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All Journal Farmaka Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology IDJP (Indonesian Journal of Pharmaceutics) JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat) Bioscientia Medicina : Journal of Biomedicine and Translational Research Majalah Farmasetika Kumawula: Jurnal Pengabdian Kepada Masyarakat Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmiah Kesehatan (JIKA) Pharmaceutical Sciences and Research (PSR)
Nasrul Wathoni
Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Nanoparticles Targeted Drug Delivery System via Epidermal Growth Factor Receptor: a Review Agus Rusdin; Nasrul Wathoni; Keiichi Motoyama; I Made Joni; Ronny Lesmana; Muchtaridi Muchtaridi
Indonesian Journal of Pharmaceutics Vol 1, Issue 3, Sept - Dec 2019
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1180.999 KB) | DOI: 10.24198/idjp.v1i3.23613

Abstract

Overexpressing of epidermal growth factor receptor (EGFR) in specific organ implicates tumour aggression and proliferation. Therefore, EGFR becomes a primary consideration for targeted cancer therapy. Nanoparticle drug delivery system is a promising multifunctional technique to provide the targeted drug delivery system. This review was aimed to discuss the nanoparticles formulation for targeted drug delivery system via EGFR. The data were collected from published journals recorded in the Scopus database. Various types of nanoparticles were widely studied to provide an EGFR-targeted drug delivery system. The formulations using specific targeting mediators were conjugated on several technologies such as polymeric nanoparticles, nanometals, and miscellaneous nanoparticles. Most of nanoparticles formulation become an excellent delivery carrier for drugs or gene to site-specific targeted by in vitro and in vivo evaluations. EGFR-targeted drug delivery system could be a promising technique to provide high effectiveness of drugs in EGFR-positive cells cancers with lower side effects to non-tumour cells.Keywords : Epidermal growth factor receptor, Cancer, Nanoparticle, targeted drug
Herbal Medication of Recurrent Aphthous Stomatitis: A Narrative Review Taufik Septiyan Hidayat; Gofarana Wilar; Nasrul Wathoni
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 1 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i1.438

Abstract

A mouth ulcer or recurrent aphthous stomatitis (RAS) is a mouth mucous tissue inflammation. This disease mainly occurs in patients 10-40 years of age, preferably in women and high socioeconomic backgrounds. The cause of mouth ulcers or RAS could be trauma, infection, digestive problems, or blood disorders. Herbal practitioners widely use herbs, folks, and society to treat various diseases. This research aimed to describe the herbal treatment for RAS. The review results show there are nine plants with the ability to cure RAS, they are Persea americana Mill., Averrhoa bilimbi L., Abrus precatorius Linn., Camellia sinensis (L.) Kuntze., Psidium guajava L., Kaempferia galanga Linn., Aloe vera, Curcuma longa and Citrus hystrix DC. The most parameters used in the studies are clinical trials and in vitro tests.
RETRACTED: Promosi Preventif SADARI (Periksa Payudara Sendiri) di Desa Sayang sebagai Upaya Pencegahan Kanker Payudara Muchtaridi Muchtaridi; Eli Halimah; Nasrul Wathoni
JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat) VOL. 5 NOMOR 2 SEPTEMBER 2021 JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (568.772 KB) | DOI: 10.30595/jppm.v5i2.5871

Abstract

Berdasarkan hasil penyelidikan secara teliti dan hati-hati terhadap artikel berjudul "Promosi Preventif SADARI (Periksa Payudara Sendiri) di Desa Sayang sebagai Upaya Pencegahan Kanker Payudara" yang terbit pada JPPM Vol 5 No. 2 September 2021.Artikel ini ditemukan melanggar etika publikasi JPPMArtikel ini mengandung isi yang sama pada artikel di Jurnal Kumawula: Jurnal Pengabdian kepada Masyarakat Vol 4 No. 1 th 2021 dengan link: http://jurnal.unpad.ac.id/kumawula/article/view/31966Dokumen dan isinya telah dihapus dari JPPM, dan upaya yang wajar harus dilakukan untuk menghapus semua referensi ke artikel ini.
Herbal Medication of Recurrent Aphthous Stomatitis: A Narrative Review Taufik Septiyan Hidayat; Gofarana Wilar; Nasrul Wathoni
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 1 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i1.438

Abstract

A mouth ulcer or recurrent aphthous stomatitis (RAS) is a mouth mucous tissue inflammation. This disease mainly occurs in patients 10-40 years of age, preferably in women and high socioeconomic backgrounds. The cause of mouth ulcers or RAS could be trauma, infection, digestive problems, or blood disorders. Herbal practitioners widely use herbs, folks, and society to treat various diseases. This research aimed to describe the herbal treatment for RAS. The review results show there are nine plants with the ability to cure RAS, they are Persea americana Mill., Averrhoa bilimbi L., Abrus precatorius Linn., Camellia sinensis (L.) Kuntze., Psidium guajava L., Kaempferia galanga Linn., Aloe vera, Curcuma longa and Citrus hystrix DC. The most parameters used in the studies are clinical trials and in vitro tests.
Review: Implementation of Overall Equipment Effectiveness (OEE) Based on Lean Manufacturing Tools in the Indonesian Pharmaceutical Industry Prilly Mutiara Sandy; Nasrul Wathoni
Indonesian Journal of Pharmaceutics Vol 4, Issue 1, Jan - April 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i1.38707

Abstract

Increasing production in the industry is important to face the current global competition. Therefore, a performance measurement system is needed for the manufacturing process. Overall Equipment Effectiveness (OEE) is a method for monitoring and improving the efficiency of manufacturing processes. In this article, overall equipment effectiveness (OEE) is described as one of the performance measurement tools that measure different types of production losses and shows areas of process improvement. The analysis is done on how OEE evolved leads to other tools such as the performance of the total equipment effectiveness, such as the effectiveness of production equipment, the effectiveness of the overall plant, and the effectiveness of the asset as a whole. OEE consist of three metric measurement; availability, performance, and quality. Purpose of review articles is to apply these metrics to compare the efficiency and effectiveness of production activity in pharmaceutical industry and to categorize the highly occurence of loss productivity in the production activity that takes place in industry, especially pharmaceutical industry. This review included studies published in ScienceDirect database with the keyword “Lean Manufacturing” and “Overall Equipment Effectiveness”. The results obtained from study of the primary source is the OEE can be used to optimize the production process in the industry, especially the pharmaceutical industry, because this method can produce products efficiently and with the good quality of products that leads to consumer’s satisfactory.
PEMANFAATAN KULIT MANGGIS DALAM SEDIAAN SABUN CAIR ANTISEPTIK DI DESA CILIANG KECAMATAN PARIGI KABUPATEN PANGANDARAN Nasrul Wathoni; Tiana Milanda; Dolih Gozali; Dwi Indra Purnomo; Ine Suharyani
Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Vol 12, No 2 (2023): Juni, 2023
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/dharmakarya.v12i2.41709

Abstract

Program Pengabdian pada Masyarakat (PPM) merupakan salah satu tugas Tri Dharma yaitu suatu bentuk pengabdian dosen kepada masyarakat. PPM periode Juni 2022dilakukan secara terpadu antara kegiatan Riset dan Pengabdian Pada Masyarakat (PPM) Dosen. Kegiatan riset yang dilakukan memberikan hasil berupa pemanfaatan limbah kulit buah manggis. Kulit buah manggis mengandung Xanthone, yang bermanfaat sebagai antiseptik, sehingga dapat dimanfaatkan sebagai alternatif antiseptik yang dapat dibuat dengan mudah dan sederhana, salah satunya adalah bentuk sabun cair dengan zat aktif kulit manggis. Pada kegiatan PPM ini, pengetahuan masyarakat tentang cara pengolahankulit buah manggis dan pemanfaatannya dalam sabun cair antiseptik, diharapkan dapat bertambah.Setelah dilakukan penyuluhan tentang manfaatbuah manggis, kami mendapatkan hasil bahwa pengetahuan masyarakat tentang manggis dan pemanfaatannya dalam sabun antiseptik meningkat, pada pre-test dengan rata-rata jawaban benar sebanyak 78,41%, sementara pada post-test meningkat menjadi 84,72% %. Ketrampilan masyarakat untuk mengolah sabun cair antiseptik dari kulit manggis pun terlihat pada proses pembuatan dihasilkan sabun yang homogen, berbusa dan wangi.
Solid Dispersion Technology for Improving the Solubility of Antiviral Drugs Butar-Butar, Maria Elvina Tresia; Wathoni, Nasrul; Ratih, Hestiary; Wardhana, Yoga Windhu
Pharmaceutical Sciences and Research Vol. 10, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Most drugs, including antiviral drugs, show low solubility in water, which affects dissolution, bioavailability, and therapeutic effectiveness. Therefore, many antiviral drugs are given in very large doses. One of the efforts to overcome these problems is the application of solid dispersions in which polymers and surfactants can trap drug molecules that are in the amorphous phase. Drugs in a hydrophilic carrier will increase wettability, water absorption capacity, and porosity of particles, so that the drug is released better. This review article will discuss the development of technology in solid-state, how solid dispersion overcomes the lack of solubility and the rate of dissolution of antiviral drugs, and solid dispersion preparation techniques. We also discuss some examples of successful applications of solid dispersion methods to antiviral drugs that have been circulating on the market. Overall, this review article offers information of innovation in the development of antiviral drugs to provide more solid dispersion antiviral drug products.
Kualifikasi Sistem Komputerisasi Perangkat Lunak pada UHPLC di Salah Satu Industri Farmasi Rahmah, Raisya; R.H.P, Fitri; Wathoni, Nasrul
Majalah Farmasetika Vol 10, No 2 (2025)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v10i2.62299

Abstract

Industri farmasi wajib menerapkan standar Cara Pembuatan Obat yang Baik (CPOB) untuk memastikan bahwa produk yang dihasilkan memiliki kualitas tinggi, aman, dan efektif. Sistem komputerisasi merupakan salah satu aspek penting pada CPOB karena  berperan dalam pengendalian mutu dengan meminimalkan risiko kesalahan manual serta memastikan data yang dihasilkan konsisten dan akurat. Penelitian ini berfokus pada kualifikasi sistem komputerisasi yang bertujuan untuk memastikan bahwa sistem komputerisasi perangkat lunak pada UHPLC sudah sesuai dengan spesifikasi dan menghasilkan data yang akurat. Penelitian ini dilakukan dengan melakukan pengujian Kualifikasi Instalasi (KI), Kualifikasi Operasional (KO), dan Kualifikasi Kinerja (KK) perangkat lunak Chromeleon pada UHPLC Thermo dengan dasar pedoman adalah CPOB dan protokol kualifikasi sistem komputerisasi di Industri Farmasi. Selanjutnya dilakukan analisis terhadap hasil kualifikasi dengan membandingkan hasil yang didapatkan dengan syarat keberterimaannya. Hasil analisis kualifikasi tersebut disajikan dalam bentuk deskriptif. Berdasarkan hasil analisis, pengujian kualifikasi yang dilakukan baik itu Kualifikasi Instalasi (KI), Kualifikasi Operasional (KO), dan Kualifikasi Kinerja (KK) telah memenuhi syarat keberterimaan sehingga dapat dipastikan bahwa sistem sudah berfungsi sesuai dengan spesifikasi yang ditetapkan serta mampu menghasilkan data yang valid, konsisten, dan dapat diandalkan. 
The Development of Nano-mist Spray Propolis as Antioxidant Suryaman, Ine Suharyani; Sulastri, Lela; Rizikiyan, Yayan; Wathoni, Nasrul; Suhandi, Cecep; Noviani, Lusy; Rahmasari, Yuni
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.52433

Abstract

Propolis is a lipid-based compound from honeybees composed of plant wax, resin, and pollen. Due to its poor water solubility, its application is limited to lipid-based formulations with low bioavailability. This study aimed to develop a water-based propolis nano-mist spray with improved dispersion and evaluate its antioxidant activity. The nano-mist formulation was prepared using soy lecithin and Tween 80 in a phosphate buffer base. Evaluations included organoleptic characteristics, pH, particle size, zeta potential, and antioxidant activity by DPPH method. The propolis extract contained flavonoids, alkaloids, and tannins. The resulting spray showed a light brown color, a pH of 6.87 ± 0.03, particle size of 272.13 ± 4.25 nm, and zeta potential of -0.433 ± 0.35 mV. Antioxidant testing revealed moderate activity with an IC₅₀ value of 83.63 ± 11.88 ppm. This study supports the potential of nano-mist spray as a promising delivery system for propolis with antioxidant properties suitable for cosmetic and pharmaceutical applications.
Formulation and Characterization of Secretome Hydrogel Based on Sodium Alginate as Anti-Aging Alquraisy, Ayatulloh; Wathoni, Nasrul; Wilar, Gofarana; Suhandi, Cecep
Jurnal Ilmiah Kesehatan (JIKA) Vol. 6 No. 3 (2024): Volume 6 Nomor 3 Desember 2024
Publisher : Sarana Ilmu Indonesia (salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v6i3.1005

Abstract

Hydrogel can be developed as a secretome delivery strategy for controlled release, thereby extending the residence time of the secretome and providing safer and more effective therapeutic effects. Secretome has great potential to prevent skin aging. The enzymes contained in the secretome have antioxidant activity. This study aimed to determine the characterization and anti-aging activity of sodium alginate-based secretome hydrogel preparations. In this research, hydrogel secretome characterization tests were carried out in the form of organoleptics, pH, viscosity, spreadability, HRTEM and also anti-aging activity testing using the DPPH scavenging assay method. The organoleptic test showed that all formulas were pale yellow in color, soft and homogeneous in consistency. pH, viscosity and spreadability tests showed that all formulas entered the standard range for topical preparations. Taking images of the hydrogel surface using HRTEM shows that the secretome has been successfully dispersed into the hydrogel. Anti-aging activity testing carried out has also proven an increase in the percentage of inhibition and IC50 value in the formula along with increasing the secretome dose.
Co-Authors Aliya Nur Hasanah Alquraisy, Ayatulloh Arief Cahyanto ARVENDA REZKY PRATAMA DIAH PERMATA SARI Dina Sembiring Dolih Gozali Dwi Indra Purnomo Ega Megawati Elasari Dwi Pratiwi Eli Halimah ELI HALIMAH Eli Halimah Fanny Seftiani Dwi Saputri Gofarana Wilar Hestiary Ratih Hidayat, Taufik Septiyan HISBAN HAMID ARIFKI I Ketut Madite Adnyane I Made Joni Ina Widia INDAH PERTIWI KATARINA SILALAHI Keiichi Motoyama Larasati Amaranggana Lela Sulastri, Lela Lisa Sophianingsih M. Ramadhan Saputro Maria Elvina Tresia Butar-Butar Marline Abdassah MAYANG KUSUMA DEWI MEGANTARA, SANDRA Mia Arifka Muchtaridi Muchtaridi Nabilah Muhamad NADYA NURUL ZAMAN Nia Yuniarsih Nita Sari Norisca Aliza Putri Norisca Aliza Putri Noviani, Lusy Nur Selvia Yuswadinata Praditya Alfathan Prilly Mutiara Sandy PUTRI EKA SAVITRY R.H.P, Fitri Rahmah, Raisya Rahmasari, Yuni Ronny Lesmana Rusdin, Agus Sriwidodo Sriwidodo Sriwidodo Sriwidodo Sriwidodo Sriwidodo Sriwidodo Sriwidodo, Sriwidodo Suhandi, Cecep Suharyani, Ine Suhendi, Cece Suryaman, Ine Suharyani Susi Afrianti Rahayu Taofik Rusdiana TIANA MILANDA VICANIA RAISA RAHMAN WENNI HARTATI P. PAKPAHAN Yayan Rizikiyan Yedi Herdiana Yoga Windhu Wardhana Yoga Windu Wardhana