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All Journal Jurnal Sain Veteriner Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Skala Kesehatan JPP Jurnal Kesehatan Poltekkes Palembang Jurnal Sains dan Teknologi Journal of Community Service and Empowerment Jurnal Pengabdian kepada Masyarakat Nusantara Prisma Sains: Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram Bakti Sekawan : Jurnal Pengabdian Masyarakat Jurnal Pengabdian Masyarakat Sehati International Journal of Science, Technology and Applications Laboratory Journal of Infectious Diseases
Ni Nyoman Ariwidiani
Universitas Bima Internasional MFH
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Identification of Bacteria in Foot Wound Swabs from Patients Diabetes Mellitus Nurul Humairoh; Ni Nyoman Ariwidiani; Baiq Isti Hijriani
Laboratory Journal of Infectious Diseases Vol. 1 No. 2 (2025): Laboratory Journal of Infectious Diseases
Publisher : Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia that predisposes patients to impaired wound healing and chronic infections, including diabetic foot ulcers. Bacterial colonization of these wounds plays a critical role in delayed healing, increased morbidity, and risk of amputation. This study aimed to identify the bacterial profiles isolated from foot wound swabs of patients with diabetes mellitus. A descriptive observational study was conducted using foot wound swab samples collected from patients with diabetes mellitus receiving wound care at Mandalika Care, Mataram City. Bacterial identification was performed through macroscopic and microscopic examination, Gram staining, and standard biochemical tests following culture on Blood Agar Plate (BAP) and MacConkey Agar (MCA). Data were analyzed descriptively and presented as frequencies and percentages. Six samples met the inclusion criteria and were analyzed. All isolates were Gram-negative bacteria. The bacterial species identified were Pseudomonas aeruginosa (33,36%), Morganella morganii (16,6%), Pseudomonas putrefaciens (16,6%), Enterobacter agglomerans (16,6%), and Pseudomonas mallei (16,6%). The conclusion is that Gram-negative bacteria predominated in diabetic foot wound infections in this study, with Pseudomonas aeruginosa being the most frequently isolated species. These findings highlight the importance of early microbiological examination to guide appropriate wound management and antimicrobial therapy in diabetic patients.
High Sensitivity C-Reaktive Protein (Hs-CRP) dan LED sebagai Penanda Inflamasi pada Penderita Tuberculosis (TBC) Ni Nyoman Ariwidiani
Jurnal Skala Kesehatan Vol. 17 No. 2 (2026): Jurnal Skala Kesehatan Edisi Juli 2026 (In progress)
Publisher : Politeknik Kementerian Kesehatan Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/jsk.v17i2.531

Abstract

Mycobacterium tuberculosis infection increases IL-6 production, thereby inducing liver cells to synthesise active phase proteins, such as CRP. Increased levels of Hs-CRP and ESR are often associated with inflammation and acute infection. This study aims to determine the relationship between Hs-CRP and ESR levels as markers of inflammation in TB patients. Data collection was conducted using an analytical observational method with a cross-sectional design. Samples were obtained via simple random sampling, with a sample of 20 tuberculosis patients. Measurement of Hs-CRP levels was carried out using ELISA, while measurement of ESR levels was carried out using Roller 20. Data analysis was carried out using a statistical correlation test to determine the relationship between the two test variables. Based on the measurement data for Hs-CRP and ESR levels, the average Hs-CRP level was 3.32 mg/L, and the average ESR level was 54.55 mm/h in tuberculosis patients. Statistical correlation test shows the relationship between Hs-CRP levels and ESR in tuberculosis patients (p=0.042 with moderate correlation and positive correlation direction (t=0.458). Overall, there is a moderate, positive correlation between Hs-CRP levels and LED, a marker of inflammation, in tuberculosis patients.
Antioxidant Activity of Ethanol Extract Combination of Cavendis Banana Peel (Musa acuminata) and Kepok Banana Peel (Musa paradisiaca) Using the DPPH Method Adriyan Suhada; Tuhfatul Ulya; Roushandy Asri Fardani; Ajeng Dian Pertiwi; Idham Halid; Pauzan Pauzan; Wulan Ratia Ratulangi; Nurul Indriani; Ni Nyoman Ariwidiani; Rosnalia Widyan; Evi Fatmi Utami; Wanda Novianty
Prisma Sains : Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram Vol. 13 No. 3: July 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/j-ps.v13i3.15782

Abstract

Banana peels, often considered agricultural waste, are rich in bioactive compounds with significant antioxidant potential. This study evaluates the antioxidant activity of a combined ethanol extract from Cavendis (Musa acuminata) and Kepok (Musa paradisiaca) banana peels using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. The extraction was performed via maceration with 96% ethanol, yielding 9.13%. Phytochemical analysis identified key compounds including flavonoids, tannins, saponins, and steroids/terpenoids, which are known to exhibit antioxidant properties. The extract demonstrated strong radical scavenging activity with an IC50 of 6.47 ppm and an Antioxidant Activity Index (AAI) of 5.40, comparable to Vitamin C (IC50 = 6.29 ppm; AAI = 5.56). These results indicate a synergistic effect from combining the two banana peel varieties, enhancing antioxidant efficacy beyond that reported for individual peels. This study supports the potential use of Cavendis and Kepok banana peel extracts as sustainable natural antioxidants for application in food preservation, nutraceuticals, and cosmetics. Future work should focus on optimizing extraction methods, detailed phytochemical profiling, stability assessment, and in vivo validation to advance product development and maximize health benefits.
Imunomodulator Zinc (Zn) Terhadap Pertumbuhan Parasitemia Pada Mencit BALB/C Yang diinfeksi Plasmodium Berghei ANKA Ni Nyoman Ariwidiani; Rosnalia Nyoman Widyan; Wulan Ratia Ratulangi
JPP JURNAL KESEHATAN POLTEKKES PALEMBANG Vol 20 No 2 (2025): JPP (Jurnal Kesehatan Poltekkes Palembang)
Publisher : Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jpp.v20i2.2975

Abstract

Background: Malaria infection is a disease with significant mortality, especially in tropical and subtropical areas. The rupture of infected red blood cells will stimulate the role of the immune system, CD4+ T cells will release IFN-γ cytokines that play a role in stimulating the activation of CD8+ T lymphocytes, which play a role in controlling parasitemia. Zinc is known to be involved in T cell signaling that can increase the expression of IFN-γ cytokines that play a role in parasite elimination. Methods: 20 minutes after being infected with P. berghei ANKA, were divided into 4 groups. Group 1-2 were given zinc as therapy with a concentration of 10mg/ml with a dose of 50mg/kgBW and 100mg/kgBW. Group 3 was a negative control (NC) given 0.5% sodium carboxylmethyl cellulose (CMCNa). Group 4 was a positive control treated with dihydroartemisinin-piperaquine (DHP) with a concentration of 187.2 mg/kgBW. Therapy was given for 4 days of observation, and parasitemia was observed every day after 24 hours of the first administration until the 4th day after administration. Results: Significant results were obtained in the parasitemia inhibition analysis after zinc administration on day 3 (p = 0.027) and day 4 (p = 0.001). Based on the results of the analysis, it was shown that zinc has anti-malarial activity that can inhibit the growth of parasitemia in test mice. Conclusion: Zinc as an antimalarial showed effectiveness in reducing parasitemia in BALB/c mice infected with P. berghei ANKA.
Co-Authors Aditiyani Nugraha Pertiwi Adriyan Suhada Adriyan Suhada Agus Supinganto Ajeng Dian Pertiwi, Ajeng Dian Ardiansyah, Lalu Dwi Sartia Atri Sri Ulandari Ayu Anulus Baiq Isti Hijriani Bustanul Atfal Dini Eka Fitriani Evi Fatmi Utami Fardani, Roushandy Asri H. Hardani Idham Halid Idham Halid Ismatullah, Nurul Khatimah Junaidin, Junaidin Kurniawati, Ari Mahavira Diputra, I Ketut Mentari, Ika Nurfajri Metriani, Putu Desy Mindi Richia Putri Muhadi, Muhadi Novianty, Wanda Nurul Hadiatun Nurul Humairoh Nurul Indriani Nurul Indriani Pauzan Pauzan Pauzan Pauzan Pauzan, Pauzan Permana, Yan Reiza Pratiwi, Dewa Ayu Astya Rachman, Muhammad Aditya Ratulangi, Wulan Ratia Reni Chairunnisah, Reni Rian Wahyul Ikhtiar Rosnalia Widyan Roushandy Asri Fardani Samsul Hadi Sri Idawati Sri Sahbany Syamsuriansyah, Syamsuriansyah Tuhfatul Ulya Ulya, Tuhfatul ustiawaty, jumari Utami, Evi Fatmi Wahdaniyah, Rabiyatun Wahyul Ikhtiar, Rian Wanda Novianty Wulan Ratia Ratulangi Wulan Ratia Ratulangi Wulandari Dewi Susilawati Yayu Angriani