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All Journal Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY BERDIKARI : Jurnal Inovasi dan Penerapan Ipteks JPSCR : Journal of Pharmaceutical Science and Clinical Research PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Farmasi Indonesia Molekul: Jurnal Ilmiah Kimia Jurnal Abdimas Madani dan Lestari (JAMALI) Sciences of Pharmacy Jurnal Pengabdian Masyarakat Bangsa
Syaiful Choiri
Universitas Sebelas Maret
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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The Effect of Poloxamer 188 on the Solubility and Dissolution Behaviors of Piroxicam-PEG 4000 Solid Dispersions Yugatama, Adi; Azizah, Anas Muti'ah Syahrul; Choiri, Syaiful; Huang, Ya-lin
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN Publishing House

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Abstract

Piroxicam (PRX), a non-steroidal anti-inflammatory drug (NSAID), is classified as a biopharmaceutical classification system class II (high permeability and low solubility), which limits its bioavailability. Enhancement of the dissolution rate is a key strategy to enhance the absorption. Solid dispersion systems, particularly when combined with amphiphilic multiple co-block polymers, offer a promising approach to address this challenge. This study aimed to investigate the effect of Poloxamer 188 (P188) and the solid dispersion technique on the solubility and dissolution rate of PRX. Polyethylene glycol (PEG) 4000-based solid dispersions containing PRX were prepared using varying concentrations of Poloxamer 188 surfactant through the fusion method. The solid dispersions were evaluated for saturated solubility in water for 24 hours. Selected formulations were further characterized using thermal analysis and vibrational spectroscopy. The optimized solid dispersion formulation was filled into capsules, and a dissolution assay was carried out to compare its performance with that of pure PRX capsules. The optimized formula, comprising 3% P188 and PEG4000, demonstrated a significant enhancement in saturation solubility parameters (p < 0.05), specifically the Cmax/S0 ratio. Additionally, dissolution testing showed a 22.22% increase in the dissolution rate of the PRX solid dispersion capsules compared to pure PRX capsules. In conclusion, P188-based solid dispersion containing PRX enhanced the solubility and dissolution rate, potentially improving therapeutic efficacy.
Swamedikasi, DAGUSIBU, dan Waspada Bahan Berbahaya Kosmetik: Pengabdian Masyarakat di Dusun Kepuhsari, Surakarta: Indonesia Ainurofiq, Ahmad; Fatimi, Hana Anisa; Prabowo, Imam; Larasati, Rizky Dwi; Choiri, Syaiful; Az Zahro, Fatimah Aqilah; Usmarini, Razita Fathya; Maharani, Vania; Fauziah, Siva; Purbowati, Dwi; Rinaldi, Rafli; Jauhari, Muh Rizqi Fadlah
Jurnal Abdimas Madani dan Lestari (JAMALI) Volume 08, Issue 1, Maret 2026
Publisher : UII

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jamali.vol8.iss1.art18

Abstract

Inappropriate self-medication limited public understanding of the DAGUSIBU (Dapatkan, Gunakan, Simpan, dan Buang) concept, and the widespread use of harmful cosmetic products remain major challenges in improving community health. This community service activity aimed to increase the knowledge of residents in Dusun Kepuhsari RW 38 regarding rational self-medication, proper application of the DAGUSIBU principle (Get, Use, Store, and Dispose of Medicine Correctly), and the risks associated with hazardous cosmetic ingredients. The activity was carried out through an educational and participatory approach consisting of a pretest, leaflet distribution, direct delivery of material by resource persons, interactive Q&A sessions, distribution of door prizes, and a posttest. The results showed an overall increase in participants' understanding across all three topics. Knowledge of self-medication increased by 1.2 times, while understanding of DAGUSIBU improved by 1.44 times. Education on harmful cosmetics also led to a significant improvement in participants' awareness of product legality, identification of dangerous substances, and associated health risks. Through this educational program, the community is expected to become more informed and responsible in using both medicines and cosmetics safely and wisely.
Co-Authors Ahmad Ainurofiq Ahmad Ainurofiq Ahmad Ainurofiq Ahmad Ainurofiq, Ahmad Ahmad Prakoso Amalia Daryati Az Zahro, Fatimah Aqilah Azizah, Anas Muti'ah Syahrul Azizah, Salma Nur Dinar Sari Cahyaningrum Wahyuni Dwi Larasati Dwi Purbowati ESTU RETNANINGTYAS N Fatimi, Hana Anisa Huang, Ya-lin Ikke Ramandhita Mulia Isnaini Ilham Kuncahyo Ilham Kuncahyo, Ilham Imam Prabowo, Imam Jauhari, Muh Rizqi Fadlah Larasati, Rizky Dwi Maharani, Vania Meila Tunjung Suryaningrum Muhammad Adam Firdausi Nestri Handayani Pratama, Tiara Dewi S. Pratama, Tiara Dewi Salindri Rafli Rinaldi Rita Rakhmawati Rita Rakhmawati, Rita Saptono Hadi Saptono Hadi Saptono Hadi, Saptono Siva Fauziah, Siva T.N. Saifullah Sulaiman Usmarini, Razita Fathya Wahyuni, Dinar Sari C Wahyuni, Dinar Sari C.