Article Per Year (5 Year)
p-Index From 2020 - 2025
1.829
P-Index
This Author published in this journals
All Journal MPI (Media Pharmaceutica Indonesiana) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) JSFK (Jurnal Sains Farmasi & Klinis) Journal of Science Innovare FITOFARMAKA: Jurnal Ilmiah Farmasi Majalah Farmasetika AS-SHIHA: JURNAL KESEHATAN Journal Of Pharmacy
Lusi Indriani
Program Studi Farmasi FMIPAKes Universitas Muhammadiyah Riau
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary

Published : 20 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 20 Documents
Search

 1   2 
EVALUASI PEMBERIAN ANTIBIOTIK PADA PASIEN DEMAM TIFOID DI INSTALASI RAWAT INAP RUMAH SAKIT AZRA KOTA BOGOR Dewi Oktavia; Lusi Indriani; Mira Dewi
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 10, No 1 (2020): FITOFARMAKA | Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (512.814 KB) | DOI: 10.33751/jf.v10i1.1938

Abstract

Demam tifoid adalah penyakit yang disebabkan oleh bakteri Salmonella typhi atau Salmonella thyposa dari genus Salmonella. Gejala penyakit demam tifoid biasanya berkembang dalam1-3 minggu pasca terpapar bakteri yang ditandai demam tinggi, malaise, sakit kepala, sembelit atau diare, bintik-bintik kemerahan pada dada, serta pembesaran limpa dan hati. Untuk memastikan penyebab demam tifoid pemeriksaan laboratorium mikrobiologi sangat diperlukan. Idealnya adalah test Widal dan kadar leukosit, selain itu perlu diperhatikan juga gejala-gejala klinis seperti suhu tubuh, tingkat kesadaran, nyeri perut, mual atau muntah dan nafsu makan. Tujuan dari penelitian ini adalah menilai efektivitas antibiotik yang digunakan pasien yang menderita demam tifoid. Penilaian dilakukan dengan melihat hasil widal test, kadar leukosit, suhu tubuh, tingkat kesadaran, nyeri perut, mual atau muntah, dan nafsu makan. Penelitian dilakukan dengan cara terlebih dahulu mengumpulkan data sekunder dari rekam medis pasien, register pasien, dan resep obat pasien yang terdiagnosis demam tifoid yang disesuaikan dengan kriteria inklusi, kemudian secara non-eksperimental dideskripsikan dengan pendekatan retrospektif. Hasil penelitian menunjukkan bahwa pemberian antibiotik terbukti efektif terhadap widal test sebanyak 85%, terhadap kadar leukosit sebanyak 97%, terhadap suhu tubuh pasien sebanyak 94%, terhadap kesadaran pasien sebanyak 100%, terhadap nyeri perut pasien sebanyak 100%, terhadap mual dan muntah pasien sebanyak 99%, dan terhadap nafsu makan pasien sebanyak 100%.
OPTIMASI EFEK ANALGESIK DAUN BINAHONG DENGAN PENAMBAHAN JAHE DAN KUNYIT SECARA IN VIVO Lusi Indriani; Oktaviana Zunnita; Muhammad Raifal Khairi
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 9, No 2 (2019): FITOFARMAKA | Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (458.902 KB) | DOI: 10.33751/jf.v9i2.1603

Abstract

Penelitian menunjukkan daun binahong (Anredera cordifolia (Ten.) Steenis) dapat dimanfaatkan sebagai analgesik. Ekstrak etanol 70% daun binahong mempunyai daya analgesik sebesar 48,06% pada dosis 1g/kgBB dan 69,33% pada dosis 4g/kgBB pada mencit putih jantan. Jahe dan kunyit sudah terbukti berkhasiat sebagai analgesik. Penelitian ini bertujuan mengoptimasi efek analgesik ekstrak daun binahong dengan penambahan ekstrak jahe dan kunyit pada mencit putih jantan. Mencit putih dibagi menjadi 6 kelompok perlakuan yaitu kelompok dosis 1 (binahong dosis tunggal 20mg/20gBB), dosis 2 binahong:jahe:kunyit (20:1:3,5mg/20gBB), dosis 3 (10:2:3,5mg/20gBB), dosis 4 (10:1:7mg/20gBB), kontrol positif (Natrium diklofenak 0,182mg/20gBB) dan kontrol negatif (CMC Na 0,5%). Efek analgesik diuji menggunakan metode induksi nyeri dengan rangsangan panas. Semua mencit diuji pendahuluan dengan menempatkan mencit di atas hot plate bersuhu 55°C. Parameter yang diamati adalah respon mencit mengangkat kaki belakang atau melompat. Selanjutnya diberikan larutan uji secara oral sesuai dengan dosis yang telah ditentukan. Pengamatan dilakukan pada menit ke- 0, 10, 20, 30, 40, 50 dan 60 setelah pemberian dosis perlakuan. Hasil penelitian menunjukkan bahwa kelompok dosis kombinasi binahong-jahe-kunyit menunjukkan efek analgesik lebih baik dibanding binahong dosis tunggal, dengan daya analgesik lebih dari 50%. Daya analgesik paling tinggi ditunjukkan oleh dosis 4 yaitu kombinasi ekstrak binahong-jahe-kunyit (10 mg/20gBB: 1mg/20gBB:7mg/20gBB) yaitu sebesar 130,87% yang setara dengan Na diklofenak (137,50%).
DRUG RELATED PROBLEMS EVALUATION OF CHRONIC KIDNEY DISEASE PATIENTS IN INPATIENT DEPARTMENT OF FATMAWATI GENERAL HOSPITAL Lusi Indriani; Anton Bahtiar; Retnosari Andrajati
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 3, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.99

Abstract

The use of drugs in patients with decreased renal function allows the occurrence of drug related problems. Pharmacist has responsibility to identify and to prevent drug related problems. This study was proposed to evaluate drug related problems in chronic kidney disease patients in Inpatient Department of Fatmawati General Hospital. It was descriptive analitic study with prospectively approach. The primary data was obtained by identifying drug related problems. The secondary data was taken from medical record of chronic kidney disease patients such as: age, sex, the stage of chronic kidney disease, comorbidity, and drug therapy. This study took place in Inpatient Department of Fatmawati General Hospital during the period of January to March 2012. Univariate analysis had done to obtain description of frequency and proportion of research variables such as the patient characteristics who received drug therapy (age, sex, the stage of chronic kidney disease, and comorbidity), the drug therapy characterictics that evaluated based on the number and type of drug therapy and drug related problems. Bivariate analysis of the Spearman correlation test was taken to evaluate whether there was correlation beetwen confounding variables and incident of drug related problems. The evaluation was taken in 40 chronic kidney disease patients with 377 number of drugs. The number of drug related problems was 98 issues (25.99% of prescribing drugs). Type of drug related problems were not optimal effect of drug treatments 62.24%, the incidence of non-allergic adverse drug events 20.41%, and the incidence of toxic adverse drug-events 17.35%. The confounding variables that significantly influence the incidence of drug related problems were comorbidities (r= 0.385; p= 0.014), and the number of drugs (r= 0.604; p= 0.000).Keywords: drug related problems, chronic kidney disease, Fatmawati General Hospital
Profil Kontrol Glikemik Antidiabetik pada Pasien DM Tipe 2 dengan Sirosis Hati Emy Oktaviani; Lusi Indriani; Haryanti Wulandari
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 12, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.68075

Abstract

Diabetes mellitus (DM) is a metabolic syndrome with multi-etiology characterized by chronic hyperglycemia. DM can cause a variety of complications, one of which is impaired liver function. The use of antidiabetics needs to get more attention because most antidiabetics are metabolized in the heart. This study aims to determine the control of antidiabetic glycemic, the relationship of antidiabetic types with effectiveness, as well as factors related to glycemic control in type 2 DM patients with liver cirrhosis.  This research was conducted in June-July at Fatmawati Central General Hospital with cross sectional design and data retrieval period of 2014-2019 conducted retrospectively. The observation parameters of glucose control in this study were current blood sugar (GDS). Of the 106 patients who met the inclusion criteria, it was seen that the use of insulin aspart single in 34 patients showed good glycemic control followed by the use of combination insulin glargine-aspart in 25 patients. The results of the Chi-square analysis showed that there was no significant relationship between the type of antidiabetic on glycemic control (p-value = 0,159). However, the results of the Chi-square test showed that there was a significant relationship between the severity of liver cirrhosis and glycemic control (p-value=0,021) and gender was another factor that also showed a significant relationship to glycemic control (p-value=0,042). The use of insulin aspart alone or in combination with insulin glargine is the best in controlling blood sugar levels while in T2DM patients with liver cirrhosis based on this study.
Penilaian Efektivitas Antihipertensi dan Efek Samping Obat di RSUP Fatmawati Lusi Indriani; Nisa Najwa Rokhmah; Nur Shania
Jurnal Sains Farmasi & Klinis Vol 9 (2022): J Sains Farm Klin 9(suplemen), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.sup.146-151.2022

Abstract

Hipertensi diartikan sebagai kondisi ketika tekanan darah mencapai atau melebihi 140/90mmHg. Dalam keputusan penggunaan obat selalu mempertimbangkan manfaat dan resikonya. Obat antihipertensi dianggap efektif jika dapat mengontrol tekanan darah. Pada penggunaan obat antihipertensi jangka panjang perlu diwaspadai kemungkinan adanya efek samping. Penelitian ini bertujuan untuk menilai efektivitas dan efek samping obat antihipertensi menggunakan data rekam medis pasien rawat inap di RSUP Fatmawati. Penelitian ini bersifat observasional (non eksperimental). Penentuan efektivitas menggunakan desain pre dan post, dan rancangan cross sectional untuk mengidentifikasi efek samping obat dengan pendekatan secara retrospektif. Pengambilan sampel ditentukan secara purposive berdasarkan kriteria tertentu. Data yang diperoleh dianalisis secara univariat dan bivariat dengan pengujian Wilcoxon, uji Spearman dan uji Fisher’s Exact. Studi ini memberikan hasil bahwa mayoritas pasien rawat inap di RSUP Fatmawati berjenis kelamin perempuan, umumnya menderita hipertensi tingkat 2, lebih banyak mendapatkan terapi gabungan. Terdapat perbedaan tekanan darah sebelum dan setelah pemberian terapi antihipertensi (p<0,05)[A1] [A2] . Kejadian efek samping obat akibat penggunaan antihipertensi ditemukan sebanyak 16%. Tidak ada hubungan yang bermakna antara jenis terapi antihipertensi dengan kejadian efek samping obat.
AVOCADO SEEDS (Persea americana Mill.): FORMULATIONS OF ELIXIR VARIED BY SOLVENTS COMPOSITION Septia Andini; Lusi Indriani; Erni Rustiani
Journal of Science Innovare Vol 3, No 1 (2020): Journal of Science Innovare, Volume 03 Number 01 2020
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jsi.v3i1.2805

Abstract

Kidney stones disease is asignificant health problem in the world and Indonesia is no exception. Traditionally, avocado seeds can be used as a laxative medicine for kidney stones disease. Elixiris a clear and sweet hidroalkohol solution intended for oral use and a flavor is usually added to enhance the taste. This study was to determine theformula of the avocado seed elixir which has the best quality and the level of flavonoids.Elixir testing was performedusing several methods such as organoleptic, limpidity, viscosity, pH and specific weightas well as total flavonoids. The result showed that the best elixir formula was the Formula I which composed of 7%avocado seed extract, 5% ethanol, 10% propylene glycol, 40% sirupus simplex, 0.1%, essence mint and 100%aquadestilata ad. Furthermore, Elixirhad a brown color, mint aroma and pretty sweettaste. The test results showed that elixir had a viscosity of 7.92 cP; pH of 5.65; specific weight of 1.0413 g/mL andtotal flavonoids of 2.1020%.
Uji Aktivitas Antiinflamasi Ekstrak Etil Asetat Daun Tumbuhan Akar Kaik-Kaik (Uncaria cordata (Lour.) Merr) pada Tikus Putih (Rattus norvegicus) Jantan Noveri Rahmawati; Dewi Gulyla Hari; Nurbaiti; Ayu Rahmawati; Nursyafni; Lusi Indriani; Tri Nova Lovena; Muhammad Arif; Nofri Hendri Sandi
As-Shiha: Jurnal Kesehatan Vol 3 No 1 (2023): As-Shiha: Jurnal Kesehatan
Publisher : Fakultas MIPA dan Kesehatan, Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Antiinflammatory activity of ethyl acetate extracts of the leaves of plant Akar Kaik-kaik Uncaria cordata (Lour.) Merr on white male rats. This research examined the quality of crude drugs and extracts ethyl acetate. It is intended to obtain raw materials which can ultimately ensure uniform pharmacologic effect. Antiinflammatory activity of the ethyl acetate extract were tested using the method of paw edema against white male rats. The research were 15 rats mile which divided into 5 groups. Negative control (Na CMC 1%), positive control (Na diklofenak dose 4,5 mg/kgBB) and extract group ethyl acetat with the dose 100, 200 and 400 mg/kgBB given orally. The volume measurement after subcutaneous injection caragen 1% performed with one hour interval for 5 hours assessing with pletysmometer and calculated the inhibition persen. The result of this study showed that the quality of crude drugs and extract ethyl acetate meet the specified requirements Indonesian Herbal Pharmacopoeia. Ethyl acetate extract has significant anti-inflammatory effects to the negative control at doses of 200 and 400 mg/kgBB while against the positive control did not differ significantly white male rats.
Potensi Aktivitas Ekstrak Etanol Daun Pucuk Merah (Syzygium myrtifolium Walp.) sebagai Antihiperurisemia pada Mencit Putih (Mus musculus) Lusi Indriani; Ayu Rahmawati; Nursyafni; Nawwar Irfan; Novita Sari
The Journal Of Pharmacy Vol. 1 No. 1 (2023): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hyperuricemia is a condition where uric acid production increases or the kidneys cannot remove uric acid from the body so that uric acid levels in the blood exceed 7.0 mg/dL in men and 6.0 mg/dL in women. One of the secondary metabolites that have the potential to act as anti-hyperuricemia is flavonoids. Red shoots contain flavonoids, alkaloids, terpenoids, chalcones, and tannins. This study aimed to determine the anti-hyperuricemia activity of ethanol extract of red shoots (Syzygium myrtifolium Walp.) in white mice. This study used 16 male white mice which were randomly divided into 4 treatment groups. Group 1 was negative control (Na-CMC 0.5%), group 2 was positive control (allopurinol 300 mg/KgBW), group 3 was dose 1 (pucuk merah ethanol extract 10 mg/kgBW), and group 4 was dose 2 (pucuk merah ethanol extract 15 mg/KgBW). Before giving treatment, mice were first induced with KBrO3 at a dose of 148 mg/KgBW intraperitoneally and initial uric acid levels were measured. Then each group was given oral treatment. Uric acid levels were measured at 30, 60, and 90 minutes. The results showed that the pucuk merah ethanol extract 15 mg/KgBW (dose 2) had an anti-hyperuricemia activity of 62.42% compared to allopurinol 65.80%.
Aktivitas Analgesik Ekstrak Etanol Daun Pucuk Merah (Syzygium myrtifolium Walp.) pada Mencit Putih Jantan (Mus musculus) Lusi Indriani; Tri Nova Lovena; Nursyafni; Nawwar Irfan; Alfahtiah Zurlina
The Journal Of Pharmacy Vol. 1 No. 2 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Analgesics are substances that reduce or eliminate pain without causing loss of consciousness. Traditional medicines are considered safer than synthetic drugs. One plant with potential as an analgesic is the red shoot plant (Syzygium myrtifolium Walp). This plant contains flavonoids, anthocyanins, phenolics, and triterpenoids. This study aimed to determine the analgesic activity of ethanol extract of red shoot leaves (EPM) in male white mice. The analgesic effect was obtained through the writhing test using 1% glacial acetic acid induction. Twenty male white mice were divided into 5 treatment groups, including negative control (0.5% Na CMC), treatment 1 (EPM 3.7 mg/kgBW), treatment 2 (EPM 7.4 mg/kgBW), and treatment 3 (EPM 14.8 mg/kgBW), and positive control (mefenamic acid 500 mg/70 kgBW). All mice were given treatment according to their respective groups. After 30 minutes, all mice were induced with 1% glacial acetic acid at a dose of 10 ml/kgBW intraperitoneally. Then, the number of writhes was observed every 5 minutes for 60 minutes. The average number of writhes data was analyzed using ANOVA and Tukey HSD tests. The results showed that treatment groups 2 (7.40 mg/kgBW) and 3 (14.80 mg/kgBW) showed analgesic activity in male white mice induced by 1% acetic acid. The best dose was 14.80 mg/kgBW with writhing protection of 34.74% and analgesic efficacy of 45.59% compared to mefenamic acid.
Aktivitas Antidiabetes Ekstrak Daun Gaharu (Aquilaria malaccensis Lam) Dan Daun Binahong (Anredera cordifolia) Pada Mencit Jantan Lusi Indriani; Dewi Gulyla Hari; Sari Ramadhani; Nurdina Putri; Siti Niqmatun Jannah
The Journal Of Pharmacy Vol. 2 No. 2 (2025): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The binahong plant (Anredera cordifolia) is known to contain active compounds such as alkaloids, flavonoids, saponins, tannins, and terpenoids that have the potential to lower blood glucose levels. This study aimed to evaluate the antihyperglycemic activity and determine the optimal dose of the combination of ethanol extract of agarwood (Aquilaria malaccensis) leaves and binahong leaves in male mice. The study was conducted experimentally using a Completely Randomized Design (CRD) using 25 mice divided into five treatment groups: a negative control (0.05% NaCMC) and a positive control (metformin). The other three groups were given a combination of agarwood and binahong extracts in dosage ratios of 1:1, 2:1, and 1:2. ANOVA results showed that all extract combinations significantly reduced blood glucose levels compared to the negative control. The 1:1 dose combination showed the best effectiveness, equivalent to metformin, especially on days 3 to 7.
Co-Authors Aldryan Racka Pratama Alfahtiah Zurlina Almasyhuri Almasyhuri Amalul Ahli Azzikri Anton Bahtiar Arfian Eka Saputri Ayu Rahmawati Ayu Rahmawati Bina Lohita Sari Cantika Zaddana D Prasetyorini Devi Fitriyanti Dewi Gulyla Hari Dewi Gulyla Hari Dewi Oktavia Emy OKTAVIANI Erni Rustiani Haryanti Wulandari Ike Yulia Wiendarlina Juniarti Sri Maryati Sitinjak Jupersio Jupersio Mira Dewi Muhammad Arif Muhammad Raifal Khairi Mutiara Oktavia Sembiring Naufal Muharam Nurdin Nawwar Irfan Nisa Najwa Rokhmah Nofri Hendri Sandi Noveri Rahmawati Novita Sari Nur Shania Nurbaiti Nurdina Putri Nursyafni Nursyafni Retnosari Andrajati Sari Ramadhani Septia Andini Siti Niqmatun Jannah Tri Nova Lovena Tri Nova Lovena Zunnita, Oktaviana