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Journal : The Indonesian Biomedical Journal

Intrauterine Transmission of Hepatitis B Cannot Be Ruled Out by A Single Negative Hepatitis B e Antigen (HBeAg) Result among Hepatitis B Surface Antigen (HBsAg) - Positive Pregnant Women Chalid, Maisuri Tadjuddin; Judistiani, Tina Dewi; Syahril, Rizalinda; Masadah, Rina; Febriani, Dwi Bahagia; Wahyuni, Ridha; Turyadi, Turyadi; Massi, Muh Nasrum
The Indonesian Biomedical Journal Vol 16, No 1 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i1.2726

Abstract

BACKGROUND: The risk factors for intrauterine transmission of hepatitis B virus (HBV) in hepatitis B surface antigen (HBsAg)-positive pregnant women are poorly understood. Numerous factors are considered to be involved, including placental barrier, obstetric environment, high viral load, and positivity of hepatitis B e antigen (HBeAg). This study was conducted to investigate the role of placenta barrier, clinical, and viral factors in intrauterine transmission of HBV.METHODS: A cross-sectional study was conducted involving 1,353 pregnant women who underwent HBsAg screening. Eighty-four (6.2%) women were detected as HBsAg positive and were examined for HBsAg level, anti-HBs, anti-HBc, HBeAg/hepatitis B e antibody (anti-HBe) status, and HBV DNA presence in cord blood. Quantitative HBV DNA was analyzed using real-time polymerase chain reaction (PCR).RESULTS: Eighty-four of 1,353 subjects were HBsAg-positive. HBV DNA was positive in 28/84 (33.7%) maternal sera, 19/79 (24.05%) placental specimens, and 9/83 (10.84%) in cord blood. There were significant associations between HBV DNA in maternal serum (p=0.000) and placental tissue (p=0.000) with HBV DNA in the cord blood. No clinical factors were associated with HBV DNA transmission in cord blood. Sixty percent of viral load >5.3 log10 copies/mL were found in the cord blood, of which 43.8% HBeAg positive and 3.1% HBeAg negative.CONCLUSION: Reduced transmission via compartments established the placenta’s barrier function in mother-to-child transmission. A high maternal viral load and positive HBeAg were risk factors for intrauterine transmission, while negative HBeAg still has the possibility of transmission.KEYWORDS: mother-to-child transmission, hepatitis B virus, intrauterine
Co-Authors ., Arbayah Abidin, Fikri Rafi Musyaffa Agustina, Salma Ahmad, Gaffar Ahsan Ridho Faturahman Akbar, Muhammad Rayhan Fasya Alamsyah, Fiqih Dien ALYA, FARAH Amrullah, Muchlis Anni Alvionita Simanjuntak Astri, Andi Asyafa, Taris Atmajani, Era Try Auliya Zulfa, Azkiya Azzahra, Marcella Batubara, Ghifari Vioga Bonde, Elsa Chalid, Maisuri Tadjuddin Dwi Desi Yayi Tarina Fadhilah Fadhilah Fadilah, Fatma Putri Fakhriya Kemal, Anurra Fattah, Ade Syaifullah Faudiah, Nurul Febriani, Dwi Bahagia Fitriana Fitriana Frefy, Fyo Akbar Putra Gunawan, Celine Hadinigsih, Eka Frenty Hakim, Moh. Akmal Taris Handayani, Nanik Herlianto, Fahrian Ichwana P, Fareta Angelica Indradewa, Rhian KHOIRUL ANAM Lestari, Erika Lutfiananda Salsabila, Dea Mahvira, Mahvira Manurung, Citra Bintang Maranatha Maria, isda Masdiana, Ismail Masyita, Gita Maulida, Zahratul Monika, Arinda Muh. Nasrum Massi Murni Deborah Hutabarat, Sylvana Nazhip, Windra Hilmi Noerman, Chiquita Thefirstly Nopalia, Peni Novyana, Hilda Nugraha, Setyo Nurhayati Peggyanita, Wynne Prananda, Mayang Talentasari Purwanti, Heni Putri, Syifadilla Subagyo Rabbani, Radiyya Alvaro Achmad Raden Tina Dewi Judistiani Rahmadani, Tasya Aulia Rahmah, Dian Dwi Nur Rahman, Nadya Novia Ramadhani, Dwi Aryanti Rasyed, Muhammad Al Rina Masadah Ritha, Aniah Ritha, Aniah Sari, Risky Tara Nabita Sifana, Firdha Simanjuntak, Max Doan Sulistyorini, Chandra Syahril, Rizalinda Tanjilatin, Tanjilatin Teluma, Theresia Roselyn Amabilis Sarbiti Tripertiwi, Sucita Turyadi Turyadi, Turyadi Valentina, Widya Wananti, Atik Zahroh, Nasywa Kamiilah