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All Journal HAYATI Journal of Biosciences Jurnal Gizi dan Pangan Jurnal Ilmu Pertanian Indonesia ACTA VETERINARIA INDONESIANA Hemera Zoa Jurnal Sain Veteriner Medical Journal of Indonesia Indonesian Journal of Pharmaceutical Science and Technology Prosiding Seminar Biologi INDONESIAN JOURNAL OF PHARMACY Journal of Medicine and Health Journal of Dentomaxillofacial Science Argipa (Arsip gizi dan Pangan) ARSHI Veterinary Letters Jurnal Ilmu dan Teknologi Kayu Tropis JURNAL KAJIAN VETERINER Britain International of Exact Sciences Journal (BIoEx Journal) Jurnal Pusat Inovasi Masyarakat Jurnal Kedokteran Hewan Journal of Medicine and Health
Vetnizah Juniantito
Institut Pertanian Bogor
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Veterinary

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PAT-4 Histopathological Study of Mice (Mus musculus) Digestive Organs Treated with Alkali pH Water Sri Estuningsih; Vetnizah Juniantito; Yenny Rakhmawati
Hemera Zoa Proceedings of the 20th FAVA & the 15th KIVNAS PDHI 2018
Publisher : Hemera Zoa

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Abstract

Water is an important part of the body. As much as 50-60% of an adult's body weight consists of water. Water functions in the body include as a means of transporting substances, regulating body temperature, regulating body pH, forming body structures, solvents for the body's chemical reactions, and helping the body's mechanical functions, such as lubrication (Insel et al. 2004; Asamadi 2008). In the event of water deficiency, the body will become dehydrated which able to cause cell death to individual death (Stanfield and Hui 2008). Recently, there are alkaline pH drinking water products that are commercially popular that have pH around 8-10 (alkaline water). Some parties claim that alkaline water can help neutralize the level of acidity (pH) of blood due to free radicals, while also having micro cluster technology that can increase oxygen solubility. According to Shirahata et al. (2012) alkaline water is beneficial for health because it can suppress oxidative stress.This study aims to know the effect of alkaline pH drinking water reviewed through histopathological studies of the digestive organs of mice (stomach, intestine, and pancreatic exocrine glands).
PF-18 Photomicrograph of Nanogel Andrographolide-Beta Cyclodextrine Inclusion Complex As Anti-Burns Bayu Febram Prasetyo; Ietje Wientarsih; Dondin Sajuthi; Vetnizah Juniantito
Hemera Zoa Proceedings of the 20th FAVA & the 15th KIVNAS PDHI 2018
Publisher : Hemera Zoa

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Abstract

Inclusion complex is a complex formed between drug molecules which act as guest or located inside the cavity of host molecule. Host molecules are commonly originated from the derivative group of cyclodextrin. Among cyclodextrin groups, beta cyclodextrin (BCD) is mostly used in formula development and drug delivery system [1].Andrographolide (AG) is a pure isolate chemically syntesized from sambiloto herbs (Andrographis paniculata Nees), in the form of needle cystal-like which is colorless and extremely bitter. AG has variety of medical properties, particularly as anti-inflamation to treat skin burns [2]. However AG has poor solubility in water. This will result in low abillity to solute, penetrate membrane, and distribute the drug when applied transdermally in burn skin. In burn skin, there is tendency to skin damage, especially in stratum corneum which acts as semipermeable barrier. The ability of drugs that applied transdermally tends to be high.Formation of inclusion complex using AG and BCD to increase the ability of AG in penetrating membrane should be done. Transmission Electron Microscope (TEM) is a fast technique to confirm the formation of drug or inclusion complex by  comparing the shape and particle size [3]. Study on percutaneous penetration of AG-BCD inclusion complex is produced through solvent evaporation method at mole ration 1:2 in viscolam gel preparation.
Co-Authors . Jumari Abdullah Baharun Agatha Grace Agus Setiyono Agus Setyono Aisyah Aisyah Akhmad Endang Zainal Hasan Alfina Zalfa Suryono Ali Khomsan Andi Arus Victor Andrea Laurentius Annisa Rahmi Antonius Anre Sianturi Aria Kekalih Armando Balses Ishimora Azizah, Hanifah Nur Baharun, Rasyid Bambang Pontjo Priosoeryanto Bayu Febram Prasetyo Bustamam, Alhadi Cesilia M Dwiriani Chatarina Umbul Wahyuni D R Agungpriyono Deded Sarip Nawawi Dewi R Agungpriyono Dondhin Sajuthi Dondin Sajuthi Dwi Rofifah Putri Jania Endang Syamsudin Eva Harlina Evy Ayu Arida Evy Damayanthi Fajar Rezandaru Femmi Dwinda Agustini Fivi Melva Diana, Fivi Melva Gregorius Bhaskara Wikanendra I Nyoman Jaya Wistara IETJE WIENTARSIH Iis Ismawati Indra Hadikrishna Itje Wintarsih Kusmardi Kusmardi L N Sutardi Lukman Edwar Madyastuti, Rini Makhroja, Lalu Faris Naufal Mardianto, Umar Miranti Fardesiana Putri Mohamad Sadikin Mokhamad Fahrudin Monica Septiani Nafrialdi Nafrialdi Ni Wayan Kurniani Karja Nina Herlina Nopen Meisaroh Novianti, Titta Nugraha, Arifin Budiman Nur Indrawaty Lipoeto Prasandhya Astagiri Yusuf Purnamiharja, Tsulatsy Puspitasari Putri Ramadhanty Rafida Nisa Maghfiroh Ranady Perwira Nuruzzaman Rimbawan , Rita Kartika Sari Safitri, Debby Endayani Sajuthi, Dondhin Sharon Aurellia Silmi Hanifah Siti Magfiroh Soni Siswanto Sri Estuningsih Sri Wahyuni Salam Sri Widia A Jusman Subangkit, Mawar Syahruddin Said Tri Rahayu Umi Cahyaningsih Vici Eko Handayani Wahono Esthi Prasetyaningtyas Wawaimuli Arozal WoroWiranti, Rahayu Yenny Rakhmawati