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All Journal Farmaka Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN Pharmaciana: Jurnal Kefarmasian Jurnal Teknosains Interest : Jurnal Ilmu Kesehatan Biology, Medicine, & Natural Product Chemistry Majalah Obat Tradisional Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Majalah Farmaseutik JURNAL PENGABDI Media Farmasi Al-Khidmah BULETIN AL-RIBAATH Jurnal Ilmu Kefarmasian Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Indonesian Journal of Pharmaceutical Education Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis Medical Sains : Jurnal Ilmiah Kefarmasian Journal Pharmacy of Tanjungpura
Luliana, Sri
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STANDARDIZATION OF SECONDARY METABOLITES AND HEAVY METAL CONTAMINATION ASSAY ON ONCHIDIID SLUG (ONCHIDIUM TYPHAE) WEST KALIMANTAN WATERS Bambang Wijianto; Annisa Larasati Nurhidayah; Sri Luliana
Jurnal Farmasi Sains dan Praktis Vol 8 No 3 (September-December 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i3.7296

Abstract

Onchidiid slug or Onchidium typhae is a marine animal commonly found in West Kalimantan waters. This gastropod is commonly used as medicine and cosmetic by the locals. This research aims to assure the content and quality of O. typhae methanol extract by determining its secondary metabolites and heavy metal contamination. Phytochemical screening of alkaloid, steroid/ triterpenoid, flavonoid, tannin, and saponin are done using reagent tests. Chromatography profile was completed using silica gel G60 F254 plate and hexane: ethyl acetate: methanol as mobile phase. Heavy metal contamination analysis was performed using atomic absorption spectrophotometry to determine Hg, As, Cd, and Pb content. The phytochemical screening and chromatography profile of O. typhae methanol extract confirm the presence of alkaloids and steroids. Heavy metal analysis stated Hg, As, Cd, and Pb content in O. typhae are < 0,0008; < 0,001; < 0,001; and 0,05 ppm respectively. Since heavy metal levels are below the maximum contamination limit, it qualifies as a natural product ingredient.
Aktivitas Antioksidan Ekstrak Air Kombinasi Kulit Pisang Kepok (Musa paradisiaca L.) dan Nanas (Ananas comosus L.) dengan Metode DPPH dan FRAP Vivian Fu; Pratiwi Apridamayanti; Sri Luliana
Indonesian Journal of Pharmaceutical Education Vol 3, No 2 (2023): Mei-Agustus 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i2.19781

Abstract

Banana kepok (Musa paradisiaca L.) and pineapple (Ananas comosus L.) are types of fruit that are widely consumed by the community. However, the skin is only disposed of as waste, where the waste of the fruit skin reaches 30% of the whole fruit. Kepok banana peels and pineapples contain phenols and flavonoids which are proven to function as antioxidants. This study aims to determine the IC50 value of the combined sample using the DPPH and FRAP methods. The extract samples were divided into 2 groups, namely the combination of kepok banana peel extract and pineapple with a ratio of 1:1 and 1:3. Extraction is done by infusion method. Analysis of the content of phenolic and flavonoid compounds was carried out by the TLC method on single samples of kepok banana peels and pineapple peels. Antioxidant activity test was carried out by 2 methods, namely DPPH and FRAP. The yield of the extract in the 1:1 combination was found to be 48% and the 1:3 combination was 47%. The chromatogram profile showed that each single sample was positive for phenols and flavonoids. The results of the analysis of the antioxidant activity of the DPPH method showed the IC50 value in the 1:1 combination group was 1188.27 ppm while in the 1:3 combination group it was 740.98 ppm. In the FRAP method, the IC50 value in the 1:1 combination group was 1251.85 ppm, while in the 1:3 combination group it was 2218.94 ppm. Based on the results of the test, there are differences in the measurement of antioxidant activity with 2 different methods based on the antioxidants action that contains in the sample, so that the more recommended method is DPPH based on the type of antioxidant compounds contained in the sample.
Isolasi Dan Identifikasi Terpenoid Fraksi Heksan Daun Premna serratifolia L. Menggunakan GC-MS Ricky Midi Candra; Isnindar Isnindar; Sri Luliana
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.15311

Abstract

Buas-buas (Premna serratifolia L.) is a plant that belongs to the Verbenaceae family. Terpenoid compounds that exist in buas-buas plants have bioactivity as medicine. Terpenoid compounds are soluble compounds in n-hexane. The purpose of this study was to isolate and identify the terpenoid compounds contained in the n-hexane fraction of buas-buas leaves using the GC-MS method. The buas-buas leaves were macerated with 96% ethanol solvent and then fractionated using a separating funnel with n-hexane as solvent. The n-hexane fraction of buas-buas leaves was isolated using column chromatography with a gradient mobile phase combination of n-hexane and ethyl acetate, then identified using the GC-MS instrument. The terpenoid compounds found in the n-hexane fraction of buas-buas leaves are estimated to be neophytadiene; 3,7,11,15-tetramethyl-2-hexadecen-1-ol; and 2 hydroxy-4a,5-dimethyl-3-(prop-1-en-2-yl) octahydronaphthalen-1-(2H)-one.
FORMULASI GRANUL INSTAN EKSTRAK MENIRAN, KUNYIT, DAN DAUN KELOR DENGAN PENGISI MALTODEKSTRIN DAN LAKTOSA: FORMULATION OF INSTANT GRANULE CONTAINING MENIRAN, TURMERIC, AND MORINGA LEAF EXTRACTS WITH MALTODEXTRIN AND LACTOSE AS DILUENTS Azizzah Dwi Rahmawati; Sri Luliana; Isnindar
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 3 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i3.429

Abstract

Pengembangan sediaan farmasi dalam bentuk granul instan kombinasi ekstrak meniran (Phyllantus niruri L.), kunyit (Curcuma longa L.), dan daun kelor (Moringa oleifera L.) dapat mempermudah masyarakat dalam mengonsumsi dan berkhasiat meningkatkan sistem imun tubuh. Penelitian ini bertujuan untuk mengevaluasi karakteristik fisik granul instan kombinasi ekstrak meniran, kunyit, dan daun kelor dengan bahan pengisi maltodekstrin dan laktosa. Metode pembuatan granul instan menggunakan metode granulasi basah. Granul instan dibuat dalam 3 formula dengan konsentrasi maltodekstrin dan laktosa yaitu, F1 (94% : 0%), F2 (0% : 94%), dan F3 (47% : 47%). Evaluasi yang dilakukan meliputi pengamatan organoleptik, kandungan lembab, waktu alir, sudut istirahat, waktu larut, dan pH. Berdasarkan evaluasi yang didapatkan, karakteristik fisik granul instan seluruh formula memenuhi persyaratan. Hasil analisis SPSS menunjukkan adanya pengaruh yang signifikan pada uji kelembaban (F1 terhadap F2; F2 terhadap F3), waktu alir (F1 terhadap F2 dan F3), sudut istirahat (F1 terhadap F2 dan F3), dan disolusi (F1 terhadap F2 dan F3; F2 terhadap F1 dan F3; F3 terhadap F1 dan F2).
Formulation and Sunscreen Activity Test of Lotion of Buas-Buas (Premna Serratifolia Linn.) Leaf Extract Adahane, Euistya Febrianti Putri; Isnindar, Isnindar; Luliana, Sri
Majalah Obat Tradisional Vol 29, No 1 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.86919

Abstract

Excessive UV exposure can cause various skin disorders, so protection from UV rays is needed by using sunscreen. One of the plants that have the potential as a sunscreen is buas-buas leaf (Premna serratifolia Linn.) which contains flavonoid compounds. Sunscreen formulated in lotion form is the most common preparation found in the market. The purpose of this study was to evaluate the physical characteristics of lotion preparations and to determine the potential of lotion of buas-buas leaf extract as a sunscreen. Buas-buas leaf extract was obtained through maceration extraction with 96% ethanol solvent. Lotion with the active substance of buas-buas leaf extract was made with concentration variations of 1, 2, and 3%. Evaluation of the physical characteristics of the lotion was tested with organoleptic observation parameters, homogeneity, pH, spreadability, and adhesion. Then, it was tested for sunscreen potential using UV-Vis spectrophotometry. Data were analyzed with SPSS Statistics 22 software, namely the One Way ANOVA (Analysis of Variance) test. The results of the study were the three lotion formulas of buas-buas leaf extract met all the requirements of the physical characteristics evaluation test. The SPF value of F1 (1%) is 7.12 (extra protection), F2 (2%) is 9.54 (maximum protection) and F3 (3%) is 15.68 (ultra protection). Based on the results of the study, it can be concluded that the lotion of buas-buas leaf extract meets the requirements of evaluating the physical characteristics of lotions and has activity as a sunscreen.
Analysis of Heavy Metal Cadmium (Cd) and Lead (Pb) in Eggplant (Solanum melongena L.) in Pontianak City by Using Atomic Absorption Spectrophotometry (AAS) Nugraha, Fajar; Oktaviani, Syila Malinda; Luliana, Sri
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.83-90

Abstract

In Indonesia, eggplant is a favored vegetable with substantial production. The main objective of this study is to investigate the level of safety of eggplants marketed in traditional wholesale markets in Pontianak City against possible contamination of the heavy metals cadmium (Cd) and lead (Pb), which are commonly discovered in water waste, vehicle exhaust, and excessive pesticide and fertilizer use. Alizarin Red S for Cd metal and Dithizon for Pb metal were used in qualitative assays. Cd and Pb levels were measures using an Atomic Absorption Spechtrophotometer (AAS) instrument. The analytical method has been verified for linearity, accuracy, precision, limit of detection, and limit of quantification. The qualitative test results showed that all samples had positive results for Cd and Pb. The quantitative test results revealed that the Cd and Pb metal contents in the FB (Flamboyan) sample were 0.056 mg/kg and 3.5066 mg/kg, consequently, while they were 0.0986 mg/kg and 3.957 mg/kg, consequently, in the PR (Puring) sample. In keeping with BPOM standard No. 5 of 2018, Cd metal levels in FB samples are at a safe threshold, while Cd metal levels in PR samples and Pb metal levels in FB and PR samples exceed the maximum thresholds that have been set.
Improving the in vitro penetration of niacinamide using span 60-based niosomal system in gel formulation Desnita, Rise; Luliana, Sri; Kasim, Zainab
Pharmaciana Vol. 8 No. 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v8i2.7696

Abstract

Niacinamide is one of the components of cosmeceutical products that reported to have skin benefits for the treatment of skin pigmentation, acne and wrinkles. However, the dermal penetration of niacinamide is poor. The carrier system which can be selected to carry the compound through the stratum corneum layer is the niosome system using span 60. This study was aimed to determine the concentration of span 60 that can trap niacinamide optimally and the ability of niosome system span 60 to increase in vitro penetration of niacinamide in gel formulation. The different formulations of nicotinamide niosome were formulated with variance concentrations of Span 60, that is, formula A 100 μmol, formula B 150 μmol, and formula C 200 μmol. The entrapment efficiency testing was conducted using dialysis membrane. The gel formulation was prepared in two formulas, niacinamide niosome gel and niacinamide gel (without niosomes) and tested diffusion using Franz diffusion cell flow-through type. The result show that Formula A provides the most optimum entrapment efficiency of 99.03±0.026%. The results of the in vitro skin penetration studies for 8 hours indicate that the niosomal formulation using Span 60 could increase skin penetration with the percent cumulative amount of niacinamide niosomes was 82.87±1.6932% compared to niacinamide in gel without noisome system about 70.27±5,3212%.
Penyuluhan dan Pendampingan Pembuatan Jamu Serbuk Instan Imunostimulan di Desa Tebang Kacang IH, Hariyanto; Isnindar, Isnindar; Nurbaeti, Siti Nani; Luliana, Sri; Yuswar, Muhammad Akib; Kurniawan, Hadi; Ropiqa, Meri
Jurnal Pengabdi Vol 7, No 2 (2024): Oktober 2024
Publisher : Universitas Tanjungpura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/jplp2km.v7i2.72379

Abstract

Abstrak: Masyarakat indonesia telah lama menggunakan tanaman obat keluarga (TOGA) sebagai upaya pencegahan timbulnya penyakit dan menjaga kesehatannya. Salah satunya adalah meniran (Phillanthus niruri L.) dan jahe (Zingiber Officinale) dimana kombinasi tanaman tersebut telah terbukti dapat meningkatkan daya tahan tubuh. Namun dalam pegolahannya masih dalam bentuk yang sederhana, oleh karena itu diperlukan edukasi dan pendampingan pemanfaatan TOGA menjadi bentuk yang lebih praktis, mudah dan memiliki nilai ekonomi yang tinggi seperti serbuk instan. Oleh karena itu tujuan dari kegiatan pengabdian masyarakat ini adalah memberikan edukasi dan pendampingan pembuatan meniran dan jahe menjadi serbuk instan sebagai imunostimulan di desa tebang kacang. Sasaran dari kegiatan PKM ini adalah ibu-ibu kader PKK yang ada di Desa Tebang Kacang. Metode dari PKM ini adalah penyuluhan dan workshop dengan tahapan kegiatan yaitu persiapan kegiatan, pelaksanaan kegiatan (penyuluhan dan workshop atau pendampingan pembuatan jamu serbuk instan), serta evaluasi kegiatan. Hasil kegiatan menunjukkan  adanya peningkatan pengetahuan peserta yang ditunjukkan dari nilai post-test rata-rata peserta, yaitu 65, jika dibandingkan terhadap nilai rata-rata pre-test, yaitu sebesar 53,33. Evaluasi kepuasan peserta dari kuesioner juga menunjukkan bahwa, materi yang disampaikan mudah dipahami, bermanfaat, menambah keterampilan, produk yang dihasilkan memiliki rasa yang enak dan dapat meningkatkan perekonomian desa.  Kata Kunci:  Serbuk Instan, Imunostimulan , Meniran, Jahe dan Desa Tebang Kacang  Abstract: Indonesians have long used family medicinal plants (TOGA) to prevent disease and maintain health. A few of them are meniran (Phillanthus niruri L.) and ginger (Zingiber Officinale). Their combination has been proven to increase the body's immune system. However, their processing was still in a simple form; therefore, education and assistance are needed to use TOGA in a more practical, easier, and highly economical value, such as instant powder. Therefore, this community service activity aims to educate and assist in making meniran and ginger into instant powder as an immunostimulant in the Tebang Kacang village. The targets of this program are PKK cadre mothers in Tebang Kacang Village. The method of this PKM is counseling and workshops with activity stages, namely preparation of activities, implementation of activities (counseling and workshops or assistance in making instant powdered herbal medicine), and evaluation of activities. The activity results showed an increase in participants' knowledge as indicated by the participants' average post-test score, which was 65%, compared to the average pre-test score, which was 53.33.% Evaluation of participant satisfaction from the questionnaire also shows that the material presented is easy to understand, valuable, increases skills, the product produced has a good taste, and can improve the village economy.  Keywords: Instant Powder, Immunostimulant, Meniran, Ginger and Tebang Kacang Village.  
Effect of extraction, ratio, and solvent concentration on total flavonoid content and antioxidant activit of singkel (premna serratifolia linn.) using dpph method Isnindar, Isnindar; Luliana, Sri; Zahid, Muhammad
Jurnal Teknosains Vol 14, No 2 (2025): June
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/teknosains.100099

Abstract

Singkel (Premna serratifolia Linn.) is a medicinal plant commonly found in tropical regions, including Indonesia, which contains flavonoids, alkaloids, polyphenols, and triterpenoids. Flavonoids in singkel leaves act as antioxidants that can prevent oxidative stress, which is a causative factor of degenerative and chronic diseases such as cancer, arthritis, and cardiovascular diseases. This study aims to determine the effects of total flavonoid content and IC50 values in singkel leaves based on extraction methods, solvent concentration, and the ratio of extract to solvent. The methods used include maceration, soxhlet extraction, and Microwave-Assisted Extraction (MAE), with ethanol solvent concentrations of 60%, 70%, 80%, and 96%, and extract-to-solvent ratios of 1:10, 1:20, and 1:30. Antioxidant activity was measured using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method with UV-Vis spectrophotometry. The results showed that the soxhlet extraction method yielded the highest total flavonoid content of 24.56±1.81 mgQE/g with an IC50 value of 20.31±1.58 μg/mL. The 96% solvent concentration provided the best results with a total flavonoid content of 26.12±0.06 mgQE/g and an IC50 value of 15.51±2.17 μg/mL. In the solvent ratio testing, the 1:20 ratio showed the highest total flavonoid content of 19.37±0.5 mgQE/g, while the 1:10 ratio provided the best IC50 value of 11.99±1.02 μg/mL. In conclusion, the extraction method, solvent concentration, and solvent ratio significantly affect the flavonoid content and antioxidant activity of singkel leaves.
FORMULATION AND EVALUATION OF FUNCTIONAL BEVERAGES INSTANT POWDER COMBINATION OF THE BUAS-BUAS LEAVES (Premna serratifolia L.), SECANG WOOD (Caesalpina sappan L.) AND GINGER Rhizome (Zingiber officinale R.) Putri, Dinda Marlinda; Isnindar, Isnindar; Luliana, Sri
Journal Pharmacy Of Tanjungpura Vol 1, No 1 (2023): Oktober
Publisher : Universitas Tanjungpura

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

BACKGROUND: The use of buas-buas leaves (Premna serratifolia L.), sappanwood (Caesalpina sappan L.) and ginger rhizomes (Zingiber officinale R.) as raw materials for instant powder drink is to make it easier to serve and has health benefits. OBJECTIVE: This study aims to determine the physical characteristics and the level of public preference for instant powder drinks. METHOD: This research is an experimental study with sugar crystallization as a method of making instant powder made in 4 different formulas. Data collection was carried out to respondents through questionnaires with a total of 20 respondents. Data analysis was performed using Oneway ANOVA on the SPSS program. RESULTS: The results showed that the resulting powder had a yellow to orange color with a distinctive aroma of wild leaves, the powder had a smooth and dry texture. CONCLUSION: The four formulas met the physical properties requirements of instant powder and F2 became the most preferred formula.Keywords: buas-buas leaves, sappan, ginger, instant powder
Co-Authors ., Nunung ., Saraswati Adahane, Euistya Febrianti Putri Amanda Angelina Sinaga Amanda Angelina Sinaga, Amanda Angelina Amanda Gita Tiaravista Amaria, Egita Feby Anastasia, Desy Siska Andhi FAHRURROJI Andhi Fahrurroji Anggraini, Silvana Annisa Larasati Nurhidayah Arief Nurrochmad Azizzah Dwi Rahmawati Bambang WIJIANTO Bary Azhari Dea Pertiwi Ellya Agustina Eneng Neni Indriyani Fajar Nugraha Hadi Kurniawan, Hadi Hafrizal Riza Hafrizal Riza Hafrizal Riza, Hafrizal Hariyanto IH Ilham Iswahyudi Islamy, Muhamad Rido Isnindar Isnindar Istiqomah, Rifqi Iswahyudi, Ilham Kasim, Zainab kasim, zainab Kris Natalia Manihuruk Kris Natalia Manihuruk, Kris Natalia Liza Pratiwi Muhamad Rido Islamy Nera Umilia Purwanti, Nera Umilia Nur Atikah Oktaviani, Syila Malinda Pratiwi Apridamayanti Pratiwi Apridamayanti, Pratiwi Putri, Dinda Marlinda Ricky Midi Candra Rise Desnita, Rise Rissa Febriyanto Robiyanto Robiyanto, Robiyanto Robiyanto, Robiyanto Ronny Martien Ropiqa, Meri Sehro Sehro Sehro, Silvana Anggraini Siti Nani Nurbaeti Susanti, Ressi Tara Kamita Riduana Utia Mufliha Vivian Fu Widia Indri Nugraha Yuswar, Muhammad Akib Zahid, Muhammad Zainab Kasim