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All Journal Farmaka Indonesian Journal of Pharmaceutical Science and Technology IDJP (Indonesian Journal of Pharmaceutics) Indonesian Food Science and TechnologyJournal Majalah Farmasetika ad-Dawaa : Journal of Pharmaceutical Sciences Community Development Journal: Jurnal Pengabdian Masyarakat Indonesian Journal of Biological Pharmacy Journal of The Indonesian Society of Integrated Chemistry Kartika : Jurnal Ilmiah Farmasi
Anis Yohana Chaerunisaa, Anis Yohana
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Beyond The Skin Barrier: How Transfersomes and Transethosomes are Revolutionizing Topical Therapies Widayanti Supraba; Husni, Patihul; Chaerunisaa, Anis Yohana
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.57146

Abstract

Introduction: The fundamental challenge of effective skin permeation has long limited the therapeutic potential of topical drug delivery systems. Conventional formulations frequently fail to achieve adequate penetration through the skin barrier, necessitating innovative approaches to enhance drug bioavailability while maintaining targeted delivery to specific skin layers.  Aims: This review evaluates the transformative impact of transfersomes and transethosomes as advanced nanovesicular systems designed to overcome traditional limitations in topical drug delivery. Methods: The review examines ultra-deformable nanovesicle technologies through comprehensive analysis of their operational mechanisms, including osmotic gradient exploitation in transfersomes and ethanol-facilitated lipid fluidization in transethosomes. Performance comparisons with conventional formulations across various therapeutic applications were conducted to assess clinical efficacy and delivery capabilities. Result: These nanovesicular systems demonstrate superior performance in delivering diverse therapeutic agents to targeted skin layers while effectively minimizing systemic absorption. The analysis reveals significant advantages over traditional formulations, with enhanced penetration capabilities that extend to macromolecular therapeutics and biologics when integrated with complementary technologies such as microneedle arrays and iontophoresis. Current research developments focus on addressing existing limitations through lyophilization techniques, hybrid polymer systems, and advanced manufacturing processes. Conclusion: Transfersomes and transethosomes represent a significant advancement in topical drug delivery technology, offering promising solutions to longstanding permeation challenges. The future trajectory toward personalized formulations and sustainable production methods using plant-derived components indicates their potential to fundamentally redefine treatment approaches in dermatology, oncology, and pain management, establishing minimally invasive yet highly effective therapeutic options as the standard in patient care.
Phytochemical Screening And Antioxidant Activity Test of Lupun Root (Poikilospermum suaveolens (Blume) Merr) from South of Borneo Mardiana, Lia; Milanda, Tiana; Hadisaputri, Yuni Elsa; Chaerunisaa, Anis Yohana
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.51350

Abstract

Lupun root is the local name for Poikilospermum suaveolens (Blume) Merr. in the Aranio region, South of Borneo, Indonesia. P.suaveolens is a medicinal plant traditionally used to treat various ailments and to enhance the body’s immune function. This study aimed to investigate the secondary metabolites and antioxidant capacity of the ethanol extract derived from the root of Lupun (P. suaveolens). Samples were collected from Aranio, South Borneo. Extraction was performed by maceration using 96% ethanol. The analysis included phytochemical screening and evaluation of antioxidant activity using the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay measured by a UV-Vis spectrophotometer. Phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, and phenolic compounds in the Lupun root extract. The antioxidant assay showed an IC50 value of 20.44 µg/mL, indicating strong antioxidant potential of the ethanol extract. These results highlight the plant’s promise as a candidate for pharmaceutical development.
Increased Toxicity Risk from Nanoparticulate System in Food and Drug Applications Hazrina, Aghnia; Muhaimin, Muhaimin; Chaerunisaa, Anis Yohana; Husni, Patihul; Wardhana, Yoga Windhu
Indonesian Food Science and Technology Journal Vol. 8 No. 2 (2025): Volume 8. Number 2, July 2025 |IFSTJ|
Publisher : Department of Technology of Agricultural product (THP) Jambi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/ifstj.v8i2.40494

Abstract

Abstract— Nanotechnology involves manipulating matter at the atomic and molecular levels, leading to the creation of new materials for food and drug application with properties that are not always easily anticipated based on existing knowledge. Among the nearly infinite variety of these substances, some are toxic to biological systems, others are generally harmless, and yet others confer health advantages. The biocompatibility and distribution of these materials must be assessed prior to their use in biological and environmental. Consequently, it is essential to comprehend the toxicity of nanomaterials. Mechanisms of cellular uptake and nanoparticles dispersion in biological settings depend on their physicochemical properties. The pathways in which exposure to nanoparticles is harmful to health are through oxidative stress and inflammation. Recent research have indicated that nanoparticles may cause major health impacts when ingested, inhaled, or applied to the skin without precaution. The main sources of toxicity in nanomaterials include their size, shape, concentration, aspect ratio, crystallinity, surface charge, dissolution, and agglomeration. This review article aims to comprehensively summarize the toxicity aspects of nanoparticles for food and drug application, including physiochemical properties, mechanisms of nanoparticle toxicity, and the health risks, so as to provide an overview for future researchers to develop nanoparticulate in a safer way.
Co-Authors Ade Zuhrotun Andrie, Agus Apriani, Diana Kurnia Aprilian, Salsa Barmi Hartesi Chaniago, Rahadatul Aisy Dwiya, Reiva Farah ELVIE RIFKE RINDENGAN, ELVIE RIFKE Erlianti, Karina Handayani, Retty Harsanti, Bunga Dacilia Hazrina, Aghnia Hindun, Siti Khairinisa, Miski Aghnia Kurniawan Syah, Insan Sunan Maisyarah, Intan Timur Mardiana, Lia Marline Abdassah, Marline MAYANG KUSUMA DEWI, MAYANG KUSUMA Muhaimin Muhaimin Patihul Husni Raden Maya Febriyanti Sriwidodo Sriwidodo, Sriwidodo TIANA MILANDA Tina Rostinawati Uce Lestari Widayanti Supraba Wulantresna, Dewi Yoga Windhu Wardhana Yoga Windu Wardhana, Yoga Windu Yuni Elsa Hadisaputri