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Sarcoidosis Manifested as Recurrent Pericardial Effusion with Signs of Impending Tamponade Christine Elizabeth Suryajaya; Susantina Prodjosoewojo; Arto Y. Soeroto; Nuraini Yasmin Kusumawardhani; Rudi Supriyadi; Laniyati Hamijoyo
Indonesian Journal of Rheumatology Vol. 13 No. 2 (2021): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v13i2.200

Abstract

Pericardial effusion is a fatal and life-threatening condition. If it is not addressed thoroughly, complications such as constrictive pericarditis may occur. Etiologies of pericardial effusion varied and one of the most common etiologies is tuberculosis. Other etiologies include inflammation, malignancy or other autoimmune disorder such as sarcoidosis. Sarcoidosis is a diagnosis of exclusion and is confirmed by biopsy result that showed non-caseating epitheloid-cell granuloma, with no other organism or particles. Epidemiology of sarcoidosis in Japan is 1-2 case per 100.000 patients, with the peak incidence between the age of 20 to 39 years old. We reported a case of 37 years old woman presented to our emergency department with shortness of breath and signs of pericardial tamponade. She was previously healthy with no other significant past medical. She was first treated as a case of extrapulmonary tuberculosis and shown no improvement with anti-tuberculosis medications. Several work ups were then done in search of other etiologies of her pericardial effusion. A biopsy form one of her abdominal lymph nodes was performed, which pathologically revealed sarcoidosis. She was placed on corticosteroid and methotrexate with improvement of symptoms. One month followed up showed complete resolution of her pericardial effusion.
Factors Related to Infection in Systemic Lupus Erythematosus Patients Admitted to the Hospital Arie Taufik; Rachmat Gunadi Wachjudi; Laniyati Hamijoyo
Indonesian Journal of Rheumatology Vol. 14 No. 1 (2022): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v14i1.201

Abstract

Background: One of the causes of the increase in hospitalized SLE patients is infection, and it is an important factor in morbidity and mortality, so it is necessary to conduct a research to identify factors related to infection and the type of infection caused in hospitalized SLE patients. Methods: This study is a retrospective, categorical descriptive study utilizing medical records of SLE patients diagnosed with and treated for infection both on admission and during their stay in Hasan Sadikin General Hospital between January 2016 to June 2018. Results: Seventy- four patients were involved into this study. Female were 70 (94.6%), aged <40 years were 69 (93.2%) patients, and all 74 (100%) were entirely in an active disease condition with a mean Mexican systemic lupus erythematosus disease activity (Mex-SLEDAI) score of 9 ± 5.2. Fifty-three (71.6%) subjects experienced major infections. Mucocutaneous and kidney were the most organs involvement found in SLE patients during infection, 63 (85.1%) and 57 (77.0%) respectively. Sixty-two (83.7%) subjects had received corticosteroids before the onset of infection, while pneumonia was the most common infection found in 33 patients (44.6%). This study also noted 12 (16.2%) patients deceased related to infection with most causes were respiratory failure (66.7%). Conclusion: Age less than 40-year-old, mucocutaneous and kidney involvement and previously on corticosteroids were found higher among in hospitalized SLE patients. Most experienced major infections and pneumonia is the most common type of infection.
RAMBUT RONTOK DAN MUDAH LUPA MERUPAKAN MANIFESTASI YANG BANYAK DIALAMI PENYANDANG LUPUS ERITEMATOSUS SISTEMIK Uni Gamayani; Laniyati Hamijoyo; Vilya Rizkianti Alita; Nadia Gita Ghassani
Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Vol 11, No 3 (2022): September, 2022
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/dharmakarya.v11i3.26102

Abstract

Lupus Eritematosus Sistemik (LES) adalah penyakit inflamasi kronik yang disebabkan oleh gangguan autoimun, autoantibodi abnormal berlebihan diproduksi dan menyalahartikan sel-sel tubuh sebagai musuh, sehingga secara langsung atau tidak langsung menyerang organ dan jaringan dan menyebabkan peradangan kronik. Lupus merupakan penyakit sistemik yang meliputi keterlibatan berbagai sistem organ seperti sistem imun, kulit dan mukosa, sendi, darah, jantung, paru ginjal, dan susunan saraf pusat. Manifestasi penyakit LES sangat beragam dengan perjalanan penyakit yang bervariasi dan memiliki risiko kematian yang tinggi. Seminar awam “Saya Lebih Kuat dari Lupus“ diadakan dengan tujuan edukasi tentang LES dan komplikasi yang mungkin terjadi kepada pasien LES. Sebanyak 52 peserta hadir pada seminar ini, 34 orang diantaranya merupakan pasien LES. Peserta diminta untuk mengisi kuesioner yang bertujuan untuk mengetahui apa saja manifestasi yang terjadi pada pasien. Hasil survei pada penderita lupus menunjukkan bahwa sebanyak  22 (64.7%) responden mengalami gangguan kognisi.
VALIDITAS DAN RELIABILITAS KUESIONER LIVING WITH MEDICINES QUESTIONNAIRE (LMQ) VERSION 3 TERHADAP PASIEN LUPUS ERITEMATOSUS SISTEMIK Aulia Nurlatifah; Melisa I. Barliana; Laniyati Hamijoyo; Rizky Abdullah
Farmaka Vol 18, No 4 (2020): Farmaka (Suplemen)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v18i4.42349

Abstract

Berbagai jenis obat harus diminum selama hidupnya oleh setiap Odapus (Orang Lupus), yang bertujuan untuk meningkatkan kualitas hidup. Berbagai jenis obat dengan jumlah banyak menghasilkan beban pengobatan yang akan menurunkan kepatuhan pasien. Ketika kepatuhan pasien menurun, maka luaran yang dihasilkan juga tidak maksimal. Beban yang terkait dengan pengelolaan penyakit kronis, termasuk pada penyakit Lupus Eritematosus Sistemik (LES), akan berdampak pada kesejahteraan pasien dan risiko terjadinya efek samping obat. Penelitian ini merupakan studi potong lintang, pengambilan data secara prospektif di Poliklinik rawat jalan Reumatologi disalah satu Rumah Sakit kota Bandung periode Februari – Maret 2019, dan menggunakan kuisioner LMQ (Living with Medicine Questionnaire) versi 3. Jumlah pasien dalam penelitian ini sebanyak 30 pasien dengan kriteria inklusi adalah pasien dengan diagnosa LES, usia minimal 18 tahun, pasien rawat jalan di Poliklinik Reumatologi, sedang meminum obat terkait pengobatan LES, dan bersedia mengikuti penelitian dengan menandatangani informed consent. Kriteria ekslusi sampel penelitian adalah pasien ibu hamil, pasien dengan gangguan pendengaran dan pasien yang tidak bisa berbicara. Uji validasi kuesioner pada penelitian ini menggunakan uji korelasi Pearson Product Moment, sedangkan uji reliabilitas kuesioner menggunakan uji Cronbach alpha coefficient. Hasil penelitian ini menunjukan bahwa nilai Koefisien Validitas (r hitung) lebih besar dari pada r tabel yaitu sebesar 0,361 (n = 30). Sedangkan koefisien reliabilitas hasil perhitungan tidak ada nilai reliabilitas yang sangat rendah (kurang dari 0,200) sehingga untuk keseluruhan item pada variabel dan domain dalam penelitian ini dapat digunakan untuk analisis variabel lebih lanjut.
THE IMPACT OF ATP-BINDING CASSETTE SUBFAMILY B MEMBER 1 (ABCB1) POLYMORPHISMS ON STANDARD TREATMENTS FOR SYSTEMIC LUPUS ERYTHEMATOSUS Muhammad Syawal Pratama; Laniyati Hamijoyo; Melisa I. Barliana
Farmaka Vol 18, No 4 (2020): Farmaka (Suplemen)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v18i4.42489

Abstract

The ATP-Binding Cassette Subfamily B Member 1 (ABCB1) gene encodes for P-glycoprotein (P-gp) which is an efflux pump used to transport a variety of xenobiotics. The role of ABCB1 polymorphisms in Systemic Lupus Erythematosus (SLE) affect outcomes of standard therapy (hydroxychloroquine, glucocorticoid (GC), azathioprine (AZA), mycophenolate mofetil (MMF), and cyclophosphamide (CYC)). We conducted an investigation assessing affiliations between the ABCB1 polymorphisms, G1199A, C1236T, G2677T/A, and C3454 and effectiveness variables. Although ABCB1 polymorphisms do not cause SLE, they exert a significant impact on therapy effectiveness. These polymorphisms significantly influenced GCs and AZA, had less effects on methotrexate (MTX), MMF, and CYC, and no impact on antimalarials. The four most influential polymorphisms were, rs1045642 (C3454), rs1128503 (C1236T), rs2032582 (G2677T/A), and rs2229109 (1199A).
Indonesian Rheumatology Association (IRA) Recommendations for Diagnosis and Management of Glucocorticoid-induced Osteoporosis Bagus Putu Putra Suryana; Rudy Hidayat; Laniyati Hamijoyo; Radiyati Umi Partan; Yulyani Werdiningsih; Surya Darma; RM Suryo Anggoro; Anna Ariane; Faisal Parlindungan; Mirza Zaka Pratama; Harry Isbagio; Handono Halim; Cesarius Singgih Wahono; Sumariyono
Indonesian Journal of Rheumatology Vol. 14 No. 2 (2022): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v14i2.216

Abstract

Background: Patients receiving long-term glucocorticoid therapy are at risk of developing GIOP. However, until today, there is still no guideline that specifically explains how to diagnose and manage GIOP patients in Indonesia. Methods: 10 selected rheumatologists from the Indonesian Rheumatologist Association (IRA) made recommendations based on key questions formed by a steering committee from IRA. These recommendation materials were taken from several online databases such as Pubmed, Science Direct, and Cochrane. Level of evidence and grades of recommendation were then assigned, and every member of the panelist team will assign a score for the level of agreement. Results: A total of 17 recommendations regarding screening, prevention, diagnosis, therapy, and monitoring for GIOP were made. Conclusion: These recommendations can be used for adult patients receiving long-term glucocorticoids with or at risk of developing GIOP. The prevention measure, diagnostic, therapy, and monitoring algorithm in this recommendation are all created with the consideration of Indonesia’s clinical setting, facility, and drug availability.
Is Quality of Life of Lupus Better than Systemic Sclerosis? Laniyati Hamijoyo; Nadia Gita Ghassani; Bernard Santoso Suryajaya; Ignatius Irawan Hidayat; Valentine Natasya Moenadi; Sasfia Candrianita; Sumartini Dewi
Indonesian Journal of Rheumatology Vol. 11 No. 1 (2019): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v11i1.119

Abstract

Background. Patients with systemic lupus erythematosus (SLE) and systemic sclerosis (SSc), have to cope with lifelong disease manifestation and impaired physical function. Limited physical activities along the disease will affect their quality of life (QoL). The QoL is recognized as an important factor of treatment strategy. This study aims to compare the quality of life of patient with SLE and SSc. Methods. This study was a cross-sectional study and conducted in rheumatology outpatient clinic of Hasan Sadikin Hospital Bandung, Indonesia from January 2015 until March 2017. The respondents were patients diagnosed as SLE and SSc who regularly visit rheumatology outpatient clinic. Respondents were asked to complete the Short Form-36 (SF-36). Baseline characteristics, including age, gender, and duration of disease, were collected during the visit. The Mann-Whitney U test was used to analyze the comparison. Results. There were 242 patients who completed the SF-36 questionnaires, consisted of 193 SLE patients and 49 SSc patients. SLE patients were slightly younger and had a longer duration of disease compared to SSc. The SF-36 Physical Component Summary (PCS) score was significantly higher on SLE patients (40.6 vs 40.4, p = 0.0001), but the mean of Mental Component Summary (MCS) score was similar among both diseases. Conclusion. Physical functioning aspect on quality of life is better in SLE patients compared to SSc patients. However, mental aspect for both diseases are relatively similar.
B-Cell Activating Factor Profile and Quality of Life in Systemic Lupus Erythematosus Patients Andri Reza Rahmadi; Habib Burahman; Nadia Gita Ghassani; Rachmat Gunadi Wachjudi; Laniyati Hamijoyo
Indonesian Journal of Rheumatology Vol. 14 No. 2 (2022): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v14i2.204

Abstract

Background: B-Cell Activating Factor (BAFF) is a cytokine that plays a role in systemic lupus erythematosus (SLE) pathogenesis. BAFF increases B cell function, which will affect disease activity. In addition to decreasing disease activity, good quality of life (QoL) is one of the goals to be achieved in SLE therapy, which is also affected by disease activity. The purpose of this study is to know the correlation of the BAFF profile with the QoL of SLE patients. Methods: This was a cross-sectional study using secondary data from a previous study. The subjects of this study were SLE patients who had visited the rheumatology outpatient clinic or were hospitalized in Hasan Sadikin Hospital Bandung from September 2016 until February 2017. Subjects were asked to complete the Short Form-36 and measure their BAFF level in serum. Demographic data were collected, and disease activity data were assessed by Mexican Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI). The statistical analysis used in this study was the Spearman test. Results: There was a positive correlation between BAFF and MEX-SLEDAI (r 0.238, p-value 0.038). There was also a negative correlation between MEX-SLEDAI and PCS, as well as the MCS score (r -0.392 and -0.371, p-value <0.05). Conclusion: BAFF levels will increase in higher disease activity which will affect a poorer quality of life.
Indonesian Rheumatology Association (IRA) Recommendations for Diagnosis and Management of Osteoarthritis (Knee, Hand, Hip) Rakhma Yanti Helmi; Najirman; Ida Ayu Ratih Wulansari Manuaba; Andri Reza Rahmadi; Pande Ketut Kurniari; Malikul Chair; Ika Vemilia Warlisti; Eka Kurniawan; Harry Isbagio; Handono Kalim; Rudy Hidayat; Laniyati Hamijoyo; Cesarius Singgih Wahono; Sumariyono
Indonesian Journal of Rheumatology Vol. 15 No. 1 (2023): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v15i1.225

Abstract

Background: Osteoarthritis (OA) is the most common form arthritis in the world, and its prevalence is predicted to rise higher in the future due to increasing life expectancy and growing number of elderly population. With the emergence of new treatment options in the last several years, a better understanding of OA diagnosis and management is required by every physician in Indonesia. Methods: A panel of eight selected rheumatologists from the Indonesian Rheumatologist Association (IRA) developed recommendations based on key questions formulated by a steering committee from IRA. These recommendation materials were taken from several online databases such as PubMed, Science Direct, and Google Scholar. Level of evidence and grades of recommendation were then assigned, and each member of the panelist team will assign a score to express their level of agreement. Results: A total of 25 recommendations discussing the diagnosis, pharmacological and non-pharmacological therapies, as well as monitoring for OA were formulated. Conclusion: These recommendations can be used to help clinicians in accurately diagnosing OA and choosing the most suitable therapy for their patients. All recommendation statements were tailored to the clinical setting, facility, and drug availability in Indonesia.
GSTA1 gene polymorphisms are associated with cyclophosphamide effectiveness in lupus nephritis patients: A case-control study in Indonesia Indrawijaya, Yen YA.; Artarini, Aluicia A.; Hamijoyo, Laniyati; Iwo, Maria I.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1144

Abstract

Glutathione-S-transferase alpha-1 (GSTA1) is an enzyme with high conjugation activity against aldophosphamide, a metabolite of cyclophosphamide and promoter polymorphisms in GSTA1 may influence the cyclophosphamide effectiveness. The aim of this study was to evaluate the effectiveness and side effects of cyclophosphamide in lupus nephritis patients, using GSTA1 variants as predictors. A case-control study was conducted at Hasan Sadikin Hospital, Bandung, Indonesia, involving 100 lupus nephritis patients from February 2023 to January 2024. The PCR-Sanger sequencing was used to genotype five selected single nucleotide polymorphisms (SNPs) in the GSTA1 promoter: -52 A>G, -69 T>C, -513 A>G, -567 G>T, and -631 G>T. The endpoint was assessed after six doses of cyclophosphamide by evaluating renal function, disease activity and side effects. Results indicated that six doses of intravenous cyclophosphamide treatment improved renal function and disease activity in the patients, as evidenced by significant changes in serum creatinine (0.79 vs 0.69 mg/dL), dipstick proteinuria (3.00 vs 1.50), creatinine clearance (98.50 vs 109.50 mL/min), and Modified Systemic Lupus Erythematosus Disease Activity Index 2000 (M-SLEDAI-2K) score (8.61 vs 6.95). The AG genotype at -513 A>G was associated with reduced cyclophosphamide effectiveness (odds ratio (OR): 0.19; 95%CI: 0.19–0.60; p=0.019). The GT genotype at -631 G>T independently increased the progression of anemia (OR: 2.41; 95%CI: 0.26–22.12; p=0.040). This study highlights that the presence of GSTA1 variants affected cyclophosphamide effectiveness in lupus nephritis patients, with heterozygous polymorphisms at -513 (AA to AG) and -631 (TT to GT) predicting reduced effectiveness of cyclophosphamide by enhancing GSTA1 promoter activity, while anemia further exacerbated lupus nephritis disease severity. GSTA1 polymorphism was not associated with the presence of alopecia, amenorrhea, gastrointestinal disorders, and leukopenia during cyclophosphamide therapy.
Co-Authors A Tjandrawati A Tjandrawati A, Muhammad Naufal Achadiyani Achadiyani Achadiyani Adhi Pribadi Adhilizha Zumrotul Khasanah Khasanah Adika Ruhani Satiadi Satiadi Afifah, Nadya Nurul Afini Tiara Resi Aini, Y H Aini, Yulia Hayatul Alfarish, M Arzan Alfi, Mohammad Abyan Alya Marsya Sabrina Amaylia Oehadian Amira Husna Bestari Bestari Andiyang R. Diredja Andri Reza Rahmadi Angkasa Ramatuan Hamdan Anjalia, Safira Anna Ariane Anna Ariane Anna Tjandrawati Arie Taufik Artarini, Aluicia A. Arto Y. Soeroto Astuti, Intan Widya Aulia Nurlatifah Awalia Awalia Azzahra, Fadhilla Zakya Bambang Setiyohadi Bambang Setiyohadi Bernard Santoso Suryajaya Bethy Suryawathy Hernowo Budi Setiabudiawan Chin Annsha Veimern Christine Elizabeth Suryajaya Coriejati Rita D Nilasari D, H Purbo Deasty Dini Imara Imara Dewi Kartika Turbawaty Dewi, Sumartini Dwi Budi Darmawati E Sutedja Edhyana Sahiratmadja Edhyana Sahiratmadja Edhyana Sahiratmadja Edhyana Sahiratmadja Sahiratmadja Eka Kurniawan Ellyana Sungkar Endang Sutedja Enrica, M Erica Kwan Yue Fadillah, Viki Fajar, Desi Reski Faliq, Muhammad Faza Farid Yudoyono Febyani, M Ferdy Ferdian Gede Kambayana Ghassani, Nadia Gita Guntur Darmawan Guntur Darmawan H Purbo D Habib Burahman Handono Halim Handono Kalim Harry Isbagio Harry Isbagio Hartati Purbo Dharmadji Hartati Purbo Dharmadji Hartati Purbo Dharmadji, Hartati Purbo I Nyoman Suarjana Ignatius Irawan Hidayat Ika Agus Rini Ika Vemilia Warlisti Indrawijaya, Yen YA. Irham Rasyid Irsan Hasan Ismiana Fatimah Modjaningrat Iwo, Maria I. Jessica Hamriani Hamriani Kasjmir, Yoga I Kemala Emrizal Kennardi, Gabriel Bagus Kevin Yonatan Budiman Lestari, Frida Dwi Lisda Amalia Lynna Lidyana M Arzan Alfarish M Enrica M Febyani Maharani, Khalista Ismaya Malikul Chair Melisa I. Barliana Melisa Intan Barliana Modjaningrat, Ismiana Fatimah Mohammad Ghozali Mohammad Ghozali, Mohammad Muhammad Azka Arrazi Arrazi Muhammad Dzakwan Farisi Farisi Muhammad Kevin Pratama Muhammad Syawal Pratama Muhammad Zafrullah Arifin Mulya Nurmansyah Ardisasmita N Suraya Nadia Gita Ghassani Nadia Gita Ghassani Nadia Gita Ghassani Nadifa, Safira Najirman Najirman Nevita Naira Dyahrani Dyahrani Nilasari, D Nita Novita Nita Novita Nur Atik Nuraini Yasmin Kusumawardhani O Suwarsa Ong, Paulus Anam Pande Ketut Kurniari Parlindungan, Faisal Patrick Philo Paulus Anam Ong Paulus Anam Ong Permatasari, Lany Indah Praptama, Suhendra Pratama, Mirza Zaka Pratama, Muhammad Kevin Pratama, Muhammad Syawal Putra, Septian Dwi Putri Vidyaniati Putri, Rahmania Devina Rachmat Gunadi Wachjudi Rachmayati, S Radiyati Umi Partan Rahadian Nugi Sutrisno Rakhma Yanti Hellmi Rakhma Yanti Helmi Rania Ziamayra Ziamayra Reza Kurniawan Tanuwihardja Ria Bandiara Riardi Pramudiyo Rizky Abdullah RM Suryo Anggoro Rudi Supriyadi Rudy Hidayat Rully Hanafi Dahlan Ryan Ardian Saputro S Rachmayati Safira Anjalia Safira Nadifa Santi Andayani Sasfia Candrianita Sasfia Candrianita Septian Dwi Putra Setyorini Irianti Sevline Esthetia Ompusunggu Sevline Esthetia Ompusunggu Shadrina, Siti Azyyati Nur Shofia Dewi Fortuna Fortuna Soeseno Hadi Soeseno Hadi Stefanie Yuliana Usman Stefanie Yuliana Usman Stefanie Yuliana Usman Suhendra Praptama Sulaiman, Aina Zakia Sumariyono Sumartini Dewi Sumartini Dewi Sumartini Dewi Suraya, N Surya Darma Suryana, Bagus Putu Putra Susantina Prodjosoewojo Sutedja, E Sutrisno, Rahadian Nugi Suwarsa, O Syarief Hidayat Syarief Hidayat Tear, Alveron Andreas Tina Rostinawati Tjandrawati, A Trinugroho Heri Fadjari, Trinugroho Heri Uni Gamayani Usman, Stefanie Yuliana Valentine Natasya Moenadi Veimern, Chin Annsha Vilya Rizkianti Alita Wahono, Cesarius Singgih Widi Palupi Ayu Padmandani Wijaya, Indra Wulansari Manuaba, Ida Ayu Ratih Y H Aini Yoga I Kasjmir Yue, Erica Kwan Yulia Hayatul Aini Yulyani Werdiningsih Yuna Islamiati Islamiati