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All Journal Jurnal e-Biomedik PHARMACON JURNAL BIOMEDIK CHEMISTRY PROGRESS Briliant: Jurnal Riset dan Konseptual Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Pharmacology and Clinical Pharmacy Research Jurnal Abdi Insani Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Vivabio : Jurnal Pengabdian Multidisiplin Jurnal Perempuan dan Anak Indonesia Jurnal Kesehatan Tambusai Indonesian Biodiversity Journal Indonesian Biodiversity Journal Pharmaceutical Science Journal Jurnal Lentera: Penelitian dan Pengabdian Masyarakat Jurnal Lentera Farma Journal of Literacy and Education
Meilani Jayanti
Universitas Sam Ratulangi
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : JURNAL BIOMEDIK

 1 
Uji Efektivitas Penghambatan Dari Ekstrak Daun Sirih (Piper Betle L.) Terhadap Bakteri Streptococcus mutans Owu, Nadya M.; Fatimawali, .; Jayanti, Meilani
Jurnal Biomedik : JBM Vol 12, No 3 (2020): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.12.3.2020.29185

Abstract

Abstract: Betel (Piper Betle L.) is one of the species of climbing plants belonging to the family Piperaceae, betel leaves contain tannin compound that are antimicrobial and can inhibit the growth of several types of bacteria. This study aims to identify tannin compounds from betel leaf extracts obtained from Southeast Minahasa and test the effectiveness of inhibition of Streptococcus mutans. Samples were extracted by maceration using ethanol as a solvent. Fractionation using n-hexane, ethyl acetate and ethanol. Antibacterial activity was tested on extracts with concentrations of 25%, 20%, 15%, 10% and 5% by the dilution method. The tannin test results showed that of the three n-hexane, ethyl acetate and ethanol fractions, only the ethanol fraction had a blackish green discoloration when FeCl3 reagent was added so that it positively contained tannin. The inhibitory test results obtained that the betel leaf ethanol extract with a concentration of 25%, 20% and 15% can inhibit the growth of Streptococcus mutans bacteria. From the results of the study it can be concluded that the ethanol extract of betel leaf contains tannin compounds and effectively inhibits the Streptococcus mutans bacteria with a MIC value at a concentration of 15%.Keywords: Betel leaf, Tannin, Antibacterial, Streptococcus mutans.  Abstrak: Sirih (Piper Betle L) merupakan salah satu jenis tumbuhan terna memanjat yang termasuk famili Piperaceae, daun sirih mengandung senyawa tannin yang bersifat antimikroba dan antijamur yang kuat dan dapat menghambat pertumbuhan beberapa jenis bakteri. Penelitian ini bertujuan untuk mengidentifikasi senyawa tanin dari ekstrak daun sirih yang diperoleh dari Minahasa Tenggara dan menguji efektifitas penghambatannya terhadap Streptococcus mutans. Sampel diekstraksi dengan cara maserasi menggunakan pelarut etanol. Fraksinasi menggunakan pelarut n-Heksan, etil asetat dan etanol. Aktivitas antibakteri diuji terhadap ekstrak dengan konsentrasi 25%, 20%, 15%, 10% dan 5% dengan metode dilusi. Hasil uji tanin diperoleh bahwa dari ketiga fraksi n-Heksan, etil asetat dan etanol, hanya fraksi etanol yang ketika ditambahkan pereaksi FeCl3 terjadi perubahan warna hijau kehitaman sehingga positif mengandung tannin. Hasil uji daya hambat diperoleh bahwa ekstrak etanol daun sirih dengan konsentrasi 25%, 20% dan 15% dapat menghambat pertumbuhan bakteri Streptococcus mutans. Dari hasil penelitian dapat disimpulkan bahwa ekstrak etanol daun sirih mengandung senyawa tannin dan efektif menghambat bakteri Streptococcus mutans dengan nilai KHM pada konsentrasi 15%.Kata kunci: Daun sirih, Tanin, Antibakteri , Streptococcus mutans.
Identifikasi Ketidaksesuaian Pengobatan pada Proses Rekonsiliasi Obat di Instalasi Rawat Inap Rumah Sakit Manuel, Jennike T.; Wiyono, Wenny I.; Jayanti, Meilani
Jurnal Biomedik : JBM Vol 13, No 3 (2021): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.13.3.2021.31769

Abstract

Abstract: Reconciliation is one of the proces that prevents drug-related problems, medication errors, and drug-related adverse events. This study aimed to identify treatment mismatches based on the results of drug reconciliation in 49 patients from the January to March 2020 study period. This research has been descriptive study with prospective data collection in inpatient installation CVBC (Cardiovascular and Brain Center) and Irina F Jantung, Prof. Dr. R. D. Kandou Manado.The results of the study based on patient characteristics showed that the number of male patients was greater than that of women, namely 31 patients and the highest number of patients was in the age group (60 - 69) as many as 23 patients. The results showed that the majority of patients were male as many as 31 patients and the most in the age group (60-69) as many as 23 patients. The characteristics of the number of drugs shown in the drug history data (BPMH), the majority of patients consumed <5 types of drugs, were 25 patients, in the ER Most consumed <5 types of drugs as many as 27 patients and also the majority of patients received ≥5 types of drugs while in the inpatient installation of 27 patients and when they left the hospital the majority of patients were given ≥5 types of drugs, namely 34 patients. The most widely used drugs are cardiovascular system drugs with a percentage of BPMH (95.92%), IGD (100%), in inpatient installations (100%) and out of prescription (100%) and the second is digestive system drugs. The percentage of unintentional discepancies was incomplete prescription (10.2%), omission medication (10.2%), and intentional discrepancies (100%).Keywords: medication discrepancies, medication reconciliation  Abstrak: Rekonsiliasi merupakan salah satu proses yang dilakukan untuk mencegah terjadinya kesalahan obat. Penelitian ini bertujuan mengidentifikasi ketidaksesuaian pengobatan berdasarkan hasil rekonsiliasi obat pada 49 pasien periode Januari–Maret 2020. Desain penelitian deskriptif dengan pengambilan data secara prospektif di instalasi rawat inap CVBC (Cardiovascular and Brain Center) dan Irina F Jantung RSUP Prof. Dr. R. D. Kandou Manado. Hasil penelitian menunjukkan mayoritas pasien adalah laki-laki sebanyak 31 pasien dan terbanyak pada kelompok usia (60-69) sebanyak 23 pasien. Karakteristik jumlah obat ditunjukkan pada data riwayat obat (BPMH) mayoritas pasien mengkonsumsi <5 jenis obat sebanyak 25 pasien, di IGD Sebagian besar mengkonsumsi <5 jenis obat sebanyak 27 pasien dan juga mayoritas pasien menerima  jenis obat saat di Instalasi rawat inap sebesar 27 pasien dan saat keluar rumah sakit mayoritas pasien diberikan  jenis obat yaitu 34 pasien. Obat yang paling banyak digunakan yaitu obat sistem kardiovaskular dengan presentase pada BPMH (95,92%), IGD (100%), di Instalasi rawat inap (100%) dan pada resep keluar (100%) dan yang kedua obat sistem pencernaan. Persentase ketidaksesuaian pengobatan yaitu Incomplete prescription sebesar (10,2%), Omission medication (10,2 %), dan ketidaksesuaian yang disengaja (100%).Kata kunci: rekonsiliasi, ketidaksesuaian pengobatan
Co-Authors Abdullah, Surya Sumantri Adam, Hilman Adithya Yudistira Andi Buanasari Andy A.N Hiola Angmalisang, Elvin Clara Antasionasti, Irma Arsyad, Aswin Asaloei, Sandra Inggrid ASARI Asep Rahman Asep Rahman, Asep Ayu Wati Ningsih Christian Alexandro Lanes Christian Aseng Citra Fatima Marsidi Debora Gebby Tumundo DEBY AFRIANI MPILA Defny Silvia Wewengkang Dian Suryanita Sari Eldy Sengkey Elly Suoth Essing, Jacklien Deswita Fadila Al-A’izzah Fathoni, Kristiani W. S. W. Fatimawali . Fatrini Djaber Febrianika Ayu Kusumaningtyas Frenly Wehantouw Gayatri Citraningtyas Gunawan, Lea Nathaniela Agneta Hariyanto, Yuanita Amalia Herny E.I. Simbala Hosea Jaya Edy I Dewa Ayu M. Melaniawati Ihsan S. Tome Imam Jayanto Irma Antasionasti Irma Antasionasti Jayanto, Imam Julianri Sari Lebang, Julianri Sari Kapondo, Gwendolyn L. Kawatu, Chelsea Keri Lestari Kojongian, Syallommita Lestari, Utami Sasmita Liling, Yessi Manuel, Jennike T. Maria Efrani Tengor Olvi Datu Owu, Nadya M. Rizky Abdulah Rizya Marchilia Mamahit Sarai Raehilda Febriansi Korban Shabrina Wahyudi Sharon Colin Tangkere Siampa, Jainer Pasca Soleman, Puput Sri Sudewi Surya Sumantri Abdullah Tengor, Maria Efrani Ticoalu, Pricilia Kesia Tinungki, Syalomita Esther Waworuntu, Injilia Sharon Queen Wenas, Glori Anjelina Preysi Weny I. Wiyono Weny I. Wiyono Weny Indayany Wiyono Weny Indayany Wiyono Weny Indayany Wiyono Weny Wiyono Wiyono, Wenny I. Wiyono, Weny Indayany Woran, Falinry Wori, Preicy Augenia Yuanita A. Hariyanto