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All Journal JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) Public Health of Indonesia Jurnal Kesehatan Vokasional Jurnal Ilmu Kesehatan Klinikal Sains (Jurnal Analis Kesehatan) Jurnal Pengabdian Magister Pendidikan IPA INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Bantenese Jurnal Pengabdian Masyarakat Jurnal Kolaboratif Sains Gema Lingkungan Kesehatan Jurnal Abdi dan Dedikasi kepada Masyarakat Indonesia Jurnal Ilmiah Kesehatan Sandi Husada Jurnal Analis Kesehatan Kendari Jurnal Ilmiah Kesehatan Sandi Husada (JIKSH)
Umar, Ani
Politeknik Bina Husada Kendari
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Analysis of the Potential of Platelet Indices as a Predictor of Hematological Comorbidity in Patients with Diabetes Mellitus Umar, Ani; Wenty, Darmayanita; Firdayanti; Susanti; Umar, Heni
Public Health of Indonesia Vol. 11 No. 4 (2025): October - December
Publisher : YCAB Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/phi.v11i4.1591

Abstract

Background: Diabetes Mellitus (DM) is one of the chronic diseases that is a global burden. The increase in DM cases poses a risk of complex comorbidities such as cardiovascular disease, kidney disease and hematological disorders. The Platelet indices (MPV, PDW, PCT, P-LCR) reflects platelet activation and has the potential to be a biomarker for predicting comorbidities, so it can help improve the quality of clinical management in DM patients. Objective: This study aims to evaluate the predictive potential of platelet indices as a biomarker of comorbidity hematology in DM patients. Methods: An analytical study with a cross-sectional design was conducted from June to July 2025 at the Bahteramas Regional Hospital, Indonesia, involving 100 patients with diabetes mellitus and 100 healthy individuals as controls selected through purposive sampling. Venous blood samples were taken from all participants to measure platelet indices (PLT, MPV, PDW, P-LCR) using an automated hematology analysis tool. Data analysis was carried out by an independent sample t-test to compare index values between groups, as well as an ROC curve to evaluate its predictive value against DM status, Statistical significance was set at p < 0.05. Results: showed that the mean platelet indices in the group of healthy individuals with PLT was 229.98 ×10³/μL and in DM patients with a mean value of 260.71 ×10³/μL, MPV in healthy individuals with MPV was obtained at 10.24 fL. In DM it rises to 10.46 fL. The PDW value in healthy individuals was 9.82 fL. In DM the average value increased to 11.80 fL, in Healthy Individuals PCT averaged 24.7%, In DM the value increased to 28.7%. The P-LCR value in healthy individuals was 22.12%. In DM, the average value increased to 25.80%, with a significant value of P< 0.05 which shows that between healthy patients and DM patients there is a significant difference in terms of PLT, MPV, PDW, PCT and P-LCR parameters. The ROC curve of each platelet parameter (PLT, MPV, PDW, PCT, and P-LCR) illustrates the sensitivity and specificity of the model in predicting the occurrence of comorbidities. This can be obtained from the Under the Curve Area Value (AUC) which shows that PDW has the highest AUC of 83.4%, which indicates the ability of the most effective parameters in predicting comorbidities in DM patients. Conclusions: This study shows that platelet indices, especially PDW values, has the most effective potential as a practical and easily accessible hematological biomarker for predicting comorbidity risk in patients with diabetes mellitus. These results confirm the role of the predictive value of platelet indices in early detection and risk stratification, which can support more proactive clinical decision-making and management of DM patients.
Platelet to cholesterol ratio of high density lipoprotein cholesterol is associated with diabetes and comorbidity risk Ani Umar; Firdayanti; Heni Umar; Angriani Fusvita; Susanti; Sri Aprilianti Idris
Gema Lingkungan Kesehatan Vol. 24 No. 2 (2026): Gema Lingkungan Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/gelinkes.v24i2.452

Abstract

This study aims to analyze the relationship between platelet to HDL cholesterol (Platelet to HDL Ratio / PHR) ratio and the presence of type 2 diabetes mellitus, as well as evaluate the ability of PHR as a predictor of comorbidity risk. Multivariate logistic regression analysis was used to estimate the odds ratio (OR) and 95% CI. The discriminatory ability of the model is evaluated with the receiver operating characteristic curve (ROC), with the area under the curve (AUC) used to measure the model's performance. Sensitivity and specificity. This study used a cross-sectional observational design with 220 participants (110 type 2 diabetes patients and 110 non-diabetic controls) from the Southeast Sulawesi Provincial General Hospital. Samples were selected based on inclusion criteria (age 30–70 years, for the diabetes group) and exclusion (such as anemia or use of anticoagulant drugs). Data were collected through clinical examinations (age, BMI, blood pressure, platelet count, HDL). PHR is calculated as the number of platelets (per μL) divided by HDL levels (mg/dL). Statistical analysis was performed using independent t-test, multivariate logistic regression, and ROC curve with SPSS software (p < 0.05). The results showed that PHR was significantly higher in the diabetes group with comorbidities (mean 5.49±2.10) than in healthy individuals (4.25±2.39; p < 0.001). The ROC curve shows an AUC of 0.70 for PHR in predicting comorbidity risk, better than HDL alone (AUC 0.55). This study shows that platelet-to-HDL ratio (PHR) is proven to be a simple and economical potential biomarker for detecting an association with diabetes and predicting the risk of vascular comorbidities. These findings support the use of PHR in routine clinical practice, especially in developing countries such as Indonesia. This research contributes to the strategy for the early prevention of diabetes complications through easily accessible hematological parameters.
Gambaran Kalsium Urin pada Lanjut Usia Warga Tobuha Kecamatan Puuwatu Kota Kendari Muhamma Sultanul Aulya; Siti kaylah; Sri Aprilianti Idris; Firdayanti; Ani Umar
coba Vol 14 No 2 (2026): Mei 2026
Publisher : Akademi Keperawatan Dharma Husada Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32831/jik.v14i2.1016

Abstract

Pendahuluan: Kadar kalsium urin yang tinggi dapat disebabkan oleh peningkatan absorpsi kalsium di saluran cerna atau penurunan deposisi kalsium ke dalam tulang. Kondisi tersebut dapat meningkatkan kadar kalsium dalam darah yang selanjutnya diekskresikan melalui urin. Lansia merupakan kelompok yang rentan mengalami perubahan metabolisme kalsium akibat proses penuaan. Penelitian ini bertujuan untuk mengetahui gambaran kadar kalsium urin pada lansia di Jalan Perkuburan, Kecamatan Puuwatu. Metode: Penelitian ini menggunakan desain deskriptif. Sampel penelitian terdiri atas 33 sampel urin lansia yang berdomisili di Jalan Perkuburan, Kecamatan Puuwatu. Pemeriksaan kadar kalsium urin dilakukan secara kualitatif menggunakan metode Sulkowitch melalui reaksi pengendapan kalsium dengan reagen Sulkowitch. Sampel urin dikumpulkan pada pagi hari dan dianalisis sesuai prosedur pemeriksaan. Hasil: Hasil pemeriksaan menunjukkan bahwa dari 33 responden, sebanyak 7 orang (21,2%) memperoleh hasil negatif, sedangkan 26 orang (78,8%) memperoleh hasil positif kalsium urin berdasarkan metode Sulkowitch. Kesimpulan: Sebagian besar lansia di Jalan Perkuburan, Kecamatan Puuwatu menunjukkan hasil positif kalsium urin berdasarkan pemeriksaan metode Sulkowitch. Temuan ini menunjukkan tingginya proporsi lansia dengan hasil positif kalsium urin sehingga diperlukan penelitian lanjutan menggunakan metode kuantitatif untuk mengukur kadar kalsium urin secara lebih akurat serta mengidentifikasi faktor-faktor yang memengaruhinya. Kata Kunci : Kalsium Urin, Lanjut Usia, Warga Perkuburan.
Analysis of blood calcium levels in calcium water consumers Bonni Rubak; Ani Umar; Reymon Reymon; Nanda Reski Jannah
Jurnal Ilmiah Kesehatan Sandi Husada Vol. 13 No. 2 (2024): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : LPPM Politeknik Sandi Karsa, South Sulawesi, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction: Water is a primary and basic human need. One of the chemical parameters that must be met for drinking water needs is mineral content, such as calcium and magnesium. Water hardness is a condition in which there is excessive calcium and magnesium content, which is commonly known as calcareous water. High water hardness that exceeds normal limits can interfere with body health if consumed long-term. Specifically, excess calcium in the body can cause hypercalcemia, hyperparathyroidism, kidney stones, and muscle tissue damage (muscle weakness). Objective: This study aims to determine blood calcium levels in individuals who consume calcareous healthy water. Methods: The type of research used is descriptive-analytical, with blood calcium level analysis carried out using the Ion Selective Electrode (ISE) method through the Electrolyte Analyzer (CBS400). Result: Based on the results of the study, it was obtained that blood calcium levels in 30 community respondents in Ranomeeto District (100%) were above the reference value, indicating high blood calcium levels. Conclusion: blood calcium levels in people who consume lime juice indicate high blood calcium levels. Consuming water with a high lime content can hurt health. Therefore, people need to consider the quality of the drinking water they drink, especially those that have a high lime content, to maintain heart and kidney health in the long term.
PROFIL LIPID PADA LANJUT USIA SEBAGAI FAKTOR RESIKO PENYAKIT METABOLIK DI KENDARI SULAWESI TENGGARA Ani Umar; Firdayanti Firdayanti; Angriani Fusvita
Klinikal Sains : Jurnal Analis Kesehatan Vol. 12 No. 2 (2024): Desember
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v12i2.5089

Abstract

Metabolic diseases are a global health problem that is increasing especially in developed countries (Silva et al., 2020). The incidence is higher in the elderly population due to physiological and metabolic changes associated with aging (Silva et al., 2020). Lipid profile is an important indicator in assessing the risk of metabolic diseases. Blood lipids include total cholesterol, LDL (Low Density Lipoprotein), HDL (high Density Lipoprotein), and triglycerides, playing a major role in the development of cardiovascular disease. (Emmanuel et al., 2022) The purpose of this study was to determine the lipid profile in the elderly as one of the metabolic diseases. This study used a cross-sectional design with a target population of 50 elderly individuals aged 60 years and over. data were collected through direct measurement of lipid profiles including total cholesterol, triglycerides, HDL, and LDL using the CHOD-PAP method (Chlorimetric Derivate- Para Amino Phenazone) using a spectrophotometer. The results of the study showed that from 50 elderly patients, the lipid profile levels obtained were total cholesterol levels in the normal category with an average cost of 1.66, where 66% of respondents obtained normal cholesterol levels, while 34% showed high cholesterol levels. in the triglyceride variable, the results obtained were 72% of respondents had normal triglyceride levels, while 28% experienced an increase. HDL levels showed more positive results, with 82% of respondents having good HDL levels, and only 18% having low HDL levels, and, analysis of LDL levels revealed that only 8% of respondents had high LDL levels, while 92% had normal LDL levels in men and women, TG/HDL limits are <150 and> 40 mg/dl, and cholesterol limits <200 and LDL <150.
Assessement of Candida albicans of the oral mucosa among type-2 diabetes mellitus patients attending Bahteramas Hospital, Southeast Sulawesi Province Firdayanti Firdayanti; Angriani Fusvita; Ani Umar
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 7 No 2 (2025): From Natural Compounds to Disease Mechanisms: An Integrated Research Outlook
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v7i2.5496

Abstract

Diabetes Mellitus (DM) is a disease characterized by hyperglycemia resulting from either insulin deficiency or insulin resistance. Candida albicans is a fungus generally found on the surface of the mucous membrane, which usually dominates and overgrows among DM patients. This study aims to identify the presence of the C. albicans fungus on the oral mucosa of individuals with Type-2 Diabetes Mellitus at Bahteramas Hospital, Southeast Sulawesi Province, Indonesia. A descriptive study was employed, and a purposive sampling technique was used to select a sample of 62 patients. Swab samples were cultured on Potato Dextrose Agar medium for Gram staining and carbohydrate assimilation tests. The resulting culture was tested using CHROMagarTM Candida (CAC) media. Among the 62 samples, 56 samples were identified to have a convex colony, a cream-color surface, a smooth texture, and a Gram-positive nature. The carbohydrate assimilation test showed that the indicated samples could ferment glucose and maltose, but not lactose and sucrose. Green colonies are formed through CHROMagarTM Candida differential media testing. There are 56 identification results for C. albicans from oral mucosal swab samples from 62 patients with Type-2 Diabetes Mellitus at the Bahteramas Hospital, Southeast Sulawesi Province, yielding six other patients with negative results.
Co-Authors Alma Dita Harun Angriani Fusvita Aulya, Muhammad Sultanul Balaka, Kemal Idris Bonni Rubak Bonni Rubak Darmayanita Wenty Ephi Trianti Fika Firdayanti Firdayanti Firdayanti Firdayanti Firdayanti Firdayanti, Firdayanti Fusvita Idris, Kemal Idris, Sri Aprilianti Jannah, Nanda Reski Jumiati Jumiati Larisu, Zulfiah Muhammad Ilyas Y Nanda Reski Jannah Nur Hijreah Samsu Nurul Afdhaliyah Nurdin Reymon, Reymon Salni Sernita Seren Setiawan, Muh. Azdar Siti kaylah Sri Rahayu Suci Devianti Ningsih SUSANTI Susanti Susanti Umar, Heni Wenty, Darmayanita Yuniar, Viranda Yusran, Sartiah