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All Journal International Journal of Public Health Science (IJPHS) International Journal of Nusantara Islam Dentino: Jurnal Kedokteran Gigi Berkala Kedokteran Universa Medicina JPKMI (Jurnal Publikasi Kesehatan Masyarakat Indonesia) Edukasi Islami: Jurnal Pendidikan Islam JURNAL PENDIDIKAN TAMBUSAI MUHARRIK: JURNAL DAKWAH DAN SOSIAL YARSI Medical Journal Jurnal Kajian Ilmiah Kesehatan Dan Teknologi (JKIKT) JRTI (Jurnal Riset Tindakan Indonesia) KESANS : International Journal of Health and Science Edu Society: Jurnal Pendidikan, Ilmu Sosial dan Pengabdian Kepada Masyarakat Mudabbir: Journal Research and Education Studies ANWARUL: Jurnal Pendidikan dan Dakwah Jurnal Semiotika-Q: Kajian Ilmu al-Quran dan Tafsir Al-DYAS : Jurnal Inovasi dan Pengabdian kepada Masyarakat Islam & Contemporary Issues Asian Journal of Islamic Studies and Da'wah Algebra Jurnal Kesehatan International Journal of Nusantara Islam Jurnal Studi Islam dan Sosial J-CEKI SINTHOP: Media Kajian Pendidikan, Agama, Sosial dan Budaya
Adenan Adenan, Adenan
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Journal : Universa Medicina

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Stenochlaena palustris aqueous extract reduces hepatic peroxidative stress in Marmota caligata with induced fever Adenan, Adenan; Suhartono, Eko
Universa Medicina Vol 29, No 3 (2010)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2010.v29.123-128

Abstract

The kelakai fern (Stenochlaena palustris) contains bioactive substances, such as flavonoids, steroids, and alkaloids. The kelakai is used by the Kenyah Dayak communities for the treatment of anemia, fever, and cutaneous disorders. Fever is increased temperature regulation of the body, which process indirectly increases the production of peroxides, leading to peroxidative stress. The aim of this research study was to evaluate the influence of an aqueous extract of the kelakai fern on peroxidative stress in the hoary marmot (Marmota caligata) with experimentally-induced fever. This was a true experimental study, with post test-only and control group design, involving 6 groups, each made up of 4 animals. Peroxide concentration was measured by a modification of the FOX2 method and peroxidase activity by the Kanehira method. The kelakai extract was administered to the animals by gavage at weight-adjusted dosages between 7.75 x 10-4 mg/kg body weight to 1.24 x 10-2 mg/kg body weight. Data were analyzed using singe linear regression test. The results showed that kelakai extract dose significantly reduced the peroxide levels, regression equation with the Y = 2.513-106.03 X (R2 = 0.8057), indicating that 80.5% variation of peroxide levels is predicted by the kelakai extract dose. From the results we conclude that kelakai aqueous extract decreases peroxide levels in hoary marmots with experimentally-induced fever.
Co-Authors Aditya, Rifal Aisyah Pulungan Andini, Fara Ariffin, Syamsul Arisa Wulandari, Arisa Arrasid, Saif Atikah Rahayu Audrian, Dimas Aurelia, Dinda Az-zahra, Luthfiyah Azera, Nur Shahidatul Azma Rosida, Azma Azmi, Amirul Maulana Azzahra, Nayla Bambang Setiawan Budi Harianto, Budi Cindyani, Cindyani Daulay, Maraimbang Eko Suhartono Ependi, Mahdar Fadhil, Muhammad Rizky Fadillah, Heny Fahrini Yulidasari Fauzi, Rama Risky Fauzie Rahman Fitri, Rina Annisa Habibie Aldiaman, Habibie Hairullah Hairullah, Hairullah Harahap, Aprilinda Harahap, Diana Sari Harahap, Elly Warnisyah Harahap, Nurul Aini Harahap, Salahuddin Harahap, Sapta Emier Hamdi Hidayah, Septia Nur Humairah, Humairah Ibad, Maulana Imam Syahputra Yamin Inasti, Nine Chintya Ayu Is, Fadhilah Izat, Qomarul Katimin, Katimin Khairunnisa ., Khairunnisa Lubis, Nurasiah Martua, Luthfi Ilham Maulana, Sajid Meitria Syahadatina Noor Mirhansyah Mirhansyah, Mirhansyah Muhammad Jailani Mulia, Sukma Musafaah Musafaah Nasution, Kasron Nirwana, Afrytha Nita Pujianti Noor Rizka Alhamidah, Noor Rizka Nurdila, Siti Nurtsaltsiyah, Metiani Prisca Listyantika, Prisca Pulungan, Aisyah Putri, Aulia Dinda Rahimi, Zukhruf Hafiz Renny Ismaya, Renny Ritonga, Mitta Syahrani Ritonga, Roni Rahmat Rosihan Adhani, Rosihan Safitri, Yuli Salamuddin Salamuddin, Salamuddin Sandika, Firman Aulia Sanyoto, Didik Dwi Saputri, Intan Ayu Siregar, Husna Sari Siti Hajar Tri Anggraini Vina Yulia Anhar Warjio Warjio, Warjio Zauldiyariza, Zauldiyariza Zulkifli Djunaidi, Zulkifli