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All Journal HAYATI Journal of Biosciences E-Jurnal Medika Udayana ILMU KELAUTAN: Indonesian Journal of Marine Sciences Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal Kesehatan Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Dinamisia: Jurnal Pengabdian Kepada Masyarakat JMM (Jurnal Masyarakat Mandiri) JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Masyarakat Merdeka (JMM) Jurnal Mandala Pharmacon Indonesia Pharmacoscript Jurnal Ilmiah Farmasi Farmasyifa Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Pharmacy Molekul: Jurnal Ilmiah Kimia Jurnal Abdi dan Dedikasi kepada Masyarakat Indonesia Borneo Journal of Pharmacy Jurnal Ilmiah Kesehatan Sandi Husada (JIKSH)
Musdalipah
Department Of Pharmacy, Politeknik Bina Husada Kendari, Southeast Sulawesi
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Aktivitas Antibakteri Rimpang Meistera chinensis terhadap Bakteri Staphylococcus aureus ATCC 25023 dan Eschericia coli ATCC 35218 Secara Difusi Agar Karmilah; Reymon; Daud, Nur Saadah; Badia, Esti; Yodha, Agung Wibawa Mahatva; Setiawan, Muh. Azdar; Tee, Selfyana Austin; Musdalipah
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 8, No 1 (2023): February 2023
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v8i1.5651

Abstract

Meistera chinensis merupakan generasi baru famili Zingiberaceae yang tumbuh di Sulawesi Tenggara. Ekstrak buah mengandung metabolit sekunder seperti flavonoid, terpenoid, alkaloid, steroid, dan tanin yang memiliki efektivitas sebagai antioksidan dan antibakteri. Namun, belum ada laporan tentang antibakteri pada bagian rimpang. Penelitian ini bertujuan untuk mengetahui kandungan metabolit sekunder dan aktivitas antibakteri ekstrak etanol rimpang M. chinensis. Serbuk kering rimpang M. chinensis diekstraksi dengan maserasi menggunakan pelarut etanol 96%. Ekstrak dipekatkan menggunakan rotary vacuum evaporator. Metode analisis aktivitas antibakteri menggunakan difusi agar dengan konsentrasi ekstrak 10%, 20%, 30%, dan kontrol positif (Ciprofloxacin 30µg) terhadap Staphylococcus aureus ACTT 25023 dan Escherichia coli ACTT 35218 selama 24 jam. Hasil penelitian menunjukkan bahwa ekstrak etanol rimpang M. chinensis mengandung flavonoid, saponin, alkaloid, steroid, dan fenol, Ekstrak terbukti menghambat pertumbuhan E. coli dengan diameter zona hambat rata-rata secara berturut-turut pada konsentrasi 10%, 20%, dan 30% sebesar 6,08±1,79; 8,16±0,11 dan  10,57±1,34 mm. Pada S. aureus, zona hambat masing-masing konsentrasi 10%, 20%, dan  30% sebesar 5,02±0,79; 6,01±0,69; 8,03±0,76. Analisis One Way ANOVA menunjukkan perbedaan aktivitas antibakteri yang signifikan antar konsentrasi ekstrak pada E. coli dan S. aureus. Dapat disimpulkan rimpang M. chinensis memiliki aktivitas sebagai antibakteri. 
Antibacterial and antiplaque effects of alpinia monopleura herbal toothpaste against streptococcus mutans Nia Afdilla; Prayoga Ridha Faisal; Musdalipah Musdalipah
Jurnal Ilmiah Kesehatan Sandi Husada Vol. 15 No. 1 (2026): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : LPPM Politeknik Sandi Karsa, South Sulawesi, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiksh.v15i1.249

Abstract

Introduction: Dental caries remains a prevalent global oral health problem primarily associated with Streptococcus mutans colonization and dental plaque accumulation. Increasing concerns about the prolonged use of synthetic antibacterial agents have prompted the exploration of plant-based alternatives. Alpinia monopleura, an endemic plant from Southeast Sulawesi, contains bioactive phytochemicals with reported antimicrobial activity. This study aimed to evaluate the antibacterial activity and antiplaque effectiveness of herbal toothpaste containing A. monopleura extract against S. mutans. Research Methodology: A quasi-experimental, randomized pre-test and post-test design was conducted involving 64 participants, allocated into two groups: F1 (20% A. monopleura extract) and F2 (30% A. monopleura extract). Antibacterial activity was assessed in vitro using the agar diffusion method against Streptococcus mutans (ATCC 25175). Clinical effectiveness was evaluated by measuring the plaque index before and after a 7-day intervention. Data were analyzed using paired and independent t-tests, followed by multivariate linear regression at α = 0.05. Results: The 30% formulation demonstrated stronger antibacterial activity with a mean inhibition zone of 14.92 mm compared to 6.87 mm in the 20% group. Both formulations significantly reduced plaque index scores. In F1, the mean plaque index decreased from 2.19 ± 0.69 to 1.34 ± 0.48 (p < 0.001), while in F2 it decreased from 2.50 ± 0.51 to 1.84 ± 0.37 (p < 0.001). Multivariate analysis confirmed extract concentration as a significant predictor of plaque reduction. Conclusion: Alpinia monopleura-based herbal toothpaste exhibits significant antibacterial activity against S. mutans and effectively reduces dental plaque. The 30% concentration shows superior antimicrobial potency, supporting its potential development as a natural dentifrice alternative for caries prevention.
Co-Authors Ado, Moldefya Wahid Adryan Fristiohady Agung Wibawa Mahatva Yodha Agustini Angriani Fusvita Apriyanto Apriyanto Arfan Asman, Muhammad Audina, Fina Austin Tee, Selfyana Badia, Esti Baru Sadarun Daud, Nur Saadah Elfirah Elfirah Eny Nur Hikma Eny Nurhikma Evi Apriani Arifin Evi Nur Indah Sari Fauziah, Yulianti Firdayanti, Firdayanti Fristiohady, Adryan Gusti Ray Sadimantara Hasnawati Hasnawati Idayati Idayati Idin Sahidin Inggit Suryaningsih Karmilah Karmilah . Karmilah, Karmilah Lilis Yusriani Lisa Wulansari Siregar Malaka, Muhammad Hajrul Mega Fatimah Rosana Muh. Arnas Muh. Ilyas Yusuf Muhammad Azdar Setiawan Muhammad Hajrul Malaka Muhammad Syaiful Saehu Murtafia Murtafia Nia Afdilla NIA AFDILLA Nirwati Rusli Nurhikma Nurhikma Nurhikma, Eny Nurhikmah, Eny Nursaadah Daud Prayoga Ridha Faisal Randa Wulaisfan Randa Wulaisfan Reymon, Reymon Rifcha Selviana Puput Rini Hamsidi Rusli, Nirwati Sahidin Sahidin . Sahidin Sahidin Sahidin Sahidin Santi Oktaviani, Santi Selfyana Austin Tee Selfyana Austin Tee Sernita Seren Setiawan, Muh. Azdar Setiawan, Muhammad Azdar Sofyan, Suhikma Suhikma Sofyan syamsu Alam Syamsu Alam Tee, Selfyana Austin WAHYUNI Wahyuni Wahyuni Wulaisfan, Randa Yusuf, Muh. Ilyas Zainal, Nur Awalia Putri