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All Journal Jambura Journal of Health Sciences and Research Jurnal Ners International Journal Of Science, Technology & Management (IJSTM) Jurnal Kesehatan: Jurnal Ilmu- Ilmu Keperawatan, Kebidanan, Farmasi dan Analis Kesehatan Jurnal Kesehatan Tambusai JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Sains dan Teknologi Jurnal Rumpun Ilmu Kesehatan Jurnal Kesehatan Amanah PCJN Pharmaceutical and Clinical Journal of Nusantara Ranah Research : Journal of Multidisciplinary Research and Development Journal of Pharmaceutical and Sciences. Jurnal Sains Student Research Jurnal Novem Medika Farmasi Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Jurnal Sains Farmasi dan Kesehatan
Muhammad Yunus
Prodi Apoteker Universitas Prima Indonesia, Medan. Sumatera Utara, Indonesia.
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Transportation Veterinary Other

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UJI EFEKTIVITAS EKSTRAK DAUN SUKUN (ARTOCARPUS ALTILIS) SEBAGAI PENURUNAN KADAR GLUKOSA DARAH YANG DI INDUKSI ALOKSAN TERHADAP TIKUS JANTAN PUTIH (RATTUS NORVEGICUS) DAN UJI ANTIOKSIDAN EKSTRAK DAUN SUKUN Keliat, Elsa Nova Q Pani; Muhammad Yunus; Sembiring, Novitaria
Jurnal Kesehatan Tambusai Vol. 5 No. 3 (2024): SEPTEMBER 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i3.32446

Abstract

Diabetes Melitus (DM) ialah penyakit jangka panjang yang ditandai oleh peningkatan kadar gula darah melebihi normal. Secara khusus, diabetes mellitus ditentukan apabila kadar gula darah saat mencapai 200mg/dL ataupun lebih, serta kadar glukosa darah puasa mencapai 126mg/dL. Salah satu tanaman tradisional yang terdapat di Indonesia dan dapat dimanfaatkan sebagai obat adalah tanaman sukun (Artocarpus altilis). Ekstrak etanol daun sukun diketahui mengandung metabolit sekunder yaitu alkaloid, falvonoid, tanin, saponin dan polifeno. Berdasarkan kandungan metabolit sekundernya yaitu tanin yang berfungsi sebagai antioksidan, astringen dan antidiabetes. Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak daun matahari (Artocarpus Altilis) pada tikus putih jantan (Rattus Norvegicus) yang diinduksi aloksan dan mengetahui perbandingan ekstrak daun sukun dan vitamin C. Dalam uji penurunan glukosa darah kadarnya menggunakan ekstrak daun sukun dosis 100mg, 200mg dan 400mg. Sebagai kontrol negatif menggunakan Na-CMC dan kontrol positif menggunakan metformin. Metode penelitian ini menggunakan metode RAL (Rancangan Acak Lengkap) Data dianalisis menggunakan uji Annova dan LSD. Uji antioksidan menghitung nilai IC50 menggunakan persamaan linier. Hasil penelitian membuktikan bahwa ekstrak etanol daun sukun (Artocarpus Altilis) efektif menurunkan kadar glukosa darah tikus jantan (Rattus Norvegicus) dengan dosis 400mg pada hari ke 9.  Hasil penelitian antioksidan menunjukkan bahwa aktivitas ekstrak etanol daun sukun lebih rendah dibandingkan Vitamin C Nilai IC50 ekstrak daun sukun sebesar 63,8 µg/ml, sedangkan vitamin C sebesar 30,5. Kesimpulan penelitian ini menunjukkan bahwa ekstrak etanol daun sukun efektif menurunkan kadar glukosa darah pada tikus jantan. Namun aktivitas antioksidan ekstrak daun sukun lebih rendah dibandingkan vitamin C.
EVALUASI PENGGUNAAN OBAT DAN IDENTIFIKASI DRUG RELATED PROBLEM (DRP) PADA PASIEN RAWAT JALAN DIABETES MELITUS TIPE 2 DI RUMAH SAKIT UMUM ROYAL PRIMA MEDAN Tafonao, Rachel Julia; Yunus, Muhammad; Lubis, Yolanda Eliza Putri
Jurnal Kesehatan Tambusai Vol. 5 No. 3 (2024): SEPTEMBER 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i3.32447

Abstract

Pengelolaan diabetes melitus tipe 2 sering kali kompleks dan membutuhkan penggunaan lebih dari satu jenis obat, yang dapat menyebabkan Drug Related Problems (DRP). Penelitian ini bertujuan untuk mengevaluasi penggunaan obat dan mengidentifikasi Drug Related Problem (DRP) yang kemungkinan terjadi pada pasien diabetes melitus tipe 2. Penelitian ini adalah penelitian deskriptif dengan pendekatan prospektif, yang dilakukan di Rumah Sakit Umum Royal Prima Medan dari September hingga November 2023. Data yang digunakan adalah 450 resep pasien rawat jalan yang berusia 18 tahun dan didiagnosis dengan diabetes melitus tipe 2, baik dengan atau tanpa komplikasi, serta menggunakan obat antidiabetes oral. Dari hasil penelitian, karakteristik pasien diabetes melitus tipe 2 yang paling banyak adalah kelompok usia dewasa (19-59 tahun) dengan 55.33% dan jenis kelamin perempuan dengan 60.44%. Metformin adalah obat antidiabetes yang paling umum digunakan dengan persentase 36.74%. Potensi DRP yang paling sering ditemukan adalah interaksi obat (97%) dan overdosis (3%). Identifikasi dan manajemen DRP yang tepat sangat penting untuk meningkatkan efektivitas terapi dan kualitas hidup pasien. Disarankan juga adanya edukasi berkelanjutan bagi pasien dan pelatihan bagi tenaga medis untuk meminimalkan risiko DRP.
Evaluation Of Drug Storage System In A Pharmacy Of Medan City Based On Pharmaceutical Services Standards Rinda Sari, Syilvi; Yunus, Muhammad; Rawitri, Kiki; Wahyuni, Sri; Rani, Zulmai; Syahputri, Hindri
International Journal of Science, Technology & Management Vol. 4 No. 4 (2023): July 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i4.872

Abstract

Pharmacy is a place where pharmaceutical services are held by pharmacists who are responsible for patients. Pharmaceutical services in pharmacies are related to drugs with the aim of achieving definite results to improve the quality of life of patients. So the management of drugs in pharmacies needs to be done properly and precisely to ensure the availability of sufficient and quality drugs in order to achieve optimal service goals by implementing a storage system that is in accordance with pharmaceutical service standards no.73 of 2016. Therefore the purpose of this research is to evaluate the drug storage system in one of the Medan city pharmacies based on pharmaceutical service standards. This research is descriptive with retrospective data collection. The data obtained were grouped into quantitative data presented in tabular form to see visual comparisons, and qualitative data obtained through observation and interviews with informants. The results showed that in several indicators of drug storage in one of the Medan city pharmacies based on Permenkes No. 73 of 2016 there are still those that have not complied with, namely in the preparation of LASA drugs and writing document numbers on drug stock cards. Meanwhile, the standard drug storage indicators are the columns on the stock card consisting of receipt or dispensing date, receipt or disbursement document number, source of origin of the drug, no. batch/no. Lot, expiry date, receipt and disbursement amount, remaining stock, and officer's initials, as well as suitability for drug storage based on dosage form, alphabetical order, and FEFO and FIFO storage methods. Based on the results of the study it was concluded that the drug storage system carried out in one of the pharmacies in the city of Medan did not meet pharmaceutical service standards based on Permenkes No. 73 of 2016.
Uji Efek Nefroprotektif Ekstrak Etanol Daun Sirih Hijau (Piper betle L.) pada Tikus Jantan yang Diinduksi Gentamisin. Tuti Putri Waruwu; Asyrun Alkhairi Lubis; Muhammad Yunus
Jurnal Ners Vol. 9 No. 3 (2025): JULI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i3.47642

Abstract

Upaya nefroprotektif bertujuan untuk menjaga kesehatan ginjal dari risiko kerusakan.Tujuan dari studi ini adalah agar memahami pengaruh efek protektif terhadap ginjal serta menentukan dosis dalam jumlah yang tepat dari ekstrak etanol daun sirih hijau yang berfungsi sebagai agen pelindung ginjal.Studi melibatkan 25 ekor tikus jantan yang terbagi kedalam lima kelompok perlakuan berbeda,dimana kelompok kontrol normal tidak diberi perlakuan,Kelompok kontrol negatif yang diinduksi dengan gentamisin,serta kelompok uji yang menerima perlakuan ekstrak etanol daun sirih hijau dengan dosis brturut turut dari 100 mg/KgBB,150 mg/KgBB dan 200 mg/KgBB.Ekstrak diberikan melalui oral sekali sehari masa 8 hari,kemudian setiap hewan uji diberikan injeksi intraperitoneal gentamisin dengan dosis 80 mg/KgBB sejam setelah pemberian ekstrak,kecuali pada kelompok normal. Hasil pemeriksaan kreatinin hari 1 dan 9 mengindikasikan bahwa ekstrak etanol daun sirih hijau berpotensi sebagai agen nefroprotektif
Kajian Potensi Etil Asetat Ekstrak Daun Andaliman : Total Fenol Flavonoid dan Aktivitas Uji Antioksidan Muhtamilatur Rahma; Roy Indrianto Bangar; Muhammad Yunus
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 1 (2026): Februari 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i1.7537

Abstract

Andaliman leaves (Zanthoxylum acanthopodium DC.) are a traditional plant native to North Sumatra with potential as a natural antioxidant source due to their phenolic and flavonoid compounds. This study aimed to evaluate the antioxidant potential of the ethyl acetate extract of andaliman leaves based on total phenolic content, total flavonoid content, and antioxidant activity. Extraction was carried out using the maceration method with ethyl acetate as the solvent. Total flavonoid content was determined using the AlCl₃ method with quercetin as the standard, while total phenolic content was analyzed using the Folin– Ciocalteu method with gallic acid as the standard. Antioxidant activity was evaluated using the DPPH radical scavenging assay. The results showed that the ethyl acetate extract of andaliman leaves contained 73.40 mg QE/g extract of total flavonoids (7.3%) and 148.48 mg GAE/g extract of total phenolics. The antioxidant activity test yielded an IC₅₀ value of 4,2485 µg/mL, indicating that the extract exhibits very strong antioxidant activity. The high levels of phenolic and flavonoid compounds are believed to play an important role in the radical scavenging activity observed. Based on these findings, it can be concluded that the ethyl acetate extract of andaliman leaves has strong potential to be developed as a natural antioxidant source for applications in the pharmaceutical and health fields.
Pengujian Efek Proteksi Jus Tomat (Solanum Lycopersicum (L.)) Terhadap Fungsi Ginjal Tikus Yang Diinduksi Parasetamol Angelia Vega; Asyrun Alkhairi Lubis; Muhammad Yunus
Jurnal Kesehatan Amanah Vol. 9 No. 1 (2025): Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v9i1.763

Abstract

Excessive doses of paracetamol can cause nephrotoxicity due to accumulation of NAPQI and oxidative stress, which damages the proximal tubules of the kidney. Tomato (Solanum tomato L.) which is rich in lycopene has the potential to prevent this damage through its antioxidant activity. This experimental study used a posttest-only control group design with 25 white rats (Rattus norvegicus) divided into 5 groups: positive control, negative control, and three treatment groups. The mice were induced with toxic doses of paracetamol, while the treatment group was given tomato juice. Evaluation is carried out through measurement of plasma creatinine and renal histopathological analysis. The results showed that toxic doses of paracetamol (250 mg/kgBW) increased creatinine levels and relative kidney weight, which indicated acute kidney damage. Giving high doses of tomato juice (800 mg/kgBW) was most effective in reducing creatinine levels and protecting kidney tissue compared to lower doses. Administration of paracetamol 250 mg/kgBW caused kidney damage which was characterized by an increase in creatinine and relative kidney weight. Tomato juice at a dose of 800 mg/kgBW provided the best protective effect by reducing creatinine levels close to the positive control. These results demonstrate the potential of tomato juice as a protective agent against paracetamol-induced kidney damage.
Comparison Of Ethanol, N-Hexane and Ethyl Acetate Extract in Andaliman Leaves (Zanthoxylum Acanthopodium DC) Anti-Bacterial Test for Staphylococcus Aureus Desmina Nur Cahaya Simanjuntak; Roy Indrianto Bangar S; Muhammad Yunus
JURNAL KESEHATAN STIKes MUHAMMADIYAH CIAMIS Vol. 13 No. 1 (2026): Jurnal Kesehatan
Publisher : LPPM STIKes Muhammadiyah Ciamis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52221/jurkes.v13i1.1003

Abstract

Skin infections caused by this bacterium remain common, and antibiotic resistance continues to increase, creating a need for natural antibacterial sources. Andaliman leaves are one plant that can be used as a natural antibacterial active ingredient due to their content of flavonoids, tannins, saponins, terpenoids, and essential oils. This study aimed to determine whether n-hexane, ethyl acetate, and ethanol extracts of andaliman leaves exhibit antibacterial activity against Staphylococcus aureus. The study was conducted experimentally, beginning with successive extraction of andaliman leaves using n-hexane, ethyl acetate, and ethanol, followed by antibacterial activity testing using the disc diffusion method at concentrations of 20%, 30%, and 40%. The results showed that the n-hexane extract produced inhibition zones of 8.3±0.12 mm at 20%, 8.8±0.16 mm at 30%, and 9.3±0.04 mm at 40%. The ethyl acetate extract showed increased inhibitory activity with inhibition zones of 9.4 ± 0.28 mm at 20%, 12.7 ± 1.52 mm at 30%, and 16.0 ± 1.31 mm at 40%. The ethanol extract exhibited the highest antibacterial activity, with inhibition zones of 13.0±1.66 mm at 20%, 15.0±1.81 mm at 30%, and 19.4±1.12mmat40%.
Efek Gel Ekstrak Daun Sirsak (Annona Muricata L.) sebagai Agen Antiulkus pada Tikus Diabetes Induksi Aloksan : Studi Histologi Magdalena Tiara V Manihuruk; Muhammad Yunus; Asyrun Alkhairi Lubis
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 3 (2026): Juni 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i3.8119

Abstract

Diabetes Melitus is a chronic hyperglikemia codition that can impair wound healing due to distrupted tissue regeneration and alterrations in skin histological structure. Burn wounds under diabetic conditions tend to experience delayed healing as a result of decreased fibroblast activity, suboptimal collagen formation, and impaired angiogenesis. Soursoup leaves (Annona muricata l.) are known to contain bioactive compounds that may support the wound healing process. This study aimed to evaluate the effectiviness of soursoup leaf extract gel on burn wound healing in alloxan-induced diabetic rats through histological into six groups, consisting of a normal control, negative control, positive control ( Bioplacenton ), and treatment groups receiving soursoup leaf extract gel at concentration of 5%,10% and 15%. The observed parameters included the percentage of wound healing and histological festures of skin tissue, namely fibroblast count, collagen density and capillary formation. The result showed that administration of soursoup leaf increased number of fibroblast, improved collagen formation and enchanced skin tissue regeneration. Soursoup leaf extract gel has the potency accelerate burn wound heaing in alloxan-induced diabetic rats through improvement of skin tissue histological structure.
FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN GEL EKSTRAK DAUN SELEDRI (Apium graveolens L) TERHADAP BAKTERI Pseudomonas aeruginosa Suci Della; Muhammad Yunus; Erida Novriani
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 2 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i2.2228

Abstract

Formulation and Antibacterial Action Assessment of Celery Leaf Extract Gel (Apium graveolens L. ) Against Staphylococcus aureus and Pseudomonas aeruginosa Bacteria Celery (Apium graveolens L.) is a plant recognized for its ability to fight bacteria because of substances like flavonoids, saponins, and tannins, which offer promising natural antibacterial alternatives. This study aimed to create a gel from celery leaf extract and test its antibacterial properties against Staphylococcus aureus and Pseudomonas aeruginosa. The celery leaves were extracted using the maceration method with 96% ethanol, achieving a yield of 17.25%. Four distinct gel formulations were produced with varying levels of extract: 0% (F0), 5% (F1), 10% (F2), and 15% (F3), utilizing HPMC as the gel base. Evaluations of the physical properties, which included sensory testing, uniformity, pH, spreadability, and viscosity, showed that all formulations met the quality criteria for gel products. The pH values ranged from 6. 63 to 6. 81, the spreadability was recorded between 5-6 cm, and the viscosity varied from 15,567 to 18,325 cPs. The antibacterial effectiveness test on Staphylococcus aureus, conducted through the disc diffusion method, revealed inhibition zones of 9.2 mm (moderate), 10.3 mm (moderate), and 11.48 mm (strong) at concentrations of 2.5%, 5%, and 10%, respectively. These results indicate that the gel made from celery leaf extract shows antibacterial effects against Staphylococcus aureus, with the highest efficacy observed at a concentration of 10%.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN SELEDRI (Apium graveolens L) TERHADAP BAKTERI PSEUDOMONAS AERUGINOSA SECARA IN VITRO Wahyuni Sihombing; Muhammad Yunus; Edy Fachrial
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 2 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i2.2230

Abstract

Celery leaves (Apium graveolens L) are plants with various properties according to people's beliefs, one of which is functioning as an antibacterial for skin infections. The skin on the largest human body organ located on the external part of the body whose function is to protect the body parts underneath. This skin disease is caused by bacteria, namely Pseudomonas aeruginosa bacteria, this bacteria is a gram-negative bacteria. The purpose of this study was to determine the effectiveness of celery leaves (Apium graveolens L) against pseudomonas aeruginosa bacteria In Vitro, with concentrations of 2.5%, 5%, 7.5%, 10%, 15%, 20%. In the negative control using 10% DMSO solution, and in the positive control using chloramphenicol disk This study is an experimental study. The research method uses the maceration method using 96% ethanol solvent, sterilization of tools, bacterial rejuvenation, media preparation, test solution preparation, and measurement of inhibition zones after incubation for 24 hours at 37 ° C. The results of this study showed that celery leaf extract (Apium graveolens L.) could inhibit bacterial growth at all tested concentrations. The conclusion is that celery leaf extract (Apium graveolens L) is effective in inhibiting bacterial growth.
Co-Authors Adelia Pratiwi Adinda Silvani Ginting Afika, Nur Angelia Vega Astriani Natalia Br Ginting Asyrun Alkhaira Lubis Asyrun Alkhairi Lubis Asyrun Alkhairi Lubis Asyrun lkhairi Lubis Brian Elberth Halu Caniago, Indri M. Clearesta Carmenita M. Cindy Tiara Situmorang Cindy Ronaldo Munthe Cristin Natali Rouli Desmina Nur Cahaya Simanjuntak Edy Fachrial Elfia Neswita Elfia Neswita Erida Novriani Fira Safitri Ginting, Astriani Natalia Br Henny Yolanda Ardilla Hindri Syahputri Jefri Naldi Jefri Naldi Keliat, Elsa Nova Q Pani Kiki Rawitri Magdalena Tiara V Manihuruk Melnihati Laia Muhammad Amin Nasution Muhammad Andry Muhtamilatur Rahma Novitaria Br Sembiring Novriani , Erida Nurasni Octavian Ashido Nababan Pricella Ginting Purba, Helprida GM Razoki Razoki Razoki Reh Malem Br Karo Roy Indrianto Bangar Roy Indrianto Bangar S Sari, Syilvi Rinda Sembiring, Novitaria Sitanggang, Titin Krisdayanti Siti Nurkholifah Sri Wahyuni Suci Della Tafonao, Rachel Julia Tamy Yolanda Putri Tiara Fortuna A.R Tuti Putri Waruwu Wahyuni Sihombing Yolanda Eliza Putri Lubis Zulmai Rani