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All Journal Jurnal Kesehatan Saintika Meditory Nusantara Hasana Journal Scientific Journal Majority Science Journal Jurnal Pengabdian Masyarakat Kesehatan (JURABDIKES) Journal of Public Health Science (JoPHS)
Irwan Triansyah, Irwan
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : Majority Science Journal

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EFFECT OF ALOIN EXTRACT ON THE INCREASE OF FIBROBLAS CELL EXPRESSION ON HEALING OF WOUND WOUNDS OF HORSE WHITE RATS (Rattus norvegicus) BY THE AGING PROCESS Dewi , Nadia Purnama; Vedora, Monica Putri; Vani, Ade Teti; Abdullah, Dessy; Triansyah, Irwan
MSJ : Majority Science Journal Vol. 1 No. 4 (2023): MSJ-December
Publisher : PT. Hafasy Dwi Nawasena

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61942/msj.v1i4.92

Abstract

Motivation/Background: The wound healing of aging skin can be assisted by using aloin that increases fibroblast cells. The aim of this research is to determine the effect of aloin extract on increasing fibroblast cells in wound healing in male rats (Rattus norvegicus) with aging process The method research is a post-test control group design. The research sample use twenty-four of six months male rats (Rattus norvergicus) which were divided into 4 groups. Fibroblast assessment was carried out on days 7 and 14 of aloin treatment. Fibroblast data was processed using normality test and significance tests, carried out using the measured repeated test followed by Bonferonni test. The results is highest number of fibroblasts on day 7 was in the control group (+) treated with 10% povidone iodine. The highest number of fibroblasts on day 14 was in treatment group 2 which was given aloin. The statistical test Measure Repeated test said that there was no significant difference between the control and treatment groups p = 0.503 (p> 0.05). However, in the Bonferonni post hoc test, the value of p = 0.000 was obtained, which means that giving aloin can increase the number of fibroblast cells. The conclusions is aloin extract increased the number of fibroblast cells in wound healing of male rats (Rattus norvegicus) with aging process, which has the same effectiveness as povidone iodine
IN VIVO ACUTE TOXICITY OF ALOIN EXTRACT ON MALE WHITE MICE (Mus musculus) Vani, Ade Teti; Putri, Amalia Rahma; Abdullah, Dessy Abdullah; Dewi, Nadia Purnama; Triansyah, Irwan
MSJ : Majority Science Journal Vol. 2 No. 1 (2024): MSJ-February
Publisher : PT. Hafasy Dwi Nawasena

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61942/msj.v2i1.101

Abstract

Aloin has many benefits potential as a medicine. However, it is necessary to carry out toxicity tests on experimental animals as a pre-screening test. Toxic effect parameters were seen from changes in body weight, tremors, convulsions, salivation, weakness, walking backward, walking on the stomach, death, and levels of SGOT and SGPT in experimental animals. This study aims to evaluate the in vivo acute aloin toxicity test results in mice (Mus Musculus) regarding potential toxic symptoms and animal death. A sample of 27 mice were separated into three groups for this investigation: the control group, the treatment group I at a dose of 2500 µg/kg BW, and the treatment group II at an amount of 5000 µg/kg BW, and 5 mice in the preliminary test. This study employed a laboratory experimental test method using a pre-post control group design study. Based on observations of experimental animals, it concluded neither the preliminary test nor the toxicity test revealed any toxic signs. Neither the initial test nor the toxicity test resulted in any observed animal fatalities. Before and after aloin administration, changes in body weight were significantly different. Treatment group II, treatment group I, and the control group's SGOT levels were classified from highest to lowest, with subsequent values of 22.4 U/L, 21.9 U/L, and 19.9 U/L. The highest value of 35.7 U/L, 32.1 U/L, and 26.2 U/L in the treatment groups II, I, and the control group was used to rank the SGPT levels. There were no toxic symptoms and no mortality in experimental animals, so it can be concluded that aloin did not cause harmful effects in mice, so it was categorized as a pseudo-lethal dose.
Co-Authors Abdullah, Dessy Abdullah, Dessy Abdullah Ade Teti Vani Anita Darmayanti Aryaldi Zulkarnaini Aryaldy Zulkarnaini Dessy Abdullah Dewi , Nadia Purnama Dewi, Nadia Purnama Elsa Ardana Etana, Estika Eva Fitriyasi, Betty Jefri Henky Khomeini Khomeini Lesdamiati Lestari, Mayang Melya Susanti Muhammad Ivan Nadia Purnama Dewi Nilas Warlem Purnama Dewi, Nadia Putri, Amalia Rahma Putri, Shyntia Peratami Revivo Rinda Pratama Rika Amran Rosmaini Sri Nani Jelmila Suharni Teti Vani, Ade Vani, Ade Teti Vedora, Monica Putri Vina Tri Septiana Yanti Fitri Yasa Zulkarnaini, Aryaldi