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All Journal Health Science Journal of Indonesia Jurnal Kesehatan Masyarakat (JKM) CENDEKIA UTAMA Mutiara Medika: Jurnal Kedokteran dan Kesehatan Jurnal Sains Psikologi Raheema Molecular and Cellular Biomedical Sciences (MCBS) Al-Hikmah Jurnal Kreativitas PKM Manuju : Malahayati Nursing Journal Jurnal Ilmu Kedokteran dan Kesehatan Majalah Kedokteran Andalas INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Kieraha Medical Journal Cermin Dunia Kedokteran Indonesian Journal of Cancer Cerdika: Jurnal Ilmiah Indonesia Jurnal Vokasi Kesehatan Indonesian Journal of Biomedicine and Clinical Sciences Biomedika Cermin Dunia Kedokteran Proceeding Mulawarman International Conference on Tropical Public Health
Sari Eka Pratiwi
Department Of Biology And Pathobiology, Faculty Of Medicine, Universitas Tanjungpura, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Hubungan antara tumor-infiltrating lymphocytes dengan parameter klinikopatologi pada kanker kolorektal Trianto, Heru Fajar; Pratiwi, Sari Eka; Ilmiawan, Muhammad In'am; Hartono, Henky; Ftrianingrum, Iit; Lestari, Desriani
Majalah Kedokteran Andalas Vol. 46 No. 4 (2023): Online Oktober
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i6.p949-958.2023

Abstract

Latar Belakang: Kanker kolorektal termasuk dalam keganasan terbanyak di dunia. Berbagai faktor turut mempengaruhi prognosis dari kanker salah satunya sistem imun. Sistem imun di sekitar tumor memiliki pengaruh terhadap progesivitas sel kanker. Salah satu sistem imun yang dapat diamati adalah Tumor-infiltrating lymphocytes (TIL). Tujuan: Penelitian ini bertujuan untuk membuktikan adanya hubungan antara TIL dengan berbagai parameter klinikopatologi pada kanker kolorektal. Metode : Penelitian ini menggunakan desain potong lintang. Subjek penelitian berupa 38 sampel blok parafin dan slide hematoksilin-eosin (HE) serta data klinikopatologi yang berasal dari sediaan operasi kanker kolorektal pada Laboratorium Patologi Anatomi RSUD Dr. Soedarso periode Januari – Desember 2020. Penilaian jumlah TIL dibagi menjadi tiga kelompok yaitu ringan (0-10%), sedang (11-59%), dan berat (60-100%). Hasil: Hasil penelitian menunjukkan bahwa jumlah TIL terbanyak adalah TIL berat yaitu sebanyak 16 kasus (42,1%). Hasil uji korelasi Spearman menunjukkan hubungan antara jumlah TIL dengan derajat diferensiasi, stadium Dukes dan stadium p TNM dengan nilai p<0,005. Tidak terdapat hubungan antara jumlah TIL dengan ukuran tumor, status metastasis kelenjar getah bening, status metastasis jauh, dan lokasi tumor. Kesimpulan: Terdapat hubungan antara jumlah TIL dengan derajat keganasan, stadium Dukes dan stadium pTNM yang merupakan faktor-faktor prognosis pada kanker kolorektal.
Differentiation of Microvessel Density Based on The Breast Cancer Patient Characteristics Including Age, Stage, Tumor Size, and Lymph Node Metastasis Salsabila, Tasya; Pratiwi, Sari Eka; Trianto, Heru Fajar; Ilmiawan, Muhammad In'am; Lestari, Desriani; Fitrianingrum, Iit; Hartono, Henky
Indonesian Journal of Cancer Vol 18, No 2 (2024): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i2.1041

Abstract

Background: Breast cancer is the most common malignant tumor in the world and Indonesia. One well-known prognostic marker is microvessel density (MVD), the numerical value of angiogenesis. In recent years, it has been recognized that tumor growth depends on angiogenesis. Therefore, this study aimed to determine the differentiation of MVD based on the breast cancer patients' characteristics including age, stage, tumor size, and lymph node metastasis in the Anatomical Pathology Laboratory of Soedarso Hospital. Methods: This research was an observational study with a cross-sectional approach. The study was conducted by observing the slides of Hematoxylin-Eosin (HE) in breast cancer patients. Samples were taken using the total sampling technique. The samples were observed by two observers. 51 tissue preparations met the inclusions and exclusions criteria. MVD cut-off points are taken by calculating the median. Research analysis was using the Kruskal-Wallis test in SPSS version 24. Results: All samples of this study were women and had invasive ductal carcinoma. Breast cancer tends to occur in patients aged 48-53 years, has stage III, lymph node metastasis (N2). The patients have a low MVD rate but have a large tumor size (T4). Kruskal Wallis test showed that there was a differentiation of MVD based on age (p = 0.029). While, there was no differentiation of MVD based on stage (p=0.974), tumor size (0.069), and lymph node metastasis (0.571). Conclusions: There was a differentiation of MVD based on the age of breast cancer patients in the Anatomical Pathology Laboratory at Soedarso Hospital.
Necrosis area, Tumor Size, and Lymph Node of Breast Cancer Laili, Kharima; Pratiwi, Sari Eka; Ilmiawan, Muhammad In'am; Trianto, Heru Fajar; Fitrianingrum, Iit
Indonesian Journal of Cancer Vol 18, No 3 (2024): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i3.1121

Abstract

Background: Breast cancer is the leading cause of cancer deaths in women worldwide in 2020. The high mortality rate is often influenced by various reasons, one of which is patients's prognosis. One of the prognostic factors is necrosis area, caused by hypoxic tumor tissue that can affect tumor growth and metastasis. Therefore, this study aims to determine the relationship between necrosis area with tumor size and lymph node metastasis in breast cancer patients. Methods: This study was an observational analytic with a cross-sectional approach. This research was conducted at the Anatomical Pathology Laboratory of Dr Soedarso Pontianak General Hospital and the Microscopy Laboratory of the Faculty of Medicine Tanjungpura University from September until November 2022. The study sample was 55 slides of Formalin-Fixed Paraffin-Embedded (FFPE). The study was conducted by observing the preparations under a microscope and then analyzed using ImageJ and SPSS software. The independent variable in this study was the necrosis area in the tumor microenvironment, and the dependent variables were tumor size and lymph node metastasis in breast tissue. Results: All study samples were female patients with invasive ductal carcinoma. Breast cancer tends to occur in patients aged 48-55 years. The highest percentage of necrosis area was 21% and the most diagnosed breast tumor size and lymph node metastasis were stage T4 and stage N2. Spearman's rho correlation test showed that there was no relationship between necrosis area and tumor size (p = 0.122; r = 0.16) and lymph node metastasis (p = 0.637; r = 0.18). Conclusions: There is no correlation between necrosis area with tumor size and lymph node metastasis of breast cancer patients in the Anatomical Pathology Laboratory at Dr Soedarso Pontianak General Hospital.
TINGKAT PENGETAHUAN MENGENAI KANKER PAYUDARA, SERTA SIKAP DAN PERILAKU PEMERIKSAAN PAYUDARA SENDIRI (SADARI) PADA SANTRIWATI PONDOK PESANTREN USHULUDDIN SINGKAWANG Alkamil, Ahmad Wildan; Pratiwi, Sari Eka; Trianto, Heru Fajar
Kieraha Medical Journal Vol 5, No 2 (2023): KIERAHA MEDICAL JOURNAL
Publisher : Fakultas Kedokteran, Universitas Khairun

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33387/kmj.v5i2.6845

Abstract

Latar Belakang: Kanker payudara adalah kanker dengan kasus baru tertinggi dan penyebab utama kematian akibat kanker pada wanita. Diagnosis dan pemahaman mengenai upaya pencegahan kanker payudara memegang peranan penting dalam meningkatkan prognosis selain faktor klinis lainnya. Oleh karena itu, penelitian ini difokuskan untuk menggambarkan tingkat pengetahuan tentang kanker payudara, sikap dan perilaku pemeriksaan payudara sendiri (SADARI). Tujuan: Penelitian ini bertujuan untuk mengetahui gambaran tingkat pengetahuan tentang kanker payudara, sikap dan perilaku pemeriksaan payudara sendiri (SADARI) pada santriwati Pondok Pesantren Ushuluddin Singkawang. Metode: Penelitian ini merupakan penelitian deskriptif yang menggambarkan tingkat pengetahuan tentang kanker payudara pada santriwati di Pondok Pesantren Ushuluddin Singkawang, sikap dan perilaku SADARI. Sebanyak 88 santriwati dipilih melalui teknik stratified random sampling. Variabel diukur dengan menggunakan kuesioner pengetahuan, sikap dan perilaku SADARI. Hasil: Sebagian besar responden memiliki tingkat pengetahuan tentang kanker payudara yang sedang yaitu sebesar 46%; Responden memiliki sikap SADARI yang positif sebanyak 85%; Responden memiliki perilaku SADARI yang baik sebanyak 86% Kesimpulan: Tingkat pengetahuan santriwati Pondok Pesantren Ushuluddin Singkawang tentang kanker payudara sebagian besar adalah sedang; Sikap santriwati Pondok Pesantren Ushuluddin Singkawang terhadap SADARI sebagian besar adalah positif; Perilaku santri Pondok Pesantren Ushuluddin Singkawang terhadap BSE sebagian besar baik.
EFEK PROTEKTIF EKSTRAK ETANOL UMBI BAWANG DAYAK TERHADAP DIAMETER DAN VOLUME TUMOR PAYUDARA TIKUS PUTIH RATTUS NORVEGICUS BETINA GALUR SPRAGUE-DAWLEY DIINDUKSI 7,12-DIMETHYLBENZ(?)ANTHRACENE Elshaddayana Sitompul, Sonia; Ilmiawan, Muhammad In’am; Pratiwi, Sari Eka
Cerdika: Jurnal Ilmiah Indonesia Vol. 3 No. 10 (2023): Cerdika : Jurnal Ilmiah Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/cerdika.v3i10.697

Abstract

Bawang dayak (Eleutherine bulbosa) merupakan tanaman herbal yang dipercaya masyarakat Indonesia memiliki efek anti kanker. Bawang dayak memiliki kandungan triterpenoid, flavonoid, antrakuinon dan naftokuinon yang memiliki aktivitas biologis sebagai antioksidan dan antikanker. Penelitian ini bertujuan untuk mengetahui efek daya hambat ekstrak etanol umbi bawang dayak (Eleutherine bulbosa) terhadap pertumbuhan jaringan tumor payudara secara makroskopis. Jenis penelitian ini adalah penelitian eksperimental dengan desain posttest-only control group. Penelitian menggunakan 30 tikus betina galur Sprague Dawley, dibagi secara acak menjadi 6 kelompok, yaitu kelompok normal, kelompok kontrol positif (tamoxifen), kelompok kontrol negatif (DMSO 5%), kelompok perlakuan I (ekstrak umbi bawang dayak 180 mg/kg BB), kelompok perlakuan II (ekstrak umbi bawang dayak 360 mg/kg BB) dan kelompok perlakuan III (ekstrak umbi bawang dayak 720 mg/kg BB). Hasil penelitian ini didapatkan data diameter tumor dan volume tumor dianalisis menggunakan program SPSS dengan One-way ANOVA dan Post hoc LSD. Ekstrak etanol umbi bawang dayak berbeda bermakna (p<0,05) dalam penghambatan pertumbuhan diameter dan volume tumor payudara. Hasil uji Post Hoc LSD menunjukkan bahwa terdapat perbedaan signifikan antar kelompok perlakuan I, II dan III terhadap kelompok kontrol negatif. Penelitian ini menyimpulkan ekstrak etanol umbi bawang dayak mempunyai daya hambat terhadap diameter dan volume tumor payudara
Pelatihan Dokter Cilik Siswa Sekolah Dasar Desa Rasau Jaya Tiga, Kubu Raya Tejoyuwono, Agustina Arundina Triharja; Mardhia, Mardhia; Pratiwi, Sari Eka; Liana, Delima Fajar
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 7, No 9 (2024): Volume 7 No 9 (2024)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v7i9.14565

Abstract

ABSTRAK Pendidikan dan kesehatan saling berhubungan dan merupakan hal penting bagi anak. Banyak kondisi kesehatan yang dapat dikelola dengan lebih baik atau dicegah jika terdeteksi sejak dini. Lingkungan sekolah dan layanan kesehatan sekolah memberikan peluang untuk intervensi tepat waktu pada berbagai kondisi, termasuk kecemasan dan depresi, perilaku kelainan, kelebihan berat badan, dan kekurangan gizi. UKS merupakan program wajib Kementerian Pendidikan dan Kebudayaan untuk menanamkan hingga melaksanakan prinsip hidup sehat dalam kehidupan sehari-hari, salah satunya melalui peran Dokter Cilik. Metode pelatihan Dokter Cilik yang digunakan adalah ceramah dan praktik. Pelatihan dilakukan pada siswa SD kelas IV dan V dari SD Negeri 2 dan SD Madrasah Ibtidaiyah dengan total peserta berjumlah 30 siswa. Hasil penilaian terhadap pelatihan adalah kemampuan siswa SD mengenai materi yang diajarkan dan kesiapan menjadi kader kesehatan cukup baik, perubahan kemampuan kognitif cukup baik, peningkatan kemampuan afektif baik, psikomotor sangat baik, penilaian praktik semua siswa memiliki kemampuan yang sangat baik. Pelatihan dokter cilik mampu merubah perilaku peserta didik. Kegiatan pelatihan dokter cilik ini sebaiknya dilakukan di tiap sekolah agar penerapan trias UKS di sekolah semakin optimal. Kata Kunci: Dokter Cilik, Kesehatan, Usaha Kesehatan Sekolah  ABSTRACT Education and health are interconnected and important for children. Many health conditions can be better managed or prevented if detected early. The school environment and school health services provide opportunities for timely intervention for a variety of conditions, including anxiety and depression, behavioural disorders, overweight, and malnutrition. The school health unit is a mandatory programme of the Ministry of Education and Culture to instill and implement the principles of healthy living in everyday life, one of which is through the role of Little Doctors. The Little Doctor training methods used are lectures and practice. The training was carried out on elementary school students in grades IV and V from SD Negeri 2 and SD Madrasah Ibtidaiyah, with a total of 30 students. The results of the assessment of the training were that elementary students' abilities regarding the material taught and their readiness to become health cadres were quite good; changes in cognitive abilities were quite good; improvements in affective abilities were good; psychomotor skills were very good; and the practical assessment of all students had very good abilities. Little doctor training is able to change student behavior. The little doctor training should be held in every school, thus the implementation of the UKS triad in schools is optimal. Keywords: Little Doctor, Health, The School Health Unit
Identification of microRNA-Based Targeted Therapy as Novel StrategyAgainst Colorectal Carcinoma: In Silico Analysis Adnan, Nohan Noer; Pratiwi, Sari Eka; Ulfah, Ridha
Mulawarman International Conference on Tropical Public Health Vol. 2 No. 2 (2025): The 4th MICTOPH
Publisher : Faculty of Public Health Mulawarman University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background : Dysregulation of microRNAs plays a key role in the development of multiple cancers, including colorectal carcinoma (CRC), the second leading cause of cancer-related mortality worldwide. The high mortality rate is partly driven by the limited effectiveness of conventional therapies. Objective : This study aimed to explore the pathogenesis of CRC and identify candidate microRNAbased targeted therapeutic agents through an in silico approach. Research Methods/ Implementation Methods : MicroRNA expression profiles were retrieved from dbDEMC 3.0. Differentially expressed microRNAs (DEMs) were identified using GEO2R and OrangeApp with a cutoff P-value ≤ 0.05 and Log2FC < −1.5. Predicted target genes of DEMs were intersected with CRC-related genes obtained from GEPIA2. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were then conducted on the intersecting genes. Results : One DEM was identified as a potential therapeutic candidate for colon cancer (hsa-miR- 139-5p) and one for rectal cancer (hsa-miR-193b-3p). A total of 780 DEGs associated with hsa-miR- 139-5p and 4,744 DEGs associated with hsa-miR-193b-3p were found. Intersection with colon cancer (33,287 DEGs) and rectal cancer (29,599 DEGs) yielded 25 overlapping DEGs for hsa-miR- 139-5p and 10 for hsa-miR-193b-3p. GO and KEGG analyses showed involvement in key biological processes and cancer-related signaling pathways. Three target DEGs of hsa-miR-139-5p (FOXO1A, ZEB1, HOXA9) were linked to transcriptional misregulation in cancer, while one DEG targeted by hsa-miR-193b-3p (14-3-3 gene) was associated with the cell-cycle pathway. Conclusion/Lesson Learned : This in silico analysis identifies hsa-miR-139-5p and hsa-miR-193b-3p as promising microRNA-based therapeutic candidates for CRC, highlighting critical genes and pathways involved in CRC carcinogenesis.
Co-Authors Abror Irsan Adnan, Nohan Noer Agusriani Putri Agustina Arundina Triharja Tejoyuwono, Agustina Arundina Triharja Aisha, Ayunda Alkamil, Ahmad Wildan Armyanti, Ita Awaliya, Rizqi Hilya Damayanti, Renita Danarto Danarto Danarto Danarto Danarto Danarto Delima Fajar Liana Desriani Lestari Desriani Lestari Didik Setyo Heriyanto Efrem, Deo Gratias Elshaddayana Sitompul, Sonia Erni Erni - ERNI - Ervando, Hizki Fatinah, Nabilah Nurul Fattarini, Winni Fitri Fujiana FITRI SUKMAWATI Fitri Sukmawati Ftrianingrum, Iit Handoko, Willy Hartono, Henky Hengky Hartono Henky Hartono Heru Fajar Trianto Heru Fajar Trianto Hizki Ervando Hizki Ervando Iit Ftrianingrum Ilmiawan, Muhammad In'am Ilmiawan, Muhammad In’am Imelda Dana Bella Ayu Fernanda Indwiani Astuti Indwiani Astuti Indwiani Astuti Joni T. Parinding Laili, Kharima Lestari, Desriani Mardhia, Mardhia Muhammad Afzalurrahman Putranda Muhammad Afzalurrahman Putranda Muhammad In&#039;am Ilmiawan Muhammad In’am Ilmiawan Muhammad In’am Ilmiawan Nabilah Nurul Fatinah Ninanda, Zahlah Nugraha, Muhammad Fikri Nur Arfian Nur Arfian Parinding, Joni T. Prastyan, Emika Putranda, Muhammad Afzalurrahman Rachma Greta Perdana Putri Rachma Greta Putri Rahmatania, Ridha Ridha Rahmatania Ridha Ulfah Risa Febriana Musawaris Saleha, Nurmukaromatis Salsabila, Tasya Sandy A.K., Risky Sari Rahmayanti Simangunsong, Glorie Hosiana Maria Sofia Mubarika Haryana Sonia Elshaddayana Sitompul Sri Nuryani Wahyuningrum Sri Nuryani Wahyuningrum Suhardiman, Eko Rustianto Tamara Septia Chairunisa Tri Wahyudi Trianto, Heru Fajar Triyana Harlia Putri Wahyudi, Dery Willy Handoko Yandion, Imanda