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All Journal Al-Kimia Majalah Farmaseutik Pharmacology and Clinical Pharmacy Research Pharmaceutical Journal of Indonesia JURNAL FARMASIMED (JFM) BERNAS: Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian UNDIKMA Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Pengabdian Masyarakat Journal of Agropharmacy Dirya : Journal of Economic Management
Wardhani, Firdha Aprillia
Departement Of Clinical And Community Pharmacy, Faculty Of Pharmacy, University Of Jember
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Association of Antiplatelet Type on Length of Stay and Neurological Outcomes in Ischemic Stroke Aprillia Wardhani, Firdha
Pharmaceutical Journal of Indonesia Vol. 10 No. 2 (2025)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Antiplatelet therapy plays an important role in preventing the progression of ischemic stroke. However, the effectiveness of different types of antiplatelet agents in improving clinical outcomes still requires further investigation. This study aimed to analyze the relationship between the type of antiplatelet used and the clinical outcomes of hospitalized ischemic stroke patients, based on changes in the National Institutes of Health Stroke Scale (NIHSS) score and length of stay (LoS). This research was a retrospective cross-sectional observational study involving 92 hospitalized patients with ischemic stroke. Patients were grouped based on the antiplatelet therapy received: Clopidogrel (CPG) (n=58), Aspirin (n=17), and dual antiplatelet therapy (DAPT) with Clopidogrel + Aspirin (n=17). Of the total patients, 43 (46.7%) showed improvement in NIHSS score, while 49 (53.2%) did not. The mean LoS was 7.033 days. The proportion of patients with NIHSS improvement by treatment group showed that the CPG group had the highest percentage of improvement, with 30 out of 58 patients (51.72%), compared to Aspirin 7/17 (41.2%) and DAPT 6/17 (35.3%). However, statistical analysis revealed no significant association between the type of antiplatelet and NIHSS improvement (p = 0.431). In addition, Kruskal-Wallis analysis revealed no significant association between LoS and antiplatelet type (p = 0.429). These findings suggest that other factors may play a more substantial role in determining the clinical outcomes of ischemic stroke patients. Keywords: antiplatelet, clinical outcome, NIHSS, ischemic stroke, LoS
Co-Authors Adelia Firandi Amalia Wardatul Firdaus Amalia Wardatul Firdaus Aryani, Dhita Aryani, Dhita Evi Dian Agung Pangaribowo Didik Hasmono Dwi Koko Pratoko Dyan Wigati Ema Rachmawati Eryani, Mikhania Christiningtyas Fifteen Aprila Fajrin Firandi, Adelia Ika Norcahyanti Khrisna Agung Cendekiawan Kusumaningrum , Yunita Dyah Lina Winarti Nafisah Isnawati NANANG MUNIF YASIN Nia Kristiningrum Ramadhani, Nuril Izzati Farihatur RR. Ella Evrita Hestiandari Shinta Mayasari Shinta Mayasari Sinta Rachmawati Syafika, Devina Sarah Zulkarnain Permana ZULLIES IKAWATI