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All Journal MPI (Media Pharmaceutica Indonesiana) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) JSFK (Jurnal Sains Farmasi & Klinis) Journal of Science Innovare FITOFARMAKA: Jurnal Ilmiah Farmasi Majalah Farmasetika Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Journal Of Pharmacy
Lusi Indriani
Program Studi Farmasi FMIPAKes Universitas Muhammadiyah Riau
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Aktivitas Antikoagulan Ekstrak Daun Pucuk Merah (Syzygium myrtifolium Walp.) pada Mencit Putih (Mus musculus L.) Lusi Indriani; Rahmawati, Noveri; Sartika Murni
The Journal Of Pharmacy Vol. 3 No. 1 (2025): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

Red shoot leaves are known to contain secondary metabolic compounds such as alkaloids, flavonoids, tannins, triterpenoids, steroids, saponins, and phenolic compounds. Flavonoids are known to have cardioprotective activity, including the ability to inhibit platelet aggregation. This study aims to determine the potential of red shoot leaf extract (Syzygium myrtifolium Walp.) as an anticoagulant. The method used is the determination of coagulation time, carried out on days 0, 3, and 6, following the initial wounding of the mice’s tails. The tail is wounded using a sterile lancet at a distance at 2 cm from the tip, and blood is subsequently absorbed using a capillary tube. Coagulation time is measured by observing the formation of fibrin threads on the broken sections of the capillary tube every 15 seconds. Coagulation time is the time required for the formation of the fibrin thread. The study results on day 6 showed that the 100 mg/KgBW dose group of red shoot leaf ethanol extract demonstrated an effect of increasing coagulation time equivalent to the 100 mg acetosal group. Meanwhile, the 125 mg/KgBW dose group of red shoot leaf ethanol extract showed a stronger effect than the 100 mg acetosal group.
Co-Authors Aldryan Racka Pratama Alfahtiah Zurlina Almasyhuri Almasyhuri Amalul Ahli Azzikri Anton Bahtiar Arfian Eka Saputri Ayu Rahmawati Bina Lohita Sari Cantika Zaddana D Prasetyorini Devi Fitriyanti Dewi Oktavia Emy OKTAVIANI Erni Rustiani Faisal Pradana Hari, Dewi Gulyla Haryanti Wulandari Ike Yulia Wiendarlina Juniarti Sri Maryati Sitinjak Jupersio Jupersio Mira Dewi Moerfiah Moerfiah Muhammad Raifal Khairi Mutiara Oktavia Sembiring Naufal Muharam Nurdin Nawwar Irfan Nisa Najwa Rokhmah Noveri Rahmawati Novita Sari Nur Shania Nurdina Putri Nursyafni Retnosari Andrajati Sari Rahmadhani Sartika Murni Septia Andini Siti Niqmatun Jannah Tri Nova Lovena Zunnita, Oktaviana