra Fatima Marsidi Debora Gebby Tumundo DEBY AFRIANI MPILA Defny Silvia Wewengkang Dian Suryanita Sari Eldy Sengkey Elly Suoth Essing, Jacklien Deswita Fadila Al-A’izzah Fathoni, Kristiani W. S. W. Fatimawali . Fatrini Djaber Febrianika Ayu Kusumaningtyas Frenly Wehantouw Gayatri Citraningtyas Gunawan, Lea Nathaniela Agneta Hariyanto, Yuanita Amalia Herny E.I. Simbala Hosea Jaya Edy I Dewa Ayu M. Melaniawati Ihsan S. Tome Imam Jayanto Irma Antasionasti Irma Antasionasti Jayanto, Imam Julianri Sari Lebang, Julianri Sari Kapondo, Gwendolyn L. Kawatu, Chelsea Keri Lestari Lestari, Utami Sasmita Liling, Yessi Manuel, Jennike T. Maria Efrani Tengor Olvi Datu Owu, Nadya M. Rizky Abdulah Rizya Marchilia Mamahit Sarai Raehilda Febriansi Korban Shabrina Wahyudi Sharon Colin Tangkere Siampa, Jainer Pasca Soleman, Puput Sri Sudewi Surya Sumantri Abdullah Tengor, Maria Efrani Ticoalu, Pricilia Kesia Tinungki, Syalomita Esther Wenas, Glori Anjelina Preysi Weny I. Wiyono Weny I. Wiyono Weny Indayany Wiyono Weny Indayany Wiyono Weny Indayany Wiyono Weny Wiyono Wiyono, Wenny I. Wiyono, Weny Indayany Woran, Falinry Wori, Preicy Augenia Yuanita A. Hariyanto