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All Journal Jurnal Kimia Mulawarman Jurnal Surya Medika Jurnal Biologi Tropis Jambura Journal of Health Sciences and Research Jurnal Sehat Mandiri INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Pendidikan dan Konseling Jurnal EduHealth Jurnal Farmasetis Health Research Journal of Indonesia Journal of Pharmaceutical and Sciences. PharmaCine: Journal of Pharmacy, Medical and Health Science Journal of Pharmascience
Vriezka Mierza
Universitas Singaperbangsa Karawang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Article Review: Potensi Senyawa Xanthone dalam Ekstrak Kulit Manggis (Garcinia Mangostana l.) sebagai Senyawa Aktif Obat Khuriyah Khuriyah; Vriezka Mierza
Jurnal Sehat Mandiri Vol 20 No 2 (2025): Jurnal Sehat Mandiri, Volume 20, No.2 Desember 2025
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v20i2.1736

Abstract

The high prevalence of communicable and non-communicable diseases in Indonesia, such as periodontal disease, malaria, diabetes, and Alzheimer’s, highlights the need for safer and more affordable alternative therapies. One promising natural source is mangosteen (Garcinia mangostana L.), which contains xanthone compounds with diverse biological activities. This study aims to review the potential of xanthones from mangosteen pericarp extract as active drug candidates. A comprehensive literature review was conducted by searching articles in Scopus, Google Scholar, and PubMed databases using relevant keywords including “xanthone” and “Garcinia mangostana.” Eligible articles were selected based on inclusion criteria (2014–2024, full-text availability, relevance, and reputable indexing). From 221 identified studies, 9 key articles were analyzed in detail. The findings reveal that xanthone compounds exhibit a wide range of pharmacological activities, including antibacterial, antimalarial, antidiabetic, anticancer, cardioprotective, anti-Alzheimer’s, protective effects against oxidative stress in keratinocytes, and potential COVID-19 therapy through ACE2 and Mpro blockade. These results suggest that xanthones from mangosteen peel hold great potential to be developed as active compounds in modern herbal medicines. Nevertheless, further studies, particularly clinical trials, are required to validate their safety and efficacy.
Penggunaan Spektrofotometri Inframerah dan Nuclear Magnetic Resonance Terhadap Penentuan Struktur Senyawa Metabolit Sekunder Yuniar Fathil Ilmi; Vriezka Mierza
JURNAL KIMIA MULAWARMAN Vol 22 No 2 (2025)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v22i2.1492

Abstract

Spektroskopi Inframerah (IR) dan Nuclear Magnetic Resonance (NMR) adalah dua teknik analisis yang digunakan secara luas dalam penentuan struktur metabolit sekunder. Metabolit sekunder merupakan senyawa organik dalam aplikasi farmasi yang signifikan, namun hanya sebagian kecil yang telah dikarakterisasi secara mendalam. Tinjauan ini bertujuan untuk mengeksplorasi prinsip kerja, metode interpretasi data, serta keunggulan dan keterbatasan teknik IR dan NMR dalam karakterisasi struktur metabolit sekunder. Metode yang digunakan adalah studi literatur sistematis dengan menganalisis artikel dalam rentang waktu 2013-2023, meliputi penerapan spektroskopi IR dan NMR secara individual maupun kombinasi keduanya. Hasil menunjukkan bahwa IR efektif dalam identifikasi gugus fungsi melalui analisis spektrum serapan inframerah, sedangkan NMR memberikan detail struktur molekul, seperti konektivitas atom dan stereokimia. Kombinasi kedua teknik ini meningkatkan efisiensi dan analisis akurasi dengan memanfaatkan keunggulan masing-masing. Studi kasus pada karakterisasi α-Mangostin menunjukkan keberhasilan penerapan integrasi IR dan NMR dalam menentukan struktur senyawa kompleks. Kesimpulannya, kombinasi IR dan NMR merupakan pendekatan strategi untuk karakterisasi metabolit sekunder, memberikan panduan praktis bagi penelitian lanjutan, serta berpotensi diterapkan dalam pengembangan obat berbasis senyawa bioaktif.
Literature Review: The Antimicrobial Potential of Xanthorrhizoland and Curcuminoids from the Rhizomes of Curcuma Xanthorrhiza (Temulawak) Habibah Habibah; Vriezka Mierza
Jurnal Biologi Tropis Vol. 26 No. 1 (2026): Januari-Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i1.10810

Abstract

Antimicrobial resistance is a global threat that drives the search for new antimicrobial agents derived from natural sources. Temulawak (Curcuma xanthorrhiza) contains two major active compounds, xanthorrhizol and curcuminoid, known for their antimicrobial properties. This review aims to analyze and compare the antimicrobial potential of these compounds to determine the most prospective candidate for development as an active natural antimicrobial agent in Indonesia. A systematic literature review was conducted using the PRISMA guideline on articles published between 2015 and 2025, obtained from Google Scholar and PubMed. Of the 251 articles identified, 10 met the inclusion criteria and were analyzed. The results indicate that xanthorrhizol exhibits stronger and broader antimicrobial activity, with a Minimum Inhibitory Concentration (MIC) of 16 µg/mL, inhibition zones of 12–14 mm, and inhibition rates exceeding 90% against Candida albicans and Enterococcus faecalis. In contrast, curcuminoid shows variable activity (inhibition zones of 0–16 mm) and its effectiveness increases after photodynamic activation (Photodynamic Therapy, PDT) through the formation of Reactive Oxygen Species (ROS). In conclusion, xanthorrhizol is more promising as a primary natural antimicrobial agent, while curcuminoid serves as a complementary compound to enhance antimicrobial effectiveness.
The Literature review: Investigasi Perbandingan Antioksidan pada Tanaman Obat Herbal di Pulau Jawa dengan Spektrofotometri UV-Vis dan Metode DPPH (2,2-difenil-1-pikrilhidrazil) Madame Marselly Sebayang; Vriezka Mierza
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.554

Abstract

Due to environmental changes and pollution due to free radicals, interest in alternative medicine is increasing, especially on the island of Java. Natural health solutions are increasingly needed, which is what prompted this research. We measured the concentration of antioxidant compounds using the UV-Vis spectrophotometric method and the free radical scavenging capacity of plant extracts using the DPPH method. Using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and UV-Vis spectrophotometric methods with IC50 value determination, this article aims to investigate and compare potential herbal plants found on the island of Java. This research was carried out using a literature review method by considering inclusion and exclusion criteria with keywords such as antioxidants, herbal medicinal plants, UV-Vis spectrophotometry, and DPPH method. The results showed that the plant species studied had different antioxidant activities. Some herbs have high levels of antioxidants, so they may be used as natural health supplements. Additionally, this study emphasizes how important it is to use accurate analytical methods to evaluate antioxidant content. To provide a comprehensive picture of the antioxidant potential of each plant, UV-Vis spectrophotometry and DPPH methods work together. The results show that this study identified several herbal plants on the island of Java that have high levels of antioxidants. These plants can be used to develop herbal-based health products. To carry out a comparative evaluation of antioxidant content, the UV-Vis and DPPH spectrophotometric methods were proven to be effective. This discovery can be the basis for further research and development of more effective and useful herbal health products.
Co-Authors Adelia Fatharani Adella Aisiyah Ahsanal Kasasiah Alfina Oktavianti Aliya Azkia Zahra Aliya Azkiya Zahra Alya Nafis Andien Ravelliani Angel Novia Fransiska Antolin Antolin Arline Rahmadianti Kusumawardhani Asri Yuniar Dwi Nanda Audi Ichsani Ayu Atikah Ramadhani Bismar Al Bara Chalisya Vanya Advaita Cindhy Maulida Nurawaliah Deborah Chennia Lau Diah Muldianah Dinda Shafira Rahmawati Diva Afiah Hanifa Irawan Elvira Julia Ariyanto Eva Zuhra Febi Febriani Hasanah Florence Devina Telaumbanua Galih Ibnu Mukti Habibah Habibah Hasna' Nisrina Ihsan Alfi Andri Imel Ramelia Hudaya Intan Ardhita Irene Virda Sakinah Jekmal Malau Khamairah Azzahrawaani Hermawan Khuriyah Khuriyah Lestari Mahardika Urbaningrum Lhidya Halizah Malik Madame Marselly Sebayang Marisah Marisah Mulidini Mulidini Munir Alinu Mulki Naila Fathna Nurul Hamidah Najla Yusiana Wahyudi Najwa Adiva Faiza Setyawan Nolla Olipia Elva Megrian Nur Aenah Nur Komala Fitri Nur Sa’diyyah Nurlaela Nurlaela Nurma Dwi Priscinya Christiana Debora PUTRI MUTIARA ISKANDAR Putri Wulanbirru Rahma Julita Regita Nailuvar Saarah Hamidah Asmara Indratno Salsabila Granadha Nibullah Shafira Intan Anggraini Shinta Puspa Dwiyanti Silvana Lestari Irwansyah Silvia Primastuti Daeli Siti Nafisa Sofianti Hidayat Sridevi Sridevi Sudarjat, Hadi Sudewi Sudewi Sumardi Sumardi Syfa Dwi Tiwi Ambarati Vina Luthfiana Hasna Welly Windari Wildani Zakiyah Yessi Febriani Yuniar Fathil Ilmi Zuyyinna Alya Abbas