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All Journal VALENSI International Journal of Renewable Energy Development Jurnal Riset Kimia Jurnal Keramik dan Gelas Indonesia Science and Technology Indonesia Al-Kimia Chimica et Natura Acta ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry PENDIPA Journal of Science Education Molekul: Jurnal Ilmiah Kimia Jurnal Keramik dan Gelas Indonesia Journal of Advanced Technology and Multidiscipline (JATM)
Yeni Wahyuni Hartati
Departemen Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Education Electrical & Electronics Engineering Energy Environmental Science Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Physics

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Study of The Interaction Carbondioxide Gas with Hydroxyapatite Using Density Functional Theory Atiek Rostika Noviyanti; Azhari Yusuf; Yeni Wahyuni Hartati; Budi Adiperdana
Jurnal Keramik dan Gelas Indonesia Vol 30, No 2 (2021): Jurnal Keramik dan Gelas Indonesia
Publisher : Balai Besar Keramik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32537/jkgi.v30i2.7175

Abstract

Hydroxyapatite (HA) is a phosphate mineral with Ca10(PO4)6(OH)2 chemical formula. The hydroxyl group in HA allows ion to exchange, so this material may be applied as a CO2 gas sensor. The interaction between HA with CO2 gas is difficult to observe directly, and ab initio modeling is necessarily to investigate the interactions between HA with CO2 gas. In this study, a simulation was conducted using the density functional theory method to determine the interaction between CO2 gas on the surface of HA. The simulation results indicate that a large HA surface is required for optimal CO2 gas adsorption. Pore diameter size needs to be larger than 2.5 Å to prevent binding on two sides of the surface pores. 
Application of Gold Silica Nanocomposites in Electrochemical Biosensors: A Review Salma Nur Zakiyyah; Diana Rakhmawaty Eddy; M. Lutfi Firdaus; Yeni Wahyuni Hartati
PendIPA Journal of Science Education Vol 5, No 2 (2021): MARCH - JUNE
Publisher : University of Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/pendipa.5.2.122-132

Abstract

Gold silica nanocomposite-based biosensors are performing well in sensor technology for biosensor development. Due to this biosensor has good selectivity, excellent conductivity, large surface area, efficient enhancement of electron transfer between enzymes and electrodes and good biocompatibility. Therefore, gold silica nanocomposite can be an ideal matrix for immobilization of biomolecules. This review describes the method of synthesizing gold silica nanocomposites and their characterization, interaction with biomolecules and application of gold silica nanocomposites in electrochemical biosensors.
Review: Sintesis Dan Karakterisasi Nanopartikel Emas (AuNP) Serta Konjugasi AuNP Dengan DNA Dalam Aplikasi Biosensor Elektrokimia Egista Istioka Fazrin; Annisa Ilma Naviardianti; Santhy Wyantuti; Shabarni Gaffar; Yeni Wahyuni Hartati
PendIPA Journal of Science Education Vol 4, No 2 (2020): MARCH - JUNE
Publisher : University of Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (726.164 KB) | DOI: 10.33369/pendipa.4.2.21-39

Abstract

The use of gold nanoparticles (AuNP) is an appropriate one in the development of biosensors because it has a unique, strong adsorption, high biocompatibility, and large surface area. AuNPs can be synthesized by various methods with the same synthesis principle by reducing Au3+ to Au. This review explains the various methods of AuNP synthesis and their characteristics, the interaction of AuNP with biomolecules including DNA, and the application of AuNP-DNA bioconjugates in biosensors. Several applications of AuNP-DNA bioconjugates as electrochemical biosensors in the past two years are proposed in this review.
An Electrochemical Immunosensor for the Detection of B-Type Natriuretic Peptide (BNP) Based on Sandwich ELISA Using Screen Printed Carbon Electrodes Yeni Wahyuni Hartati; Muhammad Hilman Daniswara; Ratna Nurmalasari; Shabarni Gaffar; Toto Subroto
Molekul Vol 13, No 1 (2018)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (448.537 KB) | DOI: 10.20884/1.jm.2018.13.1.379

Abstract

B-type natriuretic peptide (BNP) is a 32-amino acid polypeptide, a cardiac neuro hormone that specifically secreted from heart ventricle as a response towards the increase of volume and pressure in the heart. The determination of BNP concentration in patients blood is one of the method used to diagnose heart failure. An electrochemical immunosensor modified with the streptavidin/biotin system on screen printed carbon electrodes for the detection of the BNP antigen was developed in this study. Monoclonal anti-BNP capture antibody was immobilized on streptavidin-modified SPCEs to give a well oriented of antibody. Furthermore, a biotinylated anti-BNP that conjugated with horseradish peroxidase (HRP) was used as secondary antibody. The electrochemical signal produced by redox activity of substrate 3,3,5,5'-tetramethybezidine dihydrochloride (TMB/H2O2) was measured by differential pulse voltammetry. The BNP immunosensor showed a linear response between 1.0×10-2 and 1.0×102 ng/mL, and the limit of detection was 3.3 ng/mL. BNP immunosensor is a promising technology for the rapid and convenient detection of heart failure.
Study of The Interaction Carbondioxide Gas with Hydroxyapatite Using Density Functional Theory Atiek Rostika Noviyanti; Azhari Yusuf; Yeni Wahyuni Hartati; Budi Adiperdana
Jurnal Keramik dan Gelas Indonesia Vol 30, No 2 (2021): Jurnal Keramik dan Gelas Indonesia
Publisher : Balai Besar Keramik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32537/jkgi.v30i2.7175

Abstract

Hydroxyapatite (HA) is a phosphate mineral with Ca10(PO4)6(OH)2 chemical formula. The hydroxyl group in HA allows ion to exchange, so this material may be applied as a CO2 gas sensor. The interaction between HA with CO2 gas is difficult to observe directly, and ab initio modeling is necessarily to investigate the interactions between HA with CO2 gas. In this study, a simulation was conducted using the density functional theory method to determine the interaction between CO2 gas on the surface of HA. The simulation results indicate that a large HA surface is required for optimal CO2 gas adsorption. Pore diameter size needs to be larger than 2.5 Å to prevent binding on two sides of the surface pores. 
A Rapid and Sensitive Diagnosis of Typhoid Fever Based On Nested PCR-Voltammetric DNA Biosensor Using Flagellin Gene Fragment Yeni Wahyuni Hartati; Santhy Wyantuti; M. Lutfi Firdaus; Nurul Auliany; Rini Surbakti; Shabarni Gaffar
Indonesian Journal of Chemistry Vol 16, No 1 (2016)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (333.05 KB) | DOI: 10.22146/ijc.21182

Abstract

Typhoid fever caused by Salmonella typhi is an important issue for public health in the world. Laboratory methods for rapid and sensitive diagnosis are very important for disease management. The purpose of this study was to determine the performance of nested PCR–voltammetric DNA biosensor using flagellin gene (fla) of S. typhi as a marker. The differential pulse voltammetry using pencil graphite electrode was applied to measure the guanine oxidation signal of probes vs synthetic target stDNA and probes vs fla PCR product hybridizations. The probe DNA selectivity was examined by hybridized probes vs non-complementary sequence. The result showed that the first round nested PCR product can not be visualized by agarose electrophoresis, whereas using the voltammetric biosensor methods can be detected both for the first or second round nested PCR product. The average peak current of hybridized probe vs first and second round of PCR product was 2.32 and 1.47 μA respectively, at 0.9 V. Detection of the DNA sequences of the infectious diseases from PCR amplified real sample was also carried out using this voltammetric DNA biosensor methods.
An Electrochemical Aptasensor for the Detection of HER2 as a Breast Cancer Biomarker Based on Gold Nanoparticles-Aptamer Bioconjugates Yeni Wahyuni Hartati; Sari Syahruni; Shabarni Gaffar; Santhy Wyantuti; Muhammad Yusuf; Toto Subroto
Indonesian Journal of Chemistry Vol 21, No 6 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.67124

Abstract

Inaccurate diagnoses contributes to the high mortality rate of breast cancer. Human epidermal growth factor receptor 2 (HER2) is overexpressed in breast cancer tumors at around 20–30%. This study aims to develop an electrochemical biosensor for HER2 based on a gold nanoparticle-aptamer bioconjugate (AuNP@HER2 aptamer) and investigate the interaction between DNA aptamer and HER2 using computational methods. The bioconjugate was synthesized using maleimide and polyethylene glycol as a linker. The –NH2 group of cysteamine that modified the gold electrode can form a covalent bond with the bioconjugate maleimide. The interaction of the bioconjugated aptamer with HER2 was measured electrochemically based on the [Fe(CN)6]3−/4− redox system. The limit of detection, the linear range of HER2, precision, and accuracy in this study were 1.52 ng mL–1, 0.01 to 15.0 ng mL–1, 0.1298, and 94.06%, respectively. The structure of the DNA aptamer was modeled using mFold, Assemble2, and Chimera, with the interaction between the DNA aptamer and HER2 explored by NPDock. The modeling of the aptamer with HER2 showed that electrostatic interactions dominated the attractive forces. The resulting interaction pattern can be used as a template to improve the binding energy of the aptamer, thus providing insight into the development of aptamer-based biosensors.
The Effect of Acetonitrile Solvent on the Quantitative Determination of Europium (III) by Voltammetry and its Optimization using the Box-Behnken Design Uji Pratomo; Ari Hardianto; Yeni Wahyuni Hartati; Husein Hernandi Bahti; Santhy Wyantuti
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 8, No. 1, May 2022
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v8i1.22508

Abstract

There is often a drawback during the determination of Eu in aqueous solvents using the voltammetric method. The current signal from water can reduce that of the element, which causes difficulty while separating the Eu signal from other rare earth elements (REE). Therefore, this study used acetonitrile as a solvent due to its high electrical conductivity and wide potential range. The optimum conditions for the determination of Eu in acetonitrile using the Box-Behnken design include 74.56 seconds deposition time, 0.125 V amplitude modulation, and -2.0 V potential deposition. The platinum electrode's performance showed a recovery value of 98.91% and accuracy and precision (in %RSD) of 96.67% and 1.11%, respectively. Furthermore, detection and quantitation limits of 0.6 mg/L and 5.1 mg/L were recorded from the analysis. It concluded that the differential pulse voltammetry method was applied to determine the presence of Eu in acetonitrile.
Optimization of Aptamer-Based Electrochemical Biosensor for ATP Detection Using Screen-Printed Carbon Electrode/Gold Nanoparticles (SPCE/AuNP) Rahmaniar Mulyani; Nida Yumna; Iman Permana Maksum; Toto Subroto; Yeni Wahyuni Hartati
Indonesian Journal of Chemistry Vol 22, No 5 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.72820

Abstract

Electrochemical biosensors are used to detect adenosine triphosphate (ATP) levels, which are involved in a variety of biological processes, such as regulating cellular metabolism and biochemical pathways. Therefore, this research aims to develop an aptamer-based electrochemical biosensor with Screen Printed Carbon Electrode/gold nanoparticles (SPCE/AuNP) and collect data as well as information related to ATP detection. The modification of SPCE with AuNP increased the analyte’s binding sensitivity and biocompatibility. The aptamer was selected based on its excellent bioreceptor characteristics. Furthermore, aptamer–SH (F1) and aptamer-NH2 (F2) were immobilized on the SPCE/AuNP surface, which had been characterized using SEM, EIS, and DPV. Also, the ATP-binding aptamers were electrochemically characterized using the K3[Fe(CN)6] redox system and Differential Pulse Voltammetry (DPV). According to the optimization results using the Box-Behnken experimental design, the ideal conditions obtained from the factors influencing the experiment were the F1 concentration and incubation time of 4 µM and 24 h, respectively, as well as F1/F2/ATP incubation time of 7.5 min. Meanwhile, for the range of 0.1 to 100 µM, the detection (LoD) and quantification (LoQ) limits were 7.43 and 24.78 µM, respectively. Therefore, this aptasensor method can be used to measure ATP levels in real samples.
Biosensor Elektrokimia untuk Memonitor Level Hemoglobin Terglikasi (HbA1c) pada Penyakit Diabetes Melitus Sheila Destiani; Iman Permana Maksum; Yeni Wahyuni Hartati
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 1 (2023): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.1.58439.94-107

Abstract

Hiperglikemia merupakan ciri diabetes melitus, sekelompok penyakit metabolik yang disebabkan oleh kelainan sekresi insulin, kerja insulin, atau keduanya. Hiperglikemia dapat menyebabkan kerusakan jangka panjang, disfungsi, dan kegagalan berbagai organ, terutama jantung, mata, saraf, pembuluh darah, dan ginjal. Oleh karena itu, diagnosis dan pemantauan rutin kadar glukosa darah sangat penting dilakukan. Hemoglobin terglikasi (HbA1c) adalah hemoglobin yang berikatan dengan glukosa dalam darah dan ditetapkan menjadi biomarker hiperglikemia yang dapat mengindikasikan diabetes atau prediabetes. Akan tetapi, pengukuran HbA1c di laboratorium klinis membutuhkan instrumen yang canggih dan mahal, tenaga ahli khusus dan waktu lama. Oleh karena itu, biosensor elektrokimia kemudian mulai dikembangkan untuk mendeteksi kadar HbA1c karena mudah digunakan, hasil cepat, dan harga yang murah. Ulasan ini membahas biosensor elektrokimia untuk mendeteksi HbA1c dan metode imobilisasi bioreseptor.Electrochemical Biosensor for Monitoring Glycated Hemoglobin (HbA1c) Levels in Diabetes Mellitus. Hyperglycemia is a hallmark of diabetes mellitus,  a group of metabolic diseases caused by defects in insulin action, insulin secretion, or both. Hyperglycemia can cause long-term damage, dysfunction, and failure of various organs, especially the heart, blood vessels, eyes, nerves, and kidneys.. Therefore, routine diagnosis and monitoring of blood glucose levels are very important. Glycated hemoglobin (HbA1c) is hemoglobin that binds to glucose in the blood and is established as a biomarker of hyperglycemia that may indicate diabetes or prediabetes. However, measurement of HbA1c in the clinical laboratory requires large and expensive instruments, specialized experts, and takes a long time. Therefore, an electrochemical biosensor began to be developed to detect HbA1c levels because it is easy to use and has fast results at lower prices. This review discusses electrochemical biosensors for detecting HbA1c and the immobilization of bioreceptors. 
Co-Authors Afrizal Mayub Aga Adi Masyhuri Amelia Shafira Annisa Ilma Naviardianti Annisa Ilma Naviardianti Annisa Luthfiah Ari Hardianto Arum Kurnia Sari Atiek Rostika Noviyanti Azhari Yusuf Azizah, Mamlikatu Ilmi Budi Adiperdana Dewi Handayani Diana Hendrati Diana Hendrati Diana R. Eddy Diana Rakhmawaty Eddy Diding Mandala Putra Egista Istioka Fazrin Ekawardani, Savira Elin Marlin Elsa Nur Utami Fadhilah, Riana Adisti Firdaus, Muhammad Lutfi Ghina Nur Fadhilah Hesti Lina Wiraswati Husein Hernadi Bahti Husein Hernandi Bahti Iman Permana Maksum Irkham Irkham Irkham, Irkham Khaerani, Wulan Lena Rahmidar Lia Faridah Lubis, Rubianto A. M. Lutfi Firdaus M. Lutfi Firdaus M. Lutfi Firdaus Mahendra Permadi Masyhuri, Aga Adi Muhamad Diki Permana Muhammad Hilman Daniswara Muhammad Yusuf Mulyani, Rahmaniar Nida Yumna Nurmalasari, Ratna Nursaadah, Euis Nurul Auliany Pratomo, Uji PUTRI, RAFIKA Putri, Rafika Nanda Rahmaniar Mulyani Ravenna Aristantia Riana Adisti Fadhilah Rini Surbakti Rizki M. Okumura Rizki Muharami Cedia Sari Rubianto A. Lubis Rukiah Rukiah Rustaman Rustaman Safri Ishmayana Salma Nur Zakiyyah Santhy Wyantuti Sari Syahruni Savira Ekawardhani Shabarni Gaffar Shabrinna, Hanif Shauvina, Shauvina A Sheila Destiani Solihudin Solihudin Supriyadi, Isma Yustifania Titin Sofyatin Toto Subroto Uji Pratomo Yohan Yohan Yohan Yohan Zakiyyah, Salma Nur Zalfadilah, Faizal Nur Zein, Muhammad Ihda Hamlu Liwaissunati