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All Journal Journal of Biomedicine and Translational Research Mutiara Medika: Jurnal Kedokteran dan Kesehatan Biomedika KOVALEN: Jurnal Riset Kimia Medika Tadulako Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Media Medika Muda Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Kedokteran STM (Sains dan Teknologi Medik) Jambura Medical and Health Science Journal Molekul: Jurnal Ilmiah Kimia Biomedika
David Pakaya
Departemen Histologi Fakultas Kedokteran Universitas Tadulako, Palu
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Docking Study of Naphthalene Compounds from Eleutherine Bulbosa as Antidiabetic Agents on Multiple Receptors Anam, Syariful; Yuyun, Yonelian; Yusriadi, Yusriadi; Sultan, Asriana; Pakaya, David; Maulana, Saipul; Zubair, Muhammad Sulaiman
Molekul Vol 20 No 1 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.1.10942

Abstract

ABSTRACT. Diabetes Mellitus is a severe disease to the world health community; it is estimated that 700 million people worldwide will suffer from it. The approach taken to this disease includes improving lifestyle and pharmacological therapy. Recent pharmacological therapeutic approaches include inhibiting the α-glucosidase enzyme, the dipeptidyl peptidase 4 (DPP-4) enzyme, and the sodium-glucose co-transporter-2 (SGLT-2) protein. This research aims to conduct a docking study on three naphthalene compounds from Eleutherine bulbosa against three receptors: α-glucosidase, the DPP-4, and the SGLT-2 protein. The methods used are protein structure preparation, docking protocol validation, preparation of E. bulbosa test ligand structures, and molecule docking for test compounds. Validation was carried out by calculating the Root Mean Square Deviation (RMSD) values using PyMOL software; the results showed that the RMSD value of native ligands was <2Å. Molecular docking of the test compounds was conducted using Autodock Vina 1.2.3 ver 2020. Eleutherinoside A showed the highest binding against the α-glucosidase and DPP-4 protein. Eleuthoside B has the most increased binding to SGLT-2 protein. The research concluded that three naphthalene compounds from E. bulbosa can be used as an antidiabetic agent. Keywords: Antidiabetic; Docking study; Eleutherine bulbosa; Naphthalene; α-glucosidase; DPP-4; SGLT-2
Co-Authors ADITYA KURNIAWAN Anak Agung Istri Sri Wiadnyani Antari, Arlita Leniseptaria Anwar, Sarifuddin Arlita Leniseptaria Antari Armadhari, Inna Aryoko Widodo Asriana Sultan Christin Rony Nayoan Dewi, Marzela Dion Solli Ruruktipa Eileen Euides Eka Mutiara Herman Fahira, Aliyah Rezky Farid Indra Gunawan Felandina, Yeni Fitriani, Junjun Gabriella Bamba Ratih Lintin Haerani harun Ibrahim, Elfiana Imtihanah Amri Indah Saraswati Ira Cinta Lestari Joni Tandi, Joni Ketut Suarayasa Laurents Christovel Iban Demen Maramis, Maynard Andrew Marzela Dewi Merlionarsy Tammuan Mohammad Fiqri Novian Affandy Mohammad Salman Muhammad Nur Ikhsan Liwang Muhammad Sulaiman Zubair Muhammad Yoland Muliadi Niluh Puspita Dewi, Niluh Puspita Qosimah, Dahliatul Rais Trisiyambudi Rina Susilowati Saipul Maulana Sarifuddin Anwar Sarifuddin Anwar Solehah, Puput Octaviani Syariful Anam Tarusu, Fikhta Agnesya Tinta, Iniche Tri Setyawati Wiwit Setyowati Yonelian Yuyun Yuli Fitriana Yusriadi Yusriadi Yustina Andwi Ari. Sumiw