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All Journal Jurnal Ilmiah Ekonomi Islam Open Access Indonesian Journal of Medical Reviews GOVERNANCE: Jurnal Ilmiah Kajian Politik Lokal dan Pembangunan Jurnal Pengabdian dan Pemberdayaan Masyarakat Kepulauan Riau (JPPM KEPRI) Edu Society: Jurnal Pendidikan, Ilmu Sosial dan Pengabdian Kepada Masyarakat Cendekiawan: Jurnal Pendidikan dan Studi Keislaman JPLED Social Impact Journal Jurnal Bisnis Journal of Knowledge and Collaboration Mandalika Journal of Medical and Health Studies AL-Ikhtiar : Jurnal Studi Islam Jurnal El Rayyan: Jurnal Perbankan Syariah Jurnal Sektor Publik
Melani
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Religion Humanities Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Efficacy and Safety of IL-5 Pathway-Targeting Biologics (Mepolizumab, Reslizumab, Benralizumab) in the Management of Hypereosinophilic Syndromes: A Systematic Review and Meta-Analysis Yuniza; Melani; Ratna Maila Dewi Anggraini; Yenny Dian Andayani
Open Access Indonesian Journal of Medical Reviews Vol. 5 No. 5 (2025): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v5i5.780

Abstract

Hypereosinophilic syndromes (HES) are rare disorders defined by persistent eosinophilia and eosinophil-driven organ damage. Interleukin-5 (IL-5) is the central cytokine governing eosinophil maturation and survival, establishing its pathway as a critical therapeutic target. While individual trials of biologics targeting the IL-5 pathway—mepolizumab, reslizumab, and benralizumab—have shown promise, a quantitative synthesis of their class-wide efficacy and safety in HES is needed. This study aimed to meta-analyze the evidence for these agents in managing HES. Following PRISMA guidelines, we systematically searched PubMed, Embase, and Cochrane Library through December 2024 for randomized controlled trials (RCTs) and prospective observational studies of IL-5 pathway biologics in patients with HES. Primary outcomes were the proportion of patients achieving hematologic response and the annualized rate of clinical exacerbations. Key secondary outcomes included oral corticosteroid (OCS) dose reduction and adverse events (AEs). Data were pooled using a random-effects model, with extensive, pre-planned subgroup and sensitivity analyses to explore heterogeneity. Seven studies (3 RCTs, 4 observational) involving 388 patients were included. Patients receiving IL-5 pathway biologics had significantly higher odds of achieving hematologic response (Odds Ratio [OR] 9.85; 95% Confidence Interval [CI] 5.12-18.96; p<0.0001), a finding robust to sensitivity analyses of different response definitions. The annualized exacerbation rate was reduced by 64% (Rate Ratio 0.36; 95% CI 0.25-0.52; p<0.0001). The intervention led to a mean daily OCS reduction of 12.5 mg (95% CI -15.8 to -9.2 mg; p<0.0001). Subgroup analysis revealed this effect was more pronounced in observational studies than in RCTs. The overall risk of AEs was not significantly increased. This meta-analysis provides robust evidence that biologics targeting the IL-5 pathway are highly effective and generally safe for managing PDGFRA-negative HES. They induce high rates of hematologic remission, substantially reduce clinical exacerbations, and facilitate a significant corticosteroid-sparing effect. These findings strongly support their role as a foundational component of modern HES therapy, though long-term safety and efficacy within distinct HES subtypes warrant further investigation.
Empowering Non-English Teachers Implementing English for Fun in Pantai Tinjau Village Amelia Faddya Wildhani; Diah Safithri Armin; Annisa Nur Azizah; Tiara Fadiyah Rambe; Raihani; Melani; Ahmad Ridho Khuailid; Muhammad Akbar Rizky; Asti Ananta; Veriyansah
EDU SOCIETY: JURNAL PENDIDIKAN, ILMU SOSIAL DAN PENGABDIAN KEPADA MASYARAKAT Vol. 5 No. 2 (2025): June-September 2025
Publisher : Association of Islamic Education Managers (Permapendis) Indonesia, North Sumatra Province

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56832/edu.v5i2.1548

Abstract

This study aims to introduce English and empower non-English teachers at SD Negeri Pantai Tinjau, a rural school without formal English lessons. Using a descriptive qualitative approach, the program was implemented over three days with participatory and applicative methods. Activities included basic English introduction for grades 1–3 through nursery rhymes, a creative workshop for grades 4–6 to produce Classroom Expression Posters, and teacher training on using Vocabulary Wall and Classroom Expression Posters. The findings showed that students were enthusiastic and more willing to use simple English expressions, while teachers reported increased confidence in integrating English vocabulary into their lessons. The results indicate that simple, low-cost, and participatory media can effectively foster English exposure in rural schools and support teacher readiness, making it a viable model for replication in similar contexts.
Efektivitas Pengawasan Dinas Perdagangan dalam Pendistribusian Gas LPG 3 Kg di Kelurahan Baru Kecamatan Baolan Kabupaten Tolitoli Masrin Gafar; Melani
Jurnal Sektor Publik Vol 1 No 1 (2024): Juni 2024
Publisher : FISIP Universitas Madako Tolitoli

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56630/jsp.v1i1.1015

Abstract

Penelitian ini bertujuan untuk mengetahui efektivitas pengawasan Dinas Perdagangan dalam pendistribusian Gas LPG 3 Kg di Kelurahan Baru, Kecamatan Baolan, Kabupaten Tolitoli. Penelitian ini menggunakan metode deskriptif dengan pendekatan kualitatif. Data diperoleh melalui observasi, wawancara, dan dokumentasi terhadap informan yang terdiri dari pegawai Dinas Perdagangan, agen LPG, pemilik pangkalan, dan masyarakat pengguna Gas LPG 3 Kg. Penelitian ini dilaksanakan pada bulan Februari sampai dengan April tahun 2024. Analisis data dilakukan melalui tahapan reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa pengawasan Dinas Perdagangan dalam pendistribusian Gas LPG 3 Kg belum berjalan efektif. Hal ini terlihat dari masih adanya penyimpangan harga jual melebihi Harga Eceran Tertinggi (HET) dan ketidaktepatan sasaran distribusi subsidi. Penentuan ukuran pelaksanaan dan pemberian penilaian belum terlaksana optimal, meskipun tindakan korektif sudah dilakukan melalui evaluasi rutin. Oleh karena itu, diperlukan penguatan pengawasan, peningkatan jumlah petugas lapangan, serta sosialisasi intensif kepada masyarakat untuk mendukung distribusi LPG subsidi yang tepat sasaran.
Salafi Wahabi Melani; Sundari; Darul Kutni; Nyono Cahyo Putro; Winda Rizki Yanti
AL-Ikhtiar : Jurnal Studi Islam Vol. 1 No. 1 (2024): Studi Islam
Publisher : 4

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

wahabi merupakan sesuatu ajaran, atau gerakan dakwah yang dipelopori oleh Muhammad ibn Abd al wahhab saat abad ke 18 M. Beliau  memperjuangkan bersama golongannya di wilayah Najd, kemudiaan pengaruhnya menyebar di wilayah kerajaan Saudi Arabia dan wilayah di luarnya Saudi Arabia. Istilah Salafi bisa ditelusuri pada akar kata “Salafi” yang artinya orang orang yang hidup sebelum kita. ada tiga macam kelompok salafi yang berkembang di Indonesia yaitu Salafi Puris, yaitu: Sikap kelompok ini terhadap pemerintah dan negara bervariasi: ada yang menolak organisasi ataupun partai, ada yang koperatif dan terbuka dengan komunitas lain. Salafi Haraki: Merupakan kelompok yang mendukung pemurnian ajaran islam dan enggak setuju dengan ideologi dan aturan negara yang tidak berlandaskan secara langsung kepada syariat. Salafi Jihadi: melakukan penyerangan terhadap praktek ataupun kelompok yang melakukan kerusakan, pembunuhan, dan pemboman dengan mengatasnamakan jihad. Abstract Wahabı is a teaching, or missionary movement that was pioneered by Muhammad ibn Abd al Wahhab in the 18th century AD. He fought with his group in the Najd region, then its influence spread throughout the kingdom of Saudi Arabia and areas outside Saudi Arabia. The term Salafi can be traced to the root of the word "Salafi, which means people who lived before us. There are three types of Salafi groups that have developed in Indonesia, namely Salafi Puris, namely the attitude of this group towards the government and the state varies, some reject organizations or parties, some are cooperative and open to other communities. Salati Haraki is a group that supports the purification of Islamic teachings and does not agree with ideology and state regulations that are not based directly on sharia, Salafi Jihadı carries out attacks on practices or groups that commit murder and bombings in the name of TATEST jihad.
ANALISIS KUALITAS PELAYANAN TERHADAP KEPUASAN MASYARAKAT DALAM PEMBUATAN SURAT KETERANGAN AHLI WARIS DI KELURAHAN BENTENG Melani; Sapri; Adnan, Andi Astinah
GOVERNANCE: Jurnal Ilmiah Kajian Politik Lokal dan Pembangunan Vol. 12 No. 1 (2025): 2025 September
Publisher : Lembaga Kajian Ilmu Sosial dan Politik (LKISPOL)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56015/gjikplp.v12i1.506

Abstract

This study aims to analyze the quality of public services in relation to community satisfaction in the issuance of inheritance certificates at Benteng Urban Village. The main focus of this research is to identify service quality based on the five SERVQUAL dimensions developed by Parasuraman, Zeithaml, and Berry (reliability, responsiveness, tangibles, empathy, and assurance), as well as to identify the factors influencing community satisfaction, namely planning, leadership, coordination, and supervision. This research employs a descriptive qualitative approach with data collection techniques including interviews, observations, and documentation involving seven informants who have previously processed inheritance certificates at Benteng Urban Village. The results show that the dimensions of reliability and responsiveness were the most frequently criticized by the public due to unclear procedures and a lack of promptness from service staff in providing information. Meanwhile, the aspects of tangibles, assurance, and empathy showed relatively good results. In terms of public satisfaction, it was found that insufficient planning and weak leadership among staff contributed to slow and inefficient service delivery. The conclusion of this study highlights the importance of improving overall service quality, particularly in the areas of communication, staff training, and responsive leadership, in order to enhance public satisfaction
Co-Authors Adeva, Dilla julia Adnan, Andi Astinah Agun Suherly Agus Mailana Ahmad Ridho Khuailid Amelia Faddya Wildhani Annisa Nur Azizah Annisa Rizka Pratiwi Arfiana Safitri , Rika Armin, Diah Safithri Asti Ananta Athoillah, Mohamad Anton Aulia Oktaviani , Nadia Ayu Nurul Desafitri Badry, Nurkhoirina Darul Kutni Deo Irwan Saputra, Deo Ermita Fadila Ashari Isma Aulia Zamaakh Syari Kamaruzaman Kamaruzaman Kurniawan Marhumi Masrin Gafar Muhamad Fuji Hakiki Muhammad Akbar Rizky Muhammad Ridho Laia Mutia Putri Nelis Jamjam Munawaroh Nellitawati Nyono Cahyo Putro Raihani Ratna Maila Dewi Anggraini Retno Ayu Lestari Rika Arfiana Safitri Risqika Yulia Tantri Paramawidhita Ruslan Ruslan Sabandi, Ahmad Sanstya Fatma Melati Sapri Sri Mulyanti Sundari Syahbudin Talitha Zafirah Tiara Fadiyah Rambe Tresna Wulandari, Tresna Veriyansah Widya Yuningsih Winda Rizki Yanti Yenny Dian Andayani Yuniza