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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Mandala Pharmacon Indonesia Jurnal FARMAKU (Farmasi Muhammadiyah Kuningan) Jurnal Abdi Insani Jurnal Mandala Pengabdian Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian Indonesian Journal of Jamu
Niluh Puspita Dewi, Niluh Puspita
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Public Health Social Sciences

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Potensi Rumput Laut (Eucheuma cottonii J.Agardh) Terhadap Nefropati Diabetik Tikus Putih Jantan (Rattus norvegicus): (Potency of Seaweed (Eucheuma cottonii J.Agardh) Against Nephropathy Diabetic Male White Rats (Rattus norvegicus)) Tandi, Joni; Dewi, Niluh Puspita; Wirawan, Resky Chandra; Surat, Megawati R.
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 2 (2020): (October 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2020.v6.i2.15046

Abstract

ABSTRACT This study aims to determine the effect of a multilevel dose of ethanol extract of seaweed (Eucheuma cottonii J. Agardh) on the decreasing blood glucose levels and kidney tissue regeneration of hypercholesterolemia-diabetic male white rats. 24 rats were divided into 6 groups, namely groups 1-3 (normal control, negative control, and positive control/Glibenclamide, respectively) and groups 3-6 (seaweed extract doses of 100, 200, and 400 mg/kg BW per oral, respectively). Rats were induced by high fat diet and Streptozotocin. Histopathological picture of the kidney was observed by HE staining using 400 magnifications. Data scoring of the level of kidney damage were analyzed by One Way ANOVA at a 95% confidence level and a Least Significant Difference (LSD) test was conducted. Seaweed ethanol extract at a dose of 100 mg/kg BW was effective in reducing blood glucose levels with an average value of 122.25 mg/dL and effective in regenerating the kidney tissue of male white rats with an average value of damage of 1.9. Therefore, seaweed extract has potency to be developed and further investigated as an antidiabetic agent.
Efek Ekstrak Etanol Daun Pepaya Terhadap Histopatologi Ginjal Tikus Putih Yang Diinduksi Streptozotocin Yanuarty, Rezky; Tamunu, Jeine Sweet Natasya; Tandi, Joni; Dewi, Niluh Puspita
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia Special Issue for 18th Mulawarman Pharmaceu
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.469

Abstract

Ginjal merupakan organ yang mempunyai kemampuan menyaring darah dengan membuang limbah alami seperti urea. Limbah alami yang diperluas bisa menyebabkan kerusakan ginjal. Penelitian ini bertujuan untuk menentukan kandungan metabolits pilihan alkaloids, flavonoids, saponins, dan tanins dalam konsentrat etanol daun pepaya, dan untuk menentukan dampak dan porsi konsentrat yang layak pada melawan sel silinder ginjal pada tikus yang digerakkan oleh streptozotocin. Hewan pengerat diisolasi ke dalam 6 kelompok yang terdiri dari control tipikal, control negatif, control positif, perlakuan lepas tandan dengan dosis 100, 200, 300mg/kg BB. Penelitian selama 28 hari. Studi ini mencatat perkembangan yang terjadi pada sel tubullus ginjal tikus putih jantan yang dipicu oleh streptozotocin sebagai tingkat kerusakans dengan nilai yangs ditentukan sebagai persentase (%) pada setiap bagian tubullus yang rusak atau rusak. Hasil penelitian menunjukkans bahwa daun pepaya secara terpisah mengandung metabolits opsional alkaloids, flavonoids, saponins dan tanins. Pemberian konsentrat etanol daun pepaya dalam porsi 300mg/kg BB secara preventif bisa mempengaruhi sel silinder ginjals pada tikus yang diinduksis STZ, dengan nilais bahaya tipikal 0,4 dari batas 4.
Formulation, Evaluation And Antibactery Activity Test Of Gastroretentive Mukoadhesive Granul Matrix Earthworm Extract (Lumbricus rubellus) Magfirah, Magfirah; Alaydrus, Syafika; Tandi, Joni; Utami, Indah Kurnia; Dewi, Niluh Puspita
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.503

Abstract

Background: Earthworm extract (Lumbricus rubellus) has antimicrobial activity because it produces high levels of the lumbricine compound but is easily denatured in the stomach so that its solubility and biological activity change. Therefore its Application can be developed in the form of gastrorentetif mucoadhesive preparation. Objectives: The purpose of this study was to optimize and evaluate the antibacterial activity of gastroretentive mucoadhesive preparation matrix of earthworm extract (Lumbricus rubellus). Material and Methods: The matrix utilized a preparatory technique of applying wet granulation mucoadhesive polymers such as chitosan, HPMC, and sodium CMC with concentrations determined based on simple lattice design resulting in 7 granule formulas. The granule formulas obtained were then evaluated including flow time and dwell angle tests, particle size distribution tests, compressibility tests, dissolution tests, and antibacterial activity tests. Results: The results showed that the flow rate on the F3 granule formulation met the requirements of flow rate >10 g/s, a consequence of measuring the angle of repose in the F1-F5 formula had good flowability which was below 30o, in contrast to F6 and F7 which had an angle of repose of 30-40o favorable to flowability. The F1-F7 formula was mostly preserved in mesh number 20 sieve with a size of 426-850 ?m, according to the results of particle size distribution utilizing the multistage sieve method, the compressibility index of the F1-F7 granule formula was 10% and the measurement results at the 30 minute showed that the average dissolution of the F1-F3 granules was 97.77%, 97.77%, and 101.22% respectively while the F4-F7 granule formulas did not show slow drug release because at the 30th minute the drug released ranged and the antibacterial activity test of Formula 1-Formula 7 granules is respectively 6 mm, 5.5 mm, 8 mm, 3.5 mm, 4.7 mm, 2.1 mm and 3.3 mm. Conclusions: The results of the evaluation of the characteristics of earthworm extract mucoadhesive gastroretentive granule preparation demonstrated that the preparation met the requirements for granule preparation and exhibited antibacterial properties. Among the seven formulas tested, formula 3 had the highest efficacy of antibacterial activity.
Cegah Stunting Dengan Tanaman Obat Keluarga: Cegah Stunting Dengan Tanaman Obat Keluarga Alaydrus, Syafika; Rianto, Rianto; Rusliyana, Rusliyana; Dewi, Niluh Puspita; Anwarudin, Wawang
Jurnal Mandala Pengabdian Masyarakat Vol. 5 No. 1 (2024): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v5i1.369

Abstract

Indonesia has quite a serious nutritional problem which is characterized by many cases of malnutrition. Malnutrition is an impact of nutritional status. 2016 National Health Service data recorded that the prevalence of stunting reached 33.6%, this is an important health problem because the stunting problem is above the 20% threshold. Meanwhile, stunting in children under five is caused by multifactors, such as nutritional consumption during pregnancy, maternal knowledge about nutrition, limited access to services, inadequate access to sanitation and clean water. This counseling aims to help increase public knowledge, about preventing stunting in toddlers and is a form of the Tri Dharma of Higher Education. Counseling is provided using an interactive lecture method through distributing leaflets, health checks, providing nutritious food, providing TOGA books and social service. The effectiveness of the extension was tested by administering a questionnaire on community satisfaction with the activities carried out. The results of this service activity provide the Sejahtera village community with knowledge about what stunting is, the causes of stunting, the dangers of stunting in the long term and how to overcome the impact of stunting so that stunting can be minimized in children.
Enzymatic virgin coconut oil effect on urea and creatinine levels of hypercholesterolemia-diabetics induced Wistar male rats Dewi, Niluh Puspita; Alaydrus, Syafika; Nadila, Nadila; Magfirah, Magfirah; Tandi, Joni; Anggi, Viani; Astria, Nani
Pharmaciana Vol. 14 No. 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.27489

Abstract

Coconut (Cocos nucifera) is an Indonesian commodity that has high economic value tall. Virgin Coconut Oil (VCO) is one of the processed coconut products whose selling value is very high, because The composition of VCO consists of medium-chain fatty acids that can maintain a healthy body and prevent various diseases. The process of making VCO used in This research is an enzymatic method using pineapple weevil as a bromelain enzyme. This study aims to determine the effect of enzymatic administration of VCO and an enzymatic dose of VCO which is effective in reducing urea and creatinine levels in hypercholesterolemic-diabetic male white rats (Rattus norvegicus). This study was an experimental laboratory with a modified pretest and posttest randomized controlled group design using 30 test animals which were divided into 6 treatment groups. Each group consisted of 5 test animals, namely normal control, negative control, and positive control, with doses of 0.2, 0.4, and 0.8 mL/kg BW. The data obtained were analyzed using a One Way Anova and non- parametric statistical test by Kruskal Wallis. test and followed by a further Mann Whitney test to determine differences between treatments. The results showed that enzymatic VCO at a dose of 0.8 mL/kg BW was an effective dose in reducing urea and creatinine levels with an average decrease of 17.40 mg/dL and 0.36 mg/dL. The novelty in this study showed that the enzymatic VCO had an effect on reducing urea and creatinine levels in diabetic hypercholesterolemic male white rats.
Antioxidant, analgetic, and anti-inflammatory activity test of purple leaf ethanol extract (Graptophyllum pictum L. Griff) in vitro and in vivo Ocvinta, Sisca; Dewi, Niluh Puspita; Utami, Indah Kurnia; Darmayanti, Darmayanti; Alaydrus, Syafika; Anwarudin, Wawang
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.29070

Abstract

Purple leaves are one of the plants that are widely used as medicine. Purple leaves have 3 types of plant varieties, namely purple leaves, green leaves, and white mottled leaves.  Purple leaves have pharmacological activities that can be used as medicine, including antioxidants (improving the deterioration of cells in the body), anti-inflammatory (reducing or suppressing inflammation), antidiabetic (lowering blood glucose levels), analgesics (relieving pain), immunomodulators (increasing the work of the immune system in the body), antihemorrhoids (treating symptoms and complaints of hemorrhoids), and antibacterial (as an antiseptic). The purpose of this study was to determine the antioxidant activity of purple leaf ethanol extract (Graphtophyllum pictum (L.) Griff) in vitro using the DPPH method and to determine its effectiveness as an analgesic and anti-inflammatory against Wistar rats.The results showed that antioxidant activity showed an IC50 value of 72.31 ppm (strong antioxidant). Meanwhile, in the analgetic test, the highest percentage of analgesic effectiveness was found at a dose of 100 mg/kg BW (129.64%) and showed anti-inflammatory activity at a dose of 100 mg/kgBW with a percentage decrease in edem volume of 28.73% at the sixth hour.
SOSIALISASI DAN EDUKASI DAGUSIBU OBAT DENGAN BENAR PADA MASYARAKAT KELURAHAN TATURA UTARA, PALU SELATAN Dewi, Niluh Puspita; Wirawan, Wayan; Rakanita, Yasinta; Polontalo, Nani Astria; Insani, Fadillah
Jurnal Abdi Insani Vol 12 No 10 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i10.2873

Abstract

Various health problems, particularly those related to drugs, persist in the community. This can be caused by a lack of public understanding of the proper use and handling of drugs. The DAGUSIBU program is one method for proper drug management. The goal of DAGUSIBU outreach is to increase public understanding of drugs and how to manage and monitor their proper use. The methods used include public education through counseling and practical training. The effectiveness of the outreach was tested using pre- and post-tests, as well as a community satisfaction questionnaire. The results showed an increase in public knowledge and understanding after the DAGUSIBU outreach and education activities. Overall, the average increase in knowledge and understanding of DAGUSIBU among participants was 84%. This can help the government provide better health services. By improving participants' understanding of proper drug management, this outreach is expected to enable them to utilize the knowledge they gain within their families and communities.
Co-Authors Alaydrus, Syafika Athia Kurnia Kasim Darmayanti Darmayanti David Pakaya Gabriella Bamba Ratih Lintin Halik, Nur Handayani, Tien Wahyu Insani, Fadillah Joni Tandi, Joni Lakiu, Debora Rislianti Lestari, Widya Ayu Liska, Iluh Magfira Magfirah, Magfirah Maria Kanan Marsella, Mimi Nadila, Nadila Nani Astria Polontalo Ocvinta, Sisca Pamudji, Gunawan Pasaribu, Meilinda Handayani R, Yana Novika Rakanita, Yasinta Recky Patala Rianto Rianto Rusliyana, Rusliyana Solehah, Puput Octaviani Suarsana, I Made Agus Surat, Megawati R. Syafika Alaydrus Tamunu, Jeine Sweet Natasya Tarusu, Fikhta Agnesya Toding, Ficanata A. Tuldjanah, Muthmainah Utami, Indah Kurnia Viani Anggi Wawang Anwarudin Widiastuti, Aris Wirawan, Resky Chandra wirawan, Wayan Yanuarty, Rezky Yuli Fitriana