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All Journal Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Indonesian Journal of Biotechnology The Indonesian Biomedical Journal Indonesian Journal of Pure and Applied Chemistry Pharmacoscript Jurnal Insan Farmasi Indonesia Indonesian Journal of Biological Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Pharmaceuticals and Natural Sciences Medical Sains : Jurnal Ilmiah Kefarmasian Indonesian Journal of Chemical Science Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Dhania Novitasari
Departemen Analisis Farmasi Dan Kimia Medisinal, Fakultas Farmasi, Universitas Padjadjaran
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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In Silico Study of Phytochemical Compound from Daun Kluwih  (Artocarpus camansi) as an Antidiabetic Targeting Aldose Reductase Radani, Dinar Umaimah; Pintagratia, Ignasia Anindya; Syaiful, Anindya Nursanti; Renaldi, Fahri; Kautsar, Fachrizal Dwi; Novitasari, Dhania
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 1 (2026): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i1.49

Abstract

Diabetes Mellitus (DM) is a disease characterized by increased blood glucose levels. The most common type of diabetes is type 2 diabetes mellitus. Aldose Reductase is an enzyme that works in the polyol pathway. The polyol pathway is the pathway where glucose is metabolized by aldose reductase into sorbitol. The end result of this polyol pathway will accumulate in the tissue so that there is a disruption of the osmolarity of the basal membrane which can cause complications of diabetes mellitus. Therefore, the activity of the aldose reductase enzyme must be inhibited, one of which is using chemical compounds so that complications such as cataracts do not occur. Tests conducted in this study include Lipinski's RO5, ADMETox, pharmacophore screening, and molecular docking. From the test results, it was found that the most potential compound in treating Diabetes Mellitus is Cycloartenol Acetate.
Co-Authors Adam Hermawan Ade Safitri Aisyah Tasza Noor Alifa, Zahra Andhryanti, Rifa Nurfadila Andika Andika Anselma Ivanawati Ardhita Marshella Dhanu Ashriany, Raissa Rerey Azzahra, Iqlima Beni Lestari Cahyaningrum, Lydia CINDY CINDY Devyanto Hadi Triutomo Ediati Sasmito Ediati Sasmito Edy Meiyanto Edy Meiyanto Edy Meiyanto Edy Meiyanto Fadhilah, Naya Fardhan, Firghi Muhammad Fathin Nayla Maymuna Fathin, Nayla Maymuna Fa’aizah Masayu Kyla Fitriana Hayyu Arifah Gabriel, Kevin Herwandhani Putri Hess, Aurelina Yunita Ida Musfiroh -, Ida Musfiroh Ismail, Dzava Prawinsyah Fairus Jasimah, Jasimah Jun-ya Kato Kato, Jun-Ya Kautsar, Fachrizal Dwi Laeli Muntafiah Lathifah, Salma Sri Layung Sekar Sih Wikanthi Lestari, Mila Ayu Maharani, Anisa Mahardika, Bintang Satrio Mahira, Tsania Masyithah Sitti MEGANTARA, SANDRA Moordiani Moordiani Moulana, Mohammad Zaeni Muchtaridi Muchtaridi Muhammad Syahid Muljono, Fajar Oktavian Muthi Ikawati Nindi Wulandari Nur Fitra Sari Nurhaliza, Muthiah Oktaviana, Lina Pintagratia, Ignasia Anindya Pramudita, Fransisca Widi Prisnu Tirtanirmala Putri Salma Chiara Putri, Anindya Calista Nabila Putri, Nazwa Septiriana Putri, Viona Algesia Fiola Putri, Yolla Adellia Qurrotaayun, Ghina Alya Putri Radani, Dinar Umaimah Rahmadhani Nabilah Rahmaharva, Naila Dwi Rahmawati Rahmawati Ramadhani, Siti Zhahira Ratna Asmah Susidarti Renaldi, Fahri Retno Murwanti Riris Istighfari Jenie Riris Istighfari Jenie Rizal Alya Izzati Zhafira Rubianti, Retno Rusdin, Agus Rusmina Aulia Hasanah Salsabila, Sitti Kesya Salsabilla, Bunga Indra Sari Fiona Puspita Sari Haryanti Shafa, Nafis Sitompul, Joy Elizabeth Nauli Sri Handayani Syaiful, Anindya Nursanti Zahrotul Ulum Zhafirah, Noor