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All Journal Farmaka Althea Medical Journal Jurnal Farmasi Klinik Indonesia The Indonesian Biomedical Journal Indonesian Journal of Rheumatology Indonesian Journal of Obstetrics & Gynecology Science Jurnal Kreativitas PKM Narra J
Laniyati Hamijoyo, Laniyati
Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Umum Pusat Hasan Sadikin Bandung
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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ABCB1 rs1045642 Genotypes and Clinical Response in Indonesian Patients with Systemic Lupus Erythematosus Pratama, Muhammad Syawal; Afifah, Nadya Nurul; Permatasari, Lany Indah; Kennardi, Gabriel Bagus; Hamijoyo, Laniyati; Sahiratmadja, Edhyana; Barliana, Melisa Intan
Indonesian Journal of Clinical Pharmacy Vol 13, No 3 (2024)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2024.13.3.62273

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease often managed with immunosuppressants such as methylprednisolone (MP) and azathioprine (AZA), although therapeutic responses vary among individuals. Genetic variation, including polymorphisms in the ATP-Binding Cassette Subfamily B Member 1 (ABCB1) gene encoding the P-glycoprotein drug transporter, may influence treatment outcomes. The rs1045642 polymorphism has been linked to variable responses in SLE, but data in Indonesian populations are scarce. This study aimed to describe the distribution of the ABCB1 rs1045642 polymorphism in SLE patients from Bandung, Indonesia, and to explore its potential association with therapy outcomes using MP and/or AZA. We conducted a cross-sectional study of 84 SLE patients, collecting clinical data from medical records. Treatment outcome was defined as achievement of lupus low disease activity state (LLDAS). Genomic DNA was extracted and sequenced to determine rs1045642 genotypes. A total of 84 SLE patients were included, predominantly aged 26–35 years (34%). Almost half had a disease duration of 6–10 years (49%). The majority achieved LLDAS (69%), and all patients were receiving methylprednisolone, with 78.6% also receiving azathioprine. The genotype distribution of ABCB1 rs1045642 was AA 10.71%, AG 61.91%, and TT 27.38%, which deviated from Hardy–Weinberg equilibrium (p < 0.05). However, genetic variations were observed among patients with SLE. Further studies on other possible polymorphisms related to the outcome of SLE therapy are needed.
Comparison of Pregnancy Outcomes with Autoimmune Rheumatic Disease and Without Autoimmune Rheumatic Disease Sulaiman, Aina Zakia; Pribadi, Adhi; Hamijoyo, Laniyati; Irianti, Setyorini; Rahmadi, Andri Reza
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 3 November 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i3.724

Abstract

Introduction: It is known that pregnancies with autoimmunity have a higher risk of complications in the mother and fetus compared to pregnancies without autoimmunity. The purpose of this study was to determine the comparison between pregnancy outcomes with autoimmune rheumatic disease and without autoimmune rheumatic disease.Methods: This study is an observational analytic with a retrospective cross-sectional design. Data were obtained from all patients with pregnancy outcomes with autoimmune rheumatic disease and without autoimmune rheumatic disease at Hasan Sadikin Hospital Bandung 1 January - 31 December 2021-2023.Results: During this period, 71 pregnant women were found to be accompanied by autoimmune rheumatic diseases and then data on pregnant women without autoimmune rheumatic diseases were randomly taken as controls. In this study, it was found that pregnant women with autoimmune diseases experienced more neonatal outcomes of stunted fetal growth, namely 11(15.5%) compared to pregnant women without autoimmune rheumatic diseases, namely 2(2.8%) with a p-value of 0.009.Conclusion: This study found that pregnant women with autoimmune rheumatic disease experienced more neonatal outcomes of FGR compared to pregnant women without autoimmune rheumatism.Perbandingan Antara Luaran Kehamilan Dengan Penyakit Rhematik Autoimun Dan Tanpa Penyakit Rematik AutoimunAbstrakPendahuluan: Diketahui bahwa kehamilan dengan autoimun memiliki risiko komplikasi pada ibu maupun janin lebih tinggi dibandingkan dengan kehamilan tanpa autoimun. Tujuan penelitian ini untuk mengetahui perbandingan antara luaran kehamilan dengan penyakit rematik autoimun dan tanpa penyakit rematik autoimunMetode: Penelitian ini bersifat analitik observasional dengan desain potong lintang retrospektif. Data diperoleh dari seluruh pasien luaran kehamilan dengan penyakit rematik autoimun dan tanpa penyakit rematik autoimun di Rumah Sakit Hasan Sadikin Bandung 1 Januari – 31 Desember 2021-2023Hasil: Dalam periode tersebut ditemukan 71 orang ibu hamil yang disertai dengan penyakit rematik autoimun kemudian diambil data ibu hamil tanpa penyakit rematik autoimun secara random sebagai kontrol. Pada penelitian ini didapatkan ibu hamil dengan penyakit autoimun lebih banyak mengalami luaran neonatal pertumbuhan janin terhambat yaitu 11(15.5%) dibandingkan ibu hamil tanpa penyakit rematik autoimun yaitu 2(2.8%) dengan p- value0.009.Kesimpulan : Penelitian ini menemukan bahwa ibu hamil dengan penyakit rematik autoimun lebih banyak mengalami luaran neonatal pertumbuhan janin terhambat dibandingkan dengan ibu hamil tanpa rematik autoimun.Kata kunci : Luaran Maternal, Luaran Neonatal, Autoimun 
B Cell-Activating Factor (BAFF) and Ubiquitin Enzyme A20 as Functional Proteins in Targeted Therapy on Patients with Systemic Lupus Erythematosus Fajar, Desi Reski; Rostinawati, Tina; Hamijoyo, Laniyati; Barliana, Melisa Intan
The Indonesian Biomedical Journal Vol 16, No 5 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i5.3161

Abstract

BACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by inflammation. The pathogenesis of SLE involves key proteins, including B cell-activating factor (BAFF) and the ubiquitin enzyme A20, both serving as negative regulators of inflammation and contributing to B cell homeostasis. In this review, focused on interventions directed at BAFF and the A20 enzyme, utilizing monoclonal antibodies either independently or in conjunction with conventional therapy for SLE patients.METHODS: A literature search was conducted on the PubMed platform by combining various terms, including "B-cells activating factor", "TNFAIP3 protein (human)", "therapeutics" or "drug therapy", and "lupus erythematosus, systemic" (limited to the last 10 years). From total of 104 articles discovered in thr search, the total number of articles collected after being filtered was 27 articles.RESULTS: Clinical development and evaluation have been conducted regarding the use of appropriate therapy for SLE patients. Selective BAFF inhibitor has been tested in clinical trials as a blocking agent in BAFF receptor (BAFF-R) and signaling nuclear factor-kappaB (NF-κB) by A20 bindings to inhibit the activation of autoreactive B cells. Just like other antimonoclonal therapies, BAFF and the A20 enzyme can be used as therapeutic targets with a single use or combined with the standard therapy in patients with SLE. In addition, the use of BAFF and A20 also shown to have safe side effects in patients with SLE. CONCLUSION: BAFF protein and A20 enzyme present promising therapeutic targets for managing autoimmune diseases like SLE. Therapeutic interventions can be administered individually or in conjunction with standard treatments.  KEYWORDS: systemic lupus erythematosus, therapeutic targets, BAFF, A20
Co-Authors A Tjandrawati A Tjandrawati A, Muhammad Naufal Achadiyani Achadiyani Achadiyani Adhi Pribadi Afifah, Nadya Nurul Aini, Y H Aini, Yulia Hayatul Alfarish, M Arzan Alfi, Mohammad Abyan Amaylia Oehadian Andiyang R. Diredja Andri Reza Rahmadi Andri Reza Rahmadi Anjalia, Safira Anna Ariane Anna Ariane Anna Tjandrawati Artarini, Aluicia A. Astuti, Intan Widya Aulia Nurlatifah Awalia Awalia Azzahra, Fadhilla Zakya Bambang Setiyohadi Bambang Setiyohadi Bernard Santoso Suryajaya Bethy Suryawathy Hernowo Budi Setiabudiawan Chin Annsha Veimern Coriejati Rita D Nilasari D, H Purbo Dewi Kartika Turbawaty Dewi, Sumartini Dwi Budi Darmawati E Sutedja Edhyana Sahiratmadja Edhyana Sahiratmadja Eka Kurniawan Ellyana Sungkar Endang Sutedja Enrica, M Erica Kwan Yue Fadillah, Viki Faisal Parlindungan Faisal Parlindungan Fajar, Desi Reski Faliq, Muhammad Faza Farid Yudoyono Febyani, M Ferdy Ferdian Gede Kambayana Ghassani, Nadia Gita Guntur Darmawan Guntur Darmawan H Purbo D Habib Burahman Handono Halim Handono Kalim Harry Isbagio Harry Isbagio Hartati Purbo Dharmadji Hartati Purbo Dharmadji Hartati Purbo Dharmadji, Hartati Purbo I Nyoman Suarjana Ignatius Irawan Hidayat Ika Agus Rini Ika Vemilia Warlisti Indrawijaya, Yen YA. Irsan Hasan Ismiana Fatimah Modjaningrat Iwo, Maria I. Kasjmir, Yoga I Kennardi, Gabriel Bagus Lestari, Frida Dwi Lisda Amalia M Arzan Alfarish M Enrica M Febyani Maharani, Khalista Ismaya Malikul Chair Melisa I. Barliana Melisa Intan Barliana, Melisa Intan Modjaningrat, Ismiana Fatimah Mohammad Ghozali Mohammad Ghozali, Mohammad Muhammad Syawal Pratama Muhammad Zafrullah Arifin Mulya Nurmansyah Ardisasmita N Suraya Nadia Gita Ghassani Nadia Gita Ghassani Nadifa, Safira Najirman Najirman Nilasari, D Nita Novita Nita Novita Nur Atik Nur Atik O Suwarsa Ong, Paulus Anam Pande Ketut Kurniari Patrick Philo Paulus Anam Ong Permatasari, Lany Indah Praptama, Suhendra Pratama, Mirza Zaka Pratama, Muhammad Kevin Pratama, Muhammad Syawal Putra, Septian Dwi Putri Vidyaniati Putri, Rahmania Devina Rachmat Gunadi Wachjudi Rachmayati, S Radiyati Umi Partan Rahadian Nugi Sutrisno Rakhma Yanti Hellmi Rakhma Yanti Helmi Ria Bandiara Riardi Pramudiyo Rizky Abdullah RM Suryo Anggoro Rudy Hidayat Rudy Hidayat Rully Hanafi Dahlan Ryan Ardian Saputro S Rachmayati Safira Anjalia Safira Nadifa Santi Andayani Sasfia Candrianita Sasfia Candrianita Septian Dwi Putra Setyorini Irianti Sevline Esthetia Ompusunggu Sevline Esthetia Ompusunggu Shadrina, Siti Azyyati Nur Soeseno Hadi Soeseno Hadi Stefanie Yuliana Usman Stefanie Yuliana Usman Stefanie Yuliana Usman Suhendra Praptama Sulaiman, Aina Zakia Sumariyono Sumartini Dewi Sumartini Dewi Suraya, N Surya Darma Suryana, Bagus Putu Putra Sutedja, E Sutrisno, Rahadian Nugi Suwarsa, O Tear, Alveron Andreas Tina Rostinawati Tjandrawati, A Trinugroho Heri Fadjari, Trinugroho Heri Usman, Stefanie Yuliana Valentine Natasya Moenadi Veimern, Chin Annsha Wahono, Cesarius Singgih Wijaya, Indra Wulansari Manuaba, Ida Ayu Ratih Y H Aini Yoga I Kasjmir Yue, Erica Kwan Yulia Hayatul Aini Yulyani Werdiningsih