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Phytochemical Study of Ethanol Extract of Sengkubak Leaves (Pycnarrhena cauliflora (Miers) Diels) and Molecular Docking Analysis as a Potential Anti-Breast Cancer Agents Yuneta; Nugroho, Wahyu; Kalalinggi, Septaria Yolan; Toepak, Erwin Prasetya
Indonesian Journal of Chemical Analysis (IJCA) Vol. 8 No. 2 (2025): Indonesian Journal of Chemical Analysis
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/ijca.vol8.iss2.art6

Abstract

Reactive Oxygen Species (ROS) are a group of free radicals that play a major role in causing oxidative stress, which can trigger the development of degenerative diseases such as cancer. Sengkubak (Pycnarrhena cauliflora (Miers) Diels) contains antioxidant that may help protect the body from free radical exposure. This study aims to identify the metabolite compounds present in Sengkubak leaves through GC-MS analysis and to evaluate their anticancer potential of its major metabolites through in silico molecular docking analysis. The leaf simplicia was extracted using the maceration method with ethanol as the solvent. The analyses performed included GC-MS analysis and molecular docking analysis of the major compounds identified by GC-MS to evaluate their anticancer potential. GC-MS analysis identified a total of 84 compounds, with the five major ones being Phytol, Farnesol isomer a, L-Gala-L-ido-octose, E-11-HexadecenoicAacid ethyl ester, and Pentadecanoic acid ethyl ester. Furthermore, molecular docking analysis of the five major compounds demonstrated potential anticancer activity against breast cancer targets.
In Vitro Activity of Ethanol Extract of Rimbang Fruit (Solanum ferox) as an Active Ingredient in Sunscreen Preparations Kalalinggi, Septaria Yolan; Rasidah; Yuliana
Indonesian Journal of Chemical Analysis (IJCA) Vol. 7 No. 1 (2024): Indonesian Journal of Chemical Analysis
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/ijca.vol7.iss1.art8

Abstract

Solanum ferox is a typical Central Kalimantan plant widely used by Dayak’s community as a vegetable. The study aims to determine the ethanol extract of sour eggplant activities by measuring its SPF in vitro and identifying secondary metabolite contents. The sour eggplant is extracted by maceration using 96% ethanol solvent and then bound with an evaporator. The secondary metabolite groups of ethanol extract were identified using phytochemical screening. The identification results indicate the presence of flavonoid, terpenoid, steroid, and phenolic compounds. Then, the ethanol extract was fractionated with a water solvent, and its functional cluster was identified using the IR spectrum. IR spectral identification results indicate the presence of OH, C-O, C=C olefin, C -O ether, and aliphatic CH functional groups. (CH2 and CH3) SPF values were determined by measuring the absorption of ethanol and water extracts in vitro using UV-Vis spectrophotometry at UV-B wavelengths of 290-320 nm. In vitro testing has been conducted as a preliminary test in developing a sunscreen product (active substance). The SPF values of ethanol extract and water from weighted fruit extract in sequence are 40 and 23 at a 10% concentration with ultra-category.
Pengaruh Gugus terhadap Kesetimbangan Keto Enol pada Senyawa Turunan Kurkumin Saputra, Rizki Rachmad; Kalalinggi, Septaria Yolan
Bohr: Jurnal Cendekia Kimia Vol 1 No 01 (2022): Bohr: Jurnal Cendekia Kimia Vol 01 No 01
Publisher : Program Studi Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36873/bohr.v1i01.5653

Abstract

Kurkumin merupakan senyawa aktif yang ditemukan pada kunir, berupa polifenol dengan rumus kimia C21H20O6. Kurkumin memiliki dua bentuk tautomer yaitu keto dan enol. Senyawa-senyawa kurkuminoid terdapat dalam berbagai jenis turunannya. Maka dari itu digunakan sebanyak 25 jenis turunan dari kurkuminoid untuk dilakukan analisa secara komputasi. Analisa ini akan dilakukan dengan menggunakan tiga metode yaitu metode semi empirik AM1, PM3 dan RM1. Hasil yang didapat bentuk keto memiliki energi yang lebih rendah dari pada bentuk enol, hal ini dibuktikan dengan nilai tetapan kesetimbangan yang 21 dari 25 senyawa turunan kurkuminoid memiliki nilai kurang dari satu. Sehingga terlihat bahwa bentuk keto lah yang paling disukai dalam kesetimbangan. Pada saat bentuk keto panjang ikatan rantai karbon memiliki panjang rerata 1.419-1.53435 Å. Sedangkan dalam bentuk enol panjang ikatan karbonnya berkurang dengan rerata 1.3814-1.50251 Å.
Kajian Etnobotani Tanaman Khas yang Dimanfaatkan oleh Masyarakat Kalimantan Kalalinggi, Septaria Yolan; Saputra, Rizki Rachmad; Wulandari, Oktavia Rahmi; Gracia, Amanda Natania; Imelya, Marsya
Bohr: Jurnal Cendekia Kimia Vol 2 No 02 (2024): Bohr: Jurnal Cendekia Kimia Vol 02 No 02
Publisher : Program Studi Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kalimantan merupakan salah satu wilayah di Indonesia yang mempunyai keanekaragaman tumbuhan sangat tinggi. Tumbuhan maupun tanaman khas yang berada di sekitar Kalimantan perlu dikaji agar mengetahui potensi dari tanaman khas berdasarkan dari bagian yang digunakan. Metode pengumpulan data berdasarkan studi pustaka. Terdapat 9 jenis tanaman yang dikaji berdasarkan penelusuran yang telah diperoleh berdasarkan informasi studi Pustaka, diantaranya tewu tadung (G. speciosum), sangkareho (Callicarpa longifolia), bajakah tampala (Spatholobus littoralis Hassk), bawang dayak (Eleutherine americana Merr), pulantan (Alstonia scholaris), ulap (Baccaurea motleyana Merr), laban (Vitex pubescens Vahl), rambusa (Passiflora foetida L), dan anggrek uwei menyame (Bromheadia finlaysoniana). Berdasarkan hasil yang diperoleh menunjukkan masyarakat Kalimantan menggunakan bagian tanaman seperti akar, daun, batang, biji, kulit buah, daging buah, siung bawang, getah, dan kulit kayu. Selain itu, pemanfaatan oleh masyarakat setempat banyak menjadikan tanaman khas sebagai obat, bahan pangan, dan tanaman hias.
Pelatihan Perencanaan Bisnis untuk Meningkatkan Minat Wirausaha Siswa SMA 4 Palangka Raya Kalalinggi, Septaria Yolan; Ompusunggu, Dicky Perwira; Rasidah
Journal of Appropriate Technology for Community Services Vol. 5 No. 2 (2024)
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jattec.vol5.iss2.art4

Abstract

Entrepreneurship is an indicator in seeing the progress of a nation and state. To become a developed country requires a minimum of 20% of entrepreneurs from the total workforce, while Indonesia is still below 8%. Therefore, the core of this community service program is to inspire the spirit of entrepreneurship from an early age to students. Hopefully, in the future, these students will become skilled and competent entrepreneurs. Technically, this entrepreneurship service is to provide a theoretical and practical understanding of entrepreneurship to teenagers, especially students of State Senior High School 4 Palangka Raya. This training is expected to be a provision for them after graduating from school, if they want to start their own business. The method involves training with various materials and visual materials related to entrepreneurship. At the beginning of the activity, students were given an understanding of entrepreneurship in theory, namely the history of entrepreneurship, business theory, financial statements, and business feasibility studies. After that, participants were given an understanding of entrepreneurship through speakers who came from practitioners / entrepreneurs. The material from the practitioner is the experience and tips of entrepreneurship. Then this activity was continued with questions and answers between participants and speakers. Evaluation was conducted through a pre-test (before material exposure) and post-test (after material exposure and Q&A) to measure students' understanding and interest in entrepreneurship. Before receiving the training, participants may feel afraid or hesitant regarding the risks that may arise during entrepreneurship. However, after receiving the training, students began to feel more confident and realized the positive impact they could experience if they were involved in entrepreneurship. This can also be seen from the increase in understanding by 36% of all participants.
Peningkatan Produktivitas Hasil Pertanian Melalui Pelatihan Pembuatan Pupuk Organik Cair dari Tanaman Purun Kalalinggi, Septaria Yolan; Kumalasari, Meiyanti Ratna; Beladona, Siti Unvaresi Misonia; Putra, Riandy; Pratika, Remi Ayu
Journal of Appropriate Technology for Community Services Vol. 6 No. 1 (2025)
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jattec.vol6.iss1.art9

Abstract

The influence of the utilization of chemical fertilizers on agricultural land has a negative impact on the environment since it can reduce soil fertility and pollute air and water. Currently, the use of chemical fertilizers is starting to be reduced. The development of organic fertilizers derived from natural ingredients began to be developed, where the advantages of using organic fertilizers are easy to obtain, environmentally friendly, and low production costs. The Community Empowerment Assistance Lecturer Program was carried out in Tuwung Village, Pulang Pisau Regency, Central Kalimantan. This program is carried out in order to empower farmers as an effort to increase the productivity of their agricultural products. The aims of this program are; 1). Provide training to farmers related to how to make liquid organic fertilizer from purun plants; and 2).  Determine the effectiveness of the implementation of training on increasing farmers' knowledge in making liquid organic fertilizer. Training activities were presented to the introduction of purun plants and their potential as materials for making liquid organic fertilizer. Next, the activity continued with a demonstration of how to make liquid organic fertilizer from purun plants. Finally, the farmers were asked to practice directly making liquid organic fertilizer. The results of this training had an positive response on the knowledge and skills of farmers in Tuwung Village, Pulang Pisau Regency, in making liquid organic fertilizer. In addition, this activity is considered effective and efficient based on the results of the evaluation in accordance with the target achievement. 
Pelatihan Persiapan Seleksi Kompetensi Bidang Dosen ASN 2024: Kajian Evaluatif terhadap Tanggapan Peserta Admawati, Harsi; Sampetoding, Eliyah Acantha M; Appa, Felycitae Ekalaya; Chuvita, Laila; Kalalinggi, Septaria Yolan; Sepsamli, Letus; Pitrianti, Siti; Manapa, Esther Sanda
Bakti Sekawan : Jurnal Pengabdian Masyarakat Vol. 5 No. 2 (2025): Desember
Publisher : Puslitbang Sekawan Institute Nusa Tenggara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35746/bakwan.v5i2.764

Abstract

Wawancara dan microteaching merupakan bagian dari Seleksi Kompetensi Bidang (SKB) dosen Aparatur Sipil Negara (ASN) 2024. Kegiatan pengabdian ini dilaksanakan untuk meningkatkan pengetahuan dan keterampilan peserta dalam menghadapi seleksi. Metode DSRM (Design Science Research Methodology) digunakan dengan tahapan 1) identifikasi masalah dan motivasi, 2) definisi tujuan untuk solusi, 3) desain dan pengembangan, 4) demonstrasi, 5) evaluasi, dan 6) komunikasi. Peserta diberikan pemahaman konseptual dan strategi menghadapi wawancara dan microteaching pada kelas besar serta pelatihan keterampilan praktis secara intensif dalam bentuk simulasi dan bimbingan langsung pada kelas kecil. Kelas kecil terdiri dari 10 sampai 15 peserta yang dibimbing oleh seorang pengajar. Evaluasi kegiatan dilakukan dengan menggunakan angket untuk mengetahui kualitas 1) kinerja pelatih, 2) manfaat pelatihan, serta 3) efisiensi pelatihan. Hasil analisis menunjukkan bahwa kinerja pelatih, manfaat pelatihan, dan efisiensi pelatihan berkategori sangat baik dalam mempersiapkan peserta menghadapi tes SKB Non-CAT Kemendikbudristek tahun 2024.